Mesenchymal stromal cells-derived extracellular vesicles in cartilage regeneration: potential and limitations by María Piñeiro-Ramil, Iván Gómez-Seoane, Ana Isabel Rodríguez-Cendal, Isaac Fuentes-Boquete, Silvia Díaz-Prado

“…Recent evidence suggests that the beneficial effects of MSCs are largely mediated by their secreted small extracellular vesicles (sEVs), which have been shown to promote tissue repair and reduce inflammation. MSC-derived sEVs have shown promise in mitigating cartilage degradation and chondrocyte apoptosis, positioning them as a promising alternative to MSC-based therapies for OA treatment. …”
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The Role of PCNA Posttranslational Modifications in Translesion Synthesis by Montaser Shaheen, Ilanchezhian Shanmugam, Robert Hromas

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Osteogenic differentiation of mesenchymal stem cells in cell-laden culture of self-assembling peptide hydrogels by Faye Fouladgar, Robert Powell, Vishalakshi Irukuvarjula, Akhila Joy, Xiao Li, Neda Habibi

“…Mesenchymal stem cell (MSC) osteogenic differentiation requires scaffolds to support multiple stages of growth and differentiation signals. …”
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Interleukin-1β Enhances Umbilical Cord Mesenchymal Stem Cell Adhesion Ability on Human Umbilical Vein Endothelial Cells via LFA-1/ICAM-1 Interaction by Tsai-Yi Wu, Ya-Han Liang, Jiahn-Chun Wu, Hwai-Shi Wang

“…However, the underlying mechanisms of umbilical cord MSC adhesion to endothelial cells during transendothelial migration are still unclear. …”
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Analysis of Connectivity in Electromyography Signals to Examine Neural Correlations in the Activation of Lower Leg Muscles for Postural Stability: A Pilot Study by Gordon Alderink, Diana McCrumb, David Zeitler, Samhita Rhodes

“…MSC is a frequency domain measure that quantifies the linear phase relation between two signals and was analyzed in the alpha (8–13 Hz), beta (13–30 Hz), and gamma (30–100 Hz) neural frequency bands for feet together and feet tandem, with eyes open and eyes closed conditions. …”
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Nonviral Gene Delivery of Growth and Differentiation Factor 5 to Human Mesenchymal Stem Cells Injected into a 3D Bovine Intervertebral Disc Organ Culture System by Christian Bucher, Amiq Gazdhar, Lorin M. Benneker, Thomas Geiser, Benjamin Gantenbein-Ritter

“…Intervertebral disc (IVD) cell therapy with unconditioned 2D expanded mesenchymal stem cells (MSC) is a promising concept yet challenging to realize. …”
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Bone Marrow Mesenchymal Stem Cells Enhance the Differentiation of Human Switched Memory B Lymphocytes into Plasma Cells in Serum-Free Medium by Guillaume Bonnaure, Catherine Gervais-St-Amour, Sonia Néron

“…In these cultures, the secretion of CXCL12 and TGF-β, usually found in the bone marrow, was linked to the presence of MSC. The level of oxygen appeared less impactful than the contact with MSC. …”
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Delayed Manifestation of Shunt Nephritis: A Case Report and Review of the Literature by Michael Babigumira, Benjamin Huang, Sherry Werner, Wajeh Qunibi

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Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes by June Seok Heo, Youjeong Choi, Hyun Ok Kim

“…In this study, adipose-derived MSCs (AdMSCs) and human peripheral blood monocytes (PBMCs) were isolated and cultured to examine the effects of MSC-induced macrophages (iMΦ) on inflammation and immune modulation. …”
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Physical Therapy Adjuvants to Promote Optimization of Walking Recovery after Stroke by Mark G. Bowden, Aaron E. Embry, Chris M. Gregory

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THE EFFECT OF PLATELET RICH PLASMA ON MESENCHYMAL STEM CELLs (MSCs) DIFFERENTIATION INTO CHONDROBLAST by Dwikora Novembri Utomo, I Gde Adi Widiastana

