Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells by Mariia Mikhova, Noah J. Goff, Tomáš Janovič, Joshua R. Heyza, Katheryn Meek, Jens C. Schmidt

“…Abstract Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-stranded breaks (DSBs) in vertebrates. …”
Get full text

PIPKIγ promotes non-homologous end joining through LIG4 to enhance radiotherapy resistance in triple-negative breast cancer by Wenge Dong, Haiping Zhang, Zhigang Zhuang, Ying Jiang

Get full text

A nonsense mutation of human XRCC4 is associated with adult‐onset progressive encephalocardiomyopathy by Leonardo Bee, Alessia Nasca, Alice Zanolini, Filippo Cendron, Pio d'Adamo, Rodolfo Costa, Costanza Lamperti, Lucia Celotti, Daniele Ghezzi, Massimo Zeviani

“…XRCC4 plays an important role in non‐homologous end joining of DNA double‐strand breaks (DSB), a system that is involved in repairing DNA damage from, for example, ionizing radiations. …”
Get full text

H1N76/77 deamidation facilitates chromatin remodelling and genome stability during DNA damage repair by Tingting Feng, Mengyan Li, Chenmiao Hu, Yuan Tian, Wei‐Guo Zhu

“…This sequential modification‐H1 deamidation followed by acetylation‐facilitates the recruitment of repair factors involving both homologous recombination and non‐homologous end joining repair pathways, and consequently promoting DNA repair. …”
Get full text

Identifying new targets for improving terpenoid biosynthesis in Yarrowia lipolytica through random genomic cytosine base editing by Zhenxia Li, Bo Liu, Rongtao Lv, Zhe Sun, QingYan Li, XueLi Zhang

“…Despite the application of non-homologous end joining (NHEJ)-mediated genome editing in Yarrowia lipolytica, the development of alternative genome-wide mutagenesis strategies remains unexplored in this industrially relevant oleaginous yeast. …”
Get full text

Tumor treating fields combined with ionizing radiation inhibit the malignant phenotype of lung cancer brain metastasis cells by suppressing DNA damage repair pathways by Guilong Tanzhu, Haiqin Peng, Liu Chen, Gang Xiao, Jiaoyang Ning, Ling Chen, Rongrong Zhou

“…TTFields combined with IR exhibited significant suppression on homologous recombination (HR) markers (p-ATM, RAD51), non-homologous end joining (NHEJ) components (DNA-PKcs, KU70, KU80), and microhomology-mediated end joining (MMEJ) effectors (PARP1, p95-NBS1) versus RT alone. …”
Get full text