Targeting KRAS: from metabolic regulation to cancer treatment by Yanyan Shi, Huiling Zheng, Tianzhen Wang, Shengpu Zhou, Shiqing Zhao, Mo Li, Baoshan Cao

“…Abstract The Kirsten rat sarcoma viral oncogene homolog (KRAS) protein plays a key pathogenic role in oncogenesis, cancer progression, and metastasis. Numerous studies have explored the role of metabolic alterations in KRAS-driven cancers, providing a scientific rationale for targeting metabolism in cancer treatment. …”
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Simultaneous paratesticular liposarcomas with histopathological differences. A Case report by Pedro León Acosta, Pedro Rosales Torres

“…Liposarcoma is a mesenchymal origin tumor that commonly occurs in the retroperitoneum; It is slow growing and its ability to produce metastasis depends on its histological type. The purpose of this work is to present a case of simultaneous paratesticular liposarcomas with different histological types, in an 80-years-old male patient with a health history and low socioeconomic level; For two years he had been experiencing an increase in volume in the left inguinal region and ipsilateral testicle, which at first was painless; Then, as it increased in size, it became painful, covering the entire right inguinoscrotal region. …”
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Pumilio RNA-Binding Family Member 1 Plays a Promoting Role on Pancreatic Cancer Angiogenesis by Haisu Dai, Yan Jiang, Zhipeng Liu, Xingxing Su, Yishi Yang, Zhiyu Chen

“…Our previous studies showed that Pumilio RNA-binding family member 1 (PUM1) gene is abnormally expressed in pancreatic cancer (PC) tissues, and its knockdown suppresses the growth and metastasis of PC cells. Here, we aimed to further investigate its role in angiogenesis. …”
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Anaesthesia affects immune function and impact on long-term cancer prognosis: A review by Kisdyanti Yuniar Melissa, Suandika Made, Rahmawati Arni Nur

“…This article aims to identify and evaluate the evidence on the effects of anaesthesia-induced immunosuppression, to determine the mechanisms by which anaesthesia affects the immune system during surgery, and the implications for cancer proliferation, metastasis, and recurrence. In addition, this article also evaluates the type of anaesthesia and explores the relationship between immune modulation during anaesthesia and long-term survival. …”
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The Prognostic Implication of the BRAF V600E Mutation in Papillary Thyroid Cancer in a Chinese Population by Ziheng Ye, Xiaotian Xia, Peipei Xu, Wenfei Liu, Shoufei Wang, Youben Fan, Minggao Guo

“…We further demonstrated that larger tumor size (>1 cm), extrathyroidal extension (ETE), and lateral lymph node metastasis (LNM) were associated with a higher probability of PTC recurrence in patients harboring the BRAF V600E mutation. …”
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Plant-Derived Anti-Cancer Therapeutics and Biopharmaceuticals by Ghyda Murad Hashim, Mehdi Shahgolzari, Kathleen Hefferon, Afagh Yavari, Srividhya Venkataraman

“…A multifactorial and multitargeted approach is required towards intervention of the multitude of signaling pathways associated with carcinogenesis inclusive of angiogenesis and metastasis. In this context, plants provide an immense source of phytotherapeutics that show great promise as anticancer drugs. …”
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Long noncoding RNA DHRS4 antisense RNA 1 suppresses osteosarcoma cell proliferation and promotes apoptosis through a competitive endogenous RNA mechanism by Zhouzhou Tang, Zhihao Li, Guofeng Wu, Jianjun Li, Jianye Tan, Lixin Zhu

“…Recent evidence suggests that the novel long noncoding RNA DHRS4 antisense RNA 1 (DHRS4-AS1) serves an important role in cancer progression and metastasis. However, its function and molecular mechanism in OS remain largely unknown. …”
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RADIUM-223. PLACE IN THE TREATMENT OF METASTATIC CASTRATION-REFRACTORY PROSTATE CANCER by A. A. Kostin, A. G. Muradyan, A. O. Tolkachev, S. V. Popov

“…The most common localization of prostate cancer metastasis is the skeletal bone, which affects up to 90% of cases.At the same time, taking into account the increase in the morbidity of prostate cancer pathology, it dictates the need to search for new, more effective methods of treatment for this group of patients. …”
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The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials by Seidu A. Richard, Kuugbee D. Eugene

“…EZH2 is well recognized as an essential modulator of cell invasion as well as metastasis in glioma. EZH2 oversecretion was implicated in the malfunction of several fundamental signaling pathways like Wnt/β-catenin signaling, Ras and NF-κB signaling, PI3K/AKT signaling, β-adrenergic receptor signaling, and bone morphogenetic protein as well as NOTCH signaling pathways. …”
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Potential role of CTNNA3 and FRMPD4 in vascular tumorous thrombosis of colon adenocarcinoma by Bin Liu, Yu Xiang, Weihua Guo

