Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis. by You Ao, Qing Lan, Tianhua Yu, Zhichao Wang, Jing Zhang

“…Rheumatoid arthritis (RA), a long-term autoinflammatory condition causing joint damage and deformities, involves a multifaceted pathogenesis with genetic, epigenetic, and immune factors, including early immune aging. …”
Get full text

The Diagnostic Significance of Coapplying a Rabeprazole Test with the SF-36 for Gastroesophageal Reflux Disease by Ying Chen, Feng Wang, Yuanxi Jiang, Chen Wang, Liwen Yao, Ping Wu, Yili Tong, Huihui Sun, Shuchang Xu

“…Due to the complicated pathogenesis and variations in clinical manifestations, there is still no true gold standard for GERD diagnosis, and it is still difficult to diagnose this disease in some patients. …”
Get full text

Histological Characterization of the Dicer1 Mutant Zebrafish Retina by Saeed Akhtar, Sarita Rani Patnaik, Rakesh Kotapati Raghupathy, Turki M. Al-Mubrad, John A. Craft, Xinhua Shu

“…DICER1 was recently shown to have another function of silencing the toxicity of Alu RNAs in retinal pigment epithelium (RPE) cells, which are involved in the pathogenesis of age related macular degeneration. In this study, we characterized a Dicer1 mutant fish line, which carries a nonsense mutation (W1457Ter) induced by N-ethyl-N-nitrosourea mutagenesis. …”
Get full text

Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women by Fatemeh Zovari, Hadi Parsian, Ali Bijani, Ameneh Moslemnezhad, Atena Shirzad

“…Oxidative stress in saliva plays a significant role in the pathogenesis of oral diseases. The aim of this study was to investigate the total antioxidant capacity and lipid peroxidation in the serum and saliva of premenopausal and postmenopausal women. …”
Get full text

Discovery and Validation of Potential Serum Biomarkers for Heart Failure by Untargeted Metabolomics by Guisheng Zhou, Junzhi Zhang, Hongli Guo, Xiaochao Hu, Yingzhuo Wang, Kunqun Shi, Tongtong Liu, Shengyan Yin, Huanhuan Liu, Chunling Liu, Shijia Liu

“…By identifying serum biomarkers and analyzing metabolic pathways, our study provided opportunities to enhance the understanding of the pathogenesis and early diagnosis of HF.…”
Get full text

Genotype-Phenotype Correlation in Patients with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency in Cuba by Tania Mayvel Espinosa Reyes, Teresa Collazo Mesa, Paulina Arasely Lantigua Cruz, Adriana Agramonte Machado, Emma Domínguez Alonso, Henrik Falhammar

“…The CYP21A2 gene was analyzed for the presence of 5 point mutations involved in the pathogenesis of 21OHD (intron 2, deletion of 8bp, I172N, P30L, and Q318X); correlation was sought between the phenotypic characteristics and the frequencies of point mutations in the patients using the Spearman test. …”
Get full text

Virological Mechanisms in the Coinfection between HIV and HCV by Maria Carla Liberto, Emilia Zicca, Grazia Pavia, Angela Quirino, Nadia Marascio, Carlo Torti, Alfredo Focà

“…Due to shared transmission routes, coinfection with Hepatitis C Virus (HCV) is common in patients infected by Human Immunodeficiency Virus (HIV). The immune-pathogenesis of liver disease in HIV/HCV coinfected patients is a multifactorial process. …”
Get full text

Risk factors for diabetic retinopathy: a case-control study by Pratiksha Nathani, Pratik R. Kharat, Satish Wadde

“…The objective of the investigation is to identify the primary diabetes mellitus (DM) risk factors and the amount by which they influence diabetes pathogenesis. Methods The outpatient and inpatient departments participated in a matched research study. …”
Get full text

Successful treatment of rosacea by trephination combined with photodynamic therapy: A case report by YunMi Qiu, Ping Yang, Xingyun Zhao, Yingzhi Luo, Liming Wu, Jianbo Zhong

“…It presents with erythema, phymatous changes, papules, pustules, and telangiectasia. The pathogenesis of rosacea is still unknown. Patients often suffer from multiple symptoms of rosacea, requiring more precise assessments and individualized therapies [2]. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has shown promise as a safe and effective treatment for rosacea [3], especially in patients with multiple subtypes. …”
Get full text

Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors by Heng Zheng, Yong Pan

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract, with c-kit and PDGFRA mutations being the primary causes. However, GIST pathogenesis is not still fully understood. Differential expression analysis, Univariate Cox regression and Kaplan-Meier curves were utilized to screen for up-regulated and prognostically relevant genes. …”
Get full text

