Primary bronchial leiomyosarcoma: a diagnostic challenge by Dan Chen, Shuai Luo

“…Conclusions Pulmonary and bronchial leiomyosarcomas often occur in young males with rapid progression and poor prognosis, but metastasis is rare. Surgical resection is the first-line treatment. …”
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Comparative Study between Plastic and Metallic Stents for Biliary Decompression in Patients with Distal Biliary Obstruction by João Guilherme G. Cabral, Eloy Taglieri, Adriane Pelosof, Daniel Rosendo, José Celso Ardengh

“…Diagnoses were 44 pancreatic adenocarcinoma (74.6%), 9 metastasis (15.5%), 3 pancreatic neuroendocrine tumors (5.1%), and 2 adenocarcinoma in the major papilla (3.4%). …”
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Comparison of Syndecan-1 Immunohistochemical Expression in Lobular and Ductal Breast Carcinoma with Nodal Metastases by Ivana Miše, Majda Vučić

“…Syndecan-1 (Sdc1) is a transmembrane heparan sulfate proteoglycan, an extracellular matrix receptor involved in intercellular communication, proliferation, angiogenesis, and metastasis. This study determined and compared Sdc1 expression in the tumor cells and stroma of 30 invasive lobular and 30 invasive ductal breast carcinomas (ILCs/IDCs), also in the axillary node metastases of ductal type, and correlated it with clinical and tumor parameters. …”
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Associations between cancer-related coping and depressive symptoms in oral cancer patients by ChunYing Cui, Lie Wang

“…In addition, distant metastasis was associated with depressive symptoms (β = 0.084, p < 0.047). …”
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Numb Chin Syndrome as First Symptom of Diffuse Large B-Cell Lymphoma by Mario Carbone, Francesco Della Ferrera, Lucio Carbone, Gaia Gatti, Marco Carrozzo

“…Many malignant and metastatic neoplasms are causing this syndrome, like primary osteosarcoma, squamous cell carcinoma, and mandibular metastasis of primary carcinoma of breast, lung, thyroid, kidney, prostate, and nasopharynx. …”
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A Case Report on Alveolar Rhabdomyosarcoma in an Indigenous Dog by Farjana Akter, Md. Zillur Rahman, Mohammad Mahbubur Rahman, Bristy Dhar Nandita, Md. Foisal Shikder, Md. Piar Rahaman Shihab, Monoar Sayeed Pallab

“…The cause of the death and presence of metastasis could not be confirmed as follow‐up investigations were declined by the owner. …”
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Primary Acinic Cell Carcinoma of the Breast: A Clinicopathological and Immunohistochemical Study by Kiyoshi Shingu, Tokiko Ito, Gengo Kaneko, Nobuo Itoh

“…It was removed with lumpectomy, and sentinel lymph node biopsy was performed to check for metastasis. Microscopically, the tumor showed an infiltrative growth pattern with a combination of solid, trabecular, and microglandular areas. …”
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Subcutaneous Angiomatoid Fibrous Histiocytoma Mimicking Metastatic Melanoma by E. Sparreboom, C. Wetzels, M. Verdijk, S. Mulder, W. Blokx

“…This case report illustrates the importance for pathologists of knowing the typical pathology features of AFH and integrating immunohistochemical and molecular findings in order to prevent overdiagnosis of lymph node metastasis of a malignancy.…”
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Endoscopic Resection of Sinonasal Hemangiopericytoma following Preoperative Embolisation: A Case Report and Literature Review by Georg J. Ledderose, Donata Gellrich, Markus Holtmannspötter, Andreas Leunig

“…Less than 5% of hemangiopericytoma occur in the nasal cavity and are characterised by a rather benign nature with low tendency of metastasis. However, as the recurrence rate in the literature ranges from 9.5% to 50%—depending on the length of followup—a radical surgical resection is considered as the gold-standard treatment. …”
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The Role of Sulfatides in Liver Health and Disease by Lin Chen, Montserrat Elizalde, Gloria Alvarez-Sola

“…Previous studies have shown elevated levels of sulfatides in hepatocellular carcinoma (HCC), where sulfatides could act as adhesive molecules that contribute to cancer metastasis. We have recently demonstrated how loss of function of GAL3ST1, a limiting enzyme involved in sulfatide synthesis, reduces tumorigenic capacity in cholangiocarcinoma (CCA) cells. …”
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Single-cell RNA sequencing highlights the unique tumor microenvironment of small cell neuroendocrine cervical carcinoma by Tianyou Wang, Li Zhang, Song Mei, Bo Wang, Jiaqi Liu, Weiping Yang, Jiongbo Liao, Chao Wang

