How far? Travel burdens for children admitted to hospitals in the Western Cape Province of South Africa by M Richards, D le Roux, D Pienaar

“…These findings could be further interrogated for people’s choices of facility and method of travel. …”
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Metagenomics: a new frontier for routine pathology testing of gastrointestinal pathogens by Nicola Z. Angel, Mitchell J. Sullivan, Areej Alsheikh-Hussain, Liang Fang, Samantha MacDonald, Alena Pribyl, Blake Wills, Gene W. Tyson, Philip Hugenholtz, Donovan H. Parks, Paul Griffin, David L. A. Wood

“…Conclusions The advantage of mNGS compared to other syndromic testing systems is the broad range of detectable targets and the ability to interrogate samples without clinician informed or assay specific bias. …”
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Les effets des normes de sexe chez les enseignant-e-s de l’école primaire by Céline Delcroix

“…Il s’agit aussi de s’interroger sur l’influence de la masculinisation dans l’activité proprement éducative puisque la place des femmes et des hommes dans la société affectent les métiers liées à la petite enfance, et pas seulement.Partant de cet état des lieux, j’ai pris pour objet de recherche les effets des normes de sexe chez les femmes et les hommes qui font le choix de devenir enseignant-e en primaire et comment ces rôles de sexe les conduisent à intérioriser des conduites professionnelles. …”
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How far back do we need to look to capture diagnoses in electronic health records? A retrospective observational study of hospital electronic health record data by Tom Marshall, Elizabeth Sapey, Miles D Witham, Steve Harris, Rachel Cooper, Chris Plummer, Felicity Evison, James Wason, Heather J Cordell, Suzy Gallier, Fiona E Matthews, Ewan Pearson, Avan A Sayer, Mervyn Singer, Joanne Field, Mohammed Osman, Sian Robinson, Victoria Bartle, Thomas Scharf, Jadene Lewis, Rominique Doal, Peta le Roux, Ray Holding, Paolo Missier

“…This study aimed to ascertain how far back in time electronic hospital records need to be interrogated to capture long-term condition diagnoses.Design Retrospective observational study of routinely collected hospital electronic health record data.Setting Queen Elizabeth Hospital Birmingham (UK)-linked data held by the PIONEER acute care data hub.Participants Patients whose first recorded admission for chronic obstructive pulmonary disease (COPD) exacerbation (n=560) or acute stroke (n=2142) was between January and December 2018 and who had a minimum of 10 years of data prior to the index date.Outcome measures We identified the most common International Classification of Diseases version 10-coded diagnoses received by patients with COPD and acute stroke separately. …”
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Natural killer cells occupy unique spatial neighborhoods in HER2- and HER2+ human breast cancers by Femke A. I. Ehlers, Katie E. Blise, Courtney B. Betts, Shamilene Sivagnanam, Loes F. S. Kooreman, E. Shelley Hwang, Gerard M. J. Bos, Lotte Wieten, Lisa M. Coussens

“…In this study, we developed a multiplex immunohistochemistry (mIHC) antibody panel designed to quantitatively interrogate leukocyte lineages, focusing on NK cells and their phenotypes, in two independent breast cancer patient cohorts (n = 26 and n = 30). …”
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Dynamiques socio-politiques et territorialités de l’immigration ivoirienne en Tunisie by Camille Cassarini

“…In the final section, the article interrogates the way in which these migratory strategies structure the modes of integration of these people in the Tunisian space. …”
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Reflections on the Yoruba Past: Toyin Falola on Isaac Delano by Wale Oyedeji

“…More than many of his contemporaries, Toyin Falola continues to demonstrate that knowledge production from Africa is sustainable if past events are interrogated accordingly. In very many ways, he displays quality content that gives him the sort of image he has built for Africans generally, and himself particularly in the world of intellectualism. …”
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Gardé·es à vue. Domination(s) et reconfigurations des rapports entre manifestant·es et policier·es pendant le hirak (2019-2021) by Lina Benchekor

“…The contrasting emotions aroused by the violence of arrests and interrogations have consequences for the dynamics of engagement and disengagement, sometimes even for other spheres of life, and can constitute a veritable biographical bifurcation. …”
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Patient-derived response estimates from zero-passage organoids of luminal breast cancer by Róża K. Przanowska, Najwa Labban, Piotr Przanowski, Russell B. Hawes, Kristen A. Atkins, Shayna L. Showalter, Kevin A. Janes

“…Conclusions Zero-passage organoids are a rapid and scalable way to interrogate properties of luminal breast cancer cells from patient-derived material. …”
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Characterizing the microstructural transition at the gray matter-white matter interface: Implementation and demonstration of age-associated differences by Joan Y Song, Roman Fleysher, Kenny Ye, Mimi Kim, Molly E Zimmerman, Richard B Lipton, Michael L Lipton

“…This method overcomes techniques issues related to interrogating the GWI. Beyond characterizing normal aging, it could be applied to explore pathological effects at this crucial, yet under-researched region.…”
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Acetylation of proximal cysteine-lysine pairs by alcohol metabolism by Courtney D. McGinnis, Peter S. Harris, Brenton I.M. Graham, John O. Marentette, Cole R. Michel, Laura M. Saba, Richard Reisdorph, James R. Roede, Kristofer S. Fritz

