Serum metalloproteinase-7 as a biomarker of progressive pulmonary fibrosis by Márcia Araújo, Marília Beltrão, Oksana Sokhatska, Natália Melo, Patrícia Caetano Mota, Helder Novais Bastos, André Terras, David Coelho, Luís Delgado, António Morais

“…Introduction Progressive pulmonary fibrosis (PPF) corresponds to any fibrotic interstitial lung disease (ILD) other than idiopathic pulmonary fibrosis (IPF) that presents clinical, physiological and/or radiological evidence of disease progression similar to IPF. …”
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PPARG/SPP1/CD44 signaling pathway in alveolar macrophages: Mechanisms of lipid dysregulation and therapeutic targets in idiopathic pulmonary fibrosis by Ganggang Li, Yuwei Zhang, Huanyu Jiang, Xuanyu Wu, Yanwei Hao, Yuchen Su, Yutong Zou, Wenjia Xian, Fei Wang, Quanyu Du

“…Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease. It is characterized by inflammation and fibrosis in the lung parenchyma and interstitium. …”
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A rare intersection: squamous cell carcinoma of the tonsil and the anti-TIF1 syndrome masquerade by Manush Sondhi, Megan Lear, Saleha Dar, Madiha Tariq

“…Distinctive features include severe skin lesions, dysphagia, and minimal interstitial lung disease. Management focuses on early cancer detection and treatment, with options for refractory disease, including IVIg, rituximab, and emerging therapies like JAK inhibitors. …”
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Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF by Shaobo Ge, Yuer Li, Rui Li, Jin Liu, Rui Zhang, Hongyan Fu, Jingjing Tang, Jie Zhang, Nali Zhang, Ming Zhang, Ming Zhang

“…BackgroundIdiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic inflammation and progressive fibrosis. …”
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Health-related Quality of Life and Exercise Capacity in Double Lung Transplant Recipients With Baseline Lung Allograft Dysfunction by Alisha Rullay, BSc, Karina Kaur, BSc, Jennifer Holman, PT, Laura C. van den Bosch, MD, Justin G. Weinkauf, MD, Jayan Nagendran, MD, PhD, Rhea A. Varughese, MD, Alim S. Hirji, MD, Dale C. Lien, MD, Jason C. Weatherald, MD, Kieran M. Halloran, MD

“…Patients with interstitial lung disease as an indication for transplant and those who received older, female, and heavy smoking donors were at increased risk of BLAD. …”
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Phase I Trial of Upamostat Combined With Gemcitabine in Locally Unresectable or Metastatic Pancreatic Cancer: Safety and Preliminary Efficacy Assessment by Xiuping Lai, Di Cheng, Huixin Xu, Jingshu Wang, Xiaozhi Lv, Herui Yao, Liuning Li, Junyan Wu, Suiwen Ye, Zhihua Li

“…Hematological toxicity, mainly attributable to gemcitabine, was the predominant grade 3 or 4 adverse event, with additional occurrences of loss of appetite, rash, and interstitial lung disease. Sinus bradycardia possibly linked to LH011 rather than gemcitabine was noted. …”
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FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis by Yu Cheng, Yang Jiao, Wan Wei, Mengjia Kou, Yaodong Cai, Yang Li, Hao Li, Tonghua Liu

“…BackgroundIdiopathic Pulmonary Fibrosis (IPF), an interstitial lung disease of unknown etiology, remains incurable with current therapies, which fail to halt disease progression or restore lung function. …”
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3D-CT-derived lung volumes and mortality risk in patients with fibrotic hypersensitivity pneumonitis by Shusuke Yazawa, Yuzo Suzuki, Yuko Tanaka, Koshi Yokomura, Masato Kono, Dai Hashimoto, Atsuki Fukada, Yusuke Inoue, Hideki Yasui, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Takafumi Suda

