The steady-state level of plasma membrane ceramide is regulated by neutral sphingomyelinase 2 by Anne G. Ostermeyer-Fay, Abhay Kanodia, Ranjana Pathak, Maria Jose Hernandez-Corbacho, Aarnoud C. van der Spoel, Yusuf A. Hannun, Daniel Canals

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Development and Application of a LC-MS/MS Method for Simultaneous Quantification of Four First-Line Antituberculosis Drugs in Human Serum by Yunliang Zheng, Nana Xu, Xingjiang Hu, Qiao Zhang, Yanpeng Liu, Qingwei Zhao

“…A simple, rapid, and sensitive liquid chromatography (LC)/mass spectrometry (MS) method was established and validated for simultaneous quantitation of pyrazinamide, isoniazid, rifampicin, and ethambutol in human blood sample. …”
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Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots by Dos Santos Delair Silveira, Oberger Júlia Vieira, Niero Rivaldo, Wagner Theodoro, Delle Monache Franco, Cruz Alexandre Bella, Martin-Quintal Zhelmy, Cechinel Filho Valdir

“…Considering the high levels of chemical constituents and their biological activity in dichloromethane fraction, the plants were grown in different seasons and the respective dichloromethane fractions were analyzed by gas chromatography-mass spectrometry. The antimicrobial activity was evaluated against several pathogenic microorganisms by determining the minimum inhibitory concentration (MIC) using the agar dilution method. …”
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Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults by Mohammed Lamorde, Pauline Byakika-Kibwika, William S. Tamale, Francis Kiweewa, Mairin Ryan, Alieu Amara, John Tjia, David Back, Saye Khoo, Marta Boffito, Cissy Kityo, Concepta Merry

“…Drug concentrations in plasma were determined by liquid chromatography and tandem mass spectrometry. Geometric mean ratios (GMRs) and confidence intervals (CIs) of parameters were calculated (reference, fasting). …”
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The transport of polyphenols from Camellia fascicularis in Caco-2 cells based on UPLC-ESI-MS/MS by Shengjiang Duan, Hao Zheng, Junrong Tang, Huan Kan, Changwei Cao, Zhijiao Shi, Yun Liu

“…Herein, digestion samples (DS) of C. fascicularis polyphenols (CFPs) were metabolically analyzed based on their bidirectional translocation in Caco-2 cells using ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry. The results indicated that after DS transported via Caco-2 cell monolayer models nine polyphenol compounds in transit solution (TSB) from apical (AP) to basolateral (BL) side were upregulated, whereas seven in the transit solution (TSA) from BL to AP side were upregulated. …”
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Interaction of human neutrophils with Trichomonas vaginalis protozoan highlights lactoferrin secretion by Wei-Hung Cheng, Ruei-Min Chen, Seow-Chin Ong, Yuan-Ming Yeh, Po-Jung Huang, Chi-Ching Lee

“…We conducted a comprehensive profiling of soluble excretory/secretory proteins (ESPs), identifying 192 protein spots, of which 94 were successfully characterized through mass spectrometry analysis. Notably, the majority of induced ESPs from co-cultivation exhibited consistency with the trichomonad and neutrophil standalone groups, except for lactoferrin, which was observed exclusively following the interaction between neutrophils and T. vaginalis. …”
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Antifungal Activity of Essential Oil Isolated from Pelargonium roseum against Grey Mould (Botrytis cinerea) of Cherry Tomato by Fuyan LIU, Runxia YANG, Yangcuiji ZHENG, Chongjun ZHAO, Liming FAN, Fawu SU, Min YE

“…In this study, the EO of P. roseum was extracted by water vapor distillation, and the chemical components were determined by gas chromatography-mass spectrometry (GC-MS). The inhibitory effects of different concentrations of the EO and its compounds on the growth of mycelium and the germination of spores were determined by the poison food technique and dual culture method, respectively. …”
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A new portable sampler of atmospheric methane for radiocarbon measurements by G. Zazzeri, G. Zazzeri, L. Wacker, N. Haghipour, P. Gautschi, T. Laemmel, T. Laemmel, S. Szidat, S. Szidat, H. Graven

