Adjuvant Radiochemotherapy with a 23-Month Overall Survival Time in a Patient after a Surgery due to Splenic Hemangiosarcoma Rupture: A Case Report with the Literature Review by M. Bilski, D. Surdyka, I. Paśnik, M. Bilska, P. Cisek, P. Korona, J. Szumiło, L. Grzybowska-Szatkowska

“…Treatment of choice is surgical splenectomy, which rarely gives good results due to the aggressive course of the disease as well as the high potential for metastasis. Overall survival in primary spleen sarcomas as described by various authors is between 4 and 14 months. 80% of patients after spleen rupture do not survive 6 months. …”
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Impact of Surgeon Experience in the Resection of Basal Cell Carcinoma of the Head and Neck Region by Carlos Gonzalo Acosta Mayorga, Piedad Elizabeth Acurio Padilla, Guido Nino Guida Acevedo

“…<strong>Foundation:</strong> surgical excision with adequate margins is considered the standard treatment for cutaneous basal cell carcinoma, due to its association with lower rates of recurrence and postoperative metastasis. <br /><strong>Objective:</strong> to evaluate the impact of surgical experience in a high-volume head and neck surgery department in relation to margin status in basal cell carcinoma resection. …”
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Nucleotide metabolism-associated drug resistance gene NDUFA4L2 promotes colon cancer progression and 5-FU resistance by Hongxin HE, Shiyao ZHENG, Shangkun JIN, Weijie HUANG, Enhao WEI, Shen GUAN, Chunkang YANG

“…In conclusion, we found that NDUFA4L2 promotes the progression and metastasis of colon cancer, as well as resistance to 5-FU chemotherapy.…”
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Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition by Antonino Glaviano, Hannah Si-Hui Lau, Lukas M. Carter, E. Hui Clarissa Lee, Hiu Yan Lam, Elena Okina, Donavan Jia Jie Tan, Wency Tan, Hui Li Ang, Daniela Carbone, Michelle Yi-Hui Yee, Muthu K. Shanmugam, Xiao Zi Huang, Gautam Sethi, Tuan Zea Tan, Lina H. K. Lim, Ruby Yun-Ju Huang, Hendrik Ungefroren, Elisa Giovannetti, Dean G. Tang, Tullia C. Bruno, Peng Luo, Mads Hald Andersen, Bin-Zhi Qian, Jun Ishihara, Derek C. Radisky, Salem Elias, Saurabh Yadav, Minah Kim, Caroline Robert, Patrizia Diana, Kurt A. Schalper, Tao Shi, Taha Merghoub, Simone Krebs, Anjali P. Kusumbe, Matthew S. Davids, Jennifer R. Brown, Alan Prem Kumar

“…Abstract The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. …”
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Overexpression of Notch3 and pS6 Is Associated with Poor Prognosis in Human Ovarian Epithelial Cancer by Zhaoxia Liu, Rongna Yun, Xiaolin Yu, Hui Hu, Genhua Huang, Buzhen Tan, Tingtao Chen

“…In tumor tissues, Notch3 expression and pS6 expression were negatively associated with age (p>0.05) but positively associated with clinical stage, pathological grading, histologic type, lymph node metastasis, and ascites (p<0.05 or p<0.01). A follow-up survey of 64 patients with ovarian epithelial cancer showed that patients with high Notch3 and pS6 expression had a shorter survival time (p<0.01), in which the clinical stage (p<0.05) and Notch3 expression (p<0.01) played important roles. …”
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Gastric schwannoma with post-surgical gastroparesis: a case report and literature review by Ganggang Miao, Ganggang Miao, De Zhang, Jiajing Li, Yanxiang Deng, Xingwei Gu, Tingting Feng

“…Gastric schwannoma is a relatively rare submucosal mesenchymal tumor with low probability of metastasis and arises from Schwann cells of the gastrointestinal nervous plexus. …”
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The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Cristian Scheau, Ioana Anca Badarau, Raluca Costache, Constantin Caruntu, Gratiela Livia Mihai, Andreea Cristiana Didilescu, Carolina Constantin, Monica Neagu

“…While gelatinases MMP-2 and MMP-9 are the MMPs commonly cited in the EMT of HCC, MMPs belonging to other classes have been proven to be involved in this process, favoring not only invasion and metastasis (MMP-1, MMP-3, MMP-7, MMP-10, MMP-11, MMP-13, MMP-14, MMP-16, MMP-26, and MMP-28) but also angiogenesis (MMP-8 and MMP-10). …”
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Immunohistochemical evaluation of P53 in squamous cell carcinoma of the esophagus by Kala K, Sarumathy G, Nithya I, Prathiba A

“…There were no significant associations between p53 expression and site, lymph node metastasis (N classification) and stage. Conclusion: In conclusion, the expression of p53 in ESCC patients significantly correlates with age, betel nut chewing and histological grade. p53 play an important role in tumor progression and an independent variable affecting the survival. …”
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Metastatic Extrapulmonary Small Cell Carcinoma to the Cerebellopontine Angle: A Case Report and Review of the Literature by Debebe Theodros, C. Rory Goodwin, Genevieve M. Crane, Jason Liauw, Lawrence Kleinberg, Michael Lim

“…We present the first documented case of skull base metastasis of a poorly differentiated small cell carcinoma involving the CPA.…”
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Synchronous Gastric Gastrointestinal Stromal Tumor and Colon Adenocarcinoma: A Case Report by Thivi Vasilakaki, Kalliroi Koulia, Aikaterini Tsavari, Elissavet Arkoumani, Efstratios Kouroumpas, Anargiros Pavlis, Georgios Christopoulos, Konstantinos Stamatiou, Kassiani Manoloudaki, Dimitrios Zisis