“…Abstract Small cell neuroendocrine cervical carcinoma is a highly aggressive tumor characterized by early metastasis, a high recurrence rate, and poor prognosis. …”
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Psoas Muscle Infiltration Masquerading Distant Adenocarcinoma by Kamel A. Gharaibeh, Arnaldo Lopez-Ruiz, Tauqeer Yousuf

“…Malignant metastasis to the psoas muscle is rare. We report a case that clinically mimicked psoas abscess that was subsequently proven to be from metastatic disease secondary to adenocarcinoma of the duodenum. …”
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Management and Outcomes of Male Breast Cancer in Zaria, Nigeria by Adamu Ahmed, Yahaya Ukwenya, Adamu Abdullahi, Iliyasu Muhammad

“…Fifty three (93%) patients presented with advanced disease including 15 with distant metastasis. Four patients with stage II disease were treated with modified radical mastectomy, chemotherapy and tamoxifen. …”
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Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation by Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony

“…The poor prognosis can be attributed to the complex tumor microenvironment (TME) in OSCC, which is crucial for tumor progression, angiogenesis, invasion, metastasis, and therapeutic resistance. In recent years, three-dimensional (3D) in vitro models have emerged as powerful tools to study OSCC biology and evaluate targeted therapies in a more physiologically relevant context. …”
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Th22 Cells/IL-22 Serves as a Protumor Regulator to Drive Poor Prognosis through the JAK-STAT3/MAPK/AKT Signaling Pathway in Non-Small-Cell Lung Cancer by Yinan Yao, Guangdie Yang, Guohua Lu, Jiani Ye, Luyun Cui, Zhu Zeng, Junjun Chen, Jianying Zhou

“…The level of Th22 cells in peripheral blood mononuclear cells (PBMCs) was positively correlated with the TNM stage, lymph node metastasis, and clinical tumor biomarkers. Furthermore, IL-22 not only antagonized the apoptosis inducing and cell cycle arresting effect by chemotherapy and molecular targeted drugs on NSCLC cell lines but also promoted tumor cell proliferation and tumor tissue growth. …”
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Carcinoma epidermoide primitivo de mama en hombre. Presentación de un caso by Lidia Torres Aja, José Alberto Puerto Lorenzo

“…Actualmente el paciente se sigue en consulta y está libre de metástasis. Por lo inusual del caso se decide su publicación. …”
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Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy by Zhang Z, Wang R, Chen L

“…Zhongsong Zhang,1 Rong Wang,1 Long Chen2 1School of Clinical Medicine, Chengdu Medical College, Chengdu, 610550, People’s Republic of China; 2School of Basic Medical Sciences, Chengdu Medical College, Chengdu, 610550, People’s Republic of ChinaCorrespondence: Long Chen, Email chenlong@cmc.edu.cnAbstract: Cancer-associated fibroblasts (CAFs) are a heterogeneous population of non-malignant cells that play a crucial role in the tumor microenvironment, increasingly recognized as key contributors to cancer progression, metastasis, and treatment resistance. So, targeting CAFs has always been considered an important part of cancer immunotherapy. …”
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Biophysical Profiling of Tumor Cell Lines by Frederick Coffman, Rachid Hamid, Marion C. Cohen, Ralph Garippa, Stanley Cohen

“…Despite significant differences in genetic profiles, cancer cells share common phenotypic properties, including membrane-associated changes that facilitate invasion and metastasis. The Corning Epic® optical biosensor was used to monitor dynamic mass rearrangements within and proximal to the cell membrane in tumor cell lines derived from cancers of the colon, bone, cervix, lung and breast. …”
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High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis by Zhihui Wang, Wenbin Wang, Qing Luo, Guanbin Song

“…Plectin, an essential cytoskeletal linker protein, has recently emerged as a promoter of cancer progression, particularly in the context of cancer cell invasion and metastasis. However, the responsiveness of plectin to changes in ECM stiffness and its impact on HCC progression remain unclear. …”
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A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties by Floriane Lignet, Vincent Calvez, Emmanuel Grenier, Benjamin Ribba

“…Angiogenesis has been recognized as a key stage for cancer development and metastasis. In this paper, we propose a structural model of the main molecular pathways involved in the endothelial cells response to VEGF stimuli. …”
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