Chaihu Shugan San and Zuogui Yin synergistically improve premature ovarian failure in a rat model via the PI3K/Akt/mTOR pathway by Fei Zhang, RuiFang Liu, ZhenLing Xu, WenJie Chen, XiYa Lu, Yang Wang

“…This study aims to evaluate the therapeutic effects of Chaihu Shugan San, Zuogui Yin, and their combination on POI in a rat model and to elucidate the underlying mechanisms involving the PI3K/Akt/mTOR signaling pathway. Methods: In this study, a premature ovarian failure (POF) rat model was established using chronic unpredictable mild stress (CUMS) combined with cyclophosphamide injections. …”
Get full text

Mechanism of Qingjie Fuzheng Granules on alleviating 5-FU chemotherapy-induced intestinal mucositis in a mouse model of Colorectal Cancer by regulating Cathepsin B/NLRP3 pathway by Yuan Yingfei, Lin Jiumao, Lin Minghe, Zhao Jinyan, Chen Xuzheng, Liu Jinhong, Zhu Xiaoqin

“…ObjectiveTo investigate the therapeutic effect and mechanism of Qingjie Fuzheng Granules on 5-FU chemotherapy-induced intestinal mucositis in a mouse model of Colorectal Cancer based on Cathepsin B/NLRP3 pathway.MethodsTwenty-four male BALB/c mice were inoculated with CT26 cells subcutaneously in the axillary of the right forelimb to construct a mouse model of colorectal cancer subcutaneous xenograft. …”
Get full text

Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy by Jing Chen, Dan He, Chengrun Yuan, Na Li, Baohong Shi, Conway Niu, Jiangfei Yang, Liangkai Zheng, Lin Che, Ren Xu

“…However, the precise contribution of FGFR3 to the pathogenesis of HCH remains elusive. Methods: We generated an Fgfr3 (V376D) mutation mouse model using CRISPR/Cas9 technology and performed proteomic analyses to investigate the molecular mechanisms and potential therapeutic targets of HCH. …”
Get full text

A retrospective study of pembrolizumab combined with XELOX regimen in the treatment of advanced gastric cancer by FENG Huizhi, LIU Jingmei, BU Xiaoqian

“…Therefore, this study conducted regression analysis of the effect of pembrolizumab combined with XELOX regimen in the treatment of advanced gastric cancer, providing a reference for clinical treatment. Methods: Clinical data of patients with advanced gastric cancer who were admitted to Shanxi Province Cancer Hospital from March 2020 to August 2022 were retrospectively collected. …”
Get full text

Clinical characteristics and outcomes of patients with chondroblastoma undergoing surgery with various adjuvant procedures: a retrospective study of 59 cases by Toru Hirozane, Tetsuya Sekita, Eisuke Kobayashi, Tomoaki Mori, Naofumi Asano, Toru Udaka, Takashi Tajima, Rumi Nakagawa, Kazutaka Kikuta, Akira Yoshiyama, Hideo Morioka, Itsuo Watanabe, Ukei Anazawa, Michiro Susa, Keisuke Horiuchi, Yoshihisa Suzuki, Takeshi Morii, Robert Nakayama

“…We analyzed the factors contributing to chondroblastoma local recurrence and the clinical challenges associated with treating these patients. Methods This retrospective study examined 59 patients followed up at our hospitals for ≥ 1 year after surgery during 1990–2020. …”
Get full text

MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction by Teng Ma, Yueqiu Chen, Yihuan Chen, Qingyou Meng, Jiacheng Sun, Lianbo Shao, Yunsheng Yu, Haoyue Huang, Yanqiu Hu, Ziying Yang, Junjie Yang, Zhenya Shen

“…Thus, this study aimed to investigate whether MSC-derived exosomes can be used for miR-132 delivery in the treatment of myocardial ischemia. Methods. MSC-derived exosomes were electroporated with miR-132 mimics and inhibitors. …”
Get full text

Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia by Alharbi AA, Aljerian NA, Alghamdi HA, Binhotan MS, Alsultan AK, Arafat MS, Aldhabib A, Aloqayli AI, Alwahbi EB, Horner RD

