Pparg may Promote Chemosensitivity of Hypopharyngeal Squamous Cell Carcinoma by Meng Lian, Jiaming Chen, Xixi Shen, Lizhen Hou, Jugao Fang

“…This study is aimed at studying if PPARG sensitizes hypopharyngeal squamous cell carcinoma (HSCC) in chemotherapeutic treatments and at dissecting possible mechanisms of observed effects. …”
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Marine Antifouling for Underwater Archaeological Sites: TiO2 and Ag-Doped TiO2 by Silvestro A. Ruffolo, Andrea Macchia, Mauro F. La Russa, Lorenzo Mazza, Clara Urzì, Filomena De Leo, Marianna Barberio, Gino M. Crisci

“…The powders have been dispersed in a polymer and then applied to marble surface to evaluate the chromatic alteration induced by the treatments. By means of biological tests, it was possible to assess their behaviour as biofouling agents. …”
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Role of silent mutations in KRAS-mutant tumors by Jun Lu, Chao Zhou, Feng Pan, Hongyu Liu, Haohua Jiang, Hua Zhong, Baohui Han, Xiangxiang Pan

“…Despite being in early stages, research on KRAS silent mutations holds promise for uncovering novel insights that could inform personalized cancer treatments. In conclusion, this review underscores the evolving landscape of KRAS silent mutations, advocating for further exploration to bridge fundamental biology with clinical applications in oncology.…”
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CD4+ T Cells Mediate Dendritic Cell Licensing to Promote Multi‐Antigen Anti‐Leukemic Immune Response by Luis Gil‐de‐Gómez, Joseph J. Mattei, Jessica H. Lee, Stephan A. Grupp, Gregor S. D. Reid, Alix E. Seif

“…ABSTRACT Background Single antigen (Ag)‐targeted immunotherapies for acute lymphoblastic leukemia (ALL) are highly effective; however, up to 50% of patients relapse after these treatments. Most of these relapses lack target Ag expression, suggesting targeting multiple Ags would be advantageous. …”
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Effects of Feeding of Two Potentially Probiotic Preparations from Lactic Acid Bacteria on the Performance and Faecal Microflora of Broiler Chickens by Paula Fajardo, Lorenzo Pastrana, Jesús Méndez, Isabel Rodríguez, Clara Fuciños, Nelson P. Guerra

“…In the second experiment, although no differences in BWG were observed between treatments, Ross 308 broilers receiving the probiotic Lactobacillus preparation exhibited the lowest FCE values and were considered the most efficient at converting feed into live weight.…”
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The Role of Myeloid Cells on the Development of Hepatic Metastases in Gastrointestinal Cancer by Austin R. Dosch, Mary P. Martos, Samara Singh, Karishma Kodia, Nipun B. Merchant, Nagaraj S. Nagathihalli

“…Lastly, we describe burgeoning therapeutic approaches aimed at targeting specific myeloid populations to reduce liver metastases and highlight the inherent challenges that exist in studying the efficacy of these treatments in preclinical models. As the inception and outgrowth of liver metastases are primary drivers of prognosis in GI malignancies; further research into the complex mechanisms involved in this critical process is urgently needed.…”
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Effect of bagasse ash and filter cake amendments on wheat (Triticum turgidum L.var. durum) yield and yield components in nitisol by Assefa Gonfa, Bobe Bedadi, Anteneh Argaw

“…It was also found that yield and yield components that were obtained from bagasse ash overwhelmed those from filter cake treatments, except in tillers, dry biomass, and straw yield. …”
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A shallow convolutional neural network for cerebral neoplasm detection from magnetic resonance imaging by Hossein Sadr, Zeinab Khodaverdian, Mojdeh Nazari, Mohammad Yamaghani

“…Prompt diagnosis not only helps in developing more effective treatments but also has life-saving potential. Recently, machine learning algorithms have become increasingly important in medical imaging and information processing, offering a robust alternative to the time-consuming and error-prone manual diagnosis of brain tumors. …”
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The Challenges of Living with Inflammatory Bowel Disease: Summary of a Summit on Patient and Healthcare Provider Perspectives by Judith Bray, Aida Fernandes, Geoffrey C. Nguyen, Anthony R. Otley, Joan Heatherington, Jennifer Stretton, Natasha Bollegala, Eric I. Benchimol

“…Through personal vignettes, patients articulated a pressing need to increase understanding of the challenges faced by people suffering from IBD among both health care professionals and the general public, develop best practices for navigating life transitions and addressing the unique challenges faced by children with IBD, and provide equitable access to appropriate, effective, and affordable treatments. The recommendations that emerged from the summit will inform about efforts to increase public awareness, inform about advocacy strategies, and contribute to the development of research priorities.…”
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Curbing the trade in pangolin scales in China by revealing the characteristics of the illegal trade network by Fei Xi, Xiaoran Chao, Shibao Wu, Fuhua Zhang

“…We recommend that, in addition to advocating for stronger pangolin protection legislation and law enforcement in Africa, the inspection in China of cargo and baggage on ships and aircraft from Africa and of trucks entering and leaving Bozhou City should also by strengthened, as should the raising of awareness of pangolin protection among express delivery personnel, and in particular, practitioners of traditional Chinese medicine should be discouraged from using pangolin scales in treatments. These measures will further effectively curb the illegal trade in pangolins in China.…”
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Multi‐omics graph convolutional networks for digestive system tumour classification and early‐late stage diagnosis by Lin Zhou, Zhengzhi Zhu, Hongbo Gao, Chunyu Wang, Muhammad Attique Khan, Mati Ullah, Siffat Ullah Khan