“…In this study, we address this challenge by advancing the system in Zazzeri et al. (2021) into a much more compact and portable sampler and by coupling the sampler with the MICADAS (MIni CArbon DAting System) accelerator mass spectrometry (AMS) system at ETH Zurich, using a gas interface.…”
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Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro by Hyun Sang Cho, Mohammad Faysal Al Mazid, Eun-Young Lee, Md Abu Rayhan, Hyoun Sook Kim, Byung Il Lee, Hye Jin You

“…Mutation of alanine or serine instead of cysteine in RKIP proteins did not affect the biochemical characteristics, while dynamic light scattering and liquid chromatography (LC) quadrupole time-of-flight (Q-TOF) mass spectrometry (MS) suggested distinct peaks in solution, which were identified via LC–MS/MS analyses, and further clarified the role of cysteine in RKIP dimerization. rhRKIP dimer formation was abrogated by a 32-aa peptide mimicking the region between two RKIP proteins for dimerization. …”
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Analysis of the Production and Economic Indicators of Broiler Chicken Rearing in 2020–2023: A Case Study of a Polish Farm by Michalina Adaszyńska-Skwirzyńska, Paweł Konieczka, Mateusz Bucław, Danuta Majewska, Arkadiusz Pietruszka, Sławomir Zych, Danuta Szczerbińska

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Tracing the Origin of Oxide Inclusions in Vacuum Arc Remelted Steel Ingots Using Trace Element Profiles and Strontium Isotope Ratios by Christoph Walkner, Gulnaz Mukhametzianova, Stefan Wagner, Jörg C. Korp, Andreas Graf, Johanna Irrgeher, Thomas C. Meisel, Thomas Prohaska

“…In this study, the potential of elemental and isotopic fingerprinting to trace the sources of macroscopic oxide NMIs found in VAR-treated steel ingots using SEM-EDX, inductively coupled plasma mass spectrometry (ICP-MS), laser ablation ICP-MS (LA-ICP-MS), and laser ablation multicollector ICP-MS (LA-MC-ICP-MS) were exploited. …”
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Seasonal Changes in the Elemental Composition of Five Valuable Fish Species (<i>Sparidae</i>) from Bozcaada, North Aegean Sea: A Health Risk and Nutritional Benefit Assessment by İlknur Yuvka, Ali Rıza Kosker, Mustafa Durmus, Yılmaz Ucar, Yesim Ozogul

“…The concentrations of elements such as calcium, potassium, magnesium, phosphorus, copper, iron, manganese, zinc, chromium, nickel, selenium, cadmium, and mercury were analyzed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The elemental concentrations varied as follows: Ca (11,388.46–55,470.76), K (17,230.83–27,594.86), Mg (1436.02–2326.73), Na (1962.30–7847.41), P (13,112.11–15,516.57), Fe (107.61–282.00), Cu (36.44–59.13), Mn (6.19–19.87), Zn (98.67–256.26), Cr (4.54–11.96), Ni (6.33–13.89), Se (0.82–7.33), Cd (0.08–0.32), and Hg (0.08–1.50) mg/kg. …”
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Comprehensive study of Tilapia skin collagen peptide on ileal injury and intestinal flora in rats induced by high altitude hypoxia by Jingyi Wang, Hao Wang, Chunxia Li, Xiaojuan Zhang, Jin Liu, Yanzhou Hu, Ping Qian

“…Additionally, a Nano liquid chromatography-tandem mass spectrometry (nano LC-MS/MS) and virtual screening were employed to identify specific peptides that could be functionally significant. …”
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Predictive value of bile acids as metabolite biomarkers for gallstone disease: A systematic review and meta-analysis. by Xu Han, Juan Wang, Yingnan Wu, Hao Gu, Ning Zhao, Xing Liao, Miao Jiang

