Instructional design of smart technology use in teacher digital educational environment by G. B. Sarzhanova, R. S. Bobesh, G. Zh. Smagulova, A. Turkel, N. B. Serikbayeva

“…The modern teacher is supposed both to adapt to and perform the professional activity within the digital setting of the educational institution and be able to design his/her own digital educational environment to transfer the educational content and organise effective “educator-learner” educational interaction. This situation brings us to the issue of the necessity for the teacher to be aware and master the potential possibilities provided by the smart technologies in realisation of the educational activity in terms of online and mixed learning; this, in its turn, conditions the search for the solutions for the effective instructional design of smart technology application in a teacher digital educational environment.Aim. …”
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Missed opportunity for nasal continuous positive airway pressure in preterm neonates admitted at a tertiary-level hospital newborn unit in Kenya: a mixed method study by Florence Murila, Peace Kakibibi, Diana Marangu-Boore

“…However, NCPAP is not easily accessible to every preterm neonate in low- and middle-income countries, and this is the case in Kenya.Objectives To determine the proportion of preterm neonates admitted to the newborn unit (NBU) at Kenyatta National Hospital (KNH), a tertiary referral hospital in Kenya, with a missed opportunity for NCPAP and to determine the barriers and facilitators of NCPAP utilisation.Design and setting We conducted a hospital-based cross-sectional study that employed interactive explanatory concurrent mixed methods. The quantitative approach determined the proportion of missed opportunities for NCPAP in preterm neonates admitted to the KNH newborn unit, while the qualitative approach explored the barriers and facilitators of NCPAP utilisation.Participants Preterm neonates of gestation less than 37 weeks in the first 48 hours of life who met the criteria for NCPAP. …”
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Immunometabolic alterations in type 2 diabetes mellitus revealed by single-cell RNA sequencing: insights into subtypes and therapeutic targets by Huahua Li, Lingling Zou, Zhaowei Long, Junkun Zhan, Junkun Zhan

“…Machine learning models were constructed to classify T2DM subtypes based on metabolic signatures, and T-cell-monocyte interactions were explored to assess immune crosstalk. …”
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Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy by Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding

“…Weighted Gene Co-expression Network Analysis (WGCNA) was employed to screen the DN-related genes, then the differential CSRGs (DCSRGs) were identified, followed by protein–protein interaction (PPI) network construction. In addition, key biomarkers were acquired by two machine learning algorithms, then immune infiltration analysis, Gene Set Enrichment Analysis (GSEA), and potential drugs screening were conducted. …”
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Formation and fate of freshwater on an ice floe in the Central Arctic by M. M. Smith, N. Fuchs, E. Salganik, D. K. Perovich, I. Raphael, M. A. Granskog, K. Schulz, M. D. Shupe, M. D. Shupe, M. Webster

“…The fate of this freshwater, whether in surface melt ponds or thin layers underneath the ice and in leads, impacts atmosphere–ice–ocean interactions and their subsequent coupled evolution. …”
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Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway by Chen Feng, Wei Mao, Chenyang Yuan, Pin Dong, Yuying Liu

“…Immunofluorescence staining is used to analyze CHRNA5 expression and localization, and clonogenic assays are performed to measure colony proliferation after CHRNA5 knockdown and overexpression. The interaction between CHRNA5 and CES1 is examined using molecular docking, co-immunoprecipitation, and immunofluorescence. …”
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Compound identification of Shuangxinfang and its potential mechanisms in the treatment of myocardial infarction with depression: insights from LC-MS/MS and bioinformatic prediction by Yize Sun, Yize Sun, Haibin Zhao, Zheyi Wang

“…All the targets were intersected to construct the Protein-Protein Interaction (PPI) network on Metascape platform and the herb-compound-target (HCT) network on Cytoscape, to identify the hub targets. …”
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Analysis of the structure and function of the tomato <i>Solanum lycopersicum</i> L. MADS-box gene <i>SlMADS5</i> by A. V. Nezhdanova, M. A. Slugina, E. A. Dyachenko, A. M. Kamionskaya, E. Z. Kochieva, A. V. Shchennikova

“…Two-hybrid analysis showed the ability of SlMADS5 to activate transcription of the target gene and interact with TAGL1. Transgenic plants Nicotiana tabacum L. with constitutive overexpression of SlMADS5 cDNA flowered 2.2 times later than the control; plants formed thickened leaves, 2.5–3.0 times thicker stems, 1.5–2.7 times shortened internodes, and 1.9 times fewer flowers and capsules than non-transgenic plants. …”
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Impact of rock mineralogy on reactive transport of CO2 during carbon sequestration in a saline aquifer by Mohamed Gamal Rezk, Ahmed Farid Ibrahim

“…Various parameters, including CO2 plume migration, changes in pH, water density variations, mineral dissolution and precipitation, and porosity changes in the reservoir rock, are examined to understand the complex CO2–brine–rock interactions. The effect of formation mineralogy on CO2 trapping mechanisms was investigated. …”
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Determinants of Indonesian Government Bond Yield by Hestiani Wulandari, Noer Azam Achsani, Moch. Hadi Santoso

