Wogonin Attenuates Ovalbumin Antigen-Induced Neutrophilic Airway Inflammation by Inhibiting Th17 Differentiation by Rie Takagi, Masaaki Kawano, Kazuyuki Nakagome, Kumiko Hashimoto, Takehiro Higashi, Katsuya Ohbuchi, Atsushi Kaneko, Sho Matsushita

“…We found that hange-shashin-to (HST) and oren-gedoku-to (OGT) possess inhibitory activity for Th17 responses in vitro. Indeed, wogonin and berberine, major components common to HST and OGT, exhibit Th17-inhibitory activities in both murine and human systems in vitro. …”
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Female Brain and Endocrinological Research-Veteran (FemBER-Vet) study: A study protocol for identifying endocrinological, lifestyle and psychosocial determinants of brain health ou... by Tamlyn Watermeyer, Elliott Atkinson, Glyn Howatson, Gill McGill, Christina Dodds, Paul Ansdell, Chinedu Udeh-Momoh

“…Such findings highlight the need for increased and early screening of medical and psychiatric conditions, and indeed dementia, in the female veteran population. …”
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Stress in autism (STREAM): A study protocol on the role of circadian activity, sleep quality and sensory reactivity. by Clara C Gernert, Christine M Falter-Wagner, Valdas Noreika, Barbara Jachs, Nazia Jassim, Kathryn Gibbs, Joaquim Streicher, Hannah Betts, Tristan A Bekinschtein

“…Based on the risk factors identified in typical mental research, we propose the following themes central to mental health issues in autism: sleep difficulties and stress. Indeed, the prevalence of manifold circadian disruptions and sleep difficulties in autism, alongside stress related to sensory overload, forms an integral part of autistic symptomatology. …”
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Intracellular Ca2+ Stores and Ca2+ Influx Are Both Required for BDNF to Rapidly Increase Quantal Vesicular Transmitter Release by Michelle D. Amaral, Lucas Pozzo-Miller

“…Furthermore, labeling presynaptic terminals with amphipathic styryl dyes and then monitoring their post-BDNF destaining in slice cultures by multiphoton excitation microscopy revealed that the increase in frequency of mEPSCs reflects vesicular fusion events. Indeed, BDNF application to CA3-CA1 synapses in TTX rapidly enhanced FM1-43 or FM2-10 destaining with a time course that paralleled the phase of increased mEPSC frequency. …”
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Effect of the Number of Nozzles of Swirl Flow Generator Utilized in Flat Plate Solar Collector: An Entropic Analysis by Yan Cao, Hamdi Ayed, Tuqa Abdulrazzaq, Taza Gul, Abdul Bariq, Belgacem Bouallegue

“…The numerical model of the pipes of a flat plate solar collector (FPSC) with several nozzles has been investigated in the present study. Indeed, the effect of the number of nozzles of the swirl generator on the entropic characteristics has been evaluated. …”
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Study of the Influence of Plaque Growth and Hydrostatic Properties in an Atherosclerotic Artery, for the Prevention of Arterial Wall Damage: Application to Vascular Diseases by J. R. Tsafack Nzifack, J. S. Mabekou Takam, R. Moutou Pitti, M. Fogue, P. K. Talla

“…Furthermore, atherosclerosis promotes the loss of elasticity of the arterial wall and increases the density of blood mass. Indeed, all these subsequent phenomena increase arterial stress. …”
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Allosteric Fluorescent Detection of Saccharides and Biomolecules in Water from a Boronic Acid Functionalized Arene Ruthenium Assembly Hosting Fluorescent Dyes by Alaa Maatouk, Thibaud Rossel, Bruno Therrien

“…Interestingly, when fluorescein is trapped by the metalla-rectangle in the presence of D-fructose, half of the maximum fluorescence intensity is recovered at a fructose concentration of 17.2 ± 4.7 μM, while, for D-glucose, a concentration of 50.6 ± 2.5 μM is required for the same effect. Indeed, all combinations of analyte–host–dye (seven analytes, one host, three dyes) show a unique dose–response relationship in water at pH 8.0. …”
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Cultural Science Meets Cultural Data Analytics by Ibrus Indrek, Schich Maximilian, Tamm Marek

“…We think that this new transdisciplinary field of study can help define the scope of the Cultural Science Journal. Indeed, it has already found practical application in a variety of ‘post-DH’ collaborations in ‘Cultural Data Analytics’, often with the aim to explore the dynamics of meaning-making practices by computational means and by looking at a spectrum of materials (textual, sonic, visual, multimodal, etc.) both regarding the longue durée and in real-time applications, if not anticipating the future.…”
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Is hypercalcaemia immediately life-threatening? A prospective study by David Trewick, Mathilde Le Borgne, Julie Regnault, Camille Guimard

