Cerebral arterial collateral status, but not venous outflow profiles, modifies the effect of intravenous tissue plasminogen activator in acute ischemic stroke by Elif Sarionder Gencer, Ezgi Yilmaz, Ethem Murat Arsava, Rahsan Gocmen, Mehmet Akif Topcuoglu

“…Exploratory logistic models for response to IV-tPA [positive response: National Institutes of Health Stroke Scale (NIHSS) decrease 4 (or decrease to 0) at 24 h; dramatic response: NIHSS decrease ≥8 (or decrease to 0 or 1)], functional outcome (modified Rankin’s score 0–1 as “excellent” and 0–2 “good”) and tPA-associated hemorrhagic transformation were constructed. …”
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Importance of infarct topography in determination of stroke mechanism and recurrence risk: a post-hoc analysis of the dabigatran acute treatment of stroke trial by Michael D Hill, Ken Butcher, Kelvin Ng, Mukul Sharma, Shelagh B Coutts, Brian H Buck, Thalia Field, Erol Cimen, Laura C Gioia, Jodi Miller, Oscar R Benavente

“…Stroke mechanism was determined by traditional and modified (based on DWI lesion findings) Trial of Org 10 172 in Acute Stroke Treatment (TOAST) criteria (DWI-TOAST).Setting Multicentre (6) tertiary acute stroke treatment hospitals.Participants 305 adults with minor ischaemic stroke (National Institutes of Health Stroke Scale (NIHSS) score≤9).Results Of 305 patients, 148 had embolic pattern infarcts, 93 were isolated small subcortical infarcts and 64 had no infarct on baseline MRI (TIA). …”
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Thrombolysis, time-to-treatment and in-hospital outcomes among young adults with ischaemic stroke in China: findings from a nationwide registry study in China by Yong-Jun Wang, Xin Yang, Qi Zhou, Hao Li, Xia Meng, Yong Jiang, Li-Ping Liu, Yi-long Wang, Hong-Qiu Gu, Zi-Xiao Li, Xing-Quan Zhao, Chun-Juan Wang, Chelsea Liu, Hai-yan Wang, Ying-Yu Jiang

“…Compared with older adults, young adults treated with IV tPA had lower odds of in-hospital mortality (0.5% vs 1.3%, aOR 0.54, 95% CI 0.35 to 0.82) and higher odds of independent ambulation at discharge (61.0% vs 53.6%, aOR 1.15, 95% CI 1.08 to 1.22), and the associations may be partly explained by stroke severity measured by the National Institutes of Health Stroke Scale score.Conclusion Young adults with AIS were more likely to receive IV tPA than older adults, although there was no difference between the two groups in time to treatment. …”
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Oxygenation targets for endovascular therapy in acute ischemic stroke patients (Oxy-TARGET): protocol for a single-centre, open-label randomised controlled trial by Anxin Wang, Zhengfang Hu, Ruquan Han, Fa Liang, Youxuan Wu, Minyu Jian, Xinyan Wang, Yunzhen Wang, Haiyang Liu, Xuan Hou, Kangda Zhang, Zihui Zhang

“…The primary outcome is the incidence of early neurological improvement (a National Institutes of Health Stroke Scale (NIHSS) score<10 points at 24±2 hours after EVT). …”
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Impact of education and training on LGBT-specific health issues for healthcare students and professionals: a systematic review of comparative studies by Kate Jolly, Ameeta Retzer, Sarah Damery, Nicola Kay Gale, Adekemi Oluwayemisi Sekoni, Ifeoma Okafor, Bibiane Manga-Atangana, Rachel Posaner

“…Data were extracted by one reviewer and checked by a second (population, training content, development, delivery, duration/intensity and outcomes). The National Institutes of Health tool for controlled intervention studies assessed study quality. …”
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Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinica... by Jens Juul Holst, Tina Vilsbøll, Claus Thorn Ekstrøm, Helene Benveniste, Nora D Volkow, Anders Fink-Jensen, Gitte M Knudsen, Mette Kruse Klausen, Tugba Kuzey, Julie Niemann Pedersen, Signe Keller Justesen, Line Rasmussen, Ulla B Knorr, Graeme Mason, George Koob

