Dihydrotanshinone I enhanced BRAF mutant melanoma treatment efficacy by inhibiting the STAT3/SOX2 signaling pathway by Xing Luo, Yi Duan, Jinwei He, CongGai Huang, Jun Liu, Yifan Liu, Mengdei Xu, Qiong Dai, Zhihui Yang

“…The diameter and weight of tumours in each group were then measured, and IHC and HE staining were used to assess the expression of two pathways and cytotoxicity, respectively.ResultsThis study found that DHT directly interacts with STAT3 protein and it can stop the feedback activation of the STAT3/SOX2 pathway caused by the use of MAPK pathway inhibitors. …”
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Assessing and predicting the value of ecosystem services in Sanya City, Hainan Island, China by Peihong Song, Qiu Yang, Wenyin Wu, Tianyan Su, Yamin Jiang, Jingli Lu, Zhongyi Sun, Jie Zhang, Rui Yu, Peng Wang, Lan Wu, Huai Yang, Wenjie Liu

“…Factors influencing ESV and their interactions were analysed using convergent cross mapping (CCM) and global sensitivity and uncertainty analysis (GSUA). …”
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Oxaliplatin-Loaded Chitosan Nanoparticles Decorated with Cetuximab Single-Chain Variable Fragment for Human Colorectal Cancer Treatment by Khadijeh Falahzadeh, Fariba Esmaeili, Leila Nematollahi, Elham Bayat, Mehdi Khoobi, Mohammadali Mazloomi, Masumeh Jalalvand, Reza Faridi Majidi, Babak Negahdari

“…The western blotmethod and cell-based ELISA revealed successful purification of scFv and its attachment to EGFR on HCT 116 cells.The FTIR analysis determined the interactions between the scFv and OXPT-CS NPs. According to MTT and flowcytometry results, the targeted delivery system significantly reduced HCT 116 cancer cell viability and increasedapoptosis induction up to 99.8%.Conclusion: The scFv-OXPT-CS NPs demonstrated an increased cytotoxic function due to the presence of scFv in itsformulation. …”
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Six-Gene Signature Associated with Immune Cells in the Progression of Atherosclerosis Discovered by Comprehensive Bioinformatics Analyses by Bin Zhao, Dan Wang, Yanling Liu, Xiaohong Zhang, Zheng Wan, Jinling Wang, Ting Su, Linshan Duan, Yan Wang, Yuehua Zhang, Yilin Zhao

“…Methods. 29 samples of atherosclerosis-related gene expression profiling, including 16 human advanced atherosclerosis plaque (AA) and 13 human early atherosclerosis plaque (EA) samples from the Gene Expression Omnibus (GEO) database, were analyzed to get differentially expressed genes (DEGs) and the construction of protein and protein interaction (PPI) networks. Besides, we detected the relative fraction of 22 immune cell types in atherosclerosis by using the deconvolution algorithm of “cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT).” …”
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Ultrasonic Assisted Environmentally Friendly Extraction of Natural Dyes From Beta vulgaris for the Coloration of Silk Fabric Using Different Mordants by Rony Mia, Tafsir Uddin, A. Z. M. Mofasser, Nadim Ibn Sayed, Al Mojnun Shamim, Sanjida Islam, Khandaker Akil Mahadi Ohi, Moonis Ali Khan, Burhan Uddin Banna

“…For the characterization of the extracted dye, undyed, dyed, and mordanted silk fabric, infrared spectroscopy was performed. To observe the interaction of extracted dye and silk fabric, scanning electron microscopy was also accomplished. …”
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Rehydrated corn grain silage with wet brewery residue and different inoculants by E. L. L. Lelis, V. B. Tavares, R. M. A. Teixeira, B. G. C. Homem, C. H. Nogueira, J. M. Silva

“…There was a significant interaction between the inoculant LB and the silages, with 47% (DM45) and 56% (DM55) DM for the Crude Protein (CP) levels. …”
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Hydrothermal synthesis of a nickel-oxide-infused orange peel nanobiocomposite for enhanced heavy metal removal from mining wastewater by Jacques Romain Njimou, Velma Fai, Mary Tamwa Sieugaing, Djimongbaye Nguenamadje, John Godwin, Oben Bessem Genola, Guy Bertrand Noumi, Bankim Chandra Tripathy

