Assessment of soil erosion and sediment yield in response to land use and land cover changes using geospatial techniques in Dumuga Watershed, Ethiopia by Zenebe Reta Roba, Mitiku Badasa Moisa, Sanju Purohit, Kiros Tsegay Deribew, Dessalegn Obsi Gemeda

“…The area classified under very severe erosion has increased from 41.0% to 54.1%, directly correlating with a rise in sediment yield. …”
Get full text

CPK1 activates CNGCs through phosphorylation for Ca2+ signaling to promote root hair growth in Arabidopsis by Meijun Zhu, Bo-Ya Du, Yan-Qiu Tan, Yang Yang, Yang Zhang, Yong-Fei Wang

“…We report here that calcium dependent protein kinase 1 (CPK1) directly activates CNGC5/6/9 to promote Arabidopsis RH growth. …”
Get full text

Naked-Eye Molecular Testing for the Detection of <i>Xylella fastidiosa</i> in Mallorca (Balearic Island) Almond Orchards by Colorimetric LAMP by Amoia Serafina Serena, Ana Falcón-Piñeiro, Milica Pastar, José Manuel Garcìa-Madero, Nicoletta Contaldo, Mikael Muegge, Stéphane Compant, Pasquale Saldarelli, Angelantonio Minafra

“…This study shows the potential of the cLAMP application as a rapid and low-cost point-of-care diagnostic method for the timely monitoring of <i>Xf</i> directly in the field.…”
Get full text

PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway by Xiangyu Kong, Ganghao Ai, Dai Wang, Renzhen Chen, Dongbei Guo, Youliang Yao, Kai Wang, Guiye Liang, Fengjie Qi, Wenzhi Liu, Yongxing Zhang

“…To assess the expression levels of exchange protein 1 directly activated by cAMP (Epac1) and phosphodiesterase 4 (PDE4) in rectal carcinoma, and their associations with clinicopathological indexes. …”
Get full text

Water remediation and antibacterial characteristics of CdO, graphene oxide and reduced graphene oxide blended CdO nanoparticles – A comparative study by N. Manjula, A.R. Balu, N. Arunkumar, S. Chitra Devi, M. Sriramraj, V. Rajamani, A. Vinith

“…CO, GCO, and rCO all have a cubic crystal structure and tend to grow in a (1 1 1) direction. The scanning electron micrographs showed that the grains were evenly distributed. …”
Get full text

Validating a UK Geomagnetically Induced Current Model Using Differential Magnetometer Measurements by J. Hübert, C. D. Beggan, G. S. Richardson, N. Gomez‐Perez, A. Collins, A. W. P. Thomson

“…The DMM includes the installation of two fluxgate magnetometers, one directly under a power line affected by GICs, and one as a remote site. …”
Get full text

The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer by Wanli Ge, Lingdong Meng, Shouji Cao, Chaoqun Hou, Xiaole Zhu, Dongya Huang, Qiang Li, Yunpeng Peng, Kuirong Jiang

“…According to ChIP assays, SIX1 directly binds to the LDHA promoter region. Moreover, LDHA inhibitor and lactate transporter blocker treatment promoted the function of NK cells cocultured with PC cells. …”
Get full text

Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation by Mohammad Alhashmi, Abdulrahman M. E. Gremida, Santosh K. Maharana, Marco Antonaci, Amy Kerr, Shijian Fu, Sharna Lunn, David A. Turner, Noor A. Al-Maslamani, Ke Liu, Maria M. Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N. Wheeler, Robert J. van ‘t Hof, George Bou-Gharios, Kazuhiro Yamamoto

“…Mechanistically, we show that LRP1 regulates core non-canonical Wnt/planar cell polarity (PCP) components that may explain the malformation of long bones. LRP1 directly binds to Wnt5a, facilitates its cell-association and endocytic degradation and recycling. …”
Get full text

Sex estimation in a Chilean population by mandibular analysis in cone beam computed tomography images by F. Ceballos, N.F. Deana, N. Alves

“…When each mandibular measurement was analysed separately, the maximum height of the mandibular ramus presented the greatest predictive power (76.5%), while the mandibular angle was the least accurate parameter for sex estimation (58.1%). Direct method analysis presented 87.1% accuracy for sex identification of adult Chilean individuals, and joint analysis of maximum mandibular ramus height (MRH), corono-condylar distance and bigonial breadth presented 86.5% accuracy. …”
Get full text

Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells by Sara Giovannini, Yanan Li, Rosalba Pecorari, Claudia Fierro, Claudia Fiorilli, Federica Corigliano, Valeria Moriconi, Ji Zhou, Anna De Antoni, Artem Smirnov, Sara Rinalducci, Anna Maria Timperio, Massimiliano Agostini, Jinping Zhang, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

“…Here, we found that WWP1 directly interacts with TXNIP, thus promoting its ubiquitin‐dependent proteasomal proteolysis. …”
Get full text

All-Trans Retinoic Acid Inhibits Bone Marrow Mesenchymal Stem Cell Commitment to Adipocytes via Upregulating FRA1 Signaling by Linjun Xie, Liying Zou, Jie Chen, Youxue Liu