“…The level of serum DCA in the GSD patients was found to be increased by using chromatography, yet decreased by chromatography mass spectrometry.<h4>Conclusion</h4>The profiles of BAs demonstrated distinctive changes in GSD patients compared with healthy control subjects. …”
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Novel Insights into the Nobilamide Family from a Deep-Sea <i>Bacillus</i>: Chemical Diversity, Biosynthesis and Antimicrobial Activity Towards Multidrug-Resistant Bacteria by Vincenza Casella, Gerardo Della Sala, Silvia Scarpato, Carmine Buonocore, Costanza Ragozzino, Pietro Tedesco, Daniela Coppola, Giovanni Andrea Vitale, Donatella de Pascale, Fortunato Palma Esposito

“…The integration of tandem mass spectrometry molecular networking and bioassay-guided fractionation unveiled this strain as a prolific factory of surfactins and nobilamides. …”
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The concentration of selected organophosphorus pesticides associated with PM10 in agricultural ambient air in Iran: Health risk assessment using Monte Carlo simulation by Asma Tabanasl, Amin Mohammadpour, Aboozar Soltani, Mohammad Hoseini, Mohammadali Baghapour

“…Active sampling was conducted using a SKC pump with a selective air inlet, and the samples were analyzed via liquid chromatography-mass spectrometry. The results indicated that Diazinon exhibited the highest average concentration among PM10-bound organophosphate pesticides, measuring 4.23 ng/m³ in suburban areas and 2.51 ng/m³ in urban environments. …”
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Betaxanthin Profiling in Beta vulgaris Leaves and Gymnocalycium mihanovichii Grafted Cacti: A Comprehensive Study by Aneta Spórna-Kucab, Anna Tekieli, Magdalena Knapek, Marta Zużałek, Sławomir Wybraniec

“…This study was focused on the identification and quantification of betaxanthins using high-performance liquid chromatography with a diode array detector coupled to electrospray ionisation mass spectrometry (HPLC-DAD-ESI-MS) in leaves of various cultivars of Beta vulgaris (beet) and Gymnocalycium mihanovichi i grafted cacti. …”
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Comparative analysis of phytonutrients of Moringa oleifera leaves from South Africa and Nigeria, and their antimicrobial and antioxidant potentials by UPLC-ESI-QToF-MS and OPLS-DA... by Jonathan Kayembe, Cosa Sekelwa, Kokoette Bassey

“…This study aimed to conduct a comparative analysis of the phytonutrients (nutrients protectors) or supplements, antioxidant, and antimicrobial potentials of M. oleifera leaves from Nigeria and South Africa to benchmark quality control protocols for commercial beverages such as Moringa porridge.MethodsStandard techniques, including high-performance liquid chromatography-photodiode array and ultra-high-performance liquid chromatography electrospray ionization quadruple time-of-flight mass spectrometry (UPLC-ESI-QToF-MS) and chemometrics orthogonal partial least square discriminant analysis (OPLS-DA) were employed for phytoconstituents fingerprinting. …”
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Differences in central dopamine, but not serotonin, activity and welfare associated with age but not with preening cup use in commercial grow-out Pekin duck barns by M.M. Bergman, J.M. Schober, R. Novak, A. Grief, C. Plue, D. Frey, H. Parnin, G.S. Fraley

“…To evaluate the ducks’ affective state, we combined measuring welfare by walking a transect in the barn with mass spectrometry and qRT-PCR to measure brain neurotransmitter levels and gene expression for serotonin (5-HT) and dopamine (DA) synthesis and metabolism. 5-HT and DA have been established as indicators of mental state and emotions. …”
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Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants by Alain J. Benitez, Ceylan Tanes, Elliot S. Friedman, Joseph P. Zackular, Eileen Ford, Jeffrey S. Gerber, Patricia A. DeRusso, Andrea Kelly, Hongzhe Li, Michal A. Elovitz, Gary D. Wu, Babette Zemel, Kyle Bittinger

“…Here, we use a prospective longitudinal birth cohort of n = 323 healthy term African American children to determine the association between antibiotic exposure and the gut microbiome through shotgun metagenomics sequencing as well as bile acid profiles through liquid chromatography-mass spectrometry. Results Stool samples were collected at ages 4, 12, and 24 months for antibiotic-exposed (n = 170) and unexposed (n = 153) participants. …”
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