“…Background: Hypersensitivity pneumonitis (HP) is a complex and heterogenous interstitial lung disease (ILD) that occurs in susceptible individuals due to certain inhaled antigens. …”
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Network pharmacology and experimental verification reveal the mechanism of Qingfei Tongluo mixture in treating pulmonary fibrosis by Ying Zhou, Wenlong Wang, Wanping Zhu, Tingting Cai, Nannan Wang, Xia Liu, Wenmin Wang, Kequn Chai

“…Background: Pulmonary fibrosis (PF) is a chronic interstitial lung disease posing significant health risks. …”
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The Canadian Registry for Pulmonary Fibrosis: Design and Rationale of a National Pulmonary Fibrosis Registry by Christopher J. Ryerson, Benjamin Tan, Charlene D. Fell, Hélène Manganas, Shane Shapera, Shikha Mittoo, Mohsen Sadatsafavi, Teresa To, Andrea Gershon, Jolene H. Fisher, Kerri A. Johannson, Nathan Hambly, Nasreen Khalil, Theodore K. Marras, Julie Morisset, Pearce G. Wilcox, Andrew J. Halayko, Mohammad Adil Khan, Martin Kolb

“…The relative rarity and diversity of fibrotic interstitial lung disease (ILD) have made it challenging to study these diseases in single-centre cohorts. …”
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Vascular involvement in idiopathic pulmonary fibrosis by Michele Mondoni, Rocco Rinaldo, Christopher J. Ryerson, Cristina Albrici, Andrea Baccelli, Claudio Tirelli, Francesca Marchetti, Jacopo Cefalo, Giulia Nalesso, Giulia Ferranti, Fausta Alfano, Giovanni Sotgiu, Marco Guazzi, Stefano Centanni

“…Background Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrosing and progressive interstitial lung disease of unknown aetiology with a pathogenesis still partly unknown. …”
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hAMSCs regulate EMT in the progression of experimental pulmonary fibrosis through delivering miR-181a-5p targeting TGFBR1 by Yanyang Wang, Chan Liu, Nuoxin Wang, Dong Weng, Yan Zhao, Hongyu Yang, Haoyuan Wang, Shangfu Xu, Jianmei Gao, Changhui Lang, Zhenhai Fan, Limei Yu, Zhixu He

“…Abstract Background Pulmonary fibrosis (PF) is a common and multidimensional devastating interstitial lung disease. The development of novel and more effective interventions for PF is an urgent clinical need. …”
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Association of combined pulmonary fibrosis and emphysema in rheumatoid arthritis with high titer of rheumatoid factor and autoimmunity to the lung by Aiping Ma, Renliang Huang, Jiaxi Guo, Guangdong Wang, Heqing Huang, Xinze Li, Shan Zhong, Yan Huang, Shaowei Lin, Yikai Lin, Qiaomiao Zhou, Susanne Krauss-Etschmann, Frank Petersen, Zhanxiang Wang, Xinhua Yu, Xinhua Yu

“…Patient IgG and IgM autoantibodies to primary human bronchial epithelial cells (HBEC) from healthy donors were assessed using flow cytometry.FindingsAmong the 976 RA patients, 414 (42.4%) developed interstitial lung disease (ILD), with 74 (7.6%) experiencing CPFE. …”
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The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): study protocol for a randomised placebo-controlled mult... by Toby M Maher, A John Simpson, Anthony Cahn, David Thickett, Luke Vale, Allan B Clark, Nazia Chaudhuri, Ian Forrest, Lisa G Spencer, Christopher Ward, Stephen Jones, Ganesh Raghu, Andrew M Wilson, Helen Parfrey, Megan Jones, Matthew Hammond, Jaclyn Ann Smith, Shajahan Wahed

“…Secondary assessments include cough frequency (in a subgroup) measured using the VitaloJAK cough monitor, the King’s Brief Interstitial Lung Disease questionnaire, the Raghu Scale for Pulmonary Fibrosis, Medical Research Council dyspnoea score, EQ-5D-5L, Leicester Cough Questionnaire, modified DeMeester reflux symptoms questionnaire and opportunistically captured routine lung function measurements. …”
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Case report: JAK inhibitor treatment of immune dysregulation symptoms in a patient with PTPN2 deficiency by Anna Roppelt, Ulyana Markina, Irina Beloglazova, Irina Beloglazova, Vasily Parshin, Dmitry Kanner, Dmitry Pershin, Mariia Fadeeva, Elena Raykina, Maxim Aleksenko, Alexander Karaulov, Mariana Lysenko, Mariana Lysenko, Daria Fomina, Daria Fomina, Daria Fomina

