Role of physical activity in cardiovascular disease prevention: impact of epigenetic modifications by Yi Sun, Zuoying Peng, Hua Liang

“…Extensive research has pointed out that lack of adequate physical activity in life is one of the key risk factors for heart disease. Indeed, moderate exercise is not only beneficial to the heart in healthy populations, but also exerts a protective effect in pathological states. …”
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Why Did I Lose My Seat in the United States Congressional Elections? You Didn‘t Advertise Online Enough! by Milan Školník, Michael Haman, Anna Marie Nešpůrková

“…Democratic congresspeople who lost elections. Indeed, during the Democratic Party debate, voices were raised that its progressive wing was to blame for the loss of seats; in contrast, Rep. …”
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Claudin-11 regulates immunological barrier formation and spermatogonial proliferation through stem cell factor by Taichi Sugawara, Kayoko Sonoda, Nattapran Chompusri, Kazuhiro Noguchi, Seiji Okada, Mikio Furuse, Tomohiko Wakayama

“…However, there is no direct evidence that Sertoli cell TJs (SCTJs) do indeed form immunological barriers. Here, we analyzed male mice lacking claudin-11 (Cldn11), which encodes a SCTJ component, and found autoantibodies against antigens of spermatocytes/spermatids in their sera. …”
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Evidence for Proximity Effect in Superconductor–Organic Semiconductor–Superconductor Stacked Devices by Anna Kremen, Hagit Aviv, Yaakov Raphael Tischler, Amos Sharoni

“…Electrical transport measurements of the completed junctions indicate that indeed, the top and bottom contacts are superconducting and the protected MEH-PPV layer is pinhole-free, as supported by HR-TEM and EDS. …”
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Deletion of AMP-activated protein kinase impairs metastasis and is rescued by ROS scavenging or ectopic CD36 expression by Gopalakrishnan Ramakrishnan, Alexander R. Terry, Veronique Nogueira, Ahmed Magdy, Nissim Hay

“…The deletion of AMPK induces reactive oxygen species (ROS) levels in vitro and lipid oxidation in vivo, which likely impede metastasis. Indeed, antioxidants restore the ability of AMPK-deficient tumors to metastasize. …”
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Intelligent Digital Currency and Dynamic Coding Service System Based on Internet of Things Technology by Shanshen Li, Xin Jing

“…If the verification is correct, it indicates that the bill is indeed issued by the customer, and all bill elements are correct, and payment can be made. …”
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Public Transit Loyalty Modeling Considering the Effect of Passengers’ Emotional Value: A Case Study in Xiamen, China by Shi-chao Sun

“…At the same time, however, it also proved that passengers’ emotional value towards the public transit indeed affected passengers’ perception of the service value. …”
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Success or Failure in the City? Social Mobility and Rural-Urban Migration in Nineteenth- and Early-Twentieth-Century Groningen, the Netherlands by Richard Paping, Jacek Pawlowski

“…For Groningen, the findings oppose the pessimistic view of nineteenth and early-twentieth century rural-urban migrants mainly being pushed to the city by local circumstances, although their social opportunities in the countryside were indeed limited. The detailed database shows also that even a temporary movement to the city resulted on average in an improved social mobility performance, an indication that urban migrants of nearly all social backgrounds often accrued extra human capital during their stay in a large city. …”
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Success or Failure in the City? Social Mobility and Rural-Urban Migration in Nineteenth- and Early-Twentieth-Century Groningen, the Netherlands by Richard Paping, Jacek Pawlowski

“…For Groningen, the findings oppose the pessimistic view of nineteenth and early-twentieth century rural-urban migrants mainly being pushed to the city by local circumstances, although their social opportunities in the countryside were indeed limited. The detailed database shows also that even a temporary movement to the city resulted on average in an improved social mobility performance, an indication that urban migrants of nearly all social backgrounds often accrued extra human capital during their stay in a large city.…”
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A novel Fruit Fly Optimization Algorithm with quasi-affine transformation evolutionary for numerical optimization and application by Ru-Yu Wang, Pei Hu, Chia-Cheng Hu, Jeng-Shyang Pan

“…Through the above several comparative experiments, Quasi-affine Transformation evolutionary for the Fruit fly Optimization Algorithm has indeed demonstrated its strong competitiveness. Finally, we apply it to Capacitated Vehicle Routing Problem. …”
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Habiter l’exil : Retablo hispánico, Mexique, 1946 by Salomé Foehn