“…Originality/value (State of the art): This study contributes significantly to the understanding of the dynamic and complex interactions between domestic and global economic factors that affect Indonesian government bond yields. …”
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Changes in and Potential Mechanisms of Circulating IgA+CD27-Class-Switched Memory B Cells in Patients With Allergic Rhinitis by Zheng H, Xu S, Yang R, Jiao WE, Qiao YL, Liu JY, Fan HM, Zhou YT, Ni HF, Chen J, Deng YQ, Chen SM

“…Its mechanism may be associated with interactions between T and B cells.Keywords: memory B cell, IgA memory B cell, allergic rhinitis…”
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ATF3 Knockdown Exacerbates Astrocyte Activation by Inhibiting Phosphorylation of Drp1 in Ischemic Stroke by Huang R, Huang X, Yang H, Wu H, Liu F, Saw PE, Cao M

“…In vitro, ATF3 depletion worsened mitochondrial dysfunction and astrocyte activation. ATF3 interacted with Drp1 via Akt2, inhibiting mitochondrial fission and protecting astrocytes.Conclusion: ATF3 regulates mitochondrial fission and protects astrocytes in ischemic stroke, highlighting its potential as a therapeutic target for stroke recovery.Keywords: activating transcription factor 3, ATF3, acute ischemic stroke, AIS, astrocytes, mitochondrial dysfunction, dynamics-related protein 1, Drp1, threonine/serine kinase 2, Akt2…”
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Enhancing Clinical Confidence: Effects of Medical Screening and Differential Diagnosis Training for Low Back Pain by Shavit R, Kushnir T, Nudelman Y, Springer S

“…At six-month, significant interaction effects were observed for PCCS (F = 17.49, Partial η² = 0.131, p < 0.001) and PSE scores (F = 5.87, Partial η² = 0.06, p < 0.05) and PSE scores (55.32 ± 6.09, p < 0.05), with the intervention group maintaining improvements while the control group showed no significant changes. …”
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Utilisation des systèmes de test ALDM dans le cadre de l'étude des réseaux sociaux du babouin de Guinée by Julie Gullstrand, Joël Fagot, Nicolas Claldière

“…Dans un premier temps, nous avons extrait les interactions sociales d'un jeu de données d'observations comportementales (un scan toutes les 2 minutes pour chacun des 12 individus observés de 9 h à 16 h durant deux semaines). …”
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The impact of arbuscular mycorrhizal colonization on flooding response of Medicago truncatula by Vajiheh Safavi-Rizi, Vajiheh Safavi-Rizi, Helen Friedlein, Sayedhamid Safavi-Rizi, Franziska Krajinski-Barth

“…Arbuscular mycorrhizal (AM) symbiosis plays a key role in enhancing plant growth and stress tolerance, yet its interactions with environmental stressors such as flooding remain poorly understood. …”
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A novel consensus bacterial 6-phytase variant supplemented to an all-vegetable broiler diet totally replaced added trace minerals including zinc, iron, copper and manganese in two... by Yueming Dersjant-Li, Cees Kwakernaak, Abiodun Bello, Leon Marchal

“…In both experiments during all phases there were interactions (P < 0.05) between phytase and TM on BW, BW gain (BWG), feed intake (FI), FCR (experiment 2 only) and tibia Zn. …”
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Public Health Messaging on Twitter During the COVID-19 Pandemic: Observational Study by Ashwin Rao, Nazanin Sabri, Siyi Guo, Louiqa Raschid, Kristina Lerman

“…We also analyzed their interactions with political elites and the public’s engagement with PHEs to gain a deeper understanding of their influence on public discourse. …”
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Low Systemic Inflammation Response Index Predicts Good Prognosis in Locally Advanced Pancreatic Carcinoma Patients Treated with Concurrent Chemoradiotherapy by Erkan Topkan, Huseyin Mertsoylu, Ahmet Kucuk, Ali Ayberk Besen, Ahmet Sezer, Duygu Sezen, Yasemin Bolukbasi, Ugur Selek, Berrin Pehlivan

“…The primary endpoint was the interaction between the SIRI and OS results. Results. …”
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LncRNA GAS5 inhibits glioma progression through miR-135b-5p/APC axis by ZHANG Jidong, WANG Yutao, JI Jianwen

“…Objective‍　‍To explore the interaction between long non-coding RNA growth arrest-specific 5 (GAS5) and miR-135b-5p/adenomatous polyposis coli (APC) axis, and to elucidate its biological function in the proliferation, metastasis and invasion of glioma. …”
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The Relationship between Russian Identity and Political Polarization: The Role of Secure National Identification and National Narcissism by O.A. Gulevich, S.S. Kosimova

“…Participants appraised the extent to which fellow citizens with these views exhibit certain traits; expressed emotions towards them; evaluated their willingness to interact and collaborate on common issues and considered the acceptability of restricting their rights and opportunities. …”
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