Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6 by Johannes Woelk, Florian Hornsteiner, Stephanie Aschauer-Wallner, Patrizia Stoitzner, Gottfried Baier, Natascha Hermann-Kleiter

“…The therapeutic targeting of NR2F6 may be a promising strategy for boosting NKp46-dependent NK-cell-mediated tumor surveillance and metastasis.…”
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Prognostic and Risk Factors in Patients with Locally Advanced Cutaneous Squamous Cell Carcinoma of the Trunk and Extremities by de Lima Vazquez Vinicius, Cristovam Scapulatempo, Natalia Martins Perpetuo, Faheez Mohamed, Teóclito Sachetto de Carvalho, Antônio Talvane Torres de Oliveira, José Getúlio Martins Segalla, André Lopes Carvalho

“…Clinical and histopathological factors related to lymph node metastasis and prognosis were also established. Primary tumor positivity was 25.5% for EGFR, 87.3% for HER-3, and 48.1% for HER-4. …”
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EMA/CO Combination Chemotheraphy in Gestational Trophoblastic Neoplasia: Update of Our Results by Tolga Taşçı, Işın Üreyen, Günsu Kimyon, Alper Karalök, Sevgi Koç, M. Faruk Köse, Gökhan Tulunay, Taner Turan

“…When the antecedent pregnancy was term pregnancy or the histopathological diagnosis was choriocarcinoma or when there was liver metastasis, the treatment success decreased. The effects of tumor dimension and the presence of metastasis tended to be statistically significant in determining the resistance to therapy. …”
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B-CLL with negative 18F-FDG PET/CT and intensive solitary lesion on PSMA PET/CT mimicking prostate cancer bone metastases by Theresa Jung, Daniel Neureiter, Gregor Schweighofer-Zwink, Gundula Rendl, Christian Pirich, Mohsen Beheshti

“…This pattern could present an oligometastatic PCa disease, which might change the treatment plan of the patient to radiation of the bone metastasis. However, bone biopsy of the detected lesion on L2 revealed infiltrates of B-CLL. …”
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Downregulation of LPAR1 Promotes Invasive Behavior in Papillary Thyroid Carcinoma Cells by Zahra Bokaii Hosseini, Fatemeh Rajabi, Reza Morovatshoar, Mahshad Ashrafpour, Panteha Behboodi, Dorsa Zareie, Mohammad Natami

“…Conclusion: LPAR1 suppresses metastasis and is linked to EMT, as evidenced by the decreased LPAR1 expression and increased miR-221-5p in PTC. …”
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Radiomics-based Machine Learning Approach to Predict Chemotherapy Responses in Colorectal Liver Metastases by Yuji Miyamoto, Takeshi Nakaura, Mayuko Ohuchi, Katsuhiro Ogawa, Rikako Kato, Yuto Maeda, Kojiro Eto, Masaaki Iwatsuki, Yoshifumi Baba, Toshinori Hirai, Hideo Baba

“…We manually delineated three-dimensional tumor volumes, selecting the largest liver metastasis for measurement, using pretreatment portal-phase CT images and extracted 107 radiomics features. …”
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CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers by Chiara Tuccilli, Enke Baldini, Salvatore Sorrenti, Antonio Catania, Alessandro Antonelli, Poupak Fallahi, Francesco Tartaglia, Susi Barollo, Caterina Mian, Andrea Palmieri, Giovanni Carbotta, Stefano Arcieri, Daniele Pironi, Massimo Vergine, Massimo Monti, Salvatore Ulisse

“…The increased PD-L2 expression correlated with BRAFV600E mutation and lymph node metastasis, while its lower expression correlated with the follicular PTC variant. …”
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AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription by Lingshan Zhou, Yuan Yang, Qian Qiao, Yingying Mi, Yuling Gan, Ya Zheng, Yuping Wang, Min Liu, Yongning Zhou

“…Overexpression of Notch1-IC was shown to promote the proliferation, invasion, and metastasis of GC cells, while knockdown of IRS-1 partially inhibited the aforementioned effects induced by Notch1-IC overexpression. …”
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Melanoma extracellular vesicles membrane coated nanoparticles as targeted delivery carriers for tumor and lungs by María Sancho-Albero, Alessandra Decio, Reha Akpinar, Ada De Luigi, Raffaella Giavazzi, Luigi M. Terracciano, Luisa De Cola

“…We implement the EV membranes, extracted by the EVs produced by melanoma B16-BL6 cells, as a coating of organosilica porous particles with the aim of targeting tumors and lung metastasis, while avoiding systemic effects and accumulation of the NPs in undesired organs. …”
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Utilizing vaginal natural orifice to facilitate bowel manipulation during totally intracorporeal ileal conduit construction: a retrospective cohort study by Kaipeng Jia, Shiwang Huang, Zhun Wang, Yuda Lin, Yiduo Bai, Chong Shen, Zhe Zhang, Zhouliang Wu, Yunkai Qie, Hailong Hu