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Clinical and Pathological Roles of Ro/SSA Autoantibody System by Ryusuke Yoshimi, Atsuhisa Ueda, Keiko Ozato, Yoshiaki Ishigatsubo

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Babesiosis with low parasitemia as a cause of secondary hemophagocytic lymphohistiocytosis in a previously healthy adult by Max W. Jacobs, Joseph M. Rocco, Lisa K. Andersen, Thomas E. Robertson

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Chronic Kidney Disease in Disadvantaged Populations by David Martins, Lawrence Agodoa, Keith Norris

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Genotype-Based Bayesian Analysis of Gene-Environment Interactions with Multiple Genetic Markers and Misclassification in Environmental Factors by Iryna Lobach, Ruzong Fan

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The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells by Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango-Gonzalez, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernandez-Godino, Berta de la Cerda, Simon J. Clark, Simon J. Clark, Simon J. Clark, Marius Ueffing

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Automated Quantification of Retinopathy of Prematurity Stage via Ultrawidefield OCT by Spencer S. Burt, BA, Aaron S. Coyner, PhD, Elizabeth V. Roti, BS, Yakub Bayhaqi, PhD, John Jackson, MD, Mani K. Woodward, MS, Shuibin Ni, PhD, Susan R. Ostmo, MS, Guangru Liang, BS, Yali Jia, PhD, David Huang, MD, Michael F. Chiang, MD, Benjamin K. Young, MD, Yifan Jian, PhD, John Peter Campbell, MD

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Inclusive mentorship of pediatric trainees: pediatric oncology as a microcosm by Sadhana Jackson, Sadhana Jackson, Jessica W. Tsai, Jessica W. Tsai, Kyle L. MacQuarrie, Kyle L. MacQuarrie

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Generalized cue reactivity in rat dopamine neurons after opioids by Collin M. Lehmann, Nora E. Miller, Varun S. Nair, Kauê M. Costa, Geoffrey Schoenbaum, Khaled Moussawi

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Endometriosis Gene Expression Heterogeneity and Biosignature: A Phylogenetic Analysis by Mones Abu-Asab, Ming Zhang, Dennis Amini, Nihad Abu-Asab, Hakima Amri

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Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase by Monique P. Gelderman, Rodney Stuart, David Vigerust, Steven Fuhrmann, Doris L. Lefkowitz, Robert C. Allen, Stanley S. Lefkowitz, Susan Graham

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Primera parte. Hombre de 45 años con neumonía grave, infección diseminada por citomegalovirus y agammaglobulinemia by Mónica Fernandes Pineda, Andrés F. Zea-Vera

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Mixed strategies and natural selection in resource allocation by Irina Kareva, Faina Berezovkaya, Georgy Karev

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Building a Digital Health Research Platform to Enable Recruitment, Enrollment, Data Collection, and Follow-Up for a Highly Diverse Longitudinal US Cohort of 1 Million People in the... by Dave Klein, Aisha Montgomery, Mark Begale, Scott Sutherland, Sherilyn Sawyer, Jacob L McCauley, Letheshia Husbands, Deepti Joshi, Alan Ashbeck, Marcy Palmer, Praduman Jain

“…ObjectiveWe sought to design and build a secure, privacy-preserving, validated, participant-centric digital health research platform (DHRP) to recruit and enroll participants, collect multimodal data, and engage participants from diverse backgrounds in the National Institutes of Health’s (NIH) All of Us Research Program (AOU). …”
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Summer Research Internship Curriculum to Promote Self-Efficacy, Researcher Identity, and Peer-to-Peer Learning: Retrospective Cohort Study by Yulia A Levites Strekalova, Rachel Liu-Galvin, Samuel Border, Sara Midence, Mishal Khan, Maya VanZanten, John Tomaszewski, Sanjay Jain, Pinaki Sarder

“…HuBMAP, a 400-member research consortium funded by the Common Fund at the National Institutes of Health, offered a 10-week summer research internship that included an academic enrichment curriculum delivered synchronously via the web to all students across multiple sites. …”
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