“…Chromatin immunoprecipitation showed that RARG directly regulates Fra1 and FRA1 directly regulates Pparg2 and Cebpa. The results supported the conclusion that atRA inhibits BMSC adipogenesis partially through the RARG-FRA1-PPARG2 or the CEBPA axis or both. …”
Get full text

Classification of State Regulation Principles in the Field of Air Transport by O. V. Brusakova

“…It has been offered to classify these principles according to the following criteria: 1) direction of state regulation (in the field of air transport, in the field of airports and civil airfields activities, in the field of using aircraft, in the sphere of organization of air traffic and airspace, in the field of ensuring public order and safety in air transport, in the field of training aviation personnel); 2) scope of activity (general and special). …”
Get full text

Template jCEC by Editorial Team jCEC

“…You can register for one directly from your user account on  https://ORCID.org/register.  …”
Get full text

LAMB1 promotes proliferation and metastasis in nasopharyngeal carcinoma and shapes the immune-suppressive tumor microenvironment by Enzi Feng, Xinyu Yang, Jie Yang, Qianqian Qu, Xiaojiang Li

“…But at low level of fibroblasts, LAMB1 directly suppressed immune response. Tumors with high LAMB1 level had weak responses to immunotherapy. …”
Get full text

GENDER GENEALOGY OF READING AS CULTURAL PRACTICE by N. Yu. Kryvda, L. V. Osadcha

“…The paper considered the typology of human intellectual conditions according to Kant’s divided into pure and practical reason. The last one directs action-willed individual efforts so as to meet the universal relevance and ethical coherence. …”
Get full text

Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders by Jeffrey A Meyerhardt, Sunil Kumar, Jessica A Zerillo, Aparna Parikh, James M Cleary, Scott Rodig, Benjamin Schlechter, Kimmie Ng, Stephanie K Dougan, Nora Horick, Glenn J Hanna, Andrew L Coveler, Anuj K Patel, Nadine J McCleary, Douglas A Rubinson, Jeffrey W Clark, Kent Mouw, Kathleen Pfaff, Thomas A Abrams, Matthew B Yurgelun, Eliezer M Van Allen, S Jennifer Wang, Leah H Biller, Harshabad Singh, Emma L Welsh, Brandon M Huffman, Lestat R Ali, Megan T Hoffman, Katherine A Metayer, Shayla Murray, Alexandra Bird, Jennifer A Chan, Wolfram Goessling, Jeffrey S Wisch, Brendan Reardon, Robert J Mayer, Catherine Del Vecchio Fitz, Charlotte Kuperwasser

“…Background Recent trials suggest that programmed cell death 1 (PD-1)-directed immunotherapy may be beneficial for some patients with anal squamous cell carcinoma and biomarkers predictive of response are greatly needed.Methods This multicenter phase II clinical trial (NCT02919969) enrolled patients with metastatic or locally advanced incurable anal squamous cell carcinoma (n=32). …”
Get full text

The mental health impacts of the COVID-19 pandemic among individuals with depressive, anxiety, and stressor-related disorders: A scoping review. by Christine M Wickens, Veda Popal, Venesa Fecteau, Courtney Amoroso, Gina Stoduto, Terri Rodak, Lily Y Li, Amanda Hartford, Samantha Wells, Tara Elton-Marshall, Hayley A Hamilton, Graham W Taylor, Kristina L Kupferschmidt, Branka Agic

“…<h4>Eligibility criteria</h4>(1) direct study of individuals with pre-existing depressive, anxiety, and/or specified stressor-related (i.e., posttraumatic stress, acute stress) disorders/issues; (2) focus on mental health-related pandemic effects, and; (3) direct study of mental health symptoms related to depression, anxiety, or psychological distress.…”
Get full text

Microbial-Induced Carbonate Precipitation for Strengthening Soft Clay by J. Z. Xiao, Y. Q. Wei, H. Cai, Z. W. Wang, T. Yang, Q. H. Wang, S. F. Wu

“…The results are as follows: (1) directly mixing a S. pasteurii solution, nutrient salts, and soft clay considerably improves the uniformity of the spatial distribution of the bacteria and the nutrients in the soft clay. …”
Get full text

Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11 by Ling Li, Manzhi Zhao, Marjan van Meurs, Inge Brouwers-Haspels, Renske J. H. den Dekker, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Shringar Rao, Casper Rokx, Yvonne M. Mueller, Peter D. Katsikis

“…Therefore, we further investigated how bryostatin-1 directly impacts exhausted CD8+ T cells.MethodsPBMCs from people with HIV (PWH) were treated with bryostatin-1 and tracked with proliferation dye for cell expansion. …”
Get full text

Collagenolytic activity of conjunctival fluid in healthy people and patients with aseptic ulcer of the cornea of various etiologies by Brzheskaya I.V., Somov E.E

“…<br> An integral evaluation of the collagenolytic activity of the conjunctival fluid was made by estimating the drying rate of its mixture with collagen gel in a ratio of 1:1, directly dependent on the activity of the proteolytic enzymes contained in it.…”
Get full text