CAR-T cells: prospective genetic engineering approach to orchestrate solid tumor in lung cancer by Angeline Felisca Tanujaya, Dhea Anggraini, Ahmad Dzulfikri Nurhan

“…None of these therapies has showed remarkably successful treatments for lung cancer. Developing technology leads to innovation of cancer-targeted therapy as an ideal strategy. …”
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Total Phenolic Content and Antioxidant Activity of Different Types of Chocolate, Milk, Semisweet, Dark, and Soy, in Cerebral Cortex, Hippocampus, and Cerebellum of Wistar Rats by Niara da Silva Medeiros, Roberta Koslowsky Marder, Mariane Farias Wohlenberg, Cláudia Funchal, Caroline Dani

“…In the sulfhydryl assay, we observed that the levels of nonenzymatic defenses only increased with the chocolate treatments The SOD enzyme activity was modulated in the tissues treated with the chocolates. …”
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Low dose deltamethrin exposure affects gene expression in rat frontal cortex by Junze Wu, Ariv Shah, Rami Ridi, Zacharia Rashid, Ali Sajid Imami, Nilanjana Saferin, James Patrick Burkett

“…Our study provides important insight on the effects of pesticide exposure on the brain and possible treatments and preventions. This study also emphasizes the need for further research on pyrethroid pesticides and their relationship to neurodevelopmental disorders. …”
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Anti-Biofilm Agents to Overcome <i>Pseudomonas aeruginosa</i> Antibiotic Resistance by Marie Hanot, Elodie Lohou, Pascal Sonnet

“…Hence, as the WHO alerted to the need to develop new treatments, the use of anti-biofilm agents (ABAs) appeared as a promising approach. …”
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In Vivo Chemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil by Erika Evangelina Coronado-Cerda, Moisés Armides Franco-Molina, Edgar Mendoza-Gamboa, Heriberto Prado-García, Lydia Guadalupe Rivera-Morales, Pablo Zapata-Benavides, María del Carmen Rodríguez-Salazar, Diana Caballero-Hernandez, Reyes Silvestre Tamez-Guerra, Cristina Rodríguez-Padilla

“…Chemotherapy treatments induce a number of side effects, such as leukopenia neutropenia, peripheral erythropenia, and thrombocytopenia, affecting the quality of life for cancer patients. 5-Fluorouracil (5-FU) is wieldy used as myeloablative model in mice. …”
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A Case of Early Stage Bladder Carcinosarcoma in Late Recurrence of Urothelial Carcinoma after Transurethral Resection by Daisaku Hirano, Toshiyuki Yoshida, Daigo Funakoshi, Fuminori Sakurai, Shou Ohno, Yoshiaki Kusumi

“…Some early stages of bladder carcinosarcoma might have a favorable prognosis without aggressive treatments.…”
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Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, clinical characteristics: A multi-center observational study from Jordan by Marwan Shalabi, Salam Ghanem, Iyad Al-Ammouri, Amirah Daher, Enas Al-zayadneh, Alaa Alsmadi, Mais Ayyoub, Samah Abughanam, Mariam Jabr, Montaha Al-Iede

“…Cardiac findings were less common and did not include coronary findings. Treatments were mainly Corticosteroids and IVIG. No mortality was found in this series but serious disease occurred and some patients were admitted to Pediatric Intensive Care Unit. …”
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Decoding NAD+ Metabolism in COVID-19: Implications for Immune Modulation and Therapy by Shixu Song, Jialing Gan, Qiuyue Long, Zhancheng Gao, Yali Zheng

“…The persistent threat of COVID-19, particularly with the emergence of new variants, underscores the urgency for innovative therapeutic strategies beyond conventional antiviral treatments. Current immunotherapies, including IL-6/IL-6R monoclonal antibodies and JAK inhibitors, exhibit suboptimal efficacy, necessitating alternative approaches. …”
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The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach by Kellik Setiawan Volta, Affan Ali Murtadlo Ahmad, Nur Muhammad Ansori Arif, Dhea Kharisma Viol, Dayu Rahma Turista Dora

“…These findings suggest that compounds from Dayak tribal plants could be viable anti-cancer agents, providing a scientific foundation for developing culturally relevant and effective treatments for breast cancer. Further research is recommended to isolate and evaluate the bioactive compounds in preclinical and clinical settings. …”
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Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions by Grace Kuo, Ramhari Kumbhar, William Blair, Valina L. Dawson, Ted M. Dawson, Xiaobo Mao

