Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines by Kyle K. L. Phua

“…The use of nanoparticles encapsulating messenger RNA (mRNA) as a vaccine has recently attracted much attention because of encouraging results achieved in many nonviral genetic antitumor vaccination studies. …”
Get full text

A Point Mutation in the Iron-Responsive Element of the L-Ferritin in a Family with Hereditary Hyperferritinemia Cataract Syndrome by Karen Wong, Yousef Barbin, Subrata Chakrabarti, Paul Adams

“…The genetic abnormality is identified as a mutation in the 5' regulatory region of the L-ferritin messenger RNA known as the iron-responsive element (IRE). …”
Get full text

Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis by Mengjia Gao, Jingxin Xin, Xiaoling Li, Ling Gao, Shanshan Shao, Meng Zhao

“…In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and then, corresponding target microRNAs (miRNAs) and messenger RNAs (mRNAs) were predicted to construct a circRNA–miRNA–mRNA regulatory network. …”
Get full text

Base Composition Characteristics of Mammalian miRNAs by Bin Wang

“…MicroRNAs (miRNAs) are short RNA sequences that repress protein synthesis by either inhibiting the translation of messenger RNA (mRNA) or increasing mRNA degradation. …”
Get full text

Vaccination ARN messager (ARNm), modèle de transition de la biologie fondamentale à la médecine by Sansonetti, Philippe J.

“…Sixty years elapsed between the discovery of messenger RNA (mRNA) and the use of this molecule in an unprecedented global vaccination campaign that brought the Covid-19 pandemic under control. …”
Get full text

François Gros (1925–2022) by Petit, Christine, Kourilsky, Philippe

“…In 1961, he discovered the molecular nature of the proposed intermediary between the gene and the protein, a so-called messenger RNA (mRNA), and determined its main characteristics. …”
Get full text

Snake and staff symbolism and healing by Francois P. Retief, Louise Cilliers

“…In classical times it became the herald’s wand (caduceus) of Hermes, messenger of the gods who guided departed souls to the Underworld, and was seen as the protector of travellers, shepherds and merchants. …”
Get full text

NGF, Brain and Behavioral Plasticity by Alessandra Berry, Erika Bindocci, Enrico Alleva

“…Years later this vision is still relevant, and the body of evidence on the role of NGF has been strengthened and expanded from trophic factor playing a role in brain growth and differentiation to a much more complex messenger, involved in psychoneuroendocrine plasticity.…”
Get full text

RNA N6-Methyladenosine Modifications and the Immune Response by Ya-Nan Wang, Chen-Yang Yu, Hong-Zhong Jin

“…N6-methyladenosine (m6A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. …”
Get full text

Olfm4 Is Highly Expressed in HCC Patients and as a Biomarker and Therapeutic Target for HCC by Yulong Wei, Qingzhu Song, Fenglan Zhang, Tian Yuan

“…Furthermore, HCC patients also have higher messenger ribonucleic acid (mRNA) expression level in HCC tissues than in liver paracancerous tissues. …”
Get full text

Hyperosmotic Stress Induces a Specific Pattern for Stress Granule Formation in Human-Induced Pluripotent Stem Cells by Salam Salloum-Asfar, Rudolf Engelke, Hanaa Mousa, Neha Goswami, I. Richard Thompson, Freshteh Palangi, Kamal Kamal, Muna N. Al-Noubi, Frank Schmidt, Sara A. Abdulla, Mohamed M. Emara

“…Stress granules (SGs) are assemblies of selective messenger RNAs (mRNAs), translation factors, and RNA-binding proteins in small untranslated messenger ribonucleoprotein (mRNP) complexes in the cytoplasm. …”
Get full text

Regulation of electrolyte transport with IL-1β in rabbit distal colon by F. R. Homaidan, H. Desai, L. Zhao, G. Broutman, R. Burakoff

“…These data suggest that interleukin-1β causes its effect via a yet to be identified second messenger, by increasing chloride secretion through a prostaglandin E2 mediated mechanism.…”
Get full text

The Role of Traditional Environmental Knowledge in Taytnapam Toponyms by Eugene S. Hunn, Richard H. McClure Jr.

“…It is noteworthy that Taytnapam elders attribute these names to Coyote, primal messenger of the Creator, herald of the traditional law, tamánwit, which established proper order in the universe. …”
Get full text

The cell autonomous and non-autonomous roles of itaconate in immune response by Chao Chen, Xinjian Li

“…Based on these knowledges, we propose itaconate is a messenger transmitting immunologic signals from myeloid cells to other types of cells during host inflammation and immune defense.…”
Get full text

Small RNA Expression Profiling by High-Throughput Sequencing: Implications of Enzymatic Manipulation by Fanglei Zhuang, Ryan T. Fuchs, G. Brett Robb

“…sRNA-based biomarkers outperform traditional messenger RNA-based biomarkers by testing fewer targets with greater accuracy and providing earlier detection for disease states. …”
Get full text

A mutation in porcine pre-miR-15b alters the biogenesis of MiR-15b\16-1 cluster and strand selection of MiR-15b. by Wenyang Sun, Jing Lan, Lei Chen, Jinjie Qiu, Zonggang Luo, Mingzhou Li, Jinyong Wang, Jiugang Zhao, Tinghuan Zhang, Xi Long, Jie Chai, Zunqiang Yan, Zongyi Guo, Shuangbao Gun

“…MicroRNAs (miRNAs) are small non-coding RNAs that are involved in translational regulation of the messenger RNA molecules. Sequence variations in the genes encoding miRNAs could influence their biogenesis and function. …”
Get full text

COVID-19 Booster Vaccines Administration in Different Countries by Angel Yun-Kuan Thye, Loh Teng-Hern Tan, Jodi Woan Fei Law, Vengadesh Letchumanan

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that resulted in the COVID-19 global pandemic had consequently led to the development of different types of COVID-19 vaccines, including the messenger RNA (mRNA) vaccines, inactivated virus vaccines, a protein subunit vaccine, and viral vector recombinant vaccines. …”
Get full text

Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles by Bingyi Zheng, Xueting Wang, Meizhai Guo, Chi-Meng Tzeng

“…The EVs contain much DNA, messenger RNA (mRNA), microRNA, and protein components, which can exert intracellular communication to target cells. …”
Get full text

The Role of Purinergic Receptors in Cancer-Induced Bone Pain by Sarah Falk, Maria Uldall, Anne-Marie Heegaard

“…In nociception, ATP acts as an extracellular messenger to transmit sensory information both at the peripheral site of tissue damage and in the spinal cord. …”
Get full text

Competing Endogenous RNA: The Key to Posttranscriptional Regulation by Rituparno Sen, Suman Ghosal, Shaoli Das, Subrata Balti, Jayprokas Chakrabarti

“…Competing endogenous RNA, ceRNA, vie with messenger RNAs (mRNAs) for microRNAs (miRNAs) with shared miRNAs responses elements (MREs) and act as modulator of miRNA by influencing the available level of miRNA. …”
Get full text