RNA m6A-mediated post-transcriptional repression of glucocorticoid receptor in LPS-activated Kupffer cells on broilers by Yulan Zhao, Yidan Jiang, Yue Feng, Ruqian Zhao

“…The same GR and m6A responses were reproduced in LPS-activated KC cell line, implying a possible role of m6A in the post-transcriptional suppression of GR in KC. Indeed, m6A inhibitor cycloleucine alleviated LPS-induced GR protein suppression, whilst GR antagonist RU486 had no effect on global m6A methylation in KC. …”
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ASMENS TAPATUMAS by Alphonso Lingis

“…Does not dignity come in degrees? Indeed is not being a person something that comes in degrees? …”
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Democracies in Action: A Foucaultian Perspective on British and French Tax Enforcement by Coralie RAFFENNE, Marika TOUMI

“…Far from being a universal, abstract and ideological model, Democracy has to be understood as a multi-layered and complex set of relations, practices, networks and knowledge. Indeed, Michel Foucault’s concept of “gouvernementalité” provides a useful tool to understand the depth, pervasiveness and mundane nature of the contemporary exercise of power. …”
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Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography by V. Vighetto, E. Pascucci, N.M. Percivalle, A. Troia, K.M. Meiburger, M.R.P. van den Broek, T. Segers, V. Cauda

“…Highly defined and sharp sonoluminescent images of cultured cells are indeed obtained, for the first time, when ZnO-Lip are used. …”
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Fingerprints of surface flows on solid substrates ablated by phase change: from laboratory experiments to planetary landscapes by Carpy, Sabrina, Berhanu, Michael, Chaigne, Martin, Courrech du Pont, Sylvain

“…The scale of these landscapes contrasts with the scale of the physical mechanisms that govern their evolutionary dynamics. Indeed, it is the typical size of atmospheric boundary layers or meltwater/vapor/solute films that constrain the heat/concentration transfer at the phase change/dissolution interface, and hence the rate of solid ablation. …”
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Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons by Calum Harvey, Alicja Nowak, Sai Zhang, Tobias Moll, Annika K Weimer, Aina Mogas Barcons, Cleide Dos Santos Souza, Laura Ferraiuolo, Kevin Kenna, Noah Zaitlen, Christa Caggiano, Pamela J Shaw, Michael P Snyder, Jonathan Mill, Eilis Hannon, Johnathan Cooper-Knock

“…The MN-specific hypomethylated genomic regions we have derived could be usefully combined with more sensitive detection methods and perhaps with study of CSF instead of plasma. Indeed we demonstrate that neuronal-derived DNA is detectable in CSF. …”
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Community-engaged research enhances the scientific quality and societal impact of a long-term avian monitoring program in northwest Ecuador by Jordan Karubian, Jordan Karubian, Jorge Olivo, Domingo Cabrera, Juan Freile, Luke Browne, Luke Browne, H. Luke Anderson, H. Luke Anderson, Jairo Cabo, Gregory Paladines, Gloria Loor, Liat Perlin Wilde

“…Long-term avian monitoring programs, and indeed the academic and research community as a whole, are still learning how best to implement these methodologies effectively. …”
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Decentralization and Primary Health Care Service delivery in Local Governments in Uganda: A Case Study of Kabale Municipality by Julius, Kisembo

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À propos des foyers protohistoriques à pierres chauffantes en Provence-Alpes-Côte d’Azur by Denis Dubesset

“…In this area, the cooking method could have been abandoned later. Indeed, only three sites are dated from the Second Iron Age and two of them are located in Provence-Alpes-Côte d’Azur. …”
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Révision de l’espèce Homo erectus (Dubois, 1893) by Valéry Zeitoun

“…The species is very close to the founder but is characterized by a few autapomorphies indeed corresponding to a plesion.There is also two main following clades. …”
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Wnt signaling as a translational target in rheumatoid and psoriatic arthritis by Gloria Riitano, Francesca Spinelli, Valeria Manganelli, Daniela Caissutti, Antonella Capozzi, Cristina Garufi, Tina Garofalo, Roberta Misasi, Maurizio Sorice, Fabrizio Conti, Agostina Longo, Cristiano Alessandri

“…Results This study highlights significant increase in DKK1, Wnt 5a, and β-catenin levels in RA and PsA patients compared to HD, with distinct patterns of correlation with disease activity indices. Indeed, in RA patients, DKK1 levels positively correlated with DAS28-CRP score, whereas in PsA patients, DKK1 levels negatively correlated with DAPSA score. …”
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Transgressive hybrids as hopeful holobionts by Benjamin Thomas Camper, Andrew Stephen Kanes, Zachary Tyler Laughlin, Riley Tate Manuel, Sharon Anne Bewick

