Lactobacillus reuteri LR1 Improved Expression of Genes of Tight Junction Proteins via the MLCK Pathway in IPEC-1 Cells during Infection with Enterotoxigenic Escherichia coli K88 by Hongbo Yi, Li Wang, Yunxia Xiong, Zhilin Wang, Yueqin Qiu, Xiaolu Wen, Zongyong Jiang, Xuefen Yang, Xianyong Ma

“…In conclusion, L. reuteri LR1 had beneficial effects on epithelial barrier function consistent with increasing ZO-1 and occludin expression via a MLCK-dependent manner in IPEC-1 cells during challenge with ETEC K88.…”
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Giant and flexible toroidal circular dichroism from planar chiral metasurface by Shijie Kang, Haitao Li, Jiayu Fan, Jiusi Yu, Boyang Qu, Peng Chen, Xiaoxiao Wu

“…With the introduction of a displacement, or bilayer offset, between the opposite layers, we experimentally achieve giant chiral responses with the intrinsic circular dichroism (CD) reaching 0.69 in measurements, and the CD can be quantitatively manipulated in a simple manner. The giant intrinsic chirality primarily originates from distinct excitations of in-plane toroidal dipole moments under circular polarized incidences, and the toroidal chiral response is quantitatively controlled by the bilayer offset. …”
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Postnatal expression of Cat-315-positive perineuronal nets in the SAMP10 mouse primary somatosensory cortex by Hiroshi Ueno, Yu Takahashi, Sachiko Mori, Eriko Kitano, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

“…To confirm whether Cat-315-positive PNNs changed in an age-dependent manner in SAMP10 mice, we examined the primary somatosensory cortex at 21, 28, and 56 days after birth. …”
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Human Chorionic Plate-Derived Mesenchymal Stem Cells Restore Hepatic Lipid Metabolism in a Rat Model of Bile Duct Ligation by Yun Bin Lee, Jong Ho Choi, Eun Nam Kim, Jin Seok, Hyun-Jung Lee, Jung-Hwan Yoon, Gi Jin Kim

“…CPT1A expression was changed via microRNA-33—a posttranscriptional regulator of CPT1A—in a peroxisome proliferator-activated receptor α-independent manner. Cellular adenosine triphosphate production—an indicator of mitochondrial function—was reduced after BDL and was restored by CP-MSC transplantation. …”
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An EED/PRC2‐H19 Loop Regulates Cerebellar Development by Pei‐Pei Liu, Xiao Han, Xiao Li, Shang‐Kun Dai, Ya‐Jie Xu, Lin‐Fei Jiao, Hong‐Zhen Du, Li‐Hua Zhao, Rong‐Feng Li, Zhao‐Qian Teng, Yun‐Gui Yang, Chang‐Mei Liu

“…Importantly, an obvious H3K27ac enrichment is found at Ctcf, a trans‐activator of H19, and H3K27me3 enrichment at the H19 imprinting control region (ICR), suggesting that EED regulates H19 in an H3K27me3‐dependent manner. Intriguingly, H19 deletion reduces EED expression and the reprogramming of EED‐mediated H3K27me3 profiles, resulting in increased proliferation, differentiation, and decreased apoptosis of GCPs. …”
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Exome sequencing of UK birth cohorts [version 2; peer review: 2 approved, 1 approved with reservations] by Petr Danecek, Amy Hough, John Wright, Karen Ho, Nicholas J. Timpson, Sarah J. Lindsay, Davide Bonfanti, Daniel S. Malawsky, Rafaq Azad, Deborah Plowman, Sara Widaa, Gemma Shireby, Emla Fitzsimons, David Bann, Matthew E. Hurles, Hilary C. Martin, Susan M. Ring, Dan Mason, Michael A. Quail, Wei Huang, Vivek Iyer, Mahmoud Koko, Iaroslav Popov, Laurie Fabian, Gennadii Zakharov, Ruth Y. Eberhardt, Emma E. Wade, Qin Qin Huang

“…The overall objective of this coordinated effort is to make the resulting high-quality data widely accessible to the global research community in a timely manner. We describe how the datasets were generated and subjected to quality control at the sample, variant and genotype level. …”
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Authority and Moral Conflicts in the Films of Adébáyọ Fálétí: Àfọ̀njá, Gáà, Ṣawo Ṣẹ̀gbẹ̀rì and the Yorùbá Cosmopolis by Olayinka Agbetuyi

“…Authority and Moral Conflicts in the Films of Adébáyọ Fálétí 173 production, it was the last to be written among the three and is organically a prequel which builds on the success of Gáà and extends a thematic continuum in the Fágúnwà-esque manner of the novels Ògbójú Ọde Ninu Igbó Irunmọlẹ and Igbo Olódùmarè. …”
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Acute Care Practice in the United States: The Roles of Occupational Therapy and Physical Therapy in Early Rehabilitation by Suzanne E. Holm, Kelly Nelson, Angela Patterson

“…ER refers to the initiation of therapy services in an expedited manner for patients who have rehabilitative, safety, or community support needs in the acute care hospital. …”
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6G: The Intelligent Network of Everything by Harri Pennanen, Tuomo Hanninen, Oskari Tervo, Antti Tolli, Matti Latva-Aho

“…A special focus is given to a comprehensive set of potential 6G technologies, each of which is introduced in a tutorial manner, with a discussion on the vision, introduction, past, present, opportunities, challenges, literature, and future research directions. …”
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Pregnancy-Associated Plasma Protein A Induces Inflammatory Cytokine Expression by Activating IGF-I/PI3K/Akt Pathways by Weiping Li, Hongwei Li, Li Zhou, Zijian Wang, Bing Hua