“…We report on a 32-year-old male patient with interstitial lung disease, cytopenia, and lymphadenopathy accompanied by de-novo deletion in PTPN2. …”
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Quantitative N-glycoproteomic analysis reveals glycosylation signatures of plasma immunoglobulin G in systemic sclerosis by Lu Cheng, Lu Cheng, Yanhong Li, Yu Zhou, Yingying Ling, Tong Wu, Zongan Liang, Yinlan Wu, Chunyu Tan, Yi Liu, Yong Zhang

“…These changes in the levels of intact N-glycopeptides are associated with various aspects of SSc, including diffuse SSc (dSSc), interstitial lung disease (ILD), disease progression, cardiovascular involvement and C-reactive protein in the peripheral blood. …”
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Health-related quality of life and health state utility value in idiopathic pulmonary fibrosis: a systematic review and meta-analysis by Guixiang Zhao, Siyuan Lei, Ya Li, Zhenzhen Feng, Jiansheng Li

“…George’s Respiratory Questionnaire (SGRQ), EuroQoL Five Dimensions Questionnaire (EQ-5D), Short Form-36 (SF-36) and the King’s Brief Interstitial Lung Disease (KBILD) were the most common instruments, among which the EQ-5D included the HSUV and the visual analog scale (VAS). …”
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The Pathogenic Role of Expanded CD8⁺CD28^null Angiogenic T Cells in ANCA-Associated Vasculitis by Haomiao Shen, Jinlin Miao, Haoyang Sun, Kui Zhang, Renli Liu, Zichao Li, Leyang Zhang, Peiyan Zhang, Jiawei Wang, Bei Zhang, Longyu Chen, Zhaohui Zheng, Ping Zhu

“…<b>Results</b>: CD8⁺CD28^null Tang levels were significantly higher in the peripheral blood of AAV patients compared to HCs, and their levels were further increased in AAV patients with MPO⁺, p-ANCA⁺, or interstitial lung disease compared to their respective control groups. …”
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Nebulized aminoglycosides for ventilator-associated pneumonia: Methodological considerations and lessons from experimental studies by Jean-Jacques Rouby, Jing Xia, Jayesh Dhanani, Gianluigi Li Bassi, Antoine Monsel, Antoni Torres, Kostoula Arvaniti, Mona Assefi, Matteo Bassetti, Stijn Blot, Matthieu Boisson, Adrien Bouglé, Jean-Michel Constantin, Jayesh Dhanani, George Dimopoulos, Jonathan Dugernier, Pauline Dureau, Stephan Ehrmann, Timothy Felton, Marin Kollef, Antonia Koutsoukou, Anna Kyriakoudi, Pierre-François Laterre, Marc Leone, Victoria Lepère, Gianluigi Li Bassi, Xuelian Liao, Shakti Bedanta Mishra, Olivier Mimoz, Antoine Monsel, Girish B Nair, Michael Niederman, Lucy B Palmer, Jose Manuel Pereira, Konstantinos Pontikis, Garyphalia Poulakou, Jérôme Pugin, Chuanyun Qian, Jie-ming Qu, Jordi Rello, Jason Roberts, Jean-Jacques Rouby, Christina Routsi, Gerald C. Smaldone, Antoni Torres, Melda Türkoğlu, Tobias Welte, Michel Wolff, Xia Jing, Li Yang, Ting Yang, Ying-gang Zhu

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Association of occupational dust exposure with combined chronic obstructive pulmonary disease and pneumoconiosis: a cross-sectional study in China by Yali Fan, Qiao Ye, Wenjing Xu, Yuanying Wang, Yiran Wang, Shiwen Yu

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