“…A murine model of ALD was employed to quantify hepatic cysteine redox changes and lysine acetylation, revealing that alcohol metabolism significantly reduced the cysteine thiol proteome and increased protein acetylation. Interrogating both cysteine redox and lysine acetylation datasets, 1280 protein structures generated by AlphaFold2 represented by a 3D spatial matrix were used to quantify the distances between 557,815 cysteine and lysine residues. …”
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Interprofessional collaborative practice in health and social care for people living with multimorbidity: a scoping review protocol by Josephine-L. K. Murray, Virginia Hernandez-Santiago, Frank Sullivan, Joanna Hornal, Farhana Badshah, Ben Keatley, Jillian Galbraith, Pam Channer, Anne Fearfull, Anne Haddow, Eleanor Johnston, Maureen Ward, Veronica O’Carroll

“…A second comprehensive search will be used to interrogate four databases, looking back 10 years, seeking articles published in English, French, Spanish or Portuguese. …”
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Iron deposition is associated with motor and non-motor network breakdown in parkinsonism by Fangda Leng, Yue Gao, Fan Li, Luhua Wei, Yunchuang Sun, Fang Liu, Ying Zhu, Jianxing Qiu, Zhaoxia Wang, Yiwei Zhang

“…The relationship between quantitative iron deposition and brain network status was further interrogated. To further validate the findings, 13 healthy controls and 37 PD patients who had available T1 and rs-fMRI scans were selected from Parkinson’s progression markers initiative (PPMI) database, and network analysis was performed.ResultsIn local cohort, compared to PD, MSA patients showed greater iron deposition in putamen, while PSP patients had greater iron deposition in caudate nucleus and thalamus. …”
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Percepción de la recuperación de continencia y potencia sexual en pacientes llevados a prostatectomía radical: concordancia entre el reporte del paciente y la historia clínica by Jaime A. Cajigas-Plata, Gianluca Gasca-Mayans

“…Métodos: Se recolectó una muestra de hombres con cáncer de próstata llevados a prostatectomía radical. Se interrogó el tiempo de recuperación de continencia urinaria y función eréctil posterior a cirugía. …”
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Eminescu – poezia naşterii şi a stingerii (elemente de antropogonie eminesciană) by Carmina Cojocaru

“…The attitude adopted was innitially interrogative but further became meditative, analitic, with the aim of reaching a complete comprehension of the significance of the existance, of human contradictions and of discovering new divine ideals. …”
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Characterization of the genomic landscape of canine diffuse large B-cell lymphoma reveals recurrent H3K27M mutations linked to progression-free survival by Anna Darlene van der Heiden, Raphaela Pensch, Sophie Agger, Heather L. Gardner, William Hendricks, Victoria Zismann, Shukmei Wong, Natalia Briones, Bryce Turner, Karin Forsberg-Nilsson, Cheryl London, Kerstin Lindblad-Toh, Maja Louise Arendt

“…These findings underscore the critical role of epigenetic dysregulation in cDLBCL and affirm the dog as a relevant large animal model for interrogating the biological activity of novel histone-modifying treatment strategies.…”
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L’officier de police, le checkpoint et l’interrogatoire : les spatialités des performances sécuritaires dans le centre-ville du Caire by Laura Monfleur

“…In turn, security performance constructs downtown Cairo as a sensitive zone where police presence, checkpoints and interrogations are all reminders of the social order, a way of telling everyone their place and who has coercive power, but also of a spatial order, a way of signifying to whom downtown belongs.This research is based on various field surveys conducted in Cairo in 2015 and then between 2019 and 2021. …”
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Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade by Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

“…Background Obesity is a risk factor for developing cancer but is also associated with improved outcomes after treatment with immune checkpoint inhibitors (ICIs), a phenomenon called the obesity paradox. To interrogate mechanisms of divergent immune responses in obese and non-obese patients, we examined the relationship among obesity status, clinical responses, and immune profiles from a diverse, pan-tumor cohort of patients treated with ICI-based therapy.Methods From June 2021 to March 2023, we prospectively collected serial peripheral blood samples from patients with advanced or metastatic solid tumors who received ICI as standard of care at Johns Hopkins. …”
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The state of paediatric deceased-organ donation at a South African tertiary public- sector hospital: A 14-year analysis by T Siyotula, J Barrell, K Manning, D Thomson, M McCulloch, T du Toit

“…Future studies should be designed to further interrogate our findings, while accommodating for nuances specific to the paediatric deceased-donor population and their families. …”
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A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care dataResearch in context by Olivia Murrin, Ninon Mounier, Bethany Voller, Linus Tata, Carlos Gallego-Moll, Albert Roso-Llorach, Lucía A. Carrasco-Ribelles, Chris Fox, Louise M. Allan, Ruby M. Woodward, Xiaoran Liang, Jose M. Valderas, Sara M. Khalid, Frank Dudbridge, Sally E. Lamb, Mary Mancini, Leon Farmer, Kate Boddy, Jack Bowden, David Melzer, Timothy M. Frayling, Jane A.H. Masoli, Luke C. Pilling, Concepción Violán, João Delgado

“…We address this gap by integrating large-scale primary-care and genetic data from multiple studies to interrogate multimorbidity patterns and producing digital resources to support future research. …”
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