Downregulated PTEN and aberrant JAK–STAT signal pathway in essential thrombocythemia patients by Lin Luo, Xiaoyan Liu, Hui Shen, Hao Zhang, Yufeng Shang, Xian Zhang, Donglei Zhang

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FCGBP promotes ovarian cancer progression via activation of IL-6/JAK-STAT signaling pathway by Zhiqin Fu, Kelie Chen, Fang Zheng, Wangang Gong, Ding Chao, Chao Lu

“…Mechanistically, FCGBP enhanced interleukin-6 expression by interacting with NF-kappaB subunit p65, leading to activation of the JAK-STAT signaling pathway. Rescue experiments confirmed that exogenous interleukin-6 could restore the tumor-promoting effects lost upon FCGBP knockdown. …”
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Effects of Rhodotorula mucilaginosa on Growth, Antioxidant, and Immune Function, and Toll/Imd and JAK-STAT Signaling Pathways in Red Claw Crayfish (Cherax quadricanatus) by Qin Zhang, Liuqing Meng, Jiqing Li, Luoqing Li, Qinghui Zeng, Rui Wang, Dapeng Wang, Tong Tong, Yongqiang Liu, Huizan Yang

“…This study examined the effects of incorporating different levels of Rhodotorula mucilaginosa (0.0, 0.1, 1.0, and 10.0 g/kg) into the diet on growth performance, antioxidant capacity (AOC), immune function, Toll/Imd, and JAK-STAT signaling pathways in red claw crayfish (Cherax quadricanatus). …”
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Lyophilized MSC-EVs attenuates COVID-19 pathogenesis by regulating the JAK/STAT pathway by Nesrine Ebrahim, Hajir A. Al Saihati, Zahraa Alali, Sabry Younis Mohamed Mahmoud, Ali A. Rabaan, Arigue A. Dessouky, Rabab F. Salim, Ashraf A. Shamaa, Ahmed N. Abdallah, Nehal M. Elsherbiny, Gamal Othman, Abdelnaser A. Badawy, Gianpiero Di Leva, Omnia A. Badr

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The role of IL‐6/JAK/STAT signal in female infertility caused by hydrosalpinx by Jia Deng, Yufu Huang, Luying Wang, Xin Sun

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Human umbilical cord mesenchymal stem cell therapy for atopic dermatitis through inhibition of neutrophil chemotaxis by Jinjin Shao, Zhiqi Xie, Zhichao Ye, Guoyu Chen, Yiru Wang, Lili Zhang, Fang Liu, Siming Zhang, Xiaobo Lin, Jiahong Wang, Ying Chen, Yunxiang Chen, Xin Pan, Feifei Wu, Ruolang Pan, Jinfeng Liang, Lijiang Zhang

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A comprehensive overview of patient journey and management decision pathway for myelofibrosis in India: INLAND survey by Prantar Chakrabarti, Abhay Bhave, Claire Harrison, Tulika Seth, Vikram Mathews, Disha Shetty

“…Abstract Background Myelofibrosis is a myeloproliferative neoplasm characterized by stem cell-derived clonal myeloproliferative and anomalous production of cytokines with genetic mutations in the JAK/STAT signalling pathway playing a distinctive role in its pathophysiology. …”
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The regulation of cell homeostasis and antiviral innate immunity by autophagy during classical swine fever virus infection by Xiaowen Li, Yiwan Song, Xinyan Wang, Cheng Fu, Feifan Zhao, Linke Zou, Keke Wu, Wenxian Chen, Zhaoyao Li, Jindai Fan, Yuwan Li, Bingke Li, Sen Zeng, Xiaodi Liu, Mingqiu Zhao, Lin Yi, Jinding Chen, Shuangqi Fan

“…Enhanced autophagy further inhibited CSFV-induced RIG-I-IRF3 signal transduction axis and JAK-STAT signalling pathway and blocked type I interferon production while reducing autophagy inhibition of the NF-κB signalling pathway and apoptosis in CSFV infection cells. …”
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Polyinosinic-polycytidylic acid modulates Porphyromonas gingivalis-induced cell apoptosis via the janus kinase/ signal transducer and activator of transcription signaling pathway by Shengnan Zhang, Jianru Liu, Xiangying Ouyang, Wenyi Liu, Yuanbo Wang, Jinsheng Zhong

“…Additionally, treatment with Poly (I:C) activated the JAK/STAT signaling pathway, while STAT inhibitor was found to attenuate its effects. …”
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An exhaustive examination of the research progress in identifying potential JAK inhibitors from natural products: a comprehensive overview by Wendong Yang, Jiabin Lu, Peihua Luo, Zhifei Xu, Hao Yan, Bo Yang, Qiaojun He, Jialin Zhou, Xiaochun Yang

“…Abstract The JAK-STAT signaling pathway serves as a central regulator of diverse cellular processes encompassing proliferation, apoptosis, inflammation, and differentiation. …”
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Catalyst-modulated hydrogel dynamics for decoupling viscoelasticity and directing macrophage fate for diabetic wound healing by Yuening Mai, Honglei Wang, Jianyu Lu, Songsong Shi, Yixin Cai, Wei Zhang, Sujie Xie, Runzhi Huang, Shizhao Ji, Xue Qu

