Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway by Li Q, Zheng JW, Wang ZY, Liao SP, Zhu L, Wang X, Wan LH

“…Finally, molecular docking studies suggested that RA could directly interact with GRP78, PERK, and IRE1, but not with MANF.Conclusion: RA plays a protective role in improving cognitive function against endotoxemia-associated encephalopathy in mice via inhibiting the GRP78/PERK/MANF pathway.Keywords: Rosmarinic acid, endotoxin, neuronal damage, GRP78/PERK/MANF pathway…”
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Association Between Weight-Adjusted Waist Index and Cognitive Function in Older Adults Without Diabetes: A Cross-Sectional Study by Wang Q, Yin Y, Liu W, Li L, Wang Z, Tian Y, Fan J

“…We employed linear univariate and multivariate analyses, along with curve fitting, we conducted subgroup and interaction analyses to elucidate the relationships under investigation.Results: The study incorporated a cohort of 1649 participants aged 60 years and older, each with a complete set of data, enabling a thorough analysis. …”
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Machine Learning–Based Risk Factor Analysis and Prediction Model Construction for the Occurrence of Chronic Heart Failure: Health Ecologic Study by Qian Xu, Xue Cai, Ruicong Yu, Yueyue Zheng, Guanjie Chen, Hui Sun, Tianyun Gao, Cuirong Xu, Jing Sun

“…Future research should focus on prospective studies, diverse data, advanced techniques, longitudinal studies, and exploring factor interactions for better CHF prevention and management.…”
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Application of Patient-Generated Health Data Among Older Adults With Cancer: Scoping Review by Yesol Kim, Geonah Kim, Hyeonmi Cho, Yeonju Kim, Mona Choi

“…Future research should emphasize the use of PGHD, which interacts with patients to provide patient-centered care through patient engagement. …”
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Comprehensive pan-cancer analysis reveals NTN1 as an immune infiltrate risk factor and its potential prognostic value in SKCM by Fuxiang Luan, Yuying Cui, Ruizhe Huang, Zhuojie Yang, Shishi Qiao

“…We identified genes interacting with and correlated to NTN1 through STRING and GEPIA2, respectively. …”
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Ethnobotanical studies on rice landraces under on-farm conservation in Xishuangbanna of Yunnan Province, China by Fei Wang, Tao Sun, Shuai Yu, Chunhui Liu, Zhuo Cheng, Jianxin Xia, Longzhi Han

“…Abstract Background A complex interaction and mutual influence exists among landscapes, cultures, and landraces, with rice culture being a typical embodiment of this relationship. …”
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Innovative Model of Socio-Professional Development of a Student’s Personality by E. F. Zeer, V. S. Tretyakova, M. V. Zinnatova

“…Methodological framework of the research is based on the concept of subject-activity approach, according to which the personality is considered as an active, self-improving, self-actualising and self-determining actor; process and project approaches; as well as the methodology of convergence, which provides a synergistic effect of interaction of socio-humanitarian, natural-scientific and industrial-technical disciplines. …”
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Possible linking and treatment between Parkinson’s disease and inflammatory bowel disease: a study of Mendelian randomization based on gut–brain axis by Beiming Wang, Xiaoyin Bai, Yingmai Yang, Hong Yang

“…Enrichment analysis and protein‒protein interaction (PPI) network were done to explore common pathogenesis pathways. …”
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Multi-Modal Fusion of Routine Care Electronic Health Records (EHR): A Scoping Review by Zina Ben-Miled, Jacob A. Shebesh, Jing Su, Paul R. Dexter, Randall W. Grout, Malaz A. Boustani

“…<i>Background</i>: Electronic health records (EHR) are now widely available in healthcare institutions to document the medical history of patients as they interact with healthcare services. In particular, routine care EHR data are collected for a large number of patients.These data span multiple heterogeneous elements (i.e., demographics, diagnosis, medications, clinical notes, vital signs, and laboratory results) which contain semantic, concept, and temporal information. …”
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Evaluation of multidrug resistance in the Gram-negative microbiome of cancer patients and the adverse effects of their metabolites on albino rats and epithelial or fibroblasts cell... by Mervat Morsy Abbas Ahmed El-Gendy, Huda Ahmed Alghamdi, Khaled G. Abdel-Wahhab, Nabila S. Hassan, Aya A. M. El-Bondkly, Mohammed Abdel-Wahab, Ayman A. Farghaly, Ahmed Mohamed Ahmed El-Bondkly

“…This includes research into the microbial communities that influence cancer development, tumor-associated microorganisms, and the interactions between the microbiome and tumor, collectively referred to as the oncobiome. …”
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Association of neighborhood level socioeconomic status and patient reported clinical improvement following total shoulder arthroplasty by Caleb Morgan, MD, Amanda Firoved, MOT, OTR, Patrick J. Denard, MD, Justin W. Griffin, MD