“…In extreme cases, the effects of hybridization can transcend ecological timescales by introducing trait novelty upon which evolution can act. Indeed, hybridization can even have macroevolutionary consequences, for example, as a driver of adaptive radiations and evolutionary innovations. …”
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Mapping neutron biological effectiveness for DNA damage induction as a function of incident energy and depth in a human sized phantom by Alice Mentana, Virgilio Quaresima, Pavel Kundrát, Isabella Guardamagna, Leonardo Lonati, Ombretta Iaria, Andrea Previtali, Giorgia Santi Amantini, Luca Lunati, Virginia Boretti, Livio Narici, Luca Di Fino, Luca Bocchini, Claudio Cipriani, Giorgio Baiocco

“…Besides providing a better mechanistic understanding of neutron biological effectiveness, the new model can support better-informed decisions for radiation protection: indeed, current neutron weighting (ICRP)/quality (U.S. …”
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Gas-phase fractionation DDA promotes in-depth DIA phosphoproteome analysis by Zhiwei Tu, Yabin Li, Shuhui Ji, Shanshan Wang, Rui Zhou, Gertjan Kramer, Yu Cui, Fei Xie

“…This study demonstrates that GPF-DDA hybrid DIA analysis workflow can indeed promote depth of DIA analysis of phosphoproteome and could be extended to DIA analysis of other PTMs.…”
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Dynamique forestière et pression urbaine dans le Parc national du Banco (Abidjan, Côte d’Ivoire) by Nakouma Sako, Gérard Beltrando, Koffi Lazare Atta, Hyppolite Dibi N’da, Télesphore Brou

“…These data were used to map land cover in 1955 and 1998 and compare the evolution of the vegetation through a diachronic analysis.Indeed, in the year 1955, the land in the park and its periphery showed that the landscape was dominated by the forest despite the presence of a few urban space. …”
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Effect of 3D Metal on Electrochemical Properties of Sodium Intercalation Cathode P2-NaxMe1/3Mn2/3O2 (M = Co, Ni, or Fe) by Nam Pham Phuong Le, Nguyen Le Thanh Huynh, An Le Bao Phan, Dieu Thi Ngoc Nguyen, Trang Thi Thu Nguyen, Hoang Van Nguyen, Xujian Cui, Akhil Garg, Phung My Loan Le, Man Van Tran

“…The materials possessed their typical cyclic voltammogram and charge-discharge profiles; indeed, a high reversible redox reaction was obtained by NaxCo1/3Mn2/3O2 sample. …”
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Preharvest Factors Affecting Quality on “Abate Fetel” Pears: Study of Superficial Scald with Multivariate Statistical Approach by Alessandro Bonora, Enrico Muzzi, Cristiano Franceschini, Alexandra Boini, Gianmarco Bortolotti, Kushtrim Bresilla, Giulio Demetrio Perulli, Melissa Venturi, Luigi Manfrini, Luca Corelli Grappadelli

“…In fact, some preharvest factors changed considerably between the two seasons such as yield and weather conditions. Indeed, some factors seem to affect SS in both growing seasons. …”
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Quaternary ammoniums activate human dendritic cells and induce a specific T-cell response in vitro by Marine Peyneau, Mathilde Zeller, Virginie Paulet, Benoît Noël, Marie-Hélène Damiens, Natacha Szely, Andreas Natsch, Marc Pallardy, Sylvie Chollet-Martin, Luc de Chaisemartin, Saadia Kerdine-Römer

“…However, NMBA anaphylaxis exists in countries where pholcodine was unavailable, prompting the hypothesis of other sensitizing molecules, most likely quaternary ammonium compounds (QACs).Indeed, QACs are commonly used as disinfectants, antiseptics, preservatives, and detergents. …”
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Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation by Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida

“…The mitogen‐activated protein kinase (MAPK) extracellular signal‐regulated kinase 5 (ERK5) is emerging as a promising target in cancer. Indeed, alterations of the MEK5/ERK5 pathway are present in many types of cancer, including melanoma. …”
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How drinking motives mediate associations between sexual orientation and indicators of alcohol use – a study among young Swiss men by Matthias Wicki, Matthias Wicki, Simon Marmet, Joseph Studer, Joseph Studer, Kim Bloomfield, Kim Bloomfield, Kim Bloomfield, Gerhard Gmel, Gerhard Gmel, Gerhard Gmel, Gerhard Gmel

“…Homosexual men, however, displayed similar or lower scores for alcohol use indicators and AUD symptoms than heterosexual men, but these differences were not mediated by drinking motives. Indeed, homosexual men exhibited greater coping motives than heterosexual men. …”
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