Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine by Marina Agueda-Oyarzabal, Marie S. Isidor, Kaja Plucińska, Lars R. Ingerslev, Oksana Dmytriyeva, Patricia S.S. Petersen, Sara Laftih, Axel B. Pontoppidan, Jo B. Henningsen, Kaja Rupar, Erin L. Brown, Thue W. Schwartz, Romain Barrès, Zachary Gerhart-Hines, Camilla C. Schéele, Brice Emanuelli

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Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat by Caroline E. Rasmussen, Jette Nowak, Julie M. Larsen, Emma Moore, David Bell, Kai Chiu Liu, Nanna Skall Sorensen, Wendela A. Kappers, Thomas Krogh-Meibom, Hanne Offenberg

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A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs by Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen, Paolo Arosio

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Pangenome mining of the Streptomyces genus redefines species’ biosynthetic potential by Omkar S. Mohite, Tue S. Jørgensen, Thomas J. Booth, Pep Charusanti, Patrick V. Phaneuf, Tilmann Weber, Bernhard O. Palsson

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Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescentsResearch in context by Yun Huang, Sara Elizabeth Stinson, Malte Thodberg, Louise Aas Holm, Roman Thielemann, Karolina Sulek, Morten Asp Vonsild Lund, Cilius Esmann Fonvig, Min Kim, Kajetan Trost, Helene Bæk Juel, Trine Nielsen, Peter Rossing, Maja Thiele, Aleksander Krag, Cristina Legido-Quigley, Jens-Christian Holm, Torben Hansen

“…Interpretation: These findings highlight the potential long-term implications of plasma lipid genetic determinants on cardiometabolic risk. Funding: Novo Nordisk Foundation, The Innovation Fund Denmark, The Danish Heart Foundation, EU Horizon, and LundbeckFonden.…”
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Metagenome-guided culturomics for the targeted enrichment of gut microbes by Jeremy Armetta, Simone S. Li, Troels Holger Vaaben, Ruben Vazquez-Uribe, Morten O. A. Sommer

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Accurate phenotype-to-genotype mapping of high-diversity yeast libraries by heat-shock-electroporation (HEEL) by Marcus Wäneskog, Emma Elise Hoch-Schneider, Shilpa Garg, Christian Kronborg Cantalapiedra, Elena Schäfer, Michael Krogh Jensen, Emil Damgaard Jensen

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Deep learning to decode sites of RNA translation in normal and cancerous tissues by Jim Clauwaert, Zahra McVey, Ramneek Gupta, Ian Yannuzzi, Venkatesha Basrur, Alexey I. Nesvizhskii, Gerben Menschaert, John R. Prensner

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Salivary proteomics and metaproteomics identifies distinct molecular and taxonomic signatures of type-2 diabetes by Diana Samodova, Evelina Stankevic, Mathilde Sonne Søndergaard, Naiyu Hu, Tarunveer S. Ahluwalia, Daniel R. Witte, Daniel Belstrøm, Anniek Frederike Lubberding, Pratik D. Jagtap, Torben Hansen, Atul S. Deshmukh

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getphylo: rapid and automatic generation of multi-locus phylogenetic trees by T. J. Booth, S. Shaw, P. Cruz-Morales, T. Weber

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Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma by Sonja Kabatnik, Xiang Zheng, Georgios Pappas, Sophia Steigerwald, Matthew P. Padula, Matthias Mann

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Awareness and Perceptions towards the Role of Systemic Inflammation and High-Sensitivity C-reactive Protein as a Biomarker in Atherosclerotic Cardiovascular Disease and Chronic Kid... by Nikolaus Marx, Issei Komuro, Preethy Prasad, Juying Qian, José Francisco Kerr Saraiva, Amir Abbas Mohseni Zonoozi, Abhijit Shete, Alberico L. Catapano

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Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohn's Disease by Thomas Lindebo Holm, Steen Seier Poulsen, Helle Markholst, Stine Reedtz-Runge

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Unraveling the impact of SARS-CoV-2 mutations on immunity: insights from innate immune recognition to antibody and T cell responses by Rafael Bayarri-Olmos, Rafael Bayarri-Olmos, Adrian Sutta, Adrian Sutta, Anne Rosbjerg, Anne Rosbjerg, Mie Mandal Mortensen, Charlotte Helgstrand, Per Franklin Nielsen, Laura Pérez-Alós, Beatriz González-García, Laust Bruun Johnsen, Finn Matthiesen, Thomas Egebjerg, Cecilie Bo Hansen, Alessandro Sette, Alessandro Sette, Alba Grifoni, Ricardo da Silva Antunes, Peter Garred, Peter Garred

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Development of a Novel Algorithm to Identify People with High Likelihood of Adult Growth Hormone Deficiency in a US Healthcare Claims Database by Kevin C. J. Yuen, Anna Camilla Birkegard, Lewis S. Blevins, David R. Clemmons, Andrew R. Hoffman, Nicky Kelepouris, Janice M. Kerr, Jens M. Tarp, Maria Fleseriu

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Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes by Laura J. Andreasen, Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, Thorbjorn Akerstrom

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Efficacy in Japanese adults with growth hormone deficiency receiving weekly somapacitan or daily growth hormone: results from phase 3 REAL 1 trial by Fumio Otsuka, Michael Højby Rasmussen, Takaaki Endo, Claus Sværke, Shigeyuki Tahara, Gudmundur Johannsson

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Engineered Passive Glucose Uptake in Pseudomonas taiwanensis VLB120 Increases Resource Efficiency for Bioproduction by Tobias Schwanemann, Nicolas Krink, Pablo I. Nikel, Benedikt Wynands, Nick Wierckx

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JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression by Michala Prause, Christopher Michael Mayer, Caroline Brorsson, Klaus Stensgaard Frederiksen, Nils Billestrup, Joachim Størling, Thomas Mandrup-Poulsen

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Engineering a phi15-based expression system for stringent gene expression in Pseudomonas putida by Eveline-Marie Lammens, Daniel C. Volke, Alison Kerremans, Yannick Aerts, Maarten Boon, Pablo I. Nikel, Rob Lavigne

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