“…The MSC's culture were divided into three groups of modification. …”
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The role of ultrasound combined with water bath in the establishment of animal models of rat urethral stricture by Xiaojian Ye, Xianjing Lin, Yehui Chen, Rongquan Xu, Jiawei Zhou

“…TGF-β1 induced fibrosis and MSC therapy represent promising avenues for urethral stricture management. …”
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Prognostic Factors for Clinical Response in Systemic Lupus Erythematosus Patients Treated by Allogeneic Mesenchymal Stem Cells by Lihui Wen, Myriam Labopin, Manuela Badoglio, Dandan Wang, Lingyun Sun, Dominique Farge-Bancel

“…Future studies using unique immunosuppressive regimens and allogeneic MSC sources will further elucidate determinants of clinical response to MSC transplant in SLE.…”
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Colony Formation, Migratory, and Differentiation Characteristics of Multipotential Stromal Cells (MSCs) from “Clinically Accessible” Human Periosteum Compared to Donor-Matched Bone... by Heather E. Owston, Payal Ganguly, Giuseppe Tronci, Stephen J. Russell, Peter V. Giannoudis, Elena A. Jones

“…Periosteum is vital for fracture healing, as a highly vascular and multipotential stromal cell- (MSC-) rich tissue. During surgical bone reconstruction, small fragments of periosteum can be “clinically accessible,” yet periosteum is currently not ultilised, unlike autologous bone marrow (BM) aspirate. …”
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Stem cell-derived exosome treatment for acute spinal cord injury: a systematic review and meta-analysis based on preclinical evidence by Chunlin Mou, Ziyao Xia, Ziyao Xia, Ziyao Xia, Xiujuan Wang, Xunan Dai, Jiaxian Wang, Chun Zhang, Chun Zhang, Yongsheng Xu, Yongsheng Xu, Yongsheng Xu

“…Meta-analysis results showed no statistically significant differences in therapeutic efficacy among these MSC-exos sources at various treatment time points.ConclusionMSC-exos demonstrated considerable promise in improving motor function in SCI-affected rats, with bone marrow MSC-derived exosomes having particularly notable effectiveness.…”
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Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in ischemic stroke: A meta-analysis of preclinical studies by Xiaoming Zhang, Yibing Guo, Kun Fang, Xiangqian Huang, Duo Lan, Mengqi Wang, Lina Jia, Xunming Ji, Ran Meng, Da Zhou

“…This study aims to systematically evaluate the therapeutic effects of mesenchymal stem cell-derived exosomes (MSC-Exos) on IS outcomes in rodent models. Methods: A comprehensive literature search was conducted across multiple databases to identify studies investigating the effects of MSC-Exos on rodent models of IS. …”
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Unilateral Pulmonary Artery Aplasia in a Pregnant Patient by Chitra Lal, Jim Barker, Charlie Strange

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Multimodality Fusion with MRI, CT, and Ultrasound Contrast for Ablation of Renal Cell Carcinoma by Hayet Amalou, Bradford J. Wood

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In Vivo Tracking of Chemokine Receptor CXCR4-Engineered Mesenchymal Stem Cell Migration by Optical Molecular Imaging by Senthilkumar Kalimuthu, Ji Min Oh, Prakash Gangadaran, Liya Zhu, Ho Won Lee, Ramya Lakshmi Rajendran, Se hwan Baek, Yong Hyun Jeon, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn

“…MSCs were transduced with retroviruses to generate CXCR4-overexpressing MSCs (MSC-CXCR4/Fluc2) and MSCs (MSC/Fluc2). CXCR4 mRNA and protein expression was confirmed by RT-PCR and Western blotting, respectively, and it was higher in MSC-CXCR4/Fluc2 than in naive MSCs. eGFP expression was confirmed by confocal microscopy. …”
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Transplantation of Rat Mesenchymal Stem Cells Overexpressing Hypoxia-Inducible Factor 2α Improves Blood Perfusion and Arteriogenesis in a Rat Hindlimb Ischemia Model by Weifeng Lu, Xiaoli Chen, Yi Si, Shichai Hong, Zhengyu Shi, Weiguo Fu

“…Genetic modification to improve MSC behavior may enhance posttransplantation outcome. …”
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