“…This study examined SMARC’s effectiveness in facilitating mental health service access by analyzing patient transfer acceptance rates between healthcare facilities and identifying factors influencing these rates.Methods: This retrospective cross-sectional study analyzed 9722 mental health electronic referrals within SMARC from January 2020 to December 2021. …”
Get full text

Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variants by REN Yixuan, CHEN Cheng, CAI Mingci, CHEN Jiamin, YANG Xinxin, WANG Chao, LIN Xiaozhu, CHENG Shu, JIANG Xufeng, CHEN Dongxu

“…Objective·To analyze the imaging characteristics and diagnostic value of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) in mantle cell lymphoma (MCL) and explore its application to distinguishing between classic and aggressive variants of MCL.Methods·A retrospective analysis was conducted on the 18F-FDG PET/CT images and clinical data of 116 pathologically confirmed, newly diagnosed MCL patients. …”
Get full text

Perbandingan Levofloxacin dengan Ciprofloxacin Peroral dalam Menurunkan Leukosituria Sebagai Profilaksis Isk pada Kateterisasi di RSUP. Dr. M. Djamil Padang by Marwazi Sofyan, Alvarino ., Erkadius3 .

“…It is therefore a research on this efficacy between those antibiotics in lowering the incidence of leukocyturia as the measure to prevent UTI in patients with Foley catheter. Method: Subjects are 30 patients with Foley catheter, divided into two groups of 15 patients each. …”
Get full text

Perspectives and Practices of Healthcare Leaders in Supporting Healthcare Worker Well-Being: A Reality Check by Reijmerink IM, van der Laan MJ, Scheele F, Wietasch JKG

“…This study aims to unravel the current perspectives and practices of healthcare leaders in supporting HCW well-being.Methods: Semi-structured interviews were conducted with healthcare leaders at various levels within a university medical center. …”
Get full text

Application of extended care based on the PRISMS sheet for patients with chronic obstructive pulmonary disease (基于PRISMS表的延续性护理在慢性阻塞性肺疾病患者中的应用)... by WANGYUAN Jingmei (王袁婧美), LAI Wei (来薇), WEI Min (魏敏), LI Huayi (李华艺)

“…Objective To investigate the effect of extended care based on the PRISMS sheet on improving the self-efficacy and health status of patients with chronic obstructive pulmonary disease (COPD). Methods A total of 202 COPD patients were randomly divided into a control group (n=102) and an intervention group(n=102). …”
Get full text

Comparison of Long-Term Antibody Titers in Calves Treated with Different Conjunctival and Subcutaneous <i>Brucella abortus</i> S19 Vaccines by Ali Uslu, Zafer Sayın, Aslı Balevi, Yasin Gulcu, Fırat Ergen, Islam Akıner, Oguzhan Denizli, Osman Erganis

“…The collected sera were analyzed using the Rose Bengal Plate Test (RBPT), Serum Agglutination Test (SAT), and Complement Fixation Test (CFT), which are the preferred serological methods for Brucellosis eradication plans worldwide. …”
Get full text

Study of senile astheny markers against the background of acute inflammatory process in elderly and senile patients in emergency abdominal surgery by M. B. Danyliuk, S. M. Zavhorodnii, Ye. R. Fedotov, Ye. K. Mykhalchenko, I. V. Dobrodub

“…The aim of our work was to determine the influence of the acute inflammatory process on the diagnostic value of markers of senile asthenia in emergency abdominal surgery. Material and methods. The basis of the work included 92 (100.0 %) patients, the average age in the entire group was 72.0 ± 2.3 years. …”
Get full text

Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway by Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi

“…Here, we aimed to evaluate the tumoricidal impacts of metformin (MTF) on colorectal cancer (CRC) tumoroids in an in vitro system via the modulation of autophagy. Methods CRC tumoroids were developed using human umbilical vein endothelial cells (HUVECs), adenocarcinoma HT29 cells, and fibroblasts (HFFF2) in a ratio of 1: 2: 1 and 2.5% methylcellulose. …”
Get full text

Increased susceptibility to diet-induced obesity in female mice impairs ovarian steroidogenesis: The role of elevated leptin signalling on nodal activity inhibition in theca cells by Karolina Wołodko, Tjaša Šentjurc, Edyta Walewska, Elżbieta Laniecka, Magdalena Jura, António Galvão