“…We used a mixed-design analysis of variance to determine the interaction of time and improvement in PROs following surgery followed by 1-way mixed-design analysis of variance with post-hoc analysis. …”
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Associations between Life’s Essential 8 and liver function: a cross-sectional study by Qiaoli Liang, Menglong Zou, Ziming Peng

“…Subgroup analyses were performed based on sex and age to assess potential interactions.ResultsHigher LE8 scores were significantly associated with improved liver function, particularly highlighted by two major findings. …”
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Predicting User Engagement in Health Misinformation Correction on Social Media Platforms in Taiwan: Content Analysis and Text Mining Study by Hsin-Yu Kuo, Su-Yen Chen

“…At the same time, social media offers valuable interactive data, enabling researchers to analyze user engagement with health misinformation corrections and refine content design strategies. …”
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Identification of Behavioral, Clinical, and Psychological Antecedents of Acute Stimulant Poisoning: Development and Implementation of a Mixed Methods Psychological Autopsy Study by Marley Antolin Muñiz, Vanessa M McMahan, Xochitl Luna Marti, Sarah Brennan, Sophia Tavasieff, Luke N Rodda, James Knoll, Phillip O Coffin

“…ObjectiveWe aimed to develop and implement a large PA study to identify antecedents of fatal stimulant poisoning, seeking to maximize data gathering and ethical interactions during the collateral interviews. …”
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Network analysis combined with genome-wide association study helps identification of genes related to amino acid contents in soybean by Kyujung Van, Sungwoo Lee, M. A. Rouf Mian, Leah K. McHale

“…For Approach II, the individual AAs were grouped by five families according to their metabolic pathways and were examined based on the sum, ratios, and interactions of AAs within the same biochemical family. …”
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Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…This study investigated the role of High mobility group box 1 (HMGB1), a prototype DAMP molecule, in NETosis induction following photothrombotic stroke (PTS), with a particular focus on neutrophil-platelet interactions. In PTS, thrombi consist primarily of aggregated platelets and neutrophils, lacking significant fibrin content. …”
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Elevated miR-221-3p inhibits epithelial–mesenchymal transition and biochemical recurrence of prostate cancer via targeting KPNA2: an evidence-based and knowledge-guided strategy by Dingchao Li, Jingang Jian, Manhong Shi, Zihao Chen, Anguo Zhao, Xuedong Wei, Yuhua Huang, Yalan Chen, Jianquan Hou, Yuxin Lin

“…Then a knowledge-guided network strategy was applied to prioritize key targets of miR-221-3p in PCa progression based both on topological and functional characterization of genes in multi-omics miRNA-mRNA and protein-protein interaction networks. Finally, a key gene was computationally identified and experimentally validated using cell line and clinical samples through EdU assay, scratch assay, transwell assay, dual-luciferase reporter assay and the epithelial-to-mesenchymal transition (EMT)-related analysis. …”
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HISTORIOGRAPHY OF THE STUDY OF STATE PRACTICES AND THE JUDICIARY OF SOUTHERN UKRAINIAN TERRITORIES: GENERAL CHARACTERISTICS by Oleg Vuyiv, Maryna Bulkat

“…From the beginning of the annals, domestic authors adhered to pro-Ukrainian rhetoric in matters of the formation of the Kyiv state and its interaction with the Khazar Khaganate, which controlled the southern Ukrainian lands at that time, with the polities of the Pechenegs, Polovtsians, and other steppe peoples who lived there. …”
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Scoping review of Neglected Tropical Disease Interventions and Health Promotion: A framework for successful NTD interventions as evidenced by the literature. by Caroline Ackley, Mohamed Elsheikh, Shahaduz Zaman

“…<h4>Principal findings</h4>90 articles met the CASP criteria partially or fully and then underwent a qualitative synthesis to be included in the review. 75 articles specifically focus on NTD interventions and approaches to their control, treatment, and elimination, while 15 focus specifically on health promotion and provide a grounding in health promotion theories and perspectives. 29 of the articles provided a global perspective to control, treatment, or elimination of NTDs through policy briefs or literature reviews. 19 of the articles focused on providing strategies for NTDs more generally while 12 addressed multiple NTDs or their interaction with other infectious diseases. Of the 20 NTDs categorized by the WHO and the expanded NTD list identified by PLOS NTDs, several NTDs did not appear in the database search on NTD interventions and health promotion, including yaws, fascioliasis, and chromoblastomycosis.…”
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Effect of Moisture Stress on Physiological and Yield Responses of Common Bean Varieties at Lath House Condition, Hawassa University, Southern Ethiopia by Mitike Mulatu Alemu, Andargachew Gedebo, Amsalu Gobena Roro, Tatek Tamiru Geletu

“…There was a significant main and interaction effects among the measured parameters. From those significantly affected parameters, the highest stomata numbers (25) were recorded from the Dursitu variety with a daily irrigation interval. …”
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