“…The adsorption mechanism involves a two-step process where positively charged Cd2⁺ and Pb2⁺ ions diffuse toward the negatively charged surface of the Alg-OP-Ni nanobiocomposite and subsequently fix through interactions with surface oxygen atoms. Maximum adsorption capacities for Cd2⁺ and Pb2⁺ were determined to be 138.25 and 276.00 mg/g in single-component systems, and 224.00 and 317.10 mg/g in binary systems, respectively. …”
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Evaluating ChatGPT’s diagnostic potential for pathology images by Liya Ding, Lei Fan, Lei Fan, Miao Shen, Miao Shen, Yawen Wang, Kaiqin Sheng, Zijuan Zou, Huimin An, Zhinong Jiang

“…BackgroundChat Generative Pretrained Transformer (ChatGPT) is a type of large language model (LLM) developed by OpenAI, known for its extensive knowledge base and interactive capabilities. These attributes make it a valuable tool in the medical field, particularly for tasks such as answering medical questions, drafting clinical notes, and optimizing the generation of radiology reports. …”
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The current state of knowledge on the role of NKG2D ligands in multiple sclerosis and other autoimmune diseases by Aleksandra Pogoda-Wesołowska, Nina Sługocka, Agnieszka Synowiec, Klaudia Brodaczewska, Marcin Mejer-Zahorowski, Maciej Ziękiewicz, Wojciech Szypowski, Piotr Szymański, Adam Stępień

“…In this review, we aim to describe the role of NKG2D and NKG2DLs, and their interactions in the pathogenesis of MS, as well as in other autoimmune diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), and celiac disease (CeD). …”
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First genome-scale insights into the virulence of the snow mold causal fungus Microdochium nivale by Ivan Tsers, Ekaterina Marenina, Azat Meshcherov, Olga Petrova, Olga Gogoleva, Alexander Tkachenko, Natalia Gogoleva, Yuri Gogolev, Evgenii Potapenko, Olga Muraeva, Mira Ponomareva, Viktor Korzun, Vladimir Gorshkov

“….), the performed analysis pointed to a crucial role of host plant lipid destruction and fungal lipid metabolism modulation in plant-M. nivale interactions.…”
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Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGF... by Zheng Wu, Qing Ye, Shan Zhang, Li‐Peng Hu, Xiao‐Qi Wang, Lin‐Li Yao, Lei Zhu, Shu‐Yu Xiao, Zong‐Hao Duan, Xue‐Li Zhang, Shu‐Heng Jiang, Zhi‐Gang Zhang, De‐Jun Liu, Dong‐Xue Li, Xiao‐Mei Yang

“…PRRG1 localized at the plasma membrane, interacted with the HECT E3 ligase NEDD4 via the C‐terminal PPXY motif, and promoted NEDD4 self‐ubiquitination, reducing its protein levels. …”
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Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients by Sandra Crnko, Markella I. Printezi, Tijn P.J. Jansen, Laurynas Leiteris, Manon G. van derMeer, Hilde Schutte, Martijn vanFaassen, Bastiaan C. duPré, Nicolaas deJonge, Folkert W. Asselbergs, Carlo A.J.M. Gaillard, Hans Kemperman, Pieter A. Doevendans, Joost P.G. Sluijter, Linda W. vanLaake

“…The emerging understanding of circadian biology in cardiovascular disease may lead to novel applications in prognosis and diagnosis and may provide insight into mechanistic aspects of the disease–biomarker interaction. So far, it is unknown whether sST2 exhibits a diurnal rhythm. …”
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Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic review by Ramya Sekar, Selvaraj Jayaraman, Saranya Varadarajan, Thodur Madapusi Balaji, Vishnupriya Veeraraghavan, Prabhu Shankar Dayasankar, Dharshini Devi J