“…Two years later the patient showed no evidence of recurrence or metastasis.…”
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Trim13‐induced ubiquitination of RPS27A inhibits the progression of lung cancer by depending on the inactivation of NF‐κB signaling pathway by Lailing Li, Hui Zhou, Yayun Cui, Ke Xu

“…We also found that RPS27A overexpression reversed the inhibitory effect of TRIM13 overexpression on NF‐κB signaling, thereby further promoting the proliferation and metastasis of LC cell lines. Therefore, targeting the TRIM13/RPS27A/NF‐κB signaling axis may be a promising target for LC treatment.…”
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Prognostic and clinicopathological value of C-reactive protein in patients with bladder cancer: a meta-analysis by Xiangping Feng, Zongxin Zhang, Shuiying Mao

“…Nevertheless, there was no significant relationship between CRP level and sex, tumour size, tumour grade or lymph node metastasis (LNM) in BCa.Conclusions Elevated CRP levels were significantly related to poor OS, CSS, RFS and PFS of BCa patients with BCa. …”
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Allelic and Genotypic Analysis of LncRNA ANRIL rs4977574 A/G Mutations in Oral Squamous Cell Carcinoma Patients: Insights into Tumor Characteristics and Genotypic Correlations by Mohammad Amin Amiri, Delara Amiri, Mohammad Javad Mokhtari, Fatemeh Lavaee, Mohammad Javad Fattahi, Abbas Ghaderi, Bijan Khademi

“…Furthermore, the association of the genotypes with the lymph node metastasis and the tumors stage was not found to be significant (p>0.05). …”
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Winging of Scapula due to a Sinister Etiology by Shania Niromi Gunasekera, Priyanka Yogananda, Harindra Karunatilaka, Bimsara Senanayake

“…Histology of a biopsy of the cervical lymph node confirmed metastasis from a poorly differentiated adenocarcinoma of the lung. …”
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Differences in Pain Intensity of Tumors Spread to the Anterior versus Anterolateral/Lateral Portions of the Vertebral Body Based on CT Scans by Hui-Ching Hsu, Tzu-Yao Liao, Long-Sun Ro, Yu-Hsiang Juan, Chuang-Chi Liaw

“…The selection criteria were as follows: (1) advanced or metastatic solid tumor; (2) radicular pain without extremity weakness; (3) malignant lesions anteriorly, anterolaterally, or laterally located at the vertebral body either spread locoregionally or over a greater distance via metastasis based on CT scan diagnosis; and (4) patient needs to use opioids for pain relief. …”
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Malignant Granular Cell Tumor of the Back: A Case Report and Review of the Literature by Laura Stone McGuire, Danny Yakoub, Mecker G. Möller, Andrew Rosenberg, Alan Livingstone

“…By fifteen months, right axillary lymphadenopathy, multiple satellite lesions, pulmonary nodules, and distant metastasis in the right thigh were present. At sixteen months, wide local excision of recurrent mass and local satellite masses along with right axillary dissection and placement of Integra with subsequent split-thickness skin graft were performed by surgical oncology and plastic surgery teams. …”
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Tumor microbiome: roles in tumor initiation, progression, and therapy by Shengxin Zhang, Jing Huang, Zedong Jiang, Huan Tong, Xuelei Ma, Yang Liu

“…Abstract Over the past few years, the tumor microbiome is increasingly recognized for its multifaceted involvement in cancer initiation, progression, and metastasis. With the application of 16S ribosomal ribonucleic acid (16S rRNA) sequencing, the intratumoral microbiome, also referred to as tumor-intrinsic or tumor-resident microbiome, has also been found to play a significant role in the tumor microenvironment (TME). …”
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The role of lipids and lipids lowering drugs in human papillomavirus (HPV) and HPV-associated cancers by Ehsan Shabani, Aida Hasanzadi, Omer Qutaiba B. Allela, Radhwan Abdul Kareem, Riyad E. Abed, Ali M. Ali Al-Nuaimi, Zainab H. Athab, Shiva Khodarahmi

“…One of the most noticeable metabolic abnormalities in cancer is lipid metabolism reprogramming, in which cancer cells dysregulate lipid metabolism to obtain sufficient energy, building blocks for cell membranes, and signaling molecules necessary for invasion, metastasis, proliferation, and survival. Moreover, HPV proteins' stimulation of lipid production in infected cells will probably have a significant effect on oncogenesis. …”
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EGF-R is Expressed and AP-1 and NF-κ:B Are Activated in Stromal Myofibroblasts Surrounding Colon Adenocarcinomas Paralleling Expression of COX-2 and VEGF by Panagiotis A. Konstantinopoulos, Gerasimos P. Vandoros, Michalis V. Karamouzis, Maria Gkermpesi, Georgia Sotiropoulou-Bonikou, Athanasios G. Papavassiliou

“…Background: COX-2 and VEGF are important triggers of colon cancer growth, metastasis and angiogenesis. Cox-2 promoter contains transcriptional regulatory elements for AP-1 and NF-κ:B transcription factors whilst vegf is a known AP-1 downstream target gene. …”
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Colonic stenting in acute malignant large bowel obstruction: audit of efficacy and safety in a Singapore tertiary referral centre by James Weiquan Li, James Chi-Yong Ngu, Kok Ren Lim, Shu Wen Tay, Bochao Jiang, Ramesh Wijaya, Sulaiman Yusof, Calvin Jianming Ong, Andrew Boon Eu Kwek, Tiing Leong Ang

“…Local recurrence and distant metastasis were observed in 4 (10.3%) and 5 (12.8%) patients, respectively. …”
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