Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease by Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Xiaoyan Sun, Hao Song, Jing Xu, Shuijun Zhang, Hongyang Wang, Jing Fu

“…Moreover, ALB+KRT7+ epithelium‐derived ALD organoids promote the tumour growth by activating Wnt/β‐catenin signalling of liver cancer cells. Most importantly, blocking the Wnt protein secretion or knockdown the Wnt receptor suppressed the tumour promoting effect of ALD organoids. …”
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Enhancing hepatocellular carcinoma therapy with DOX-loaded SiO2 nanoparticles via mTOR-TFEB pathway autophagic flux inhibition by Huanyu Chen, Jun Liu, Zhichao Cao, Jiajia Li, Hong Zhang, Qianqian Yang, Jian Cheng, Yuxian Shen, Kewu He

“…This novel diagnostic-integrated nanocarrier is expected to be a promising tool for targeted liver cancer treatment.…”
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Propensity Score Matching Analysis for Alcohol‐Related Liver Disease by Fangfang Duan, Shanshan Song, Hang Zhai, Yazhi Wang, Jun Cheng, Song Yang

“…ABSTRACT Objectives This study aims to investigate the impact of comorbidity with chronic hepatitis B (CHB) on the survival rates and incidence of liver cancer in patients with alcohol‐related liver disease (ARLD). …”
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Endoplasmic reticulum stress-related super enhancer promotes epithelial-mesenchymal transformation in hepatocellular carcinoma through CREB5 mediated activation of TNC by Anqi Wang, Sitong Yan, Jiatao Liu, Xiang Chen, Mengyao Hu, Xiao Du, Weijia Jiang, Zhipeng Pan, Lulu Fan, Guoping Sun

“…Mechanistically, CREB5 upregulates the transcription of tenascin-C (TNC) by directly binding to its promoter region, thereby promoting EMT in liver cancer cells. In summary, our findings suggest that ERS activation promotes EMT in liver cancer cells via SE-mediated upregulation of the CREB5/TNC pathway. …”
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ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

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Neoadjuvant atezolizumab plus bevacizumab prior liver transplantation for hepatocellular carcinoma by Parissa Tabrizian, Rebecca Marino, Sherrie Bhoori, Marcus Zeitlhoefler, Neil Mehta, Vanessa Banz, Salvatore Gruttadauria, Massimo Iavarone, Chiara Mazzarelli, Nicolò Simonotti, Francis Yao, Vincenzo Mazzaferro, Josep M. Llovet

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Epidemiological trends in gastrointestinal cancers and risk factors across U.S. states from 2000 to 2021: a systematic analysis for the global burden of disease study 2021 by Jiahao Jiang, Zhiqin Xie, Qingbin Wang, Bingkun Wang, Rong Huang, Weikai Xu, Changzhen Shang, Yajin Chen

“…Results From 2000 to 2021, liver cancer exhibited the greatest increase in both the ASIR and the ASMR, followed by pancreatic cancer. …”
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Safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcino... by Lei Yu, Lan Zhang, Xin Xu, Zheng Wang, Jian Zhou, Jia Fan, Wentao Wang, Zhenggang Ren, Lixing Li, Peiran Huang

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Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy by Minni Zhang, Kailin Huang, Qiushi Yin, Xueqin Wu, Mingyue Zhu, Mengsen Li

“…The role of spatial heterogeneity of immune cells in the microenvironment of HCC in the progression and influence of immunotherapy on improving the treatment and prognosis of HCC were comprehensively analyzed, providing new inspiration for the subsequent clinical treatment of liver cancer.…”
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Comprehensive profiling of serum microRNAs in normal and non-alcoholic fatty liver disease (NAFLD) patients by Jian-Wei Zhang, Kamran Ullah, Nauman Khan, Hai-Tao Pan

“…Abstract Pediatric non-alcoholic fatty liver disease (NAFLD) is emerging as a worldwide health concern with the potential to advance to cirrhosis and liver cancer. NAFLD can also directly contribute to heart problems through inflammation and insulin resistance, even in individuals without other risk factors. …”
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Metabolic Dysfunction-Associated Steatotic Liver Disease and All-Cause and Cause-Specific Mortality by Rosa Oh, Seohyun Kim, So Hyun Cho, Jiyoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim

