Primary Malignant Melanoma of the Rectum: Report of Two Cases by Kodai Tomioka, Hitoshi Ojima, Makoto Sohda, Akiko Tanabe, Yasuyuki Fukai, Akihiko Sano, Takahiro Fukuda, Masahiko Murakami

“…The clinical diagnosis for each was rectal carcinoma at stage IIIc according to the tumor-node-metastasis classification (6th edition), and the patients underwent abdominoperineal resection with dissection of lymph nodes. …”
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Intraosseous Mucoepidermoid Carcinoma in the Mandible by George Borja de Freitas, Arthur José Barbosa de França, Stefanny Torres dos Santos, Miqueias Oliveira de Lima Júnior, Adilis Stepple da Fonte Neto, Paula Bernardon

“…The main modality of treatment for patients with this neoplasm is radical surgical resection, offering a greater chance of cure than the more conservative procedures, such as enucleation or curettage, due to the great possibility of recurrence and tumor metastasis. This paper reports a rare case of intraosseous mucoepidermoid carcinoma occasionally discovered after panoramic radiography of the jaws, which was treated with segmental resection through hemimandibulectomy.…”
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Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations by Yingjun Xie, Yien Xiang, Jiyao Sheng, Dan Zhang, Xiaoxiao Yao, Yongsheng Yang, Xuewen Zhang

“…In recent years, tumor immunotherapy has emerged as a promising method owing to its safety and efficacy with respect to delaying the progression of advanced tumors and protecting postoperative patients against tumor relapse and metastasis. Immune tolerance and suppression in tumor microenvironments are the theoretical basis of immunotherapy. …”
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Phoenix dactylifera L. (date palm) fruit extracts and fractions exhibit anti-proliferative activity against human pancreatic cancer cell lines by Reem A. Al Alawi, Jörg D. Hoheisel, Mohamed Saiel Saeed Alhamdani, Younis Baqi

“…Pancreatic cancer has a very poor prognosis due to its high resistance to chemotherapeutic drugs, late diagnosis, and early metastasis, making it the most aggressive and lethal cancer. …”
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Antioxidant Peptide Derived from Spirulina maxima Suppresses HIF1α-Induced Invasive Migration of HT1080 Fibrosarcoma Cells by Won Suk Kim, Won Kyo Jung, Sun Joo Park

“…The initiation of tumor metastasis requires invasive cell migration. Here, we show that an antioxidant peptide derived from Spirulina maxima suppresses hypoxia-induced invasive migration of HT1080 human fibrosarcoma cells. …”
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FIRST RUSSIAN EXPERIENCE OF USING THE INTEGRATED SYSTEM OF LASER THERMOABLATION THERAPY IN THE TREATMENT OF METASTATIC LIVER CANCER by D. V. Sidorov, S. O. Stepanov, M. V. Lozhkin, L. O. Petrov, O. V. Gutz, A. A. Kostin, A. G. Isaeva

“…This article presents two observations of the clinical application of the laser ablator “Echolaser X4”: open laser ablation of the metastatic focus with subsequent atypical liver resection and percutaneous laser ablation of the metastasis of the neuroendocrine tumor into the liver. …”
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Comparison of Conventional Open Thyroidectomy and Endoscopic Thyroidectomy via Breast Approach for Papillary Thyroid Carcinoma by Zhuo Tan, JiaLei Gu, QianBo Han, WenDong Wang, KeJing Wang, MingHua Ge, JinBiao Shang

“…The rates of lymph node metastasis in endo group and open group were 23.5% (8/34) and 13.3% (4/30), respectively, without statistically significant difference (P=0.351). …”
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Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach by Amir Taherkhani, Parita Khodadadi, Lida Samie, Zahra Azadian, Zeynab Bayat

“…Mitogen-activated protein kinase 3 (MAPK3) mediates the onset, progression, metastasis, drug resistance, and poor prognosis in various malignancies, including glioma, liver, ovarian, thyroid, lung, breast, gastric, and oral cancers. …”
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Features of diagnosis and treatment of gastrointestinal stromal tumors by N. I. Bogomolov, T. V. Burdinskaya, M. A. Goncharova, A. G. Goncharov, N. N. Tomskikh

“…In the remote period after surgery one patient died due to tumor metastasis, in 7 patients GIST was primarily diagnosed at the autopsy. …”
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Cutaneous Metastases from Primary Hepatobiliary Tumors as the First Sign of Tumor Recurrence following Liver Transplantation by Adam T. Hauch, Joseph F. Buell, Margit McGowan, Parisha Bhatia, Eleanor Lewin, Mary Killackey, Nathan J. Shores, Luis A. Balart, Martin Moehlen, Bob Saggi, Anil S. Paramesh

“…Cutaneous metastasis from hepatobiliary tumors is a rare event, especially following liver transplantation. …”
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Pseudomyxoma Peritonei Originating from Transverse Colon Mucinous Adenocarcinoma: A Case Report and Literature Review by Yingbo Gong, Xin Wang, Zhi Zhu