“…Hydrogels with enhanced network dynamics significantly activated the JAK/STAT signaling pathway, promoting macrophage M2 polarization. …”
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Mitigation of radiation-induced esophageal fibrosis by macrophage-targeted phosphatidylserine-containing liposomes with partial PEGylation by Gyeung Mi Seon, In Gul Kim, Sun Woo Um, Eun-Jae Chung, Hyeong-Cheol Yang

“…Analysis of the IL-4-induced JAK-STAT signaling pathway indicated that the PEG-PSL-mediated suppression occurred at or beyond the point of JAK-1 phosphorylation. …”
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N6-methyladenosine-modified circDCP2 promotes carbon black nanoparticle-induced malignancy in human bronchial epithelial cells via PI3K-AKT pathway and macrophage homeostasis by Shulin Qin, Kexin Chen, Shanfeng Chen, Xin Chen, Yi Hu, Wenlong Peng, Zhenyu Pan, Xin Ji, Peng Pang, Qiaoming Luo, Wen Liu

“…Additionally, circDCP2 facilitates the IGF2BP3-JAK-STAT signaling pathway, which promotes the reprogramming of tumor-associated macrophages (TAMs) into the M2-type TAMs via cytokines secretion, contributing to the formation of an immunosuppressive microenvironment that further accelerates tumorigenesis and progression. …”
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Experience of using the drug upadacitinib in a child with severe atopic dermatitis by G. D. Alemanova, L. Yu. Popova, E. A. Zlodeeva, O. V. Kirichenko, E. I. Pogrebnova

“…The disease has a complex pathogenesis, which significantly complicates its treatment. The JAK-STAT signaling pathway plays a central role in the modulation of several immune axes involved in the immunopathogenesis of AtD. …”
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Machine learning-based construction of Immunogenic cell death-related score for improving prognosis and personalized treatment in glioma by Guoyin Li, Yukui Zhao, Yubo He, Zhaoqiang Qian, Yiwen Liu, Xiaoyan Li, Lili Li, Zhiqiang Liu

“…We developed an ICDS marker to evaluate the prognosis and drug response of glioma patients, and confirmed that SERPINH1 promotes the malignant phenotype of gliomas by modulating the JAK/STAT signaling pathway.…”
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Holistic regulation of the diabetic osteo-microenvironment via NIR-II nanocarriers with dual NO/pH responsiveness for enhanced bone regeneration by Xudong Xie, Junli Yang, Chong Ding, Yiming Li, Fawwaz Ai-Smadi, Kangkang Zha, Chuanlu Lin, Ze Lin, Chenyan Yu, Ruiyin Zeng, Weixian Hu, Jiewen Liao, lizhi Ouyang, Tian Xia, Peng Zhao, Bobin Mi, Guohui Liu

“…Under near-infrared (NIR) irradiation, the nanoparticles induce macrophage repolarization toward M2 phenotypes through JAK/STAT signaling pathway, followed by upregulating anti-inflammatory mediators (TGF-β, PD-L1) and tissue-regenerative factors (BMP-2/4, VEGF-B), while suppressing pro-inflammatory cytokines (CCR2, S100A4). …”
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STAT1β modulates the tumor immune microenvironment to improve prognosis in ovarian cancer: a comprehensive study of transcriptional and protein expression differences by Ning Lan, Xintong Li, Yifan Qiao, Siyi Zhang, Min Chen, Xiaofeng Yang, Yuliang Zou, Juan Ren, Meili Pei

“…Abstract Objectives As a central regulator of the JAK/STAT signaling pathway, STAT1 generates functionally distinct α and β protein isoforms through alternative splicing. …”
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Meprin β activity modulates cellular proliferation via trans-signaling IL-6-mediated AKT/ERK pathway in IR-induced kidney injury by Shaymaa Abousaad, Faihaa Ahmed, Ayman Abouzeid, Christine Adhiambo, Elimelda Moige Ongeri

“…We previously showed that meprin β modulates cellular survival B-Cell Lymphoma/Leukemia 2 (BCL-2) through IL-6/Janus kinase/ Signal Transducer and Activator of Transcription (IL-6/JAK/STAT) signaling pathway in IR-induced kidney injury. However, it’s not known how meprin β modulation of the IL-6 signaling pathway impacts the cellular proliferation in IR-induced acute kidney injury. …”
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Integrated proteomics and transcriptomics analysis reveals key regulatory genes between ER-positive/PR-positive and ER-positive/PR-negative breast cancer by Zhengjia Lu, Jiao Yang, Yang Feng, Jia Ming

“…Additionally, there were differences in functional pathway enrichment analysis (galactose_metabolism, glycolysis_gluconeogenesis, jak_stat_signaling_pathway, pentose_phosphate_pathway, et al.) and immune cell infiltration (CD8 T cell, Macrophages M1, et al.) between the high-risk and low-risk groups. …”
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