“…In the MICUD group, there was one case of local tumor recurrence, two cases of distant metastasis, including one death from progression; in the ECUD group, one patient had distant metastasis and died from progression.Conclusion RARC with MICUD represents a safe, feasible and easy-to-learn minimally invasive surgical approach. …”
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Evaluating the influence of anti-PD-1 immunotherapy combined with IMRT on thyroid dysfunction in nasopharyngeal carcinoma by Liqianqi Chen, Zihuang Li, Xianming Li, Shihai Wu, Long Gong, Gang Xu, Shanyi Chen, Yucong Zhang

“…T-tests, rank-sum tests, multivariate logistic regression analysis, ROC curves, and Cox proportional hazards models were used to evaluate the effects of anti-PD-1 immunotherapy combined with chemoradiotherapy on thyroid function.ResultsPatients with pre-treatment smoking history, thyroid nodules, and cervical lymph node metastasis were more likely to develop thyroid dysfunction (P<0.05). …”
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DLAT is involved in ovarian cancer progression by modulating lipid metabolism through the JAK2/STAT5A/SREBP1 signaling pathway by Hui Wang, Shen Luo, Yue Yin, Yang Liu, Xiaomei Sun, Ling Qiu, Xin Wu

“…A subcutaneous tumor model was established in BALB/c mice to confirm the role of the DLAT/SREBP1 axis in OC growth and metastasis in vivo. Results DLAT expression was significantly upregulated in OC patient tissue and associated with poor prognosis. …”
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ACOX1 activates autophagy via the ROS/mTOR pathway to suppress proliferation and migration of colorectal cancer by Bo Shi, Junjie Chen, Haoran Guo, Xinyu Shi, Qingliang Tai, Guoliang Chen, Huihui Yao, Xiuwei Mi, Runze Zhong, Yang Lu, Yiyuan Zhao, Liang Sun, Diyuan Zhou, Yizhou Yao, Songbing He

“…Additionally, in vitro as well as in vivo, ACOX1 overexpression dramatically reduced the proliferation and metastasis of CRC cells. Mass spectrometry revealed the crucial role of ACOX1 in fatty acid β-oxidation, as its overexpression led to a substantial increase in reactive oxygen species (ROS) derived from fatty acid β-oxidation. …”
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Cutaneous Squamous Cell Carcinoma with Invasion through Ear Cartilage by Julie Boisen, C. Helen Malone, Brent Kelly, Richard F. Wagner

“…Cutaneous squamous cell carcinoma of the ear represents a high-risk tumor location with an increased risk of metastasis and local tissue invasion. However, it is uncommon for these cancers to invade through nearby cartilage. …”
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Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases by Vivek Alaigh, Debapriya Datta

“…We report a case of spontaneous TLS in a patient with leiomyosarcoma of the uterus, with metastasis to lung. Such a case has never been reported before.…”
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A Rare Clinical Presentation of Cholangiocarcinoma by Elisa Gravito-Soares, Marta Gravito-Soares, Pedro Figueiredo, Luis Tomé

“…Cholangiocarcinoma is an uncommon tumor, often diagnosed in the context of obstructive jaundice. Brain metastasis rarely occurs with the cerebellum being a rare site of spread of this type of tumor. …”
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An incidental diagnosis of an unusually located echinococcus alveolaris by Ganime Çoban, Anas Abdallah, Zuhal Gücin, Alpay Alkan

“…A 45-year-old male patient was diagnosed with an intracranial mass suggesting a metastasis in the frontal region shown in the cranial computed tomography (CT) scan following a cranial trauma. …”
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Interactions between the tumor microbiota and breast cancer by Hua Guo

“…This review builds on existing research to comprehensively analyze the role of gut and intratumoral microbiota and their metabolites in the development and metastasis of breast cancer. We also explore the potential function of the microbiota as biomarkers for prognosis and therapeutic response, highlighting the need for further research to clarify the causal relationship between the microbiota and breast cancer. …”
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Metaplastic Carcinoma of the Breast with Squamous Differentiation: A Case Report from the University Teaching Hospital of Kigali (CHUK), Rwanda by Delphine Uwamariya, Carine Nyampinga, Anne Yvette Nsenguwera, Belson Rugwizangoga

“…It presents with large mass and frequently with distant metastasis at time of diagnosis. Morphologically, it is characterized by the differentiation of neoplastic epithelium into epithelial or mesenchymal-looking elements like squamous cells, spindle cells, cartilage, or bone and has poor prognosis with its triple negative status.…”
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Multiple Myeloma Breast Involvement: A Case Report by Heba O. E. Ali, Zafar Nasir, Ahmed M. S. M. Marzouk

“…The patient was managed for multiple spinal lesions that were primarily thought to be metastasis from primary breast cancer.…”
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