Effectiveness of the Modified WHO Labour Care Guide to Detect Prolonged and Obstructed Labour Among Women Admitted at Eight Publicly Funded, Midwife-Led Community Health Facilities... by Mugyenyi GR, Tumuhimbise W, Atukunda EC, Tibaijuka L, Ngonzi J, Kayondo M, Kanyesigye M, Musimenta A, Yarine FT, Byamugisha JK

“…Godfrey R Mugyenyi,1,2 Wilson Tumuhimbise,3 Esther C Atukunda,2,4 Leevan Tibaijuka,1 Joseph Ngonzi,1 Musa Kayondo,1 Micheal Kanyesigye,2 Angella Musimenta,3 Fajardo T Yarine,1 Josaphat K Byamugisha5 1Obstetrics and Gynaecology Department, Mbarara University of Science and Technology, Mbarara, Uganda; 2Support Mom’s Project, Mbarara University of Science and Technology, Mbarara, Uganda; 3Computing and Informatics Department, Mbarara University of Science and Technology, Mbarara, Uganda; 4Pharmacy department, Mbarara University of Science and Technology, Mbarara, Uganda; 5Obstetrics and Gynaecology department, Makerere University College of Health Sciences, Kampala, UgandaCorrespondence: Godfrey R Mugyenyi, Email gmugyenyi@must.ac.ugBackground: Obstructed labour, a sequel of prolonged labour, remains a significant contributor to maternal and perinatal deaths in low resource settings.Objective: We evaluated the modified WHO labour care guide (LCG) in detecting prolonged/obstructed labour compared to the traditional partograph at publicly funded maternity centers in Southwestern Uganda.Methods: LCG was deployed to monitor labour by trained health care providers in 2023. …”
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LINC01089 governs the miR-1287-5p/HSPA4 axis to negatively regulate osteogenic differentiation of mesenchymal stem cells by Hao Zou, Fei Hu, Xin Wu, Bin Xu, Guifeng Shang, Dong An, Dehao Qin, Xiaolei Zhang, Aofei Yang

“…In this study, we aimed to disclose how LINC01089 functions in human mesenchymal stem cell (hMSC) osteogenic differentiation, and to study the mechanism by which LINC01089 regulates MSC osteogenesis. Methods: Quantitative reverse transcription polymerase chain reaction (RT-qPCR) and western blotting were performed to analyze LINC01089, miR-1287-5p, and heat shock protein family A (HSP70) member 4 (HSPA4) expression. …”
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ATP1B3 may promote glioma proliferation and migration through MAPK/NF-KB signaling pathway by Qikang Yan, Quan Sun, Yan Feng, Qingyun Hu, Jinling Zhu

“…ObjectiveTo investigate the function of ATPase Na+/K+ Transporting Subunit Beta 3 (ATP1B3) in gliomas and the molecular mechanisms associated with them in order to identify a novel target and approach for glioma clinical diagnosis and treatment.MethodsThe Cancer Genome Atlas (TCGA), a public tumor database, and the Chinese Glioma Genome Atlas (CGGA) were used to evaluate the differential expression of ATP1B3 in glioma cells of various grades. …”
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ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…However, the role of ELA in promoting BMSCs migration and homing to injured cardiomyocytes remains unclear.MethodsPrimary BMSCs and neonatal rat ventricular myocytes (NRVMs) were isolated and cultured. …”
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The initial results of using brolucizumab (Beovu®), an angiogenesis inhibitor, for choroidal neovascularization in patients with age-related macular degeneration by N.S. Zhayvoronok, O.V. Kolenko, L.P. Danilova, E.L. Sorokin

“…</p> <p> <b>Patients and Methods:</b> clinical assessment of the efficacy of brolucizumab was performed in 25 patients (25 eyes) with neovascular AMD. …”
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Anosmia, dysgeusia and malnutrition in chronic kidney disease: A systematic review by Gaetano Ferrara, Sara Morales Palomares, Giuliano Anastasi, Mauro Parozzi, Lea Godino, Domenica Gazineo, Marco Sguanci, Stefano Mancin

