Inhibition of p70 Ribosomal S6K1 Protects the Myocardium against Ischemia/Reperfusion-Induced Necrosis through Downregulation of RIP3 by Hui Shang, Jinjin Shi, Jun Zhu, Yunfeng Guo, Xiaoyan Wang

“…The relationship between S6K1 and receptor-interacting protein kinase 3 (RIP3) was analyzed by immunoprecipitation. …”
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Unfolding insights about resilience and its coping strategies by medical academics and healthcare professionals at their workplaces: a thematic qualitative analysis by Salman Yousuf Guraya, Jacqueline Maria Dias, Mohamed Ahmed Eladl, Ayah Mohammad Rajai Rustom, Fatima Audi Saleem Alalawi, Majid Hassan Saleh Alhammadi, Yusra Ahmed Mohammed Ahmed, Amna Ali Omran Taryam Al Shamsi, Sarah Juman Bilalaga, Alfred Nicholson, Hani Malik, Shaista Salman Guraya

“…These factors highlighted a complex interaction between cognitive mastery, emotional well-being, and conative efficiency. …”
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Factors influencing gender and youth integration in agricultural research and innovation in Africa by Mastewal Yami, Oyewale Abioye, Sougrynoma Zainatou Sore, Aline Mugisho, Tahirou Abdoulaye

“…The desk review was supplemented by 30 interviews with key informants in FNSSA projects across Africa including Benin, Democratic Republic of the Congo, Cameroon, Ghana, Madagascar, Nigeria, Kenya, Senegal, Sudan, Togo, and Uganda, and an interactive workshop with key stakeholders working on gender and youth integration issues across Africa. …”
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PET imaging of 52Mn labeled DOTATATE and DOTAJR11 by James M. Omweri, Hailey A. Houson, Shannon E. Lynch, Volkan Tekin, Anna G. Sorace, Suzanne E. Lapi

“…As an agonist, [68Ga]Ga-DOTATATE has demonstrated significant internalization upon interaction with receptor ligands, whereas [68Ga]Ga-DOTA-JR11(as an antagonist) exhibits limited internalization but better pharmacokinetics and increased tumor uptake. …”
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Effects of exercise intensity and diet on cardiac tissue structure and FGF21/β-Klotho signaling in type 2 diabetic mice: a comparative study of HFD and HFD + STZ induced type 2 dia... by Sevda Moharamzadeh, Majid Kashef, Mojtaba Salehpour, Meysam Torabi, Samira Vesali, Zakieh Samsonchi, Ensiyeh Hajizadeh-Saffar

“…Results Statistical analyses showed that the main effect of diabetes inducing model (DIM) was significant for all variables (p < 0.05), except vascular density (p = 0.055); the main effect of ET type on fasting blood glucose and FGF21 was significant (p < 0.001); and the interaction was significant for fasting blood glucose, heart weight and FGF21 (p < 0.001). …”
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Toxicity assessment of DMSO extracts of environmental aged beached plastics using human cell lines by Florane Le Bihanic, Bettie Cormier, Emilie Dassié, Sophie Lecomte, Justine Receveur, Stéphane Le Floch, Jérôme Cachot, Bénédicte Morin

“…Since most of these substances are only loosely bound to the polymer via non-covalently interactions, i.e., van der Waals forces, they may leach to the surrounding environment. …”
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Evaluating the Effectiveness of InsightApp for Anxiety, Valued Action, and Psychological Resilience: Longitudinal Randomized Controlled Trial by Victoria Amo, Falk Lieder

“…During the 1-week intervention phase, the treatment group engaged with InsightApp, while participants in the control group interacted with a placebo version of the app that delivered executive function training. …”
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In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders by Stephen Tunmise Akanbi, Joshua Ayodele Yusuf, Thompson Oluwaferanmi Ayandele, Dayo Samson Oladipupo, Darasimi Racheal Olorunlowu, Blessing Dorcas Olawuyi, Joshua Oluwafisayo Adepoju, Dolapo Emmanuel Opasina, Elizabeth Kehinde Opoola, Uchenna Victor Ugwuanyi, Olufunto Omodele Adeleye

“…Differential gene expression analysis was carried out using with Limma, filtering for genes with |logFC|> 1 (fold change) and p < 0.05 (p-value). Protein–Protein Interaction networks were constructed using stringDB (combined score > 0.7) and analyzed in Cytoscape to identify hub genes based on various topological measures (EPC, MCC, MNC, Degree, and EcCentricity). …”
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The impact of side and top arm techniques during the backstroke breakout phase on 15-meter swimming performance by Zhenyu Jin, Yuhang Zhou, Dapeng Wang, Yuhong Wen

