Presenting a model of ecotourism and sustainable tourism development with an emphasis on foreign exchange and economic development of Qeshm Island by Naser Rajabi, Vahid Reza Mirabi, Khosro Moradi Shahdadi

“…Causal factors include cultural and social factors, the potential of Qeshm Island for tourism and economic and political factors, background features including geographical location, capacity and potential facilities of Qeshm and geosites, intervening conditions including lack of strategy and proper planning and infrastructural problems as well as strategies and interactions include goal-setting and strategy determination to achieve the goal, education and culture building, and providing suitable infrastructure for tourism. …”
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Atmospheric Black Carbon Evaluation in Two Sites of San Luis Potosí City During the Years 2018–2020 by Valter Barrera, Cristian Guerrero, Guadalupe Galindo, Dara Salcedo, Andrés Ruiz, Carlos Contreras

“…This study presented information from two zones of a growing city in Mexico to generate new air pollutant indicators to have a better understanding of pollutant interactions in the city, to decrease the emission precursor sources, and reduce the health risks in the population.…”
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Contribution of cuproptosis and immune-related genes to idiopathic pulmonary fibrosis disease by Chengji Jin, Jia Li, Qiaoyu Li, Lipeng Zhang, Shaomao Zheng, Qiong Feng, Yongjie Li, Yu Zheng, Qiuli Nie, Jin Liang, Jing Wang, Jing Wang

“…Additionally, four immune-related hub genes were screened using a protein–protein interaction (PPI) network and evaluated through the receiver operating characteristic (ROC) curve. …”
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miR-1458 is inhibited by low concentrations of Vitamin B6 and targets TBX6 to promote the formation of spermatogonial stem cells in Rugao Yellow Chicken by Qingqing Geng, Cai Hu, Ziduo Zhao, Zhe Wang, Fufu Cheng, Jing Chen, Qisheng Zuo, Yani Zhang

“…High-throughput sequencing results showed that miR-1458 interacted with TBX6, one of the target genes of miR-1458, involved in affecting cell differentiation, and dual-luciferase reporter vectors confirmed the targeting relationship between the two. …”
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Salmonella pathogenicity Island 1 undergoes decay in serovars adapted to swine and poultry by Martina Tambassi, Melissa Berni, Chiara Bracchi, Ilaria Menozzi, Alessandra Dodi, Laura Mazzera, Marina Morganti, Erika Scaltriti, Stefano Pongolini

“…On one side, our results contribute to the knowledge of the interaction between livestock populations and their host-adapted serovars of Salmonella. …”
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Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals by Ruxing Zhao, Yujing Sun, Yongyuan Zhang, Weili Wang, Shouyu Wang, Chuang Wang, Jinbo Liu, Ling Gao, Zhao Hu, Jianchun Fei, Xinguo Hou, Huizhen Zheng, Li Chen

“…The immune system poses the critical interactive chain between the human body and the virus. …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…SEL accelerates the ubiquitination and subsequent degradation of XPO1 by disrupting the interaction between XPO1 and USP7. The expression of USP7 is negatively correlated with patient prognosis and the sensitivity of MM cells to SEL. …”
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Atrial fibrillation outcomes in patients from Asia and non-Asia countries: insights from GARFIELD-AF by Karen Pieper, Xian-hong Fang, Kai Sun, Ajay K Kakkar, Saverio Virdone, Shinya Goto, Gloria Kayani, Zhi-Cheng Jing, John Camm, Chun-Yan Cheng, Tian-Yu Lian, Xi-Jie Zhu, Xian-Mei Li

“…Associations of moderate-to-severe chronic kidney disease and vascular disease with increased risk of all-cause mortality were stronger in Asian versus non-Asian patients (interaction p values: 0.0250 and 0.0076, respectively). …”
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Dissemination of IncQ1 Plasmids Harboring NTE_KPC-IId in a Brazilian Hospital by Camila Maria dos Santos Boralli, Julian Andres Paganini, Rodrigo Silva Meneses, Camila Pacheco Silveira Martins da Mata, Edna Marilea Meireles Leite, Anita C. Schürch, Fernanda L. Paganelli, Rob J. L. Willems, Ilana L. B. C. Camargo

“…In addition to IncQ1 with NTE_KPC, <i>Enterobacter cloacae</i> BHKPC28 contained the <i>mcr-9</i> gene in an IncHI2/IncHI2A conjugative plasmid, which may help the mobility of IncQ1 and the dissemination of two resistance determinants to last-resort antibiotics. Understanding the interaction between plasmids and high-risk lineages can help develop new therapies to prevent the dissemination of resistance traits.…”
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Relationship between dietary fiber physicochemical properties and feedstuff fermentation characteristics and their effects on nutrient utilization, energy metabolism, and gut micro... by Feng Yong, Bo Liu, Huijuan Li, Houxu Hao, Yueli Fan, Osmond Datsomor, Rui Han, Hailong Jiang, Dongsheng Che