“…Quality assessment and risk of bias were evaluated using JBI guidelines, while the certainty of evidence was assessed with the Oxford Centre methods. Seven studies were included: two focusing on anosmia and five on dysgeusia. …”
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BCL-2 overexpression exosomes promote the proliferation and migration of mesenchymal stem cells in hypoxic environment for skin injury in rats by Ying Wang, Guang Li, Guofeng Li, Yutao Pan, Zhongmin Liu

“…Abstract Objective The direction of this study was to detect and analyze the specific mechanism of anti-apoptosis in mesenchymal stem cells (MSCs) cells caused by high expression of BCL2. Methods Bioinformatics was completed in Link omics. …”
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Reduced Serum Glucagon Like Peptide-1 In Children with Osteoporosis of Chronic Liver Diseases: A Single Center Trial by Nashwa F. Mohamed Elmetwaly, Ola G. Behairy, Manal S. EL-Defrawy, Ola E. Seleim, Dina S. Abdelmotaleb

“…Aim of the work: to study the relationship between GLP- 1 and osteoporosis among children with CLD. Subjects and Methods: This cross-sectional study included 60 children with CLD as a study group and 60 healthy participants as a control group. …”
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Surgical repair of conjunctival defects: perspectives and limitations by M.B. Gushсhina, A.V. Tereshchenko, A.V. Gushchin, D.S. Afanasyeva

“…</i> </p> <p> <i><b>Patients and Methods:</b> a retrospective analysis of the outcomes of surgical repair of conjunctival defects using full-thickness and/or split-thickness autografts of the labial or cheek mucosa in 27 patients. …”
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Complex program for the prevention of the development and progression of refractive errors in school year children by T.K. Botabekova, N.A. Aldasheva, V.R. Abdullina, I.S. Stepanova, B.I. Isergepova, Zh.S. Iskakbaeva

“…</i> </p> <p> <i><b>Patients and Methods: </b>1,760 pupils of elementary, secondary, and high school of eight schools of Almaty (1,302 pupils of gymnasiums and 458 pupils of general education schools and sport boarding school) were examined. …”
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Modeling Portfolio Optimization based on behavioral Preferences and Investor’s Memory by vahideh mousavi kakhki, Sanaz Khatabi

“…Behavioral preferences, on the other hand, encompass a range of psychological factors that influence investor behavior, such as risk aversion, overconfidence, and herding. MethodsWe perceive stock portfolio optimization as a multi-objective challenge, considering two primary criteria. …”
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Development and Validation of a Cost-Effective Machine Learning Model for Screening Potential Rheumatoid Arthritis in Primary Healthcare Clinics by Wu W, Hu X, Yan L, Li Z, Li B, Chen X, Lin Z, Zeng H, Li C, Mo Y, Wu Y, Wang Q

“…This study focuses on a screening model for primary healthcare, aiming to improve early RA screening accuracy and efficiency at a relatively lower cost, reducing delays in GPs’ recognition of RA.Methods: We randomly selected 2106 participants from the RA group or combined control group (comprising healthy individuals and patients with non-RA rheumatic diseases) at Peking University Shenzhen Hospital as the developing cohort. …”
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Effects of colchicine adjuvant therapy on disease control, serum NALP3, sICAM-1, MMP-9 and MMP-13 in patients with coronary heart disease and acute gout attack by Bingxun Wang, Yongqing Liu, Wenya Han, Bing Li, Pang Jie, Wenwen Yang, Zengcai Ma, Zesheng Xu

“…Background: To investigate the impact of colchicine adjuvant therapy on disease control and serum levels of nucleotide-binding oligomerization domain-like receptor (NALP) 3, soluble intercellular adhesion molecule (sICAM)-1, matrix metalloproteinase (MMP)-9, and MMP13 in patients with coronary heart disease (CHD) complicated by acute gout attacks. Methods: Ninety-two patients with CHD and acute gout attacks admitted to our hospital from October 2021 to January 2023 were randomly divided into an observation group and a control group, with 46 patients in each group. …”
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Efficacy of PD-1 blockade plus chemotherapy in patients with oncogenic-driven non-small-cell lung cancer by Haowei Wang, Lei Cheng, Jian Chen, Peixin Chen, Zhuoran Tang, Qianyi Wang, Ying Ma, Chao Zhao, Xuefei Li, Tao Jiang, Fei Zhou, Xiaoxia Chen, Caicun Zhou

