Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. by Shoujun Huang, Zhao Zhang, Chunxia Zhang, Xiangdong Lv, Xiudeng Zheng, Zhenping Chen, Liwei Sun, Hailong Wang, Yuanxiang Zhu, Jing Zhang, Shuyan Yang, Yi Lu, Qinmiao Sun, Yi Tao, Feng Liu, Yun Zhao, Dahua Chen

“…Hedgehog signaling has an unusual reception system consisting of two transmembrane proteins, Patched receptor and Smoothened signal transducer. …”
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Acute Transverse Myelitis (Ascending Myelitis) as the Initial Manifestation of Japanese Encephalitis: A Rare Presentation by Varshney Ankur Nandan, Kumar Nilesh, Behera Dibyaranjan, Tiwari Ashutosh, Anand Ravi, Anand Arvind

“…Acute transverse myelitis, as the initial manifestation of Japanese encephalitis, is an unusual manifestation and is seldom reported. We hereby report a case of 13-year-old adolescent boy who presented to us with fever and acute onset paraparesis with urinary retention initially, progressing to quadriparesis and then followed by headache and altered sensorium. …”
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Angiomatoid fibrous histiocytoma with EWSR1-CREB1 gene fusion occurs in lungs and ribs with systemic multiple metastases: a case report and review of the literature by Dongmei Feng, Ying Li, Zhengjin Li, Yun Pan, Yixuan Gao, Jinyan Cha, Chunmei Zhang

“…We encountered a unique AFH case where, the tumor was discovered initially in unusual locations—the left lung and the left 4th rib. …”
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Compartment Syndrome of the Flexor Compartment of the Arm Secondary to Pectoralis Major Tendon Rupture by M. A. Tranovich, J. B. Stirton, J. C. Maier, M. B. Tanios, J. E. Lea, N. A. Ebraheim, J. D. Miller

“…Due to the potentially devastating consequences of a missed compartment syndrome, it is imperative that physicians maintain a high level of suspicion in patients with these unusual injuries presenting with severe swelling and pain.…”
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Genus <i>Nicotiana</i> L.: a review of traits significant for ornamental crop production by E. G. Baranova, K. I. Ivanitsky, V. I. Suchkov

“…Many species have ornamental features and properties: bright color and unusual morphology of the corolla, aroma, peculiar plant shape and others, and are promising for use in landscaping and garden designing. …”
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Giant Popliteal Artery Aneurysm: Case Report and Review of the Literature by Christos Verikokos, Georgios Karaolanis, Mikes Doulaptsis, Georgios Kouvelos, Aikaterini Kotzadimitriou, Viktoria-Varvara Palla, Christos Klonaris

“…They usually affect men over 60 years old with established cardiovascular disease caused by atherosclerosis. Other more unusual conditions such as trauma, congenital popliteal aneurysm, mycotic aneurysm, inflammatory arteritis, or popliteal entrapment are responsible. …”
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Gastric Emphysema in a Critically Ill Patient Successfully Treated without Surgery by Hiromi Ihoriya, Tetsuya Yumoto, Masaya Iwamuro, Noritomo Fujisaki, Takaaki Osako, Hiromichi Naito, Atsunori Nakao

“…Physicians should be aware of this unusual condition in such critically ill patients complaining of abdominal pain and needing close monitoring and observation to exclude gastric necrosis or perforation.…”
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Persistent Mixed Donor Chimerism following Double Umbilical Cord Transplantation in a Patient with T-Cell Prolymphocytic Leukemia by Ronak H. Mistry, Elizabeth O. Hexner, James K. Mangan

“…Here, we present the case of a patient treated with double umbilical cord blood transplantation, which resulted in initial complete remission. An unusual outcome of this case is that coengraftment of both cords was established. …”
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Appendicitis-Like Picture Induced by Foreign Body in a 2-Year-Old Boy by Sadi A. Abukhalaf, Rami A. Misk, Hussam I. Alzeerelhouseini, Ismaeel M. Irziqat, Abdulrahman H. Asaferah, Osama Y. Aljabarein, Khalil N. Abuzaina

“…Background and Aim. Appendicitis is unusual in toddlers and foreign body- (FB-) induced appendicitis is rare. …”
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Obliteration of Intercondylar Notch Mimicking Flexion-Extension Gap Imbalance in a Cruciate Retaining Total Knee Arthroplasty by Harun Resit Gungor, Esat Kiter, Semih Akkaya, Nusret Ok, Cagdas Yorukoglu

“…Here, we report on an unusual case referred from another hospital because of continuous pain and restriction of knee motion in early postoperative period following CR-designed TKA that was initially thought to be due to flexion-extension imbalance. …”
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Primary Hairy Cell Leukemia/Lymphoma of the Breast: A Case Report and Review of the Literature by Monika Pilichowska, Ahmad Shariftabrizi, Ian Mukand-Cerro, Kenneth Miller

