PPARs and Xenobiotic-Induced Adverse Effects: Relevance to Human Health by Christopher Lau, Barbara D. Abbott, J. Christopher Corton, Michael L. Cunningham

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Editorial: World antimicrobial awareness week by Dalal Hammoudi Halat, Issmat I. Kassem, Marwan Osman, Vera Manageiro, Vera Manageiro, Vera Manageiro

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Automated characterisation of cerebral microbleeds using their size and spatial distribution on brain MRI by Vaanathi Sundaresan, Giovanna Zamboni, Robert A. Dineen, Dorothee P. Auer, Stamatios N. Sotiropoulos, Nikola Sprigg, Mark Jenkinson, Ludovica Griffanti

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Role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review by Claire Goodman, Tom Dening, Neil H Chadborn, Maria Zubair, Lídia Sousa, John R F Gladman, Adam, L Gordon

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Effect of chronic restraint stress on body weight of male Sprague Dawley rats by Sadia Moazzam, Irfan Afzal Mughal, Noor Ul Ain Irfan, Ilqa Attique, Fareeha Zaheer, Asma Irfan

“…Study design:  Experimental     Materials and Methods:  The study was conducted in  National  Institute  of  Health  (NIH),  Islamabad Sixty male Sprague Dawley rats (mean wt 250 ± 50 grams) were used and divided into 2 groups.   …”
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Erratum to “An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population” by Miira Klemetti, Leena M. Hiltunen, Sanna Heino, Seppo Heinonen, Eero Kajantie, Hannele Laivuori

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SPIRIT-DEFINE explanation and elaboration: recommendations for enhancing quality and impact of early phase dose-finding clinical trials protocolsResearch in context by Moreno Ursino, Guillermo Villacampa, Jan Rekowski, Munyaradzi Dimairo, Olga Solovyeva, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Thomas R. Jeffry Evans, Elizabeth Garrett-Mayer, Robert M. Golub, Christina Guo, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Adrian Mander, Lynley V. Marshall, James Matcham, Dhrusti Patel, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka, Christopher J. Weir, Johann de Bono, Christina Yap

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Error-Prone Translesion DNA Synthesis by Escherichia coli DNA Polymerase IV (DinB) on Templates Containing 1,2-dihydro-2-oxoadenine by Masaki Hori, Shin-Ichiro Yonekura, Takehiko Nohmi, Petr Gruz, Hiroshi Sugiyama, Shuji Yonei, Qiu-Mei Zhang-Akiyama

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Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial by David Coyle, Paula Ormandy, Nancy Fernandes da Silva, Simon Davies

“…Funding This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number 14/216/01. …”
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History of the Organisation for Economic Co-operation and Development (OECD) test guidelines for non-animal test methods in Japan by Hajime Kojima

“…Within the TGs, the National Institute of Health Sciences (NIHS) has standardized 16 OECD TGs for human health, implemented four major revisions, and developed one test method for the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) S10 guidelines on photosafety. …”
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Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant by Patsy R Tomlinson, Rachel G Knox, Olga Perisic, Helen Su, Gemma V Brierley, Roger L Williams, Robert K Semple

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Longitudinal associations between air pollution and incident dementia as mediated by MRI-measured brain volumes in the UK Biobank by Rhiannon Thompson, Xinning Tong, Xueyi Shen, Jinjun Ran, Shengzhi Sun, Xiaoxin Iris Yao, Chen Shen

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A Digital Tool for Clinical Evidence–Driven Guideline Development by Studying Properties of Trial Eligible and Ineligible Populations: Development and Usability Study by Shahzad Mumtaz, Megan McMinn, Christian Cole, Chuang Gao, Christopher Hall, Magalie Guignard-Duff, Huayi Huang, David A McAllister, Daniel R Morales, Emily Jefferson, Bruce Guthrie

“…Guideline developers from the National Institute for Health and Care Excellence and the Scottish Intercollegiate Guidelines Network provided positive feedback on the tool. …”
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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2 by Brigitta Buttari, Antonella Tramutola, Ana I. Rojo, Niki Chondrogianni, Sarmistha Saha, Alessandra Berry, Letizia Giona, Joana P. Miranda, Elisabetta Profumo, Sergio Davinelli, Andreas Daiber, Antonio Cuadrado, Fabio Di Domenico

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Diagnostic and therapeutic recommendations in pancreatic ductal adenocarcinoma. Recommendations of the Working Group of the Polish Pancreatic Club by Katarzyna Winter, Renata Talar-Wojnarowska, Andrzej Dąbrowski, Małgorzata Degowska, Marek Durlik, Anita Gąsiorowska, Stanisław Głuszek, Grażyna Jurkowska, Aleksandra Kaczka, Paweł Lampe, Tomasz Marek, Anna Nasierowska-Guttmejer, Ewa Nowakowska-Duława, Grażyna Rydzewska, Janusz Strzelczyk, Zbigniew Śledziński, Ewa Małecka-Panas

“…A vast majority of the statements are based on data obtained in clinical studies and experts’ recommendations on PDAC management, including the following guidelines: International Association of Pancreatology/European Pancreatic Club (IAP/EPC), American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), National Comprehensive Cancer Network (NCCN) and Polish Society of Gastroenterology (PSG) and The National Institute for Health and Care Excellence (NICE). All recommendations were voted on by members of the Working Group of the Polish Pancreatic Club. …”
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Development of malaria diagnosis with convolutional neural network architectures: a CNN-based software for accurate cell image analysis. by Emrah ASLAN

“…The studies were carried out using the Malaria Dataset supplied by the National Institute of Health (NIH), and our proposed architecture was shown to function with 99.12% accuracy. …”
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Chronic Q Fever with No Elevation of Inflammatory Markers: A Case Report by Matteo Boattini, André Almeida, Rita Barata Moura, João Abreu, Ana Sofia Santos, Miguel Toscano Rico

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Development of a Recombinant Fusion Vaccine Candidate Against Lethal <i>Clostridium botulinum</i> Neurotoxin Types A and B by Eun-Sun Choi, Seong-Wook Pyo, So-Hyeon Kim, Jun-Ho Jeon, Gi-Eun Rhie, Mi-Ran Yun, Hwajung Yi, Yoon-Seok Chung

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Visual Mapping of Operating Theater Team Dynamics and Communication for Reflexive Feedback and Surgical Practice Optimization by Surya Surendran, MA, Candice Bonaconsa, MSc, Vrinda Nampoothiri, PharmD, Oluchi Mbamalu, PhD, Anu George, PGDip, Swetha Mallick, MCh, Sudheer OV, MCh, Alison Holmes, MD, Marc Mendelson, PhD, Sanjeev Singh, PhD, Gabriel Birgand, PhD, Esmita Charani, PhD

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Language and Cognitive Behavioural Therapy Practice Paper-Literature Review and Case Example by Satwant Singh

“…CBT is one of the recommended therapies by National Institute of Health and Clinical Excellence (NICE) for the treatment of depression and anxiety disorders. …”
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