“…While significant progress has been made in understanding α-synucleinopathy, the pursuit of efficacious treatments remains challenging. Several strategies involving decreasing α-syn production and aggregation, increasing α-syn degradation, lowering extracellular α-syn, and inhibiting cellular uptake of α-syn are presented. …”
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Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention by Kashish Azeem, Sadaf Fatima, Asghar Ali, Ayesha Ubaid, Fohad Mabood Husain, Mohammad Abid

“…The exploration of combination therapies, involving antimicrobial agents, biofilm-disrupting enzymes, and immunomodulators, is emphasized to enhance the efficacy of existing treatments and overcome biofilm resilience.…”
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Prepuce: Phimosis, Paraphimosis, and Circumcision by Yutaro Hayashi, Yoshiyuki Kojima, Kentaro Mizuno, Kenjiro Kohri

“…Various kinds of effective alternatives to circumcision have been described, including manual retraction therapy, topical steroid therapy, and several variations of preputioplasty. All of these treatments have the ability to retract the foreskin as their goal and do not involve the removal of the entire foreskin. …”
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Characterization and Digital Restauration of XIV-XV Centuries Written Parchments by Means of Nondestructive Techniques: Three Case Studies by L. Pronti, M. Perino, M. Cursi, M. L. Santarelli, A. C. Felici, M. P. Bracciale

“…The elemental and molecular results provided the identification of the inks, pigments, and superficial treatments. In particular, all manuscripts have been written with iron gall inks, while the capital letters have been realized with cinnabar and azurite. …”
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IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels by José Fernando Maya-Vetencourt, Laura Baroncelli, Alessandro Viegi, Ettore Tiraboschi, Eero Castren, Antonino Cattaneo, Lamberto Maffei

“…Recent studies have challenged this dogma providing evidence that both pharmacological treatments and paradigms based on the manipulation of environmental stimulation levels can be successfully employed as strategies for enhancing plasticity in the adult nervous system. …”
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Multi-environment field trials for wheat yield, stability and breeding progress in Germany by Tien-Cheng Wang, Till Rose, Holger Zetzsche, Agim Ballvora, Wolfgang Friedt, Henning Kage, Jens Léon, Carolin Lichthardt, Frank Ordon, Rod J Snowdon, Andreas Stahl, Hartmut Stützel, Benjamin Wittkop, Tsu-Wei Chen

“…The dataset encompasses MET spanning six years (2015–2020), six locations and nine crop management scenarios (consisting of combinations for three treatments, unbalanced in each location and year) comparing 228 cultivars released between 1963 and 2016, amounting to a total of 526,751 data points covering 24 traits. …”
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Co-targeting of glial activation and inflammation by tsRNA-Gln-i-0095 for treating retinal ischemic pathologies by Ying Zhang, Yan Ma, Yu-Ke Ji, Yi-Fei Jiang, Duo Li, Wan Mu, Mu-Di Yao, Jin Yao, Biao Yan

“…Abstract Ischemic retinopathies are the major causes of blindness, yet effective early-stage treatments remain limited due to an incomplete understanding of the underlying molecular mechanisms. …”
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Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease: A UK Case Series by T. Foltynie, C. Magee, C. James, G. J. M. Webster, A. J. Lees, P. Limousin

“…Treatment options in advanced Parkinson’s disease (PD) include subcutaneous apomorphine, pallidal or subthalamic nucleus Deep Brain Stimulation (DBS), or levodopa/carbidopa intestinal gel (LCIG/Duodopa). …”
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Age-structured cell population model to study the influence of growth factors on cell cycle dynamics by Frédérique Billy, Jean Clairambault, Franck Delaunay, Céline Feillet, Natalia Robert

“…&nbsp; &nbsp; This study thus aims at helping biologists to elicit the impact of growth factor concentration on cell cycle regulation, at making more precise the dynamics of key mechanisms controlling the division cycle in proliferating cell populations, and eventually at establishing theoretical bases for optimised combined anticancer treatments.…”
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Responses of dry edible bean crop growth and water productivities under different irrigation scenarios in the U.S. high plains by Angie Gradiz, Xin Qiao, Saleh Taghvaeian, Wei-zhen Liang, Daran Rudnick, Abia Katimbo, Jun Wang, Swathi Palle

“…This three-year (2021–2023) study investigated the impacts of irrigation treatments, ranging from rainfed to over-irrigated conditions, on soil water dynamics, canopy cover, leaf area index, yield, actual evapotranspiration, and water productivities for dry edible beans grown in western Nebraska, U.S. …”
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Tissue‐resident memory T cells in diseases and therapeutic strategies by Daoyuan Xie, Guanting Lu, Gang Mai, Qiuyan Guo, Guofeng Xu

“…Insights into TRM cells’ biology hold promise for innovative treatments for infectious diseases, cancer, and autoimmune conditions.…”
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