“…We also analyzed all-cause, liver-, cancer-, hepatocellular carcinoma (HCC)- and cardiovascular (CV)-related mortalities. …”
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Dual-drug loaded chondroitin sulfate embolization beads enhance TACE therapy for HCC by integrating embolization, chemotherapy, and anti-angiogenesis by Jin-Xin Huang, Rui Yang, Huan Long, Jie Kong, Guo-Qiang Shao, Fei Xiong

“…In clinical practice, combined therapy for liver cancer using TACE and oral targeted drugs often encounters the limitation that targeted drugs cannot efficiently reach the tumor site following TACE. …”
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Prophylactic Role of Averrhoa carambola (Star Fruit) Extract against Chemically Induced Hepatocellular Carcinoma in Swiss Albino Mice by Ritu Singh, Jyoti Sharma, P. K. Goyal

“…Liver cancer remains one of the severe lethal malignancies worldwide and hepatocellular carcinoma (HCC) is the most common form. …”
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Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations by Yingjun Xie, Yien Xiang, Jiyao Sheng, Dan Zhang, Xiaoxiao Yao, Yongsheng Yang, Xuewen Zhang

“…Primary liver cancer is a common kind of digestive cancers with high malignancy, causing 745,500 deaths each year. …”
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Coinfection of Hepatitis B and C Viruses and Risk of Hepatocellular Carcinoma: Systematic Review and Meta-analysis by Abdullah A. Awadh, Abdulrahman A. Alharthi, Basil A. Alghamdi, Seraj T. Alghamdi, Mohammed K. Baqays, Ibrahim S. Binrabaa, Israa A. Malli

“…Methods: Based on PRISMA recommendations and guidelines, we developed a search strategy by combining the keywords (“hepatitis B”) and (“hepatitis C”) and (“hepatocellular carcinoma” or “liver cancer”). First, we performed a title and abstract screening and, later, a full-text screening. …”
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Exploring the impact of insufficient thermal ablation on hepatocellular carcinoma: NDST2 overexpression mechanism and its role in facilitating growth and invasion of residual cance... by Weijun Wan, Danxia Guo, Tong Kang, Jinshu Pang, Yunjing Pan, Jiamin Chen, Wei Liao, Yuji Chen, Peng Lin, Lipeng Li, Hong Yang, Yun He

“…This study aims to investigate the expression changes of NDST2 following ITA of HCC and its impact on residual cancer cells.Methods An in vitro model of heat stress-induced liver cancer was constructed to measure the expression of NDST2 using Quantitative Real-Time PCR and Western blotting experiments. …”
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Immunotherapy of Liver Diseases by Dechun Feng, YinYing Lu, Xiaoni Kong, Feng Li

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Modulation of DAPK1 expression by its alternative splice variant DAPK1-215 in cancer by QingShui Wang, ShuYun Weng, WenTing Zhong, YouYu Lin, Yan Yu, YiMin Huang, LiLin Ge, XiuLi Zhang, FangQin Xue, Yehuda G. Assaraf, Yao Lin

“…Finally, clinical liver cancer specimens were analyzed to assess the prognostic relevance of DAPK1-215 and DAPK1 mRNA levels. …”
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How does the knowledge level of physicians and nurses working at primary health centers affect their preference for oral contraceptives in an inland Turkish province? by Gamze Dur, Ayşen Mert, Rıza Dur, Mine Kanat Pektas

“…There is a significantly higher number of male health care givers who claim that OCPs cause acne, sexual dysfunction, ectopic pregnancy, deep vein thrombosis, and liver cancer (respectively p = 0.040, p = 0.028, p = 0.001, p = 0.001, and p = 0.020). …”
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Evaluation of cytotoxic, antimicrobial, and antioxidant activi-ties of Echium italicum L. in MCF-7 and HepG2 cell lines by Dilek Arslan Atessahin, Semih Dalkilic, Lütfiye Kadioglu Dalkilic, Dudu Bayindir, Elif Cetinkaya

“…Its anticancer effect was tested in HepG2 (liver cancer) and MCF-7 (breast cancer) cell lines. Its antimicrobial effect was also investigated in Candida albicans, Klebsiella pneumoniae, Escherichia coli, Bacillus megaterium and Staphylococcus aureus. …”
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