Predicting the hub interactome of COVID-19 and oral squamous cell carcinoma: uncovering ALDH-mediated Wnt/β-catenin pathway activation via salivary inflammatory proteins by Pradeep Kumar Yadalam, Deepavalli Arumuganainar, Prabhu Manickam Natarajan, Carlos M. Ardila

“…Abstract Understanding shared pathways and mechanisms involved in the pathogenesis of diseases like oral squamous cell carcinoma (OSCC) and COVID-19 could lead to the development of novel therapeutic strategies and diagnostic biomarkers. …”
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Celiac Artery Compression Syndrome: An Experience in a Single Institution in Taiwan by Jen-Wei Chou, Chih-Ming Lin, Chun-Lung Feng, Chun-Fu Ting, Ken-Sheng Cheng, Yung-Fang Chen

“…The clinical manifestations of CACS include the triad of postprandial pain, vomiting, and weight loss. The pathogenesis of CACS is the external compression of celiac artery by the MAL or celiac ganglion. …”
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Nanonization of ethanolic tulsi leaf extract and its major compound eugenol and evaluation of their inhibitory potential against calcium oxalate crystal (a kidney stone component) by Sourav Ghosh, Tarakdas Basu

“…Future in vivo pharmacological and toxicological studies will surely lead to the development of the TLE-NPs and ENPs as potential therapeutic agents against calcium oxalate pathogenesis.…”
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Insects Induced Mango Fruit Rot: Unraveling the Culprits by Sivagami Subramaniam, Noor Aisyah Md Noordin, Noor Azrizal-Wahid, Nur Ain Izzati Mohd Zainudin

“…They act as a threat to the crops through various mechanisms of pathogenesis that compromise the immune system of the plants, such as developing any ways to attack the plants, seeking entry via open pores or exposed surface or wound, and sourcing nutrients forcefully for their growth and development. …”
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Regenerative Medicine for Neurological Disorders by Dong-Hyuk Park, David J. Eve, Yong-Gu Chung, Paul R. Sanberg

“…The 16th ASNTR meeting focused on a variety of different topics, including the unknown pathogenesis or mechanisms of specific neurodegenerative diseases, stem cell biology, and development of novel alternative medicines or devices. …”
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Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro by Jingxuan Sun, Boyu Yuan, Yancheng Wu, Yuhong Gong, Wenjin Guo, Shoupeng Fu, Yongxin Luan, Wei Wang

“…Aβ plays an important role in the pathogenesis of AD. Sodium butyrate (NaB) is a short-chain fatty acid salt that exerts neuroprotective effects such as anti-inflammatory, antioxidant, antiapoptotic, and cognitive improvement in central nervous system diseases. …”
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Screening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence. by Raphael Adu-Gyamfi, Juliana Enos, Kwame Yeboah, Veronika Shabanova, Nicola Hawley, Deda Alangea Ogum, Adwoa Agyei Nkansah, Elijah Paintsil, Kwasi Torpey

“…The duration of exposure to the virus and antiretroviral drugs plays a vital role in the pathogenesis, putting perinatally infected children and adolescents at higher risk than behaviorally-infected ones, supporting the calls for increased surveillance of Hypertension among them. …”
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The antioxidant potential of bacoside and its derivatives in Alzheimer's disease: The molecular mechanistic paths and therapeutic prospects by Dipanjan Karati, Swarupananda Mukherjee, Souvik Roy

“…Extracellular beta-amyloid accumulation and intracellular tau hyperphosphorylation are two key characteristics of the pathogenesis of AD. Because of the multifactorial character of many disorders, new medicine-based psychoactive treatments have had limited success. …”
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Differences in the Antigens of Helicobacter pylori Strains Influence on the Innate Immune Response in the In Vitro Experiments by Miha Skvarc, Andreja Natasa Kopitar, Janko Kos, Natasa Obermajer, Bojan Tepes

“…The immune response to Helicobacter pylori importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria. …”
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The anti-sigma factor TcdC modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of Clostridium difficile. by Glen P Carter, Gillian R Douce, Revathi Govind, Pauline M Howarth, Kate E Mackin, Janice Spencer, Anthony M Buckley, Ana Antunes, Despina Kotsanas, Grant A Jenkin, Bruno Dupuy, Julian I Rood, Dena Lyras

“…These results have important implications for C. difficile pathogenesis and virulence since they suggest that strains carrying a similar mutation have the inherent potential to develop a hypervirulent phenotype.…”
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Value of Biochemical Indexes of Bone Metabolism in Predicting Osteoporotic Lumbar Fractures by Fen Feng, CiLa Zhou, Ping Huang, QiaoLin Zhu, Gang Wang, Bin Zhou

