Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications by Mariam Rima, Mariam Dakramanji, Elie El Hayek, Tia El Khoury, Ziad Fajloun, Mohamad Rima

“…These nano-sized, membrane-encapsulated entities have captured substantial interest due to their diverse roles in pathogenesis and promising therapeutic applications. …”
Get full text

The Prognostic Role and Relationship between E2F1 and SV40 in Diffuse Large B-Cell Lymphoma of Egyptian Patients by Rehab M. Samaka, Hayam A. Aiad, Mona A. Kandil, Nancy Y. Asaad, Nanes S. Holah

“…Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphomas worldwide. The pathogenesis of lymphomas is not yet well understood. …”
Get full text

Serum Cytokines in Young Pediatric Patients with Congenital Cardiac Shunts and Altered Pulmonary Hemodynamics by Leína Zorzanelli, Nair Yukie Maeda, Mariana Meira Clavé, Vera Demarchi Aiello, Marlene Rabinovitch, Antonio Augusto Lopes

“…Inflammation is central in the pathogenesis of pulmonary hypertension. We investigated how serum cytokines correlate with clinical features, hemodynamics, and lung histology in young patients with pulmonary hypertension associated with congenital cardiac shunts. …”
Get full text

The association between urinary lead concentration and the likelihood of kidney stones in US adults: a population-based study by Dan Liang, Chang Liu, Mei Yang

“…However, further prospective clinical trials are needed to confirm the role of urine lead in the pathogenesis of kidney disease and to validate urine lead as a reliable predictor of kidney stone risk.…”
Get full text

Detection of reproducible liver cancer specific ligand-receptor signaling in blood by Aram Safrastyan, Aram Safrastyan, Damian Wollny, Damian Wollny, Damian Wollny

“…Additionally, a robust panel of 30 liver cancer-specific LRIs presents a bridge linking liver cancer pathogenesis to discernible blood markers. In summary, our approach shows the plausibility of detecting liver LRIs in blood and builds upon the biological understanding of cell-free transcriptomes.…”
Get full text

The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy by Eduardo Spinedi, Daniel P. Cardinali

“…Maturation of the luteinizing hormone-releasing hormone secretion pattern in girls in puberty is closely related to changes in the sleep-wake cycle and could have relevance in the pathogenesis of polycystic ovary syndrome. This review article focuses on two main issues in the polycystic ovary syndrome-metabolic syndrome phenotype development: (a) the impact of androgen excess on white adipose tissue function and (b) the possible efficacy of adjuvant melatonin therapy to improve the chronobiologic profile in polycystic ovary syndrome-metabolic syndrome individuals. …”
Get full text

Impact of controlled high-sucrose and high-fat diets on eosinophil recruitment and cytokine content in allergen-challenged mice. by Caroline M Percopo, Morgan McCullough, Ajinkya R Limkar, Kirk M Druey, Helene F Rosenberg

“…While obesity has been clearly recognized as contributing to metabolic syndrome and the pathogenesis of adult asthma, recent evidence has linked high sugar intake alone to an increased risk of developing asthma in childhood. …”
Get full text

Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-Acetylcysteine by Gang Chen, Jixin Shi, Zhigang Hu, Chunhua Hang

“…Cerebral inflammation plays an important role in the pathogenesis of secondary brain injury after TBI. However, it has not been investigated whether NAC modulates TBI-induced cerebral inflammatory response. …”
Get full text

What Is in the Field for Genetics and Epigenetics of Diabetic Neuropathy: The Role of MicroRNAs by V. Spallone, C. Ciccacci, A. Latini, P. Borgiani

“…Genetics may address these needs by providing genetic biomarkers of susceptibility, giving insights into pathogenesis, and shedding light on how to select possible responders to treatment. …”
Get full text

DNA Methyltransferase 3B Gene Promoter and Interleukin-1 Receptor Antagonist Polymorphisms in Childhood Immune Thrombocytopenia by Margarita Pesmatzoglou, Marilena Lourou, George N. Goulielmos, Eftichia Stiakaki

“…Although the etiology of ITP is unclear, in the pathogenesis of the disease, both environmental and genetic factors including polymorphisms of TNF-a, IL-10, and IL-4 genes have been suggested to be involved. …”
Get full text

Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study by Yijing Yang, Ying Deng, Ye Tian, Zhen Yao, Yasha Zhou, Ying Wang, Qinghua Peng, Jun Peng

