Inferring the energy cost of resistance to parasitic infection and its link to a trade-off by Frédéric Douhard, Carole Moreno-Romieux, Andrea B. Doeschl-Wilson

“…Abstract Background In infected hosts, immune responses trigger a systemic energy reallocation away from energy storage and growth, to fuel a costly defense program. …”
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Genomic characterization and evolutionary analysis of a Getah virus variant from piglets in central China by Zhenhua Guo, Yao Jiang, Peng Li, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang

“…Most of these special sites were distributed in domain A, B, and C of E2 protein, which are usually associated with the GETV infection and immune response.DiscussionOur study expands knowledge of GETV pathogenicity and deepens understanding of GETV genetic and adaptive evolution, which would be valuable for the development of diagnosis and prevention for GETV.…”
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The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer by Si Chen, Caihong Yao, Na Tian, Chunying Zhang, Yuemei Chen, Xuting Wang, Yue Jiang, Tonghao Zhang, Tingting Zeng, Yali Song

“…The influence of these infections on immune checkpoints emphasizes the crucial role of the immune system in cancer treatment. …”
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Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway by Chunxue Li, Rongrong Zhang, Yating Zhan, Jianjian Zheng

“…Liver fibrosis, which results from chronic liver injury due to factors such as chronic alcohol consumption, hepatitis virus infections, and immune attacks, is marked by excessive deposition of extracellular matrix (ECM). …”
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Monitoring for respiratory viruses among wild canids, Texas by Lyudmyla V. Marushchak, Laura A. Pulscher, Judith U. Oguzie, Diego B. Silva, Kenneth A. Waldrup, Douglas M. Watts, Gregory C. Gray

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Autoimmune hepatitis under the COVID-19 veil: an analysis of the nature of potential associations by Chaojie Yu, Wenrui Wang, Qian Zhang, Zhenjing Jin

“…Currently, the overall mutational trend of SARS-CoV-2 indicates heightened infectivity and immune evasion capabilities. Consequently, vaccination remains crucial for universal protection against this disease. …”
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Downmodulation of Vaccine-Induced Immunity and Protection against the Intracellular Bacterium Francisella tularensis by the Inhibitory Receptor FcγRIIB by Brian J. Franz, Ying Li, Constantine Bitsaktsis, Bibiana V. Iglesias, Giang Pham, Raju Sunagar, Sudeep Kumar, Edmund J. Gosselin

“…Thus, the generation of Ag-specific IgG in response to infection or immunization has the potential to downmodulate immune protection against infection. …”
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Antibody and serum bactericidal response to Burkholderia pseudomallei in acute localized and septicemic melioidosis cases with diabetes mellitus by Sraboni Mazumder, Md. Shariful Alam Jilani, Lovely Barai, KM Shahidul Islam

“…Conclusion: The results indicate that high anti- B. pseudomallei IgM/IgG and serum bactericidal antibodies are induced in diabetic patients with septicemia and suppurative infections. This immune response in diabetics might be important to contain the infection and help in recovery. …”
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Genomic and epidemiological analysis of SARS-CoV-2 variants isolated in Guinea: a routine sequencing implementation by Aminata Mbaye, Haby Diallo, Thibaut Armel Cherif Gnimadi, Kadio Jean Jacques Olivier Kadio, Abdoul Karim Soumah, Joel Balle Koivogui, Jean Louis Monemou, Moriba Kowa Povogui, Djiba Kaba, Castro Hounmenou, Laetitia Serrano, Christelle Butel, Nicolas Fernandez Nuñez, Nicole Vidal, Emilande Guichet, Eric Delaporte, Ahidjo Ayouba, Martine Peeters, Abdoulaye Toure, Alpha Kabinet Keita, AFROSCREEN Team

“…Abstract Background Several variants of SARS-CoV-2 have a demonstrated impact on public health, including high and increased transmissibility, severity of infection, and immune escape. Therefore, this study aimed to determine the SARS-CoV-2 lineages and better characterize the dynamics of the pandemic during the different waves in Guinea. …”
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Research Progress on Animal Models of Sepsis-Related Organ Injury by YANG Jiahao, DING Chunlei, QIAN Fenghua, SUN Qi, JIANG Xusheng, CHEN Wen, SHEN Mengwen

“…Sepsis is a multi-organ dysfunction syndrome caused by infection and immune dysfunction, with a high mortality rate. …”
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Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease by Hiam Naiditch, Michael R. Betts, H. Benjamin Larman, Moshe Levi, Avi Z. Rosenberg

“…Lymphopenia, more apparent among natural killer (NK) cells, CD8+ T-cells, and B-cells, can contribute to disease severity and may reflect direct cytopathic effects of SARS-CoV-2 or end-organ sequestration. Direct infection and immune activation of endothelial cells by SARS-CoV-2 may be a critical mechanism through which end-organ systems are impacted. …”
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Early COVID-19 and protection from Omicron in a highly vaccinated population in Ontario, Canada: a matched prospective cohort study by Altynay Shigayeva, Christopher Kandel, Lubna Farooqi, Zoe Zhong, Anne-Claude Gingras, Brenda L. Coleman, Lois Gilbert, Wayne L. Gold, Maria Major, Tony Mazzulli, Samira Mubareka, Jelena Vojicic, Jingyan Yang, Pingping Zhang, Catherine Martin, Moe H. Kyaw, John M. McLaughlin, Allison McGeer

“…Abstract Objectives Predictions regarding the on-going burden of SARS-CoV-2, and vaccine recommendations, require an understanding of infection-associated immune protection. We assessed whether early COVID-19 provided protection against Omicron infection. …”
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Bifurcation analysis of multistability and hysteresis in a model of HIV infection by I. V. Mironov, M. Yu. Khristichenk, Yu. M. Nechepurenko, D. S. Grebennikov, G. A. Bocharov

“…HIV-1 control efforts with reliance on immunotherapy remain at a conceptual stage due to the complexity of a set of processes that regulate the dynamics of infection and immune response. For this reason, it is extremely important to use methods of mathematical modeling of HIV-1 infection dynamics for theoretical analysis of possibilities of reducing the viral load by affecting the immune system without the usage of antiviral therapy. …”
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