“…The dietary apparent viscosity and β-glucan-to-arabinoxylan ratios had linear interaction effects on the digestible energy, metabolizable energy, retained energy (RE), and net energy (NE) of the diets (P < 0.05). …”
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Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome by Fabien Robert, Feriel Benchenouf, My Ngoc Ha, Alessandra Cuomo, Mina Ottaviani, Maxime Surbier, Raphaël Thuillet, Corinne Normand, Florent Dumont, Céline Verstuyft, Frederic Fiore, Frederic Guinut, Marc Humbert, Audrey Coilly, Emmanuel Gonzales, Olivier Sitbon, Ly Tu, Christophe Guignabert, Laurent Savale

“…RNA sequencing coupled with ingenuity pathway analysis identified significant interactions between PlGF and pulmonary eNOS activity. …”
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Relation among zootechnical performance, biochemical indicators, water quality, and small invertebrates (zooplankton) abundance reared in biofloc-supplemented systems by Ahmed Said Al-Souti, Marwa M. Zaher, Amr M. Helal, Dina T. Meshhal, Mansour D. H., Afify D. G. Al-Afify, Mohamed M. Rafaey, Abeer El-Saharty, Ehab El-Haroun, Marian G. Nassif, Abdallah Tageldein Mansour, Abdallah Tageldein Mansour, Mohamed Ashour

“…The present study was conducted to investigate the interaction of biofloc water supplementations and potential zooplankton abundance and structure in Nile tilapia Oreochromis niloticus-rearing systems on zootechnical performance and biochemical indicators. …”
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Application of various canopy resistance calculation methods in vineyard evapotranspiration simulation at daily scale in Northwest China by Jingying Zhang, Dianyu Chen, Xiaotao Hu, Lucheng Qiu, Shujian Wang, Xuanrong Zhu, La Zhuo, Dongyan Zhang, Linzhe Wu, Linlin Zhang

“…Here, the Jarvis (JA) model, the coupled surface resistance (CO) model, the Farias (FA) model, the Kelliher-Leuning (KL) model, the Katerji-Perrier (KP) model and the new coupling (N) model which considering interaction among different factors were used for rc calculation in a vineyard in Northwest China. …”
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Associations of co-exposure to polycyclic aromatic hydrocarbons and vitamin D with early lung dysfunction: Mediating roles of metabolic score-visceral adiposity index by Baihao Lin, Wanlu Liu, Hank-Han Wang, Haixia Qian, Xinyu Zhu, Mengya Xu, Yuyu Zheng, Nada Alhazmi, Yansen Bai

“…Multiple metabolic disorder indicators were calculated using biochemical markers. The interaction effects between vitamin D and PAHs were evaluated using multiple linear and logistic regression models. …”
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Dysbiosis of gut microbiota in COVID-19 is associated with intestinal DNA phage dynamics of lysogenic and lytic infection by Aya Ishizaka, Azumi Tamura, Michiko Koga, Taketoshi Mizutani, Seiya Yamayoshi, Kiyoko Iwatsuki-Horimoto, Atsuhiro Yasuhara, Shinya Yamamoto, Hiroyuki Nagai, Eisuke Adachi, Yutaka Suzuki, Yoshihiro Kawaoka, Hiroshi Yotsuyanagi

“…SARS-CoV-2 infection, which follows a transient pathological course from disease onset to cure, may provide a reliable model to investigate these interactions in the gut environment. Therefore, this study aimed to elucidate the correlation between gut microbiota and intestinal DNA virome dynamics in COVID-19 pathogenesis. …”
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Climate change rivals fertilizer use in driving soil nitrous oxide emissions in the northern high latitudes: Insights from terrestrial biosphere models by Naiqing Pan, Hanqin Tian, Hao Shi, Shufen Pan, Josep G. Canadell, Jinfeng Chang, Philippe Ciais, Eric A. Davidson, Gustaf Hugelius, Akihiko Ito, Robert B. Jackson, Fortunat Joos, Sebastian Lienert, Dylan B. Millet, Stefan Olin, Prabir K. Patra, Rona L. Thompson, Nicolas Vuichard, Kelley C. Wells, Chris Wilson, Yongfa You, Sönke Zaehle

“…However, permafrost soil N2O emissions continued increasing attributable to climate warming; the interaction of climate warming and increasing CO2 concentrations on nitrogen and carbon cycling will determine future trends in NHL soil N2O emissions. …”
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AICpred: Machine Learning-Based Prediction of Potential Anti-Inflammatory Compounds Targeting TLR4-MyD88 Binding Mechanism by Lucindah N. Fry-Nartey, Cyril Akafia, Ursula S. Nkonu, Spencer B. Baiden, Ignatus Nunana Dorvi, Kwasi Agyenkwa-Mawuli, Odame Agyapong, Claude Fiifi Hayford, Michael D. Wilson, Whelton A. Miller, Samuel K. Kwofie