“…To do so, I will propose a theoretical framework based on recent works in two complementary fields : historiography of philosophy and Spanish exile studies. Indeed, as unhoused « pilgrims », they present an « altarpiece » which is also meant as the « justification » of exile as the redeeming perspective of a much darker Spain, that of the Black Legend. …”
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The 500-year Cultural & Economic Trajectory of Tobacco: A Circle Complete by Christopher A. Jones, Amanda Wassel, William Mierse, E. Scott Sills

“…Global tobacco consumption rose sharply after 1914 and became especially prevalent following World War II, particularly among men. Indeed, overall tobacco sales increased by more than 60% by the mid-20th century, and cigarettes were a critical driver of this growth. …”
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An evidence perspective on topical relevance types and its implications for exploratory and task-based retrieval by Xiaoli Huang, Dagobert Soergel

“…</b> The concept of relevance lies at the heart of intellectual access and information retrieval, indeed of reasoning and communication in general; in turn, topical relevance lies at the heart of relevance. …”
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Pilocarpine-Induced Status Epilepticus Is Associated with Changes in the Actin-Modulating Protein Synaptopodin and Alterations in Long-Term Potentiation in the Mouse Hippocampus by Maximilian Lenz, Marina Ben Shimon, Thomas Deller, Andreas Vlachos, Nicola Maggio

“…This makes SP an interesting marker for epilepsy-associated alterations in synaptic function. Indeed, single dose intraperitoneal pilocarpine injection (250 mg/kg) in three-month-old male C57BL/6J mice leads to a rapid reduction in hippocampal SP-cluster sizes and numbers (in CA1 stratum radiatum of the dorsal hippocampus; 90 min after injection). …”
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Insights into the dependence of post-stroke motor recovery on the initial corticospinal tract connectivity from a computational model by Dongwon Kim, Leah M. O’Shea, Naveed R. Aghamohammadi

“…Abstract There is a consensus that motor recovery post-stroke primarily depends on the degree of the initial connectivity of the ipsilesional corticospinal tract (CST). Indeed, if the residual CST connectivity is sufficient to convey motor commands, the neuromotor system continues to use the CST predominantly, and motor function recovers up to 80%. …”
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« Leprous literature » : le modèle de la transmission contesté par les théories esthétiques d’Oscar Wilde by Carole Delhorme

“…This lexicon echoed the legal standards that defined the limits to freedom of expression. Indeed, according to the leading case R v Hicklin (1868), which set a precedent for almost a century, a publication was defined as obscene if it had a ‘tendency... to deprave and corrupt those whose minds are open to such immoral influences’, regardless of its literary merit. …”
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A Different Path to the Same Old Question: Why Should Cartels be Criminalised? by Nuno Castro Marques

“…We deem it essential to think about what legal interests are harmed in each of the different types of competition infringements, so as to conclude if indeed and to what extent cartels and bid rigging are capable of impairing more or different legal interests, or in a different intensity, than those potentially violated by other types of competition infringements. …”
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Mineral Composition of Lentils: Physiological Functions, Antinutritional Effects, and Bioavailability Enhancement by Asmaa Benayad, Youssef Aboussaleh

“…Hence, it is imperative that the scientists continue to show the significance of pulses as a mineral source and their effects on human health. Indeed, lentils should be exploited for a variety of purposes, mainly towards eliminating malnutrition, on the condition of being well-balanced. …”
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The Promise of Human Induced Pluripotent Stem Cells in Dental Research by Thekkeparambil Chandrabose Srijaya, Padmaja Jayaprasad Pradeep, Rosnah Binti Zain, Sabri Musa, Noor Hayaty Abu Kasim, Vijayendran Govindasamy

“…Recent advances in the use of induced pluripotent stem cells have the potential for developing disease-specific iPSC lines in vitro from patients. Indeed, this has provided a perfect cell source for disease modeling and a better understanding of genetic aberrations, pathogenicity, and drug screening. …”
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Developmental defects in ectodermal appendages caused by missense mutation in edaradd gene in the nfr mangrove killifish kryptolebias marmoratus by Hussein A. Saud, Paul A. O’Neill, Brian C. Ring, Tetsuhiro Kudoh

“…To confirm the crucial role of edaradd during fin development, CRISPR RNAs were designed to suppress the gene in another killifish species, Arabian killifish. Indeed, Arabian killifish edaradd crispants showed a potent reduction of the fin development with 100% frequency. …”
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