“…Additionally, significant differences were found between the two genders (F = 11.189, p = 0.002, η2 = 0.286) and breakout techniques (F = 8.014, p = 0.008, η2 = 0.223), with no interaction effect (F = 0.037, p = 0.849, η2 = 0.001). …”
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Pharmacognostic analysis and antimalarial evaluation of quercetin in Ilex umbellulata bark using HPTLC, in vitro screening, molecular docking, and network pharmacology by James H. Zothantluanga, Dipak Chetia, Yasangam Umbon, T. C. Lalhriatpuii, Dhritiman Roy, Nidahun Lamare, Salem Lalvenhimi

“…Multi-target molecular docking with a validated docking protocol revealed that quercetin could potentially interact with 20 proteins of P. falciparum that are highly expressed during the schizont and trophozoite stages. …”
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Study protocol of a randomised controlled trial on SISU, a software agent providing a brief self-help intervention for adults with low psychological well-being by Harald Baumeister, Ann-Marie Küchler, David Ebert, Natalie Bauereiss, Eileen Bendig, Benjamin Erb, Lena Weger, Echo Meißner

“…Assessment takes place before (t1), during (t2) and after (t3) the interaction with SISU, as well as 4 weeks after randomisation (t4). …”
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Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain by Binglin Chen, Jiabao Guo, Chan Gong, Chenchen Zhu, Yang Wu, Shengbo Wang, Yili Zheng, Haixia Lu

“…Gene Ontology (GO) annotations, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and protein–protein interaction networks were employed to explore the biological importance of DEPs. …”
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Bergapten alleviates senescence of chondrocytes in osteoarthritis by YE Yuanlan, LIU Kaiwen, PAN Yiming

“…The obtained targets were intersected with Venny2.1.0, protein-protein interaction (PPI) analysis was performed using the STRING database, and molecular docking was conducted by AutoDock Vina. …”
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Rumen DNA virome and its relationship with feed efficiency in dairy cows by Xiaohan Liu, Yifan Tang, Hongyi Chen, Jian-Xin Liu, Hui-Zeng Sun

“…Abstract Background The rumen harbors a diverse virome that interacts with other microorganisms, playing pivotal roles in modulating metabolic processes within the rumen environment. …”
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Mindfulness Intervention for Health Information Avoidance in Older Adults: Mixed Methods Study by Chenyu Gu, Liquan Qian, Xiaojie Zhuo

“…Nevertheless, the results revealed a significant interaction effect between mindfulness and cyberchondria on health information avoidance (effect=‒0.357, P=.002, 95% CI ‒0.580 to ‒0.131), suggesting that mindfulness intervention effectively inhibited the transformation of cyberchondria into health information avoidance behavior. …”
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Exploring the Use of Smartwatches and Activity Trackers for Health-Related Purposes for Children Aged 5 to 11 years: Systematic Review by Lauren Thompson, Sydney Charitos, Jon Bird, Paul Marshall, Amberly Brigden

“…These devices often provide limited data feedback and functionality to support children’s independent engagement with the data, relying on paired smartphone apps managed by caregivers, who control access and facilitate children’s interaction with the data. Future research should adopt child-centered methods in the design and evaluation of these technologies, integrating children’s perspectives alongside their caregivers, to ensure that they are not only feasible and acceptable but also meaningful and effective for young children. …”
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It is time to tackle psychological determinants of obesity and eating disorders by Pietro Crescenzo

“…Nutrition is a complex problem, where obesity, undernutrition and climate change interact to challenge the global food system, as about 3 billion people are undernourished or overnourished and food production is exceeding planetary boundaries. …”
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The revival of spiritual practices: factors influencing the “seeking deities and offering prayers” behavior of China’s Generation Z on social media in an atheistic context by Jing Wang, Balamuralithara Balakrishnan, Xiaohui Wan, Qirui Yu, Qiqi Ye

“…In contemporary China, young people face immense pressures stemming from workplace competition, social interactions, and economic burdens. Social media offers these young individuals broader opportunities for connection, community formation, and identity construction, as well as various possibilities for organizing their social lives. …”
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GENETIC VARIABILITY AND DROUGHT PARAMETERS AMONG SOME GRAIN SORGHUM GENOTYPES USING QUANTITATIVE TRAITS AND RAPD MARKERS by Bahaa A. Zarea, M.E.M. El-Sagheer, H.M. Hafez, A.Y.M. Ahmed

“…The results indicated highly significant differences among the genotypes, irrigation treatments and their interaction for all traits, suggesting that these genotypes were highly variable, therefore, would respond to selection. , the genotypes G3, G7, G8, G13 and G16 gave the best performance for grain yield/plant under both environments and their combined data. …”
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Soil organic carbon and related properties under conservation agriculture and contrasting conventional fields in Northern Malawi by Muneta G. Manzeke-Kangara, Ivy S. Ligowe, Austin Tibu, Timothy N. Gondwe, Henry M. R. Greathead, Marcelo V. Galdos, Marcelo V. Galdos

“…Tillage type and soil depth had significant interaction effects on SOC. For example, larger contents of SOC were measured at depths of 0-10 cm compared to 10-30 cm under CA plots. …”
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