“…Moreover, the levels of P1NP, 25(OH)D, OSTEOC, and PTH are important factors affecting the pathogenesis of osteoporosis. The area under the curve (AUC) of fracture in patients with osteoporosis predicted by the combination of P1NP, 25(OH)D, OSTEOC, and PTH levels was 0.886, which was greater than the AUC predicted by each index (0.796, 0.753, 0.670, and 0.824). …”
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An autopsy case with tubular obstruction by impacted swollen blebs due to ischemic acute kidney injury by Yukako Akiyama, Mitsuhiro Sato, Yoshio Taguma

“…Conclusion Our distinct finding of bleb formation with tubular obstruction strongly indicates that blebbing could be related to the mechanism of oliguric AKI in human, which supports the tubular obstruction theory as a contributing factor to the pathogenesis of ischemic AKI.…”
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Bacteria Living in Biofilms in Fluids: Could Chemical Antibiofilm Pretreatment of Culture Represent a Paradigm Shift in Diagnostics? by Lorenzo Drago, Andrea Fidanza, Alessio Giannetti, Alessio Ciuffoletti, Giandomenico Logroscino, Carlo Luca Romanò

“…While other ongoing research continues to unveil the complexity of biofilm formation in biological fluids and its impact on infection pathogenesis and diagnosis, we here hypothesize that the routine use of a chemical antibiofilm pretreatment of fluid and semi-solid samples may lead to a paradigm shift in the microbiological approach to the diagnosis of biofilm-related infections and should be further investigated and eventually implemented in the clinical setting.…”
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Efficacy And Safety Of Low Dose Tofacitinib As Induction Therapy In Moderate To Severe Ulcerative Colitis: A Pilot Study by Sadia Ahmed, Muhammad Umar, Muhammad Kamran, Misbah Noureen, Iqra Ashraf, Javeria Khan

“… Objective: The Inflammatory cascade has been the root cause of ulcerative colitis's pathogenesis, and its treatment would centre upon reducing its intensity. …”
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Western diet promotes the progression of metabolic dysfunction‐associated steatotic liver disease in association with ferroptosis in male mice by Nicole Maddie, Nefia Chacko, David Matatov, Maria Alicia Carrillo‐Sepulveda

“…These findings suggest that ferroptosis is a potential mechanism involved in the pathogenesis of MASLD in male mice.…”
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Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression by Georgia Tsaouli, Elisabetta Ferretti, Diana Bellavia, Alessandra Vacca, Maria Pia Felli

“…By analyzing their relevant roles in the pathogenesis of the two ALL forms, new molecular mechanisms able to modulate cancer cell invasion may be visualized. …”
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Integrated Analysis of mRNA and lncRNA Expression Profiles Reveals Regulatory Networks Associated with Decompensated Cirrhosis by Li Zhang, Xiaoyu Fang, Suhua Wang, Shasha Ma, Jinyan Zhang, Xiang Dong, Jing Dai, Chuanmiao Liu, Yu Gao

“…In summary, this study identified differentially expressed mRNAs (DE-mRNAs) and DE-lncRNAs and predicted the biological processes and signaling pathways involved in cirrhotic decompensation, which might provide new ideas for further revealing the molecular mechanism of DCC pathogenesis.…”
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Diagnosis and treatment of the functional dyspepsia: clinical guidelines of the Russian Gastroenterological Association by V. T. Ivashkin, I. V. Mayev, A. A. Sheptulin, T. L. Lapina, A. S. Trukhmanov, I. M. Kartavenko, V. A. Kiprianis, O. Z. Okhlobystina

“…To present the modern concept on etiology and pathogenesis of functional dyspepsia (FD) to general practitioners, as well as with the accepted approach to diagnostics and treatment of this disease. …”
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Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain by Cui Yan Lu, De Xiang Liu, Hong Jiang, Fang Pan, Cyrus S. H. Ho, Roger C. M. Ho

“…We aimed to observe the role of GABAAR subunits changes induced by juvenile trauma in the pathogenesis of subsequent PTSD in adulthood. In addition, we investigated the protective effects of exercise for 6 weeks and benzodiazepine (clonazepam) for 2 weeks. …”
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Single-cell transcriptomes reveal cell-type-specific and sample-specific gene function in human cancer by Huating Yuan, Xin Liang, Xinxin Zhang, Yu Cao

“…Accurate annotation of gene function in individual samples and even in each cell type is essential for understanding the pathogenesis of cancers. Single-cell RNA-sequencing (scRNA-seq) provides unprecedented resolution to decipher gene function. …”
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