Dasatinib and Doxorubicin Treatment of Sarcoma Initiating Cells: A Possible New Treatment Strategy by Ninna Aggerholm-Pedersen, Christina Demuth, Akmal Safwat, Peter Meldgaard, Moustapha Kassem, Boe Sandahl Sorensen

“…An immortalised nontransformed human stromal (mesenchymal) stem cell line hMSC-TERT4 and a transformed cell line hMSC-TERT20-CE8, known to form sarcoma-like tumours when implanted in immune-deficient mice, were used as models. …”
Get full text

Fate and Effect of Intravenously Infused Mesenchymal Stem Cells in a Mouse Model of Hepatic Ischemia Reperfusion Injury and Resection by T. C. Saat, S. van den Engel, W. Bijman-Lachger, S. S. Korevaar, M. J. Hoogduijn, J. N. M. IJzermans, R. W. F. de Bruin

“…Mesenchymal stem cells (MSC) are reported to have anti-inflammatory and regeneration promoting properties. …”
Get full text

Human Bone Marrow Contains Mesenchymal Stromal Stem Cells That Differentiate In Vitro into Contractile Myofibroblasts Controlling T Lymphocyte Proliferation by Yves Lecarpentier, Olivier Schussler, Antonija Sakic, José Maria Rincon-Garriz, Priscilla Soulie, Marie-Luce Bochaton-Piallat, Vincent Kindler

“…Mesenchymal stromal stem cells (MSC) that reside in the bone marrow (BM) can be amplified in vitro. …”
Get full text

Callus Formation in Fractured Femur of Rats Treated with Injection of Human Umbilical Cord Mesenchymal Stem Cell-Conditioned Medium by Marla Anggita, Widagdo Sri Nugroho, Yuda Heru Fibrianto, Setyo Budhi, Teguh Budipitojo

“…Mesenchymal stem cells-conditioned medium (MSC-CM) is the extraction from stem cell medium containing biological substances, including growth factors and cytokines. …”
Get full text

Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc by Bin Chen, Jing Yu, Qianqian Wang, Yuanyuan Zhao, Li Sun, Changgen Xu, Xiangdong Zhao, Bo Shen, Mei Wang, Wenrong Xu, Wei Zhu

“…In this study, we observed that hBM-MSC-conditioned medium (hBM-MSC-CM) promotes gastric cancer development via upregulation of c-Myc. …”
Get full text

Mesenchymal Stem Cells (MSCs): A Novel Therapy for Type 2 Diabetes by Shuang Gao, Yuanyuan Zhang, Kaini Liang, Ran Bi, Yanan Du

“…Recent studies proved that symptoms of T2DM patients who are unresponsive to conventional medications could be relieved with mesenchymal stem/stromal cell (MSC) therapy. However, the lack of systematic summary and analysis for animal and clinical studies of T2DM has limited the establishment of standard guidelines in anti-T2DM MSC therapy. …”
Get full text

Effect of Stem Cell-Derived Extracellular Vesicles on Damaged Human Corneal Endothelial Cells by Raffaele Nuzzi, Lola Buono, Simona Scalabrin, Marco De Iuliis, Benedetta Bussolati

“…In the selected serum deprivation damage conditions, the treatment with different doses of MSC-EVs resulted in a significantly higher proliferation rate of HCECs at all the tested concentrations of EVs (5‐20×103 MSC-EV/cell). …”
Get full text

Protective effects and possible mechanisms of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles against kidney fibrosis in animal models: a systematic... by Yuanchen Lv, Zibo Hua, Xiaomei Lu

“…The hUCB MSC and MSC-Exos offer a promising alternative due to their lower price and accessibility. …”
Get full text

靶向性荧光示踪间充质干细胞治疗急性肺损伤 by 刘耕龙, 吕海金, 易小猛, 安玉玲, 魏旭霞, 周朝荣, 易慧敏

“…【目的】通过构建小鼠急性肺损伤（ALI）模型，示踪间充质干细胞（MSC）治疗急性肺损伤。【方法】以MSC表面 神经节苷脂（GD2）特异性抗原靶向的单克隆抗体Anti?…”
Get full text

小鼠骨髓间质干细胞的体外培养与多向分化潜能的鉴定

“…【结果】 小鼠MSC在体外可以诱导成成骨细胞?脂肪细胞?肌肉细胞?MSC连续传代培养达30代以上,细胞的形态?…”
Get full text

成人骨髓间质干细胞基本生物学特性 by 张丽蓉, 李　艳

“…【目的】研究成人骨髓间质干细胞(MSC)基本生物学特性。【方法】采用Ficoll-Paque 淋巴细胞分离液分离成人 MSC , 体外扩增, 比较不同培养基和血清含量对MSC 生长的影响, 流式细胞仪检测MSC 表面抗原表达。…”
Get full text

