Therapeutic Potential of Targeting Ferroptosis in Periprosthetic Osteolysis Induced by Ultra-High-Molecular-Weight Polyethylene Wear Debris by Takuya Ogawa, Shunichi Yokota, Liyile Chen, Yuki Ogawa, Yoshio Nishida, Taiki Tokuhiro, Hend Alhasan, Tomoyo Yutani, Tomohiro Shimizu, Daisuke Takahashi, Takuji Miyazaki, Tsutomu Endo, Ken Kadoya, Mohamad Alaa Terkawi, Norimasa Iwasaki

“…Furthermore, polyethylene wear debris was implanted onto calvarial bone and mice were treated with the ferroptosis inhibitors DFO and Fer-1. These treatments alleviated the inflammatory and pathological bone resorption induced by the wear debris implantation. …”
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Biofertilizing Effect of Soil Cyanobacterium <i>Anabaena cylindrica</i>–Based Formulations on Wheat Growth, Physiology, and Soil Fertility by Zineb Hakkoum, Farah Minaoui, Amer Chabili, Mountasser Douma, Khadija Mouhri, Mohammed Loudiki

“…Among the different treatments, soil inoculation with crude culture (living cells) and growth medium filtrate at 50% were the most efficient. …”
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Novel carbon dots with dual Modulatory effects on the bone marrow and spleen as a potential therapeutic candidate for treating spinal cord injury by Junjin Li, Hongda Wang, Yuanquan Li, Chunzhen Wang, Haiwen Feng, Yilin Pang, Jie Ren, Chuanhao Li, Erke Gao, Dejing Zhang, Dunxu Hu, Pengtian Zhao, Han Ding, Baoyou Fan, Tao Zhang, Xiaomeng Song, Zhijian Wei, Guangzhi Ning, Yong-Qiang Li, Shiqing Feng

“…Simultaneously, bone marrow hematopoietic stem cells (HSCs) and splenic leukocytes rapidly mobilize to replenish the depleted peripheral blood leukocyte pool. However, current treatments for spinal cord injuries overlook interventions targeting peripheral immune organs and tissues, highlighting the need to develop novel drugs capable of effectively regulating peripheral immunity and treating spinal cord injuries. …”
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Magnetic field-induced synergistic therapy of cancer using magnetoplasmonic nanoplatform by Siqi Gao, Iuliia Golovynska, Jiantao Liu, Zhenlong Huang, Hao Xu, Jinghan Qu, Fangrui Lin, Galyna Ostrovska, Junle Qu, Tymish Y. Ohulchanskyy

“…Histological studies showed striking differences in development and malignancy between tumors treated with the combination of NPs, MF and an 808 nm laser, and the control treatments, revealing a synergy of the MF-induced NIR PTT and chemotherapy and suggesting a promising strategy for cancer therapy.…”
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Mechanistic elucidation of human pancreatic acinar development using single-cell transcriptome analysis on a human iPSC differentiation model by Atsushi Mima, Azuma Kimura, Ryo Ito, Yu Hatano, Hiraku Tsujimoto, Shin-Ichi Mae, Junko Yamane, Wataru Fujibuchi, Norimitsu Uza, Taro Toyoda, Hiroshi Seno, Kenji Osafune

“…Abstract Few effective treatments have been developed for intractable pancreatic exocrine disorders due to the lack of suitable disease models using human cells. …”
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Real world pharmacovigilance assessment of drug related macular degeneration risks by Xiaodong Chen, Shinan Wu, Shaopan Wang, Chaofeng Yu, Zihan Guo, Shiya Huang, Peixin Cai, Yanliang Miao, Shiying Li, Qian Chen

“…Among these, 42 drugs were linked to significant risks, including treatments for breast cancer (tamoxifen, raloxifene, anastrozole, letrozole) and diabetes (insulin lispro, insulin human). …”
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A computational approach to drug design for multiple sclerosis via QSPR modeling, chemical graph theory, and multi-criteria decision analysis by Fozia Bashir Farooq, Nazeran Idrees, Esha Noor, Nouf Abdulrahman Alqahtani, Muhammad Imran

“…While disease-modifying therapies can slow progression, there is a need for more effective treatments. Quantitative structure-activity relationship (QSAR) modeling using topological indices derived from chemical graph theory is a promising approach to rationally design new drugs for MS. …”
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Effect of fermented restaurant waste meal addition on growth performance of pangasius catfish (Pangasius pangasius) for promoting sustainable aquaculture by Andriani Yuli, Iskandar, Pratama Rusky I., Dwi Cahya Muhamad, Prima Mochamad Galuh N.