“…In this study, we investigated how variable susceptibility to obesity in mice affects ovarian steroidogenesis, with a particular focus on the leptin-mediated dysregulation of Nodal signalling pathway in theca cells (TC). Methods: C56BL/6J (B6) and 129S1/SvlmJ (129) mice, models of maternal obesity (MO), were fed a chow diet (CD) and a high fat diet (HFD) for 16 weeks. …”
Get full text

Provocation of brachial plexus and systemic symptoms during the elevated arm stress test in individuals with myalgic encephalomyelitis/chronic fatigue syndrome or idiopathic chroni... by Charles C. Edwards, Julia M. Byrnes, Camille A. Broussard, Alba M. Azola, Meghan E. Swope, Colleen L. Marden, Renee L. Swope, Ying Wei Lum, Richard L. Violand, Peter C. Rowe

“…Objectives To estimate the proportion of patients with fatiguing illness who experience local and systemic symptoms during a common maneuver used in evaluating TOS—the elevated arm stress test (EAST). Methods Patients were eligible for this retrospective study if they had been referred to the Johns Hopkins Chronic Fatigue Clinic between January 2020 and July 2023 and (a) reported difficulty maintaining arms-overhead postures, (b) were evaluated with an abbreviated one-minute EAST, and (c) had not undergone surgery in the upper limb, neck, or skull base. …”
Get full text

Effect of five-element cupping therapy on postoperative wound pain of patients with mixed hemorrhoids (五行能量罐治疗混合痔术后伤口疼痛效果观察) by WEI Yongchun (魏永春), QIN Shasha (秦沙沙), ZHANG Kaiye (张凯烨), WANG Yali (王亚丽), DONG Yuxia (董玉霞), E Haiyan (鄂海燕), TANG Ling (唐玲)

“…Objective To investigate the effect of Traditional Chinese Medicine (TCM) five-element cupping therapy on postoperative wound pain of patients undergoing Milligan-Morgan surgery for mixed hemorrhoids of damp-heat type. Methods Totally 60 patients undergoing Milligan-Morgan surgery for mixed hemorrhoids of damp-heat type were randomly divided into the observation group and control group, with 30 cases in each group. …”
Get full text

Identification of Clusters in a Population With Obesity Using Machine Learning: Secondary Analysis of The Maastricht Study by Maik JM Beuken, Melanie Kleynen, Susy Braun, Kees Van Berkel, Carla van der Kallen, Annemarie Koster, Hans Bosma, Tos TJM Berendschot, Alfons JHM Houben, Nicole Dukers-Muijrers, Joop P van den Bergh, Abraham A Kroon, Iris M Kanera

“…ObjectiveThis study aimed to identify potential clusters and relevant variables among individuals with obesity using a data-driven and hypothesis-free machine learning approach. MethodsWe used cross-sectional data from individuals with abdominal obesity from The Maastricht Study. …”
Get full text

Relationship between pregnant women's combined exposure to heavy metals and their offspring's congenital heart defects in Lanzhou, China by Lulu Chen, Lulu Chen, Yaqin Zhao, Yaqin Zhao, Jianhao Sun, Jianhao Sun, Xinjuan Jiao, Zhenzhen Wu, Zhenzhen Wu, Jian Wang, Jie Qiu, Baohong Mao, Baohong Mao, Qing Liu, Qing Liu

“…This study seeks to investigate the association between combined heavy metal exposure in pregnant women and the incidence of CHDs in their offspring in Lanzhou, China.MethodsWe conducted a comprehensive review of the birth cohort study undertaken at our hospital from 2010 to 2012, with the objective of investigating the association between combined heavy metal exposure in pregnant women and the incidence of CHDs in their offspring. …”
Get full text

Etude et cartographie de la dynamique de l’occupation et de la dégradation des sols de Yagoua (Mayo-Danay, Extrême-Nord Cameroun) by Denis TIKI, Lionelle Bitom-Mamdem, Sabine Danala Danala, Amina Aboubakar, Ibrahim Bienvenue Achille, Ahmadou Yerima Yaya Alim, Djakba Simon Basga, Olivier Leumbe Leumbe

“…Cependant, la pratique de l’agroforesterie, la rotation de culture, l’intensification des méthodes de lutte antiérosive et la lutte biologique apparaissent comme des pratiques pouvant permettre de renverser la tendance.…”
Get full text