Therapeutic Effects of GDF6-Overexpressing Mesenchymal Stem Cells through Upregulation of the GDF15/SIRT1 Axis in Age-Related Hearing Loss by Jiali Liu, Haisen Peng, Yuehui Liu, Chunhua Li, Wen Xie

“…Hearing function and loss of outer hair cells (HCs) in ARHL rats were measured using the auditory brainstem response and cochlear silver nitrate staining, respectively. MSC proliferation was evaluated with the Cell Counting Kit-8 assay. …”
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Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells by Peng Wang, Haiyue Zhao, Wei Chen, Yuhui Guo, Shuo Zhang, Xin Xing, Shuai Yang, Fengkun Wang, Juan Wang, Zengwu Shao, Yingze Zhang

“…Mechanical loading shows potential to optimize MSC-EVs for OA treatment, while the underlying mechanism is not clear. …”
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Determination of Carbapenemase-Producing OXA- 48 and KPC Genes in Antibiotic-Resistant Gram-Negative Bacilli Isolated from Infectious Samples of Cardiovascular Patients Hospitalize... by Mina Owrang, Ebrahim Taheri Hossein Abad, Shakiba Shafaie

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Water Risk and Mining Firms’ Stock Return by Maryam Davallou, Shirin Mehrali

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Assessing paramedic performance and background factors in emerging disease outbreak by Karim Javanmardi, Abbas Dadashzadeh, Hossein Feizollahzadeh, Neda Gilani, Mansour Ghafourifard, Javad Dehghannejad

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IL-1β Pretreatment Improves the Efficacy of Mesenchymal Stem Cells on Acute Liver Failure by Enhancing CXCR4 Expression by He Nie, Fangmei An, Jie Mei, Cheng Yang, Qiang Zhan, Qinglin Zhang

“…The results of tracing experiments with CM-Dil-labeled cells confirmed that more cells migrated to the damaged liver in the Pre-MSC group. In terms of mechanism, the CXCR4 expression was significantly enhanced by IL-1β pretreatment, and an increased migration ability towards SDF-1 that could be reversed by AMD3100 was found in Pre-MSCs. …”
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SPIO 标记下大鼠骨髓间充质干细胞生物学特性及 多向分化潜能及体外MR成像

“…【目的】 探讨超顺磁氧化铁纳米颗粒(SPIO)标记对骨髓间充质干细胞生物学特性和多向分化潜能的影响以及体外磁共振(MRI)成像的可行性,为移植干细胞活体MRI成像提供实验基础65377; 【方法】 采用梯度密度离心法和贴壁法获取大鼠骨髓间充质干细胞(BMSC),采用25 μg/mL SPIO联合0.75 μg/mL多聚赖氨酸(PLL)标记BMSC,比较标记和未标记MSC细胞活力65380;增值65380;细胞周期65380;凋亡和成骨65380;成脂多向分化能力;应用1.5T MR对不同数量级细胞分别进行T1WI65380; T2WI和T2*WI序列扫描65377; 【结果】 普鲁士兰染色显示SPIO(25 μg Fe/mL, 48 h)对细胞的标记率接近100%,细胞活力65380;增殖65380;周期和凋亡检测,均显示SPIO标记细胞与未标记细胞间无统计学差异(P > 0.05);成骨65380;成脂诱导显示,BMSC和标记BMSC均具备成骨65380;成脂分化能力;对不同数量级的SPIO标记BMSC行MR扫描,T1WI65380; T2WI和T2*WI能检测到的最小数量级细胞分别为2 × 104, 1 × 104, 0.5 × 104, 呈低信号65377; 【结论】 25 μg/mL SPIO联合0.75 μg/mL PLL能有效标记BMSC,不影响BMSC的活力65380;增值65380;细胞周期65380;凋亡和多向分化能力,1.5T MR示踪标记细胞可行,与T1WI和T2WI序列相比,T2*WI最敏感65377;…”
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Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells by Nicolas Espagnolle, Benjamin Hebraud, Jean-Gérard Descamps, Mélanie Gadelorge, Marie-Véronique Joubert, Laura Do Souto Ferreira, Murielle Roussel, Anne Huynh, Luc Sensébé, Louis Casteilla, Michel Attal, Hervé Avet-Loiseau, Frederic Deschaseaux, Philippe Bourin, Jill Corre

“…For the first time, we present a transcriptomic, phenotypic, and functional comparison of ASCs from MM patients and healthy donors (HDs) relying on their autologous MSC counterparts. In contrast to MM MSCs, MM ASCs did not exhibit major abnormalities. …”
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Designing a Digital Transformation Model in the Offshore Oil and Gas Industry in Iran by Saeid Noadoust, Mostafa Safdari Ranjbar

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The role of the microbiota and metabolites in the treatment of pulmonary fibrosis with UC-MSCs: Integrating fecal metabolomics and 16S rDNA analysis. by Yukai Luo, Shuang Zhou, Xiaojing Zhang, Yijian Lin, Jun Liu, Wenzhao Cheng, Yiming Zeng

“…<h4>Methods</h4>Bleomycin injection was utilized to establish a mouse model of lung fibrosis, followed by the application of 16S rDNA sequencing and LC-MS/MS metabolomics to explore the underlying mechanism of UC-MSC treatment for lung fibrosis. Seventy-five mice were allocated into five groups, namely Control, Model, and low/medium/high dose of UC-MSCs groups, and survival metrics, lung morphology, and the levels of the inflammatory cytokines TNF-α, IL-1β, IL-6, and TGF-β1 were subsequently evaluated. …”
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Effects of Adipose-tissue Derived Mesenchymal Stem Cells on PBMCs in Co-culture with HeLa Cell Line by Maryam Dorfaki, mahdi ghatrehsamani, fahimeh Lavi Arab, Mona Roozbehani, Majid Khoshmirsafa, Reza Falak, Fatemeh Keshavarz, Fatemeh Faraji