“…It was diagnosed during resective surgery, involved ovarian metastasis, and survival was short. We did an extensive literature review in order to describe the clinical characteristics, histopathological findings, genetic profile, and potential treatments of PMP caused by nonappendiceal mucinous adenocarcinoma.…”
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Vitamin A and its influence on tumour extracellular matrix by Guoqing Xie, Shun Cao, Guangchun Wang, Xianzhong Zhang, Yu Zhang, Haofan Wu, Shuxian Shen, Jiandong Le, Keqiang Li, Zhenlin Huang

“…The ECM profoundly affects tumour behaviour, including proliferation, invasion, and metastasis. Alterations in the ECM can facilitate tumour progression, and vitamin A derivatives have shown potential in modulating these changes. …”
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Prognostic significance of tumor angiogenesis markers in advanced cervical cancer undergoing chemotherapy by I Nyoman Bayu Mahendra, I Gde Sastra Winata, William Alexander Setiawan, Ida Bagus Agung Widnyana Putra, Putu Bagus Darmayasa

“…Studies have demonstrated significant correlations between VEGF levels and important prognostic parameters, including tumor size, metastasis, and chemotherapy response. Consequently, tumor angiogenesis markers like VEGF and VEGFR hold potential as valuable predictive tools to guide the management of advanced cervical cancer, particularly in patients undergoing chemotherapy.…”
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Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer by Ximo Zhang, Abdullah Al‐Danakh, Xinqing Zhu, Dan Feng, Linlin Yang, Haotian Wu, Yingying Li, Shujing Wang, Qiwei Chen, Deyong Yang

“…Abstract The tumor microenvironment (TME) is critical for cancer initiation, growth, metastasis, and therapeutic resistance. The extracellular matrix (ECM) is a significant tumor component that serves various functions, including mechanical support, TME regulation, and signal molecule generation. …”
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A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology by Yanhua Fang, Yanhua Fang, Juan Pan, Piao Wang, Piao Wang, Ruoyu Wang, Shanshan Liang

“…Numerous studies have demonstrated that Schisandrin B exhibits significant antitumor activity against various malignant tumors in preclinical studies, which is achieved by inhibiting cell proliferation and metastasis and promoting apoptosis. As a potential antitumor agent, Schisandrin B holds broad application prospects. …”
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Colgajo bilobulado de Esser modificado para su empleo en localización atípica. Presentación de un caso by Carla María García San Juan, José Daniel Gil Milá

“…Es la segunda neoplasia cutánea más frecuente dentro de las de tipo no melanoma, con predominio de 2,1: 1 en la relación hombre-mujer y el cáncer que con más frecuencia causa metástasis. Esta presentación de caso tiene como objetivo describir la técnica quirúrgica del colgajo bilobulado de Esser para la resección de un carcinoma epidermoide situado en el canto externo del ojo, técnica no indicada para esta región de la cara, pero con la se obtuvo un resultado satisfactorio en el tratamiento a una paciente de color de piel blanca, de 75 años que acudió al Servicio de Cirugía Máxilofacial del Hospital General de Cienfuegos, remitida por el Servicio de Dermatología, debido a la presencia de una lesión ulcerada de aproximadamente 5 cm., de diámetro localizada en la mencionada región. …”
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Efficacy and safety of selective pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors in FGFR-altered urothelial carcinoma by Yuxuan Song, Yiqing Du, Shan Jiang, Yun Peng, Xing Luo, Tao Xu

“…It is worth noting that patients with liver metastasis might benefit from FGFRi in terms of both prognosis and response. …”
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Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer by Emre Ozoran, Fadime Didem Can Trabulus, Duygu Erhan, Bahadir Batar, Mehmet Guven

“…Breast cancer risk was 5.43 times more in individuals with AA genotype of Bax G(-248) A (rs4645878) (P=0.002). The risk of metastasis was 11 times with this genotype. It was associated with 6 times more risk of having a tumor larger than 2 cm. …”
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Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer by Nan Zhang, Xinjia Wang, Yu Li, Yiwei Lu, Chengcheng Sheng, Yumeng Sun, Ningye Ma, Yisheng Jiao

“…Studies have demonstrated that circRNAs can interact with RNA-binding proteins (RBPs), which play crucial roles in tumorigenesis, metastasis, and drug response in cancer by influencing gene expression and altering the processes of tumor initiation and progression. …”
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A case report of infantile fibrosarcoma with BRAF gene mutation with incomplete intestinal obstruction by Fan Zhu, Liang Fan, Guanhua Cui, Hai Jian, Hongjie Zhou, Jianfeng Xu, Fengshun Chen

“…Postoperative follow-up over 8 months showed no recurrence or metastasis on abdominal ultrasound. A review of this case alongside 20 reported cases of intestinal IFS revealed that intestinal perforation and obstruction were the most common presentations, with favorable overall prognoses.ConclusionIntestinal IFS is a rare soft tissue sarcoma predominantly occurring in early infancy. …”
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