Mesenchymal Stem Cells and their Derived Exosomes Promote Malignant Phenotype of Polyploid Non-Small-Cell Lung Cancer Cells through AMPK Signaling Pathway by Lili Wang, Mingyue Ouyang, Sining Xing, Song Zhao, Shuo Liu, Lingyan Sun, Huiying Yu

“…This study is aimed at investigating the effects of MSCs and their derived exosomes on the biological characteristics of polyploid NSCLC cells and the potential mechanisms. We found that MSC conditioned medium (CM), MSCs, and MSC-exosomes had no effect on cell proliferation of the polyploid A549 and H1299 cells. …”
Get full text

Induced Pluripotent Stem Cell-Differentiated Chondrocytes Repair Cartilage Defect in a Rabbit Osteoarthritis Model by Yu-Hsun Chang, Kun-Chi Wu, Dah-Ching Ding

“…The aim of this study was to explore the therapeutic effect of iPSC-mesenchymal stem cell (MSC)-derived chondrocytes in a rabbit osteoarthritis (OA) model. …”
Get full text

Human Bone Marrow Mesenchymal Stromal Cells Promote Bone Regeneration in a Xenogeneic Rabbit Model: A Preclinical Study by Juan Francisco Blanco, Jesús García-Briñon, Lorena Benito-Garzón, David Pescador, Sandra Muntión, Fermín Sánchez-Guijo

“…Two experimental groups, TCP and hMSC + TCP, were compared. Combination of TCP and hMSC did not affect cell viability or osteogenic differentiation. …”
Get full text

Enhanced Healing of Diabetic Wounds by Subcutaneous Administration of Human Umbilical Cord Derived Stem Cells and Their Conditioned Media by Chandrama Shrestha, Liling Zhao, Ke Chen, Honghui He, Zhaohui Mo

“…The expression levels of PDGF-β and KGF were higher in CM-treated wounds than those in UC-MSC-treated wounds. Conclusion. Both the transplantation of UC-MSC and their CM are beneficial to diabetic wound healing, and CM has been shown to be therapeutically better than UC-MSC, at least in the context of diabetic wound healing.…”
Get full text

胎肝造血期胎肝间充质干细胞的分离、培养及生物学特性 by 吴北燕, 黄绍良, 陈惠芹, 张绪超, 魏菁

“…【目的】分离、培养人胎肝造血期胎肝间充质干细胞(MSC) , 研究其生长特性及表面标记的表达。 【方法】取孕16～20 周人胚胎肝脏, 分离培养胎肝MSC, 传代培养成系并检测其增殖能力, 应用流式细胞术、免 疫荧光方法检测其造血相关表面标记和细胞蛋白表达。…”
Get full text

Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid by Leah A. Marquez-Curtis, Yuanyuan Qiu, April Xu, Anna Janowska-Wieczorek

“…Mesenchymal stromal cells (MSC) have great potential for cellular therapies as they can be directed to differentiate into certain lineages or to exert paracrine effects at sites of injury. …”
Get full text

Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials by Baocheng Xie, Minyi Chen, Runkai Hu, Weichao Han, Shaobo Ding

“…In recent years, human mesenchymal stem cell (hMSC) transplantation has become a promising therapeutic strategy for CP. …”
Get full text

人脐带间充质干细胞移植治疗小鼠慢性输卵管炎

“…通过阴道内接种沙眼衣原体建立小鼠输卵管炎模型，感染后４周随机分成ｈＵＣ－ＭＳＣ移植组及对照组。ｈＵＣ－ＭＳＣ移植组小鼠阴道内接种人脐带间充质干细胞，对照组小鼠阴道内注射等体积ＰＢＳ。…”
Get full text

Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic... by Anna Lethicia L. Oliveira, Gisele G. L. Santos, Renan F. Espirito-Santo, Gessica Sabrina A. Silva, Afrânio F. Evangelista, Daniela N. Silva, Milena B. P. Soares, Cristiane Flora Villarreal

“…Based on the antioxidant and antinociceptive properties of mesenchymal stem/stromal cells (MSC), the present study tested the hypothesis that MSC induce antinociceptive effects during OIPN by promoting regulation of redox environment and mitochondrial homeostasis in the nociceptive primary afferents. …”
Get full text