“…Materials and Methods: The effect of MSC cells on proliferation, apoptosis, and gene expression of the cytokines tumor necrosis factor alpha (TNF-&#945;), transforming growth factor beta (TGF-&#946;), interleukin (IL)-4, IL-2, and interferon-&#947; in PBMCs cultured together with HeLa cells was investigated using flow cytometry and real-time polymerase chain reaction (PCR), respectively. …”
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Reimagining Global Health: Accelerating Change for a Sustainable Future by Melissa Salm, Ala Alwan, Maureen Lichtveld, Patricia J. García, Peter H. Kilmarx, Nelson K. Sewankambo, Rebecca Martin, Tahmeed Ahmed, Judith N. Wasserheit

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Strategies to Improve the Quality and Freshness of Human Bone Marrow-Derived Mesenchymal Stem Cells for Neurological Diseases by Da Yeon Lee, Sung Eun Lee, Do Hyeon Kwon, Saraswathy Nithiyanandam, Mi Ha Lee, Ji Su Hwang, Shaherin Basith, Jung Hwan Ahn, Tae Hwan Shin, Gwang Lee

“…Depending on timing, before hBM-MSC transplantation into patients, after detaching them from the culture dish, cell viability, deformability, cell size, and membrane fluidity are decreased, whereas reactive oxygen species generation, lipid peroxidation, and cytosolic vacuoles are increased. …”
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Optically Transparent Anionic Nanofibrillar Cellulose Is Cytocompatible with Human Adipose Tissue-Derived Stem Cells and Allows Simple Imaging in 3D by Jonathan J. Sheard, Mesude Bicer, Yiming Meng, Alessia Frigo, Rocío Martínez Aguilar, Thomas M. Vallance, Donata Iandolo, Darius Widera

“…Moreover, it is shown that aNFC is cytocompatible, allowing for MSC proliferation, maintaining cell viability and multilineage differentiation potential. …”
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The Human Mesenchymal Stromal Cell-Derived Osteocyte Capacity to Modulate Dendritic Cell Functions Is Strictly Dependent on the Culture System by Sara Trabanelli, Federico La Manna, Marco Romano, Valentina Salvestrini, Michele Cavo, Marilena Ciciarello, Roberto M. Lemoli, Antonio Curti

“…In vitro differentiation of mesenchymal stromal cells (MSC) into osteocytes (human differentiated osteogenic cells, hDOC) before implantation has been proposed to optimize bone regeneration. …”
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Bioimpedance Spectra Confirm Breast Cancer Cell Secretome Induces Early Changes in the Cytoskeleton and Migration of Mesenchymal Stem Cells by Ana Laura Sánchez-Corrales, César Antonio González-Díaz, Claudia Camelia Calzada-Mendoza, Jesús Arrieta-Valencia, María Elena Sánchez-Mendoza, Juan Luis Amaya-Espinoza, Gisela Gutiérrez-Iglesias

“…Mesenchymal stem cell (MSC) treatments take advantage of the ability of these cells to migrate to target sites, although they have been shown to move in response to tumor influence. …”
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The phosphorus negotiation game (P-Game): first evaluation of a serious game to support science-policy decision making played in more than 20 countries worldwide by Nils Haneklaus, Mary Kaggwa, Jane Misihairabgwi, Sherif Abu El-Magd, Naima Ahmadi, Jamal Ait Brahim, Aloyce Amasi, Andrea Balláné Kovács, Łukasz Bartela, Hajar Bellefqih, Redouane Beniazza, Jaroslav Bernas, Essaid Bilal, Tomislav Bituh, Yelizaveta Chernysh, Viktoriia Chubur, Jelena Ćirić, Claudia Dolezal, Andrea Figulová, Janja Filipi, Gordana Glavan, Tibor Guzsvinecz, László Horváth, Sasho Josimovski, Martin Kiselicki, Maja Lazarus, Maja Kazazić, István Komlósi, Ali Maged, Tebogo Mashifana, Gordana Medunić, Emina Mehić, Felhi Mongi, Kelvin Mtei, Dennis Mwalongo, Jerome Mwimanzi, Jakub Nowak, Oqba Basal, Khaoula Qamouche, Małgorzata Rajfur, Hynek Roubík, Mijalche Santa, Cecília Sik-Lányi, Maike Sippel, Gerald Steiner, Anna Skorek-Osikowska, Anton Slavov, Paweł Świsłowski, Ali Tlili, Kalina Trenevska-Blagoeva, Ivan Tschalakov, Tomáš Vlček, Stanisław Wacławek, Ivan Zlatanović, Matúš Mišík, Hendrik Brink, Tzong-Ru Lee

“…Quantitative results indicate that female participants and MSc students benefitted the most significantly from the P-Game, with their self-reported knowledge about phosphorus science and negotiation science/practice increasing by 71–93% (overall), 86–100% (females), and 73–106% (MSc students in general). …”
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Housing Price Forecasting Using AI (LSTM) by Hossein Ziyadi, Erfan Salavati, Mohammad Mahdi Lotfi Heravi

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The Effect of Whole-Body Vibration on Upper Extremity Function in Children with Cerebral Palsy: A Pilot Study by Marianna Kelaiditi, Alexandra Lepoura, Anna Christakou, Nikolaos Chrysagis, Vasiliki Sakellari

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The Effectiveness of Mindfulness-Based Stress Reduction Therapy on Disease signs and Symptoms and Psychological Distress in Women with Oral Lichen Planus by Fatemeh Sarebannezhad, Abdollah Omidi, Zahra Zanjani, Elaheh Ghasemzadeh Hoseini, Narges Gholizadeh

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