“…To investigate the characteristics of blood in nonsyndromic retinitis pigmentosa (RP) and reveal the pathogenesis of blood cells involved in blood stasis in RP. …”
Get full text

Immunohistochemical Study of Expression of Cyclynd1 Expression in Invasive and Non-invasive Odontogenic Cysts by Najmeh Jafari, Seyed Hosein Tabatabaei, Raheleh Karimi

“…Conclusion: Based on the findings of this study، the high expression of this marker in odontogenic Keratocyst may signify its involvement in the pathogenesis and progression of this cyst in contrast to other cysts.…”
Get full text

Association between HMGB1 and COPD: A Systematic Review by Sebastiano Gangemi, Marco Casciaro, Giovanni Trapani, Sebastiano Quartuccio, Michele Navarra, Giovanni Pioggia, Egidio Imbalzano

“…This underlines the need for finding new molecular targets involved in disease pathogenesis in order to block pathology progression. …”
Get full text

Accumulation of Oxidized Low-Density Lipoprotein in Psoriatic Skin and Changes of Plasma Lipid Levels in Psoriatic Patients by Nilgun Solak Tekin, Ishak Ozel Tekin, Figen Barut, Emine Yilmaz Sipahi

“…Our purpose was to evaluate the plasma lipids and oxidized low-density lipoprotein accumulation in psoriatic skin lesion in order to ascertain the possible participation of oxidative stress and oxidative modification of lipids in pathogenesis of psoriasis. Methods. The study group included 84 patients with psoriasis, and 40 sex- and age-matched healthy volunteers. …”
Get full text

Keratoconus with two consecutive re-emergences: a case report by Peicheng Zhang, Yanchao Wu, Lixiao Ma, Dong Wang

“…Conclusions Keratoconus is a complex disorder with a multifaceted etiology and pathogenesis, including genetic, environmental, biomechanical, and cellular factors. …”
Get full text

Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis by Lijun Du, John J. Kim, Binrui Chen, Yawen Zhang, Hui Ren

“…Clustering of patients with FD in families highlights the role of genetic factors in the pathogenesis of FD. We performed a systematic review and meta-analysis to clarify the associations between specific gene polymorphisms and FD susceptibility. …”
Get full text

The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response by Liqian Zhu, Clinton Jones, Gaiping Zhang

“…Therefore, secondary signaling by PLC is implicated in the pathogenesis of numerous inflammatory diseases. This review provides an overview of our current knowledge on how PLC signaling regulates the macrophage-mediated inflammatory response.…”
Get full text

OZONE IMPROVES AUTOGENOUS GRAFT HEALING IN EXPERIMENTAL DIABETES MELLITUS: A MORPHOMETRIC AND IMMUNOHISTOCHEMICAL STUDY by Aysan Lektemür Alpan, Hülya Toker, Hatice Özer

“…Backround: Diabetes mellitus (DM) is a metabolic disorder which plays crucial role in the pathogenesis of periodontitis. Ozone have several actions such as antimicrobial ,immunostimulating, antihypoxic effects, and activates antioxidant enzymes and angiogenesisAim: The aim of this study is to investigate the effect of gaseous ozone on bone healing in diabetic rat calvarial defects treated with autogenous bone graft, morphometrically and immunohistochemically.Material and Methods: Diabetes was induced and critical size defects were created on rats. …”
Get full text

Invasion of Chicken Intestinal Cells Is Higher for <i>Enterococcus cecorum</i> Lesion Strains Compared to Cloacal Strains in an Organoid Model by Lonneke Vervelde, Thijs T. M. Manders, Samira Kammourieh, Jeanine Wiegel

“…Translocation and bacteremia are pivotal to the pathogenesis and clinical disease. Virulence typing to distinguish extra-intestinal disease of lesion from cloacal strains remains difficult. …”
Get full text

Lipopolysaccharide inhibits osteoblast formation and receptor activator of nuclear factor-κB ligand degradation via autophagy inhibition by Huaizhi Zhang, Jianhua Lin, Xu Chen, Jianhui Dai, Haibin Lin

“…Lipopolysaccharide (LPS) and Receptor Activator of Nuclear Factor-κB Ligand (RANKL) are the two important factors causing bone loss, which is an important pathogenesis for osteoporosis. However, the relationship between LPS and RANKL is not yet clear. …”
Get full text