“…Background: Vascular tumorous thrombosis is a crucial pathological feature of malignant tumors that is closely associated with lymph node metastasis and is considered a form of tumor micrometastasis. …”
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Angiogenesis in Spontaneous Tumors and Implications for Comparative Tumor Biology by C. Benazzi, A. Al-Dissi, C. H. Chau, W. D. Figg, G. Sarli, J. T. de Oliveira, F. Gärtner

“…Angiogenesis is a prognostic indicator for a variety of tumors, and it coincides with increased shedding of neoplastic cells into the circulation and metastasis. Several molecules such as cell surface receptors, growth factors, and enzymes are involved in this process. …”
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False Positive 18F-FDG Uptake in Mediastinal Lymph Nodes Detected with Positron Emission Tomography in Breast Cancer: A Case Report by Gamze Uğurluer, Mustafa Kibar, Sinan Yavuz, Akin Kuzucu, Meltem Serin

“…It is accepted that lymph node involvement with metastatic tumor and the presence of distant metastasis are the most important prognostic factors. …”
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Exosomal circRNAs: Deciphering the novel drug resistance roles in cancer therapy by Xi Li, Hanzhe Liu, Peiyu Xing, Tian Li, Yi Fang, Shuang Chen, Siyuan Dong

“…These stable, non-coding RNAs encapsulated in exosomes participated in cancer progression, tumor growth, metastasis, drug sensitivity and the tumor microenvironment (TME). …”
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Carcinoma de corteza suprarrenal. Presentación de un caso y revisión de la literatura by Dayana Calzada Urquiola, Ana Lourdes Vasallo Díaz, Bernardo Heredia Martínez

“…Entre el 40 y el 70 % de los pacientes tienen metástasis cuando se inicia el estudio. Se presenta de manera general en adultos, aunque también afecta a los niños. …”
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Very Late Relapse of Testicular Tumour in Combination with Renal Cancer and Their Retroperitoneoscopic Removal by Mihály Murányi, Morshed Ali Salah, Béla Tállai, Mátyás Benyó, Tibor Flaskó

“…Retroperitoneoscopy is feasible approach for the removal of retroperitoneal lymph node metastasis and resection of renal tumor.…”
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An Acute Jejunojejunal Intussusception Revealing a Metastatic Combined Lung Cancer by Feryel Letaief-Ksontini, Ryma Boujnah, Yosra Yahiaoui, Yosra Zaimi, Meriem Ksentini, Raoudha Aloui, Khedija Meddeb, Amel Mezlini

“…He underwent an en bloc resection, and pathological findings concluded to a metastasis of a pulmonary combined small cell carcinoma and adenocarcinoma. …”
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Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score by M. Hakan Ulusoy, Yalcin Cirak, Yasemen Adali

“…Lipocalin-2 has an important role in tumor progression, invasion, and metastasis. However, its role in prostate cancer remains unclear. …”
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Safety and Efficacy of Combined Yttrium 90 Resin Radioembolization with Aflibercept and FOLFIRI in a Patient with Metastatic Colorectal Cancer by Andre De Souza, Kevin Pelham Daly, James Yoo, Muhammad Wasif Saif

“…A 56-year-old female with history of bilateral breast cancer and metastatic colon cancer with prior hemicolectomy and 4 previous chemotherapy regimens developed liver metastasis. She was started on aflibercept and FOLFIRI and concurrently underwent two treatments of radioembolization with Y90, initially targeting the largest right lobe tumor, and then a subsequent treatment targeting the smaller left lobe tumor with retreatment of the right lobe tumor. …”
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Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii by Surapan Khunamornpong, Jongkolnee Settakorn, Kornkanok Sukpan, Prapaporn Suprasert, Sumalee Siriaunkgul

“…Despite FIGO stage IA by optimal staging procedure and the absence of identifiable lymphovascular invasion, the patient developed pulmonary metastasis 15 months after surgery and died from the progression of the disease 7 years after the diagnosis. …”
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Complete PSA Remission without Adjuvant Therapy after Secondary Lymph Node Surgery in Selected Patients with Biochemical Relapse after Radical Prostatectomy and Pelvic Lymph Node D... by Alexander Winter, Jens Uphoff, Rolf-Peter Henke, Friedhelm Wawroschek

“…Results. 9 of 10 patients with histologically confirmed LNM showed a PSA response. 4 of 9 patients with single LNM had a complete permanent PSA remission (mean followup 31.8, range 1–48 months). Of metastasis-suspicious LNs (14) 12 could be histologically confirmed. …”
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