“…H19, reactivated in cancers, interacts with microRNAs and signaling pathways such as p53 and PI3K/AKT to affect tumor growth, invasion, and metastasis. …”
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Effects of stair riser height on ankle proprioception in individuals with and without chronic ankle stability by Xueying Wang, Xueying Wang, Zheng Wang, Roger Adams, Roger Adams, Yang Gao, Jie Lyu, Jia Han, Jia Han

“…Significant differences in proprioceptive acuity were found between 15 cm and higher risers (p < 0.001), but not between 17.5 cm and 20 cm (p = 0.675), alongside a significant linear downward trend with increasing riser height (F = 15.476, p < 0.001). No significant interaction was observed between the group and riser height (F = 0.745, p = 0.478).ConclusionThe presence of ankle instability and increased riser height significantly negatively affected ankle inversion proprioceptive performance during stair descent, which may increase the risk of ankle sprain.ApplicationPotential applications of this research include the assessment of ankle proprioception during stair descent attributable to effective ankle instability rehabilitation and riser height selection for safe stair design.…”
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Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors by Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu

“…Molecular hybridization, with the advantage of simplified pharmacokinetics and drug-drug interactions, emerged as one of the important avenues for discovering potential drugs. …”
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The potential use of brewers' spent grain-based substrates as horticultural bio-fertilizers by Angela Bianco, Angela Bianco, Sara Melito, Matteo Garau, Vittoria Giannini, Giacomo Zara, Giacomo Zara, Davide Assandri, Safa Oufensou, Safa Oufensou, Roberta Coronas, Niccolò Pampuro, Marilena Budroni, Marilena Budroni

“…Moreover, the CPE 4% treatment demonstrated superior performance, resulting in statistically significant differences (p < 0.05) in the chlorophyll content (α and β) and carotenoid parameters when compared to the control treatment C2. The interaction between the treatment and the pathogen was statistically significant only for the carotenoid content in the CPE 4% treatment and for the flavonoid content in most of the treatments.DiscussionThe most promising results were obtained at the nursery phase, highlighting the potential use of processed BSG-based substrates as bio-fertilizers. …”
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Transition to home after very preterm birth: improving outcomes of children and their families—a systematic review protocol by Beatrice Latal, Ulrike Held, Ursula Kiechl-Kohlendorfer, Sandra Siegfried, Vivienne Engel, Valentina Mauron-Papadimitriou, Lea Bührer, Laura Ebner, Lena Keller, Martina Gosteli

“…According to the WHO, preparation for this transition yields positive effects on crucial aspects such as nutrition, parent–child interaction and parental well-being. However, there is significant heterogeneity as to which interventions are in place and regarding their level of efficacy. …”
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CitySEIRCast: an agent-based city digital twin for pandemic analysis and simulation by Shakir Bilal, Wajdi Zaatour, Yilian Alonso Otano, Arindam Saha, Ken Newcomb, Soo Kim, Jun Kim, Raveena Ginjala, Derek Groen, Edwin Michael

“…Here, we describe how we have coupled advances in the construction of digital or virtual models of real-world cities with an agile, modular, agent-based model of viral transmission and data from navigation and social media interactions, to overcome these challenges in order to provide a new simulation tool, CitySEIRCast, that can model viral spread at the sub-national level. …”
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Surface functionalization of titanium implants with controlled-release glutathione conjugate for antioxidant and osteogenesis by Huichuan Xu, Kosuke Nozaki, Ziniu Yu, Nobuyuki Kawashima, Takeshi Ueno, Huaze Wu, Hao Wu, Noriyuki Wakabayashi

“…Oxidative stress induced by the overproduction of reactive oxygen species (ROS) during the interaction between titanium (Ti) surfaces and cells commonly results in delayed or compromised osteogenic differentiation. …”
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Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing by Yafeng Jiang, Zhaolan Hu, Roujie Huang, Kaying Ho, Pengfei Wang, Jin Kang, Jin Kang

“…CellChat analysis identified CD45 and CCL5 as key pathways facilitating macrophage-monocyte interactions in ACPA− RA, prominently involving iron-mediated metabolite communication. …”
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