“…However, other sites of primary involvement do occur and can present a diagnostic and therapeutic challenge. We present an unusual case of HCL involving predominantly the breast that was diagnosed as an incidental finding during an elective reduction mammoplasty in an otherwise healthy asymptomatic woman. …”
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Brunner’s Gland Hamartoma: A Rare Cause of Gastrointestinal Bleeding – Case Report and Review of the Literature by David R Stolpman, Gordon C Hunt, Brett Sheppard, Hahn Huang, Deepak V Gopal

“…An unusual cause of upper gastrointestinal bleeding is described in a previously healthy 45-year-old man who was admitted to hospital with weakness and fatigue, and had experienced an episode of melena two days before admission. …”
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Reflection of two-dimensional surface polaritons by metallic nano-plates on atomically thin crystals by Lee Seojoo, Kang Ji-Hun

“…Owning to their unusual optical properties, such as electrical tunability and strong spatial confinement, two-dimensional surface polaritons (2DSPs) hold great promise for deep sub-wavelength manipulation of light in a reduced low-dimensional space. …”
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Crystalline-Like Keratopathy after Intravenous Immunoglobulin Therapy with Incomplete Kawasaki Disease: Case Report and Literature Review by Elif Erdem, Emine Kocabas, Hande Taylan Sekeroglu, Özlem Özgür, Meltem Yagmur, T. Reha Ersoz

“…We present a case who was diagnosed as incomplete Kawasaki disease along with bilateral diffuse crystalline-like keratopathy. We supposed that unusual ocular presentation may be associated with intravenous immunoglobulin treatment.…”
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Abnormal link detection algorithm based on semi-local structure by Haoran SHI, Lixin JI, Shuxin LIU, Gengrun WANG

“…With the research in network science, real networks involved are becoming more and more extensive.Redundant error relationships in complex systems, or behaviors that occur deliberately for unusual purposes, such as wrong clicks on webpages, telecommunication network spying calls, have a significant impact on the analysis work based on network structure.As an important branch of graph anomaly detection, anomalous edge recognition in complex networks aims to identify abnormal edges in network structures caused by human fabrication or data collection errors.Existing methods mainly start from the perspective of structural similarity, and use the connected structure between nodes to evaluate the abnormal degree of edge connection, which easily leads to the decomposition of the network structure, and the detection accuracy is greatly affected by the network type.In response to this problem, a CNSCL algorithm was proposed, which calculated the node importance at the semi-local structure scale, analyzed different types of local structures, and quantified the contribution of edges to the overall network connectivity according to the semi-local centrality in different structures, and quantified the reliability of the edge connection by combining with the difference of node structure similarity.Since the connected edges need to be removed in the calculation process to measure the impact on the overall connectivity of the network, there was a problem that the importance of nodes needed to be repeatedly calculated.Therefore, in the calculation process, the proposed algorithm also designs a dynamic update method to reduce the computational complexity of the algorithm, so that it could be applied to large-scale networks.Compared with the existing methods on 7 real networks with different structural tightness, the experimental results show that the method has higher detection accuracy than the benchmark method under the AUC measure, and under the condition of network sparse or missing, It can still maintain a relatively stable recognition accuracy.…”
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When Stroke Disguises as Dementia: A Case of Missed Cerebral Venous Thrombosis by Tina Moghadam Fard, Mehrnaz Hosseinzadeh, MohammadAli Shokri, Mostafa Almasi‐Dooghaee, Fatemeh Sadat Mirfazeli

“…Although some symptoms of cerebrovascular thrombosis are typical and lead to early diagnosis, they can sometimes present with rare and unusual symptoms, complicating the diagnostic process. …”
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Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests by Meghan Glibbery, Adam Fleming, Rahul Chanchlani, Olufemi Abiodun Ajani, Norma Marchetti, Alexa Marr, M. Constantine Samaan

“…This case highlights an unusual combination of adverse reactions to clonidine and arginine in children undergoing GH stimulation testing to assess for GHD. …”
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A Simple Bone Cyst in Cervical Vertebrae of an Adolescent Patient by Adriana Bruges Boude, Lina González Vásquez, Fernando Alvarado-Gomez, María Constanza Bedoya, Andrés Rodríguez-Múnera, Luis Carlos Morales-Saenz

“…Spinal simple bone cysts, also known as solitary cysts, are extremely unusual benign primary bone tumors with few cases reported in the literature. …”
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Belief and Disbelief in the Space Between, 1914-1945 by Jean-Christophe MURAT

“…Hyde, a prominent member of the British Communist Party (CPGB) from 1928 to 1948, occupies a position in the history of twentieth-century communism that is at once typical and unusual. His becoming a member of the Communist Party in 1928 represented a form of “going-over” shared by many young men and women of his generation. …”
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Tuberculosis of the thyroid gland: A rare case report by Manisha Kamlesh Galani, Kamlesh Jamnadas Galani, Swati Nileshkumar Lakhani

“…This case underscores the significance of clinicians’ awareness regarding unusual tuberculosis presentations and the availability of advanced diagnostic tools to ensure timely and appropriate management.…”
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