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A proof-of-concept study in small and large animal models for coupling liver normothermic machine perfusion with mesenchymal stromal cell bioreactors
Published 2025-01-01“…The study involved three work packages: 1) Development (n = 5): MSC-bioreactors were subjected to 4 h-liverless perfusion; 2) Rat model (n = 10): livers were perfused for 4 h on the MSC-bioreactor-circuit or with the standard platform; 3) Porcine model (n = 6): livers were perfused using a clinical device integrated with a MSC-bioreactor or in its standard setup. …”
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Efficacy and Safety of Mesenchymal Stem Cells in Treatment of Complex Perianal Fistulas: A Meta-Analysis
Published 2020-01-01“…Local mesenchymal stem cell (MSC) therapy for perianal fistula has shown considerable promise but still remains controversial. …”
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Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab
Published 2015-01-01Get full text
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Real-Time Analysis of Endogenous Wnt Signalling in 3D Mesenchymal Stromal Cells
Published 2016-01-01“…Here, we used mesenchymal stromal cell (MSC) EGFP reporter lines responsive to Wnt pathway activation in a 3D spheroid culture system to mimic better the in vivo environment. …”
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Caspase-3沉默对缺血缺氧大鼠骨髓间充质干细胞凋亡的影响
Published 2013-01-01“…【目的】 探讨沉默caspase-3对大鼠骨髓间充质干细胞(MSC)在体外缺血缺氧环境下凋亡的影响。【方法】 构建靶向caspase-3的shRNA重组慢病毒并转染MSC。…”
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间充质干细胞对B细胞增殖及免疫调节功能的影响
Published 2019-01-01“…【目的】研究观察间充质干细胞(MSC)在体外培养体系对B细胞增殖和免疫调节作用的影响。【方法】采用密度梯度离心法分离健康捐献者来源的骨髓30mL。…”
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Isolation and Characterisation of Mesenchymal Stem Cells from Rat Bone Marrow and the Endosteal Niche: A Comparative Study
Published 2018-01-01“…Within bone, mesenchymal stromal cells (MSCs) exist within the bone marrow stroma (BM-MSC) and the endosteal niche, as cells lining compact bone (CB-MSCs). …”
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Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis
Published 2025-02-01“…ObjectiveThis is a protocol for systematic review and meta-analysis that will aggregate and synthesize high-level clinical data on the effects of MSC therapy for acute MI. The findings of this study may serve as evidence for clinicians and researchers in guiding the use of MSC therapy as an adjunct to reperfusion and optimal medical therapy in patients with acute MI. …”
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Mesenchymal Stem Cells Attenuate Cisplatin-Induced Nephrotoxicity in iNOS-Dependent Manner
Published 2017-01-01“…Similar effects were observed after intraperitoneal injection of MSC-conditioned medium (MSC-CM) indicating that MSCs exert their beneficial effects in paracrine manner. …”
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Evaluation of Midnight Salivary Cortisol as a Predictor Factor for Common Carotid Arteries Intima Media Thickness in Patients with Clinically Inapparent Adrenal Adenomas
Published 2015-01-01“…Either patients or control subjects underwent MSC measurement as outpatients and carotid arteries ultrasound (US) imaging studies. …”
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The effects of secretome of umbilical cord mesenchymal stem cells on regeneration of sciatic nerve defects in Sprague dawley rats.
Published 2024-01-01“…Mesenchymal stem cell (MSC) implantation holds promise, with studies indicating their efficacy through the secretome. …”
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Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells
Published 2020-01-01“…Mesenchymal stem cell- (MSC-) based therapy has important biological and therapeutic implications for curtailing DKD progression. …”
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The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration
Published 2020-01-01“…Herewith, we used a B16F10 murine melanoma model to investigate whether timing of MSC administration in tumor-bearing mice was crucially important for their effects on antitumor immunity. …”
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LINC01089 governs the miR-1287-5p/HSPA4 axis to negatively regulate osteogenic differentiation of mesenchymal stem cells
Published 2024-12-01“…In this study, we aimed to disclose how LINC01089 functions in human mesenchymal stem cell (hMSC) osteogenic differentiation, and to study the mechanism by which LINC01089 regulates MSC osteogenesis. …”
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Maximal steered coherence in accelerating Unruh–DeWitt detectors
Published 2024-12-01“…Notably, when $$\Delta _0=1$$ Δ 0 = 1 , MSC is generated as Unruh temperature increases. …”
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Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis
Published 2020-01-01“…Thus, we here review epigenetic dysregulations that contribute to MSC aging and osteoporosis. Comprehending detailed epigenetic mechanisms could provide us with a novel horizon for dissecting MSC-related pathogenesis and further optimizing MSC-mediated regenerative therapies.…”
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EFFICACY OF AMNIOTIC MEMBRANE MESENCHYMAL STEM CELL THERAPY FOR BURN WOUNDS: META-ANALYSIS STUDY
Published 2020-06-01“…Highlights: • The healing potential of stem cell therapy for burn wounds, primarily attributed to angiogenesis and anti-inflammatory effects. • AM-MSC therapy has a beneficial impact on burn wound healing, particularly by promoting angiogenesis and reducing inflammation. …”
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