“…The research identified the optimal fermentation duration and FRWF inclusion rate through a completely randomized design with five treatments (0%, 10%, 20%, 30%, and 40% FRWF) and three replicates each. …”
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Effectiveness of Fibers from “Cabernet Sauvignon” (Vitis vinifera) Pomace as Fining Agents for Red Wines by Mariona Gil, Rubén Del Barrio-Galán, Cristina Úbeda, Álvaro Peña-Neira

“…Color and phenolic composition of the treated wines were determined immediately after the treatments and after four and nine months of wine bottle ageing. …”
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Physical and functional characterization of whey protein-lignin biocomposite films for food packaging applications by Yihong Deng, Sierra Kolodjski, Grace Lewis, Gary Onan, Youngmi Kim

“…WPI solutions were subjected to heat treatments at 60 °C, 90 °C, and a 1:1 mixture of 20 °C and 90 °C to induce varying levels of protein denaturation. …”
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Effects of environmental enrichment and lack of beak trimming on aspects of health, behaviour and production of commercial turkeys by Josiane G. Busatta, Luciana Foppa, Jhonatan Sperandio, Daniele S. Martins, Cristiane G. Titto

“…Material and methods: A total of 3,116 female turkeys of the Nicholas Super Select line were equally distributed across four treatments in a 2 × 2 factorial scheme with the presence or absence of EE and BT or intact beak. …”
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Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy by Xiaopeng Li, Yang Zhong, Pengyuan Qi, Daoming Zhu, Chenglong Sun, Nan Wei, Yang Zhang, Zhanggui Wang

“…Radiotherapy (RT) is one of the most common treatments for cancer. However, intracellular glutathione (GSH) plays a key role in protecting cancer from radiation damage. …”
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Effect of Glazing on Flexural Strength of Full-Contour Zirconia by Hattanas Kumchai, Patrapan Juntavee, Arthur F. Sun, Dan Nathanson

“…Two-way ANOVA showed a significant influence of surface treatments on flexural strength of zirconia materials (P≤0.05). …”
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Comparison of Clinical Efficacy of Intravenous Acetaminophen with Intravenous Morphine in Acute Renal Colic: A Randomized, Double-Blind, Controlled Trial by Kambiz Masoumi, Arash Forouzan, Ali Asgari Darian, Maryam Feli, Hassan Barzegari, Ali Khavanin

“…A repeated measure analysis of variance revealed that the difference between the two treatments was significant (P=0.0001). The VAS reduction at primary endpoint (30 min after drug administration) was significantly higher in the acetaminophen group than in the morphine group (P=0.0001). …”
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Red wine maceration with grapevine-cane residues: Influence of format and toasting level by Verónica R. Olate-Olave, Liudis L. Pino-Ramos, Paula A. Peña-Martínez, Ricardo I. Castro, Marcelo Muñoz-Vera, Sergio Reyes-Manríquez, Gerard Casaubon, V. Felipe Laurie

“…., 30.1 ± 0.2 and 5.3 ± 0.1 mg/g extract respectively), and that their maceration in red wine, produced variable outcomes depending mainly on the format employed. For instance, treatments with powder vine canes led to a reduction in total phenolics (−19.4 %), antioxidant capacity (−14.9 %), total anthocyanins (−19.5 %), and catechins (−9.5 %), compared to the untreated control. …”
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GPA-MDS: A Visualization Approach to Investigate Genetic Architecture among Phenotypes Using GWAS Results by Wei Wei, Paula S. Ramos, Kelly J. Hunt, Bethany J. Wolf, Gary Hardiman, Dongjun Chung

“…This tool will help researchers to investigate common etiology among diseases, which can potentially lead to development of common treatments across diseases. We evaluate the proposed GPA-MDS framework using a simulation study and apply it to jointly analyze GWAS datasets examining 18 unique phenotypes, which helps reveal the shared genetic architecture of these phenotypes.…”
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Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy by Yuki Matsui, MD, PhD, Hirotaka Kishi, MD, Chihiro Matsui, MD, Jun Morita, MD, PhD, Hiroshi Mizuno, MD, PhD, Hatan Mortada, MBBS, Haruaki Sasaki, MD, PhD, Takashi Fukagai, MD, PhD

“…Chemotherapy-induced peripheral neuropathy (CIPN) affects 29%–68% of patients undergoing anticancer treatments within the first month. Traditional cryotherapy methods, such as frozen gloves, can pose risks. …”
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An Exploration of the Cellular Microenvironment of the Female Pig Urethra: Translational Insights for Urological Research by Agustín Cartes, Caroll Stoore, María Soledad Baquedano, Christian Hidalgo, Felipe Lillo, Eduardo Landerer, Galia Ramírez-Toloza, Rodolfo Paredes

“…Urinary incontinence is a widespread issue, particularly among women, with effective treatments remaining elusive. The pig, and especially the female pig, stands as a promising animal model for the study of this condition, due to its anatomical similarities to humans. …”
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COVID-19 Mortality in a Pediatric Patient with Hemoglobin SC Disease and Alpha-Thalassemia Trait by Joshua E. Motelow, Stacie Kahn, Patrick T. Wilson

“…We outline clearly the course of illness and treatments trialed, which can prove beneficial to providers facing similar challenges as this virus continues to strike areas around the world. …”
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Organic Greenhouse Container Herb Production in South Florida: Fertilizer and Potting Media by Danielle Treadwell, Kati Migliaccio, Teresa Olczyk, Yun Qian, Yuncong Li, George Hochmuth, Robert Hochmuth, Eric H. Simonne, Lance S. Osborne, Richard K. Sprenkel

“…However, some differences in plant production for basil and dill were identified among the different fertilizer treatments (Natural Safe, Perdue, Fertrell, and Control). …”
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