Closure of Full-thickness Macular Hole after Pars Plana Vitrectomy (23G) with Cataract Phacoemulsification, Artificial Intraocular Lens Implantation, and Silicone Oil Administratio... by Maria Stec, Mikołaj Kuźniak, Sebastian Sirek

“…This case study contributes to the evolving understanding of macular hole pathogenesis and reinforces the significance of tailored surgical approaches for optimal patient outcomes.…”
Get full text

ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis by Jing Bao, Bin Ye, Yuhan Ren

“…However, the roles of ABIN1 in ulcerative colitis pathogenesis remain unclear. Methods. The mRNA and protein expression level of ABIN1 and necroptosis-associated genes (RIPK1, RIPK3, and MLKL) were conducted to investigate the relationship between ABIN1 and necroptosis in clinical UC specimens. …”
Get full text

MicroRNA-4735-3p Facilitates Ferroptosis in Clear Cell Renal Cell Carcinoma by Targeting SLC40A1 by Cairong Zhu, Zhiquan Song, Zhen Chen, Tianqi Lin, Haili Lin, Zhenqiang Xu, Fen Ai, Shijiao Zheng

“…Clear cell renal cell carcinoma (ccRCC) is the major histopathological subtype of renal cancer, and ferroptosis is implicated in the pathogenesis of ccRCC. The present study was aimed at investigating the role and underlying mechanisms of microRNA-4735-3p (miR-4735-3p) in ccRCC. …”
Get full text

Oral Tolerance: A New Tool for the Treatment of Gastrointestinal Inflammatory Disorders and Liver-Directed Gene Therapy by Yaron Ilan

“…Inflammatory bowel diseases are immune-mediated disorders where an imbalance between proinflammatory (T helper cell type 1) and anti-inflammatory (T helper cell type 2) cytokines are thought to play a role in the pathogenesis. In the experimental colitis model, the feeding of colitis-extracted proteins downregulated the anticolon immune response. …”
Get full text

Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes by Baobing Zhao, Hui Liu, Yang Mei, Yijie Liu, Xu Han, Jing Yang, Amittha Wickrema, Peng Ji

“…Our results reveal developmentally conserved nuclear envelop and histone dynamic changes in human terminal erythropoiesis and indicate that disruption of the histone release process plays a critical role in the pathogenesis of dyserythropoiesis in MDS.…”
Get full text

The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review by Blake Collie, Jacopo Troisi, Martina Lombardi, Steven Symes, Sean Richards

“…Despite this condition being very common, the pathogenesis is not well understood. Metabolomics is the study of the array of low-weight metabolites in a given sample. …”
Get full text

Transition of Thyroid Autoantibodies by Rituximab Treatment in Women with Rheumatoid Arthritis by Hüseyin Demirci, Ebru Aydoğan, Bilge Ceydilek

“…To understand the effect of rituximab treatment on the pathogenesis of Hashimoto's disease further studies involving a large series is required.…”
Get full text

Pharmacological Correction of Stress-Induced Gastric Ulceration by Novel Small-Molecule Agents with Antioxidant Profile by Konstantin V. Kudryavtsev, Anna O. Markevich, Oleksandr V. Virchenko, Tetyana M. Falalyeyeva, Tetyana V. Beregova, Lyudmyla I. Ostapchenko, Dmitry V. Zabolotnev, Nikolay S. Zefirov

“…This study was designed to determine novel small-molecule agents influencing the pathogenesis of gastric lesions induced by stress. To achieve this goal, four novel organic compounds containing structural fragments with known antioxidant activity were synthesized, characterized by physicochemical methods, and evaluated in vivo at water immersion restraint conditions. …”
Get full text

Enhanced detection of chronic wasting disease in muscle tissue harvested from infected white-tailed deer employing combined prion amplification assays. by Caitlyn N Kraft, David W Bissinger, Erin E McNulty, Nathaniel D Denkers, Candace K Mathiason

“…These findings further demonstrate the utility of amplification assays as tools to detect very low levels of prion burden and supports their use to fill knowledge gaps in our understanding of CWD pathogenesis and zoonotic potential.…”
Get full text

C/EBPβ in Alzheimer’s disease: An integrative regulator of pathological mechanisms by Xiaoting Luo, Junyi Liang, Xue Lei, Fengqi Sun, Minghai Gong, Bin Liu, Zhongguang Zhou

“…This review systematically explores the multifaceted roles of C/EBPβ in the pathogenesis of AD, delving into its crucial involvement in neuroinflammation, Aβ production, tau pathology, and lipid metabolism dysregulation. …”
Get full text