“…Conclusions: We found no cases of immediately life-threatening cardiac arrhythmias. Three patients had indeed a life-threatening neurological complication but always had at least one other major factor that could severely alter mental status, such as profound metabolic acidosis.…”
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La restitution architecturale et hydraulique du rampant des Massues sur l’aqueduc de la Brévenne à Lyon et ses conséquences sur l’aval du parcours by Paul François

“…The determination of the flow rate using our proposed method, on the other hand, makes it possible to test the relevance of certain hypotheses advanced by architectural restoration or reconstruction of the aqueducts’ course. Indeed, it becomes possible to quickly verify whether the formulated hypotheses risk dangerously constraining the flow of the aqueduct or not.This is the approach that was used in the restitution of the overflow reservoir of the Massues rampant, in Lyon. …”
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Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future by S. Gitto, G. Vitale, E. Villa, P. Andreone

“…However, the pathogenesis of steatohepatitis is highly complex and is determined by different parallel hits; indeed, the association of different drugs that act on various levels has been suggested. …”
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La famille choisie toujours d’actualité ? Vers une diversification des formes de liens familiaux pour les minorités sexuelles et de genre au Québec by Marianne Chbat, Geneviève Pagé, Isabel Côté, Martin Blais

“…However, despite the increasingly favorable inclusion of LGBTQ+ communities within Québec customs, the chosen family still acts today as a support and safety net for the majority of people who identify with these communities, regardless of their age. Indeed, the chosen family always seems to meet the emotional and material needs for several sexual and gender minorities. …”
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Structural modeling of NAD+ binding modes to PARP-1 by N. V. Ivanisenko, D. A. Zhechev, V. A. Ivanisenko

“…The structure of complex of human poly (ADP-ribose) polymerase-1 with NAD+ can be a starting point for rational design of small molecule inhibitors based on NAD+ derivatives. Indeed there is no crystal structure of complex poly (ADP-ribose) polymerase-1 with nicotinamide adenine dinucleotide (NAD+) available yet. …”
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Dual-Mode Encryption for UC-Secure String OT from Learning with Errors by Momeng Liu, Yupu Hu, Qiqi Lai, Shanshan Zhang, Huiwen Jia, Wen Gao, Baocang Wang

“…Through a comprehensive performance analysis, we demonstrate that our proposal can indeed strike a balance between security and efficiency.…”
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Aesthetic and Mechanical Suitability of a Clear Synthetic Resin as a Unconventional Binder for Road Pavements by Marco Pasetto, Andrea Baliello, Giovanni Giacomello, Emiliano Pasquini

“…Current environmental awareness interests several aspects of civil engineering, including road construction. Indeed, new challenges related to environmental pollution and landscape preservation must be faced. …”
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Freshwater sponges in the southeastern U.S. harbor unique microbiomes that are influenced by host and environmental factors by Jacqueline G. Keleher, Taylor A. Strope, Noah E. Estrada, Allison M. Griggs Mathis, Cole G. Easson, Cara Fiore

“…Our results support recent work indicating that freshwater sponges indeed harbor a distinct microbiome composition compared to the surrounding water and that these varied across sampling site indicating both environmental and host factors in shaping this distinct community. …”
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The Cost Effectiveness of Hand Held Ultrasound Scanning for Abdominal Aortic Aneurysm in Older Males with a History of Smoking by Denver Phiri, Peter J. Mallow, John A. Rizzo

“…**Results:** Opportunistic scanning is cost effective. Indeed, when surgical intervention is limited to medium (5.0-5.4 cm) or large (≥5.5 cm) aneurysms, such scanning is dominant; that is, it costs less and increases QALYs compared to usual care. …”
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Novel metal–organic framework biosensing platform for detection of COVID-19 RNA by Aya Elgazar, Rana Sabouni, Mehdi Ghommem, Amin F. Majdalawieh

“…This ZIF-8 biosensing platform showed high sensitivity towards COVID-19 RNA with an ultra-low limit of detection of 6.24 pM, a rapid detection time of 8 min, and high selectivity to COVID-19 RNA. Indeed, ZIF-8 experienced much lower fluorescence recovery when tested on two mismatched RNAs. …”
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Improvement of Physical and Mechanical properties of High-performance Sand Concrete with different Silica Fume content by Kaci Chalah, Aghiles Hammas, Abdelbaki Benmounah

“…However, the lowest value of water absorption was obtained for the sample with 6 % SF content. Indeed, at this concentration of SF, the water absorption and the capillarity values of HPSC samples decreased by 8,80 and 8,57 %, respectively.…”
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Real-time rapid accident detection for optimizing road safety in Bangladesh by Md Shamsul Arefin, Md Ibrahim Shikder Mahin, Farzana Akter Mily

“…It also reduces the impact on society resulting from traffic accidents. Indeed, this is a giant step towards harnessing artificial intelligence potentials for public safety and infrastructural development.…”
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