“…This study introduces AICpred, a robust, free, user-friendly, and easily accessible machine learning-based web application for predicting inhibitors against TLR4 by targeting the TLR4-myeloid differentiation primary response 88 (MyD88) interaction. MyD88 is a crucial adaptor protein in the TLR4-induced hyper-inflammation pathway. …”
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Uptake and 4-week outcomes of an ‘opt-out’ smoking cessation referral strategy in a London-based lung cancer screening setting by Anthony Edey, Neal Navani, Kitty Chan, Graham Robinson, Janine Zylstra, Paul Robinson, Laura Green, Anand Devaraj, Jane Rowlands, Allan Hackshaw, Carolyn Horst, Arjun Nair, Sam M Janes, Kate Davies, Jeannie Eng, Mamta Ruparel, Samantha L Quaife, Jennifer L Dickson, Magali Taylor, Angshu Bhowmik, Hasti Robbie, Joseph Jacob, Laura Farrelly, Sophie Tisi, Tanya Patrick, Andrew Creamer, Helen Hall, Samanjit Hare, Jon Teague, Samuel M Janes, Esther Arthur-Darkwa, Thea Buchan, Stephen Ellis, Thomas Callender, Rachael Sarpong, John McCabe, Zaheer Mangera, Ethaar El-Emir, Terry O'Shaughnessy, Geoff Bellingan, Nick Screaton, Priyam Verghese, William M Ricketts, Vicky Bowyer, Kylie Gyertson, Fanta Bojang, Claire Levermore, Tania Anastasiadis, Ruth Prendecki, Amyn Bhamani, Malavika Suresh, Judy Airebamen, Alice Cotton, Kaylene Phua, Elodie Murali, Simranjit Mehta, Karen Parry-Billings, Columbus Ife, April Neville, Zahra Hanif, Helen Kiconco, Ricardo McEwen, Dominique Arancon, Nicholas Beech, Derya Ovayolu, Christine Hosein, Sylvia Patricia Enes, Qin April Neville, Aashna Samson, Urja Patel, Fahmida Hoque, Hina Pervez, Sofia Nnorom, Moksud Miah, Julian McKee, Mark Clark, Anant Patel, Sara Lock, Rajesh Banka, Ugo Ekeowa, Charlotte Cash, Tunku Aziz, Alberto Villanueva, Elena Stefan, Charlie Sayer, Navinah Nundlall, Andrew Crossingham, Tanita Limani, Kate Gowers, Andrew Perugia, James Rusius, Anne-Marie Hacker, Monica L Mullin, Evangelos Katsampouris, Chuen R Khaw, Chuen Khaw, Sheetal Karavadra, Alan Shaw, Chris Valerio, Ali Mohammed, Lynsey Gallagher, Mehran Azimbagirad, Burcu Ozaltin, Maureen Browne, Eleanor Hellier, Catherine Nestor

“…The 4-week quit rate among those setting a quit date and all individuals referred was 57.4% (n=132/230) and 17.8% (n=132/742), respectively.Conclusion A proactive, ‘opt-out’ smoking cessation referral strategy for individuals currently smoking tobacco who interact with an LCS programme may be beneficial.…”
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Association study of the JAK/STAT signaling pathway with susceptibility to COVID-19 in moroccan patient and in-silico analysis of rare variants by Meriem El Houdi, Hanaa Skhoun, Meriem El Fessikh, Reda Benmansour, Fatima-Zahra El Yousfi, Chaimae Nebhani, Mohamed Rida Tagajdid, Idriss Lahlou Amine, Hicham El Annaz, Rabii Ameziane El Hassani, Zohra Ouzzif, Redouane Abouqal, Khalid Ennibi, Ahmed Bouhouche, Jamila El Baghdadi

“…Notably, IFNAR1 p.Val168Leu mutated C allele was significantly associated with reduced susceptibility to COVID-19 severity (p=0.028, OR=0.5936 [0.3725 – 0.9461]), under the additive model (p=0.045, OR=0.626 [0.3958 – 0.9899]).Rare variants IFNAR1 p.Trp318Cys, p.Ser476Phe, and IFNAR2 p.Cys271Tyr were predicted deleterious, impacting protein structure via hydrogen bond and hydrophobic interaction alterations. Burden analysis of rare variants revealed a protective cumulative effect against COVID-19 severity for TYK2 (p=0.0013, OR=0.1438 [0.04237 – 0.4803]) under the dominant model.This study underscores the role of genetic factors in COVID-19 susceptibility and advocates further explorations regarding functional impacts of JAK/STAT pathway rare variants.…”
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Neospora caninum infection specifically suppresses the expression of a host lncRNA XR_001919077.1 to facilitate parasite propagation by modulating host cell mitochondrial function... by Shan-Shan Zhao, De-Liang Tao, Jin-Ming Chen, Ming-Yi Zhang, Xin Yang, Jun-Ke Song, Qun Liu, Guang-Hui Zhao

“…Our findings provide a novel insight to understand the interactions between N. caninum and host cells.IMPORTANCEThe uterus is an indispensable reproductive organ for embryo implantation and fetal growth. …”
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