“…Results showed that PAPP-A significantly stimulated the expression of MCP-1, TNF-α, and IL-6 at both transcriptional and translational levels in a dose-dependent and time-dependent manner. The secretion of these inflammatory cytokines by macrophages was also increased after PAPP-A treatment. …”
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Optimized Path Planning and Scheduling in Robotic Mobile Fulfillment Systems Using Ant Colony Optimization and Streamlit Visualization by Isam Sadeq Rasham

“…These systems involve the use of self- governed mobile chares to collect shelves as well as orders for deliveries with regard to optimization of task allocation and with reduced expenses. However, in a manner to implement such systems, one needs to find enhanced algorithms pertaining to resource mapping and the planning of movement of robots in sensitive environments. …”
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Propofol Regulates ER Stress to Inhibit Tumour Growth and Sensitize Osteosarcoma to Doxorubicin by Hua Wei, Xinhui Du, Huaping Zhao, Peipei Sun, Jianjun Yang

“…Propofol treatment led to significant growth inhibition in MG63 and 143B cells in a dose-dependent manner (p<0.05). Osteosarcoma migration (MG63 91.4 (82–102) vs. 56.8 (49–65), p<0.05; 143B 96.6 (77–104) vs. 45.4 (28–54), p<0.05) and invasion (MG63 68.6 (61–80) vs. 32 (25–39), p<0.05; 143B 90.6 (72–100) vs. 39.2 (26–55), p<0.05) were reduced after propofol treatment. …”
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Discovering the anti-parasitic activity of melatonin loaded lecithin/chitosan nanoparticles against giardiasis and cryptosporidiosis in Balb/c infected mice by Mohamed Nasser, Mona B. Abd El-atif, Habiba Alaa, Mariam Abdelaziz, Mariam Mustafa, Mustafa Masour, Salma Magdy, Salma Mohsen, Yomna El Karamany, Alyaa Farid

“…Mel was consistently discharged from nanoparticles in a regulated and enduring manner for 36 h. Moreover, Mel in NPs has an entrapment efficiency (EE) of 33.6% and a drug loading capacity (DLC) of 7.2% and significant reduction (100% and 99.4%, respectively) in the shedding of Giardia cysts and Cryptosporidium oocysts. …”
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Different functions of PHF10 isoforms – subunits of the PBAF chromatin remodeling complex by A. A. Sheynov, V. V. Tatarskiy, A. M. Azieva, S. G. Georgieva, N. V. Soshnikova

“…All isoforms are highly regulated and included in the PBAF complex in a mutually exclusive manner. Two of the PHF10 isoforms (PHF10-P) are expressed at a high level in neuronal and myeloid progenitors and are necessary for cell proliferation. …”
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A pilot study on diabetes detection using handheld fundus camera and mobile app development by Hamada R. H. Al-Absi, Gilbert Njihia Muchori, Saleh Musleh, Syed Abdullah Basit, Mohammad Tariqul Islam, Younss Ait Mou, Tanvir Alam

“…We invited participants from the community to share their demographic information, history of diabetes, and captured their retinal fundus images using the oDocs Nun IR handheld non-mydriatic fundus camera in a non-invasive manner (no dilation is required). Subsequently, we developed a deep learning model for early diagnosis of diabetes based on fundus image only. …”
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Mechanical properties and piecewise constitutive model of fine sandstone in mining area of western China by Qing Wang, Dongxiao Zhang, Fei Han, Yongqiang Zhao, Pengfei Zhang, Feng Xiong

“…The results indicate that (1) the cumulative ringing counts and cumulative energy of the AE increase in a stepwise manner with an increase in the cyclic loading and unloading times. …”
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Shared genetics between breast cancer and predisposing diseases identifies novel breast cancer treatment candidates by Panagiotis N. Lalagkas, Rachel D. Melamed

“…Similarly, for all drugs treating the predisposing disease, we link their targets to pathways. In this manner, we are able to prioritize a list of drugs based on each predisposing disease, with each drug linked to a set of implicating pathways. …”
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Soft intersection almost bi-quasi-interior ideals of semigroups by Aslıhan Sezgin, Zeynep BAŞ, Aleyna İlgin

“…In this context, the concept of Bi-Quasi-Interior Ideal (BQI-ideal) was proposed as a generalization of interior ideal, quasi-ideal, bi-ideal, bi-quasi ideal, and bi-interior ideal in a semigroup in a manner similar to how the notion of soft intersection BQI-ideal was presented to generalize the soft intersection interior ideal, quasi-ideal, bi-ideal, bi-quasi ideal, and bi-interior ideal in a semigroup. …”
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Regulation of S100A8/A9 (Calprotectin) Binding to Tumor Cells by Zinc Ion and Its Implication for Apoptosis-Inducing Activity by Yuichi Nakatani, Masatoshi Yamazaki, Walter J. Chazin, Satoru Yui

“…We previously reported that S100A8/A9 induces apoptosis of EL-4 lymphoma cells via the uptake of extracellular zinc in a manner similar to DTPA, a membrane-impermeable zinc chelator. …”
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Odontogenic differentiation of dental pulp stem cells by glycogen synthase kinase-3β inhibitory peptides by Vidhyashree Rajasekar, Mohamed Mahmoud Abdalla, Mohammed S. Basbrain, Prasanna Neelakantan, Cynthia KY Yiu

“…However, all the tested peptides significantly increased ALP activity and calcium deposition in a dose-dependent manner (p < 0.05). Specifically, L803-mts showed significantly greater ALP activity and mineralization compared to the other peptides and the controls (p < 0.05). …”
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