“…Whether NSCLC patients with oncogenic drivers could benefit from PD-1 blockade plus chemotherapy remains undetermined. Methods Three hundred twelve NSCLC patients with at least one oncogenic driver alteration received PD-1 plus chemotherapy or each monotherapy were retrospectively identified. …”
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Effect of Bian-stone hot ironing-massage and Chinese herbal medicine penetration combined with auricular acupoint sticking and pressing on relief of incomplete intestinal obstructi... by ZHANG Lihua (张丽华), XUE Li (薛丽), HUANG Yanping (黄砚萍), WANG Guifang (王贵芳)

“…Objective To observe the effect of Bian-stone hot ironing-massage Chinese herbal medicine penetration combined with auricular acupoint sticking and pressing on relief of incomplete intestinal obstruction. Methods Totally 60 patients with incomplete intestinal obstruction were randomly divided into the treatment group and control group, with 30 cases in each group. …”
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Meta Analysis of Effectiveness on Acupuncture Assisted Rehabilitation after Total Knee Arthroplasty by LI Naping, YANG Shaofeng, KUANG Gaoyan, ZENG Fan, TU Duxing, LU Min

“…ObjectiveTo evaluate the effectiveness of acupuncture as adjuvant therapy for postoperative rehabilitation after total knee arthroplasty (TKA).MethodsThe randomized controlled trials (RCTs) of acupuncture assisted postoperative rehabilitation studies were searched from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, Cochrane Library and Web of Science. …”
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MiR-4298 and lncKRTAP5-6-3 regulated Cathepsin D expression through ERK-MAPK signaling pathway in chronic UVB-damaged HaCaT cells by Xinling Chen, Feng Zhou, Yao Lin, Yue Xia, Jie Zhang, Wenyi Hou, Yu Sun, Wei Lai, Yue Zheng

“…In this study, we investigated the expression changes and interactions between miR4298 and lncKRTAP5-6-3 in chronically UVB-damaged human keratinocyte cell line (HaCaT) cells and explored miR4298-MAPK/ERK signaling pathway-Cathepsin D-lncKRTAP5-6-3 mechanisms in photoaging cells.MethodsHaCaT cells were irradiated with 12 mJ/cm2 UVB once a day for 7 days. miR-4298 mimics and miR-4298 inhibitors were transfected into HaCaT cells by lipo3000 transfection reagent, and the HaCaT cells were divided into three groups: blank control group; UVB-damaged group; and UVB damage+miR-4298 regulation (overexpression or inhibition) group. …”
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Investigation on the current situation of research and development capacity of ICU specialist nurses in Guangxi, China (广西壮族自治区ICU专科护士科研和发展能力现状调查)... by HUANG Yingqiong (黄映琼), JIANG Li (蒋莉), TIAN Weiyi (田韦毅), MO Jinli (莫金莉), ZHANG Yun (张云), NING Chuanyi (宁传艺)

“…Objective To understand the current situation of research level and development ability of ICU specialist nurses in Guangxi, China, and to provide a reference basis for further improving the use and training of ICU specialist nurses. Methods A cross-sectional survey was conducted using a self-made structured questionnaire on the specialist nurses who obtained the ICU specialist nurse certification in Guangxi from 2010 to 2022. …”
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Impact of Sex on Infection Risk in Patients with Systemic Lupus Erythematosus by R. Borrelli, S. Nicola, F. Corradi, I. Badiu, L. Lo Sardo, N. Rashidy, A. Quinternetto, M. Mazzola, F. Meli, E. Saracco, I. Vitali, S. Negrini, L. Brussino

“…However, only a small number of studies have attempted to analyze this risk using real-life data, and even fewer have successfully assessed the influence of sex. <b>Materials and Methods:</b> A retrospective study was conducted, enrolling patients and dividing them into two groups based on their biological sex. …”
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New Insights on Keller–Osserman Conditions for Semilinear Systems by Dragos-Patru Covei

“…Based on certain standard assumptions regarding the potential functions <i>p</i> and <i>q</i>, we introduce new conditions on the nonlinearities <i>f</i> and <i>g</i> to investigate the existence of entire large solutions for the given system. The method employed is successive approximation. Additionally, for specific cases of <i>p</i>, <i>q</i>, <i>f</i> and <i>g</i>, we employ Python code to plot the graph of both the numerical solution and the exact solution.…”
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