“…The accurate diagnosis of DST is paramount for vigilant patient monitoring and the judicious selection of optimal treatments. Addressing this challenge, the authors introduce a novel methodology, denominated as the Multi‐omics Graph Transformer Convolutional Network (MGTCN). …”
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Investigating the effects of diurnal and nocturnal pollinators on male and female reproductive success and on floral trait selection in Silene dioica by Barbot, Estelle, Dufaÿ, Mathilde, Godé, Cécile, De Cauwer, Isabelle

“…Female plants in all treatments achieved full seed set, suggesting no differences in pollination efficiency between diurnal and nocturnal pollinator communities in S. dioica. …”
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Effect of Replacing Inorganic Copper, Zinc, and Selenium with Chelated Minerals on Productive Performance, Nutrient Utilization, Tibia Morphology, and Intestinal Histology of Growi... by Carlos A. Gaona rodríguez, Hugo Bernal Barragán, Nydia C. Vásquez aguilar, Adriana Morales Trejo, Miguel Cervantes Ramírez, Cecilia Ramírez Hernández, Humberto González Rodríguez, Emilio Olivares Sáenz, Jesús J. Hernández escareño

“…Quails fed the OM67 diet exhibited higher (P < 0.05) viability, daily weight gain, and live weight than the other groups, with no significant difference in feed intake or feed efficiency across treatments. The utilization rates of Cu and Fe were lower in the OM33 group. …”
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Muscular Dystrophies at Different Ages: Metabolic and Endocrine Alterations by Oriana del Rocío Cruz Guzmán, Ana Laura Chávez García, Maricela Rodríguez-Cruz

“…These facts all suggest that there is a need for better comprehension of metabolic and endocrine implications for muscular dystrophies with the purpose of developing improved clinical treatments and/or improvements in the quality of life of patients with dystrophy. …”
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Three-Dimensional Modeling of Spatial Reinforcement of Soil Nails in a Field Slope under Surcharge Loads by Yuan-de Zhou, Kai Xu, Xinwei Tang, Leslie George Tham

“…Incremental elastoplastic analyses have been performed to study the internal deformation within the slope and the development of nail forces during the application of top surcharge loads. Different treatments of the grillage constraints at nail heads have been studied. …”
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THE INFLUENCE OF ORGANIC FERTILIZER (POTASSIUM HUMATE) ON THE GENETICS, PHENOTYPIC VARIATIONS, AND HERITABILITY OF WHEAT VARIETIES by O. H. Al-Rawi, M. A. Hamed, A. A. Bedn, N. H. Khalaf

“…Data analysis showed significant differences across all variables and treatments. The genetic variance was found to be greater than the environmental variance for all tested variables, and this difference increased with higher levels of humic fertilizer. …”
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Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury by Wen-zhao Liu, Zhan-jun Ma, Ji-he Kang, Ai-xin Lin, Zhao-heng Wang, Hai-wei Chen, Xu-dong Guo, Xue-gang He, Xue-wen Kang

“…Spinal cord injury (SCI) is a highly disabling disorder for which few effective treatments are available. Grape seed proanthocyanidins (GSPs) are polyphenolic compounds with various biological activities. …”
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Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair by Jean-Baptiste Huré, Louis Foucault, Litsa Maria Ghayad, Corentine Marie, Nicolas Vachoud, Lucas Baudouin, Rihab Azmani, Natalija Ivljanin, Alvaro Arevalo-Nuevo, Morgane Pigache, Lamia Bouslama-Oueghlani, Julie-Anne Chemelle, Marie-Aimée Dronne, Raphaël Terreux, Bassem Hassan, François Gueyffier, Olivier Raineteau, Carlos Parras

“…Abstract Oligodendrocytes are critical for CNS myelin formation and are involved in preterm-birth brain injury (PBI) and multiple sclerosis (MS), both of which lack effective treatments. We present a pharmacogenomic approach that identifies compounds with potent pro-oligodendrogenic activity, selected through a scoring strategy (OligoScore) based on their modulation of oligodendrogenic and (re)myelination-related transcriptional programs. …”
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Warming alters plankton body-size distributions in a large field experiment by Dania Albini, Emma Ransome, Alex J. Dumbrell, Samraat Pawar, Eoin J. O’Gorman, Thomas P. Smith, Thomas Bell, Michelle C. Jackson, Guy Woodward

“…We addressed this gap by conducting an extensive freshwater mesocosm experiment across 36 large field mesocosms exposed to intergenerational warming treatments of up to +8 °C above ambient levels. We found a nonlinear decrease in the overall mean body size of zooplankton with warming, with a 57% reduction at +8 °C. …”
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Diseases impact the performance of maize hybrids in southern Minas Gerais by Guilherme Vieira Pimentel, Luiz Daniel Rodrigues da Silva, Natalia Costa, Amanda Santana, Elisabete da Cruz Silva Watanabe, Silvino Guimarães Moreira

“…The experimental design was randomized blocks (DBC), with treatments consisting of eight maize hybrids (DKB 390, DKB 230, DKB 177, 30F53, KWS 9110, KWS 9006, KWS 9004 and Supremo), in five replications. …”
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