Infective Endocarditis: Systemic Inflammatory Response in Preoperative Heart Failure by Hanna B. Koltunova, Mikhailo Yu. Antomonov, Olena V. Rudenko

“…The use of a complex of several inflammatory markers can potentially improve the analysis of the inflammatory response system and the assessment of treatment dynamics. The aim. To evaluate the dynamics of systemic inflammatory response markers in patients with IE complicated by acute heart failure undergoing cardiopulmonary bypass surgery. …”
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Influence of High-Frequency Repetitive Transcranial Magnetic Stimulation on Neurobehavioral and Electrophysiology in Patients with Disorders of Consciousness by Jian-Min Chen, Qing-Fa Chen, Zhi-Yong Wang, Yang-Jia Chen, Nan-Nan Zhang, Jian-Wen Xu, Jun Ni

“…The elevation of neural connectivity levels may lay a foundation for successful HF-rTMS treatment for DOC patients.…”
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Real-Time Digitized Visual Feedback in Exercise Therapy for Lower Extremity Functional Deficits: Qualitative Study of Usability Factors During Prototype Testing by Klaus Widhalm, Lukas Maul, Sebastian Durstberger, Peter Putz, Carissa Klupper, Franz Werner

“…Thus, training physiological movement patterns may help in the treatment of such functional deficits. Motivation to exercise frequently is of utmost importance and can be promoted by using digital real-time feedback. …”
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USC-Derived Small Extracellular Vesicles-Functionalized Scaffolds Promote Scarless Vaginal Defect Repair via Delivery of Decorin and DUSP3 Proteins by Xu Y, Li J, Qiu Y, Wu F, Xue Z, Liu B, Fan H, Zhou Y, Wu Q

“…The efficacy of sEVs-loaded scaffolds in the treatment of vaginal defects in rabbits was assessed by histological analysis. …”
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In Vivo Functional Assessment of Sodium-Glucose Cotransporters (SGLTs) Using [18F]Me4FDG PET in Rats by Yohji Matsusaka, Xinyu Chen, Paula Arias-Loza, Rudolf A. Werner, Naoko Nose, Takanori Sasaki, Steven P. Rowe, Martin G. Pomper, Constantin Lapa, Takahiro Higuchi

“…To confirm the specificity of [18F]Me4FDG and responsiveness to treatment, a subset of animals was also pretreated with the SGLT inhibitor phlorizin. …”
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SGLT2 inhibition and adipose tissue metabolism: current outlook and perspectives by Cassandra Morciano, Shawn Gugliandolo, Umberto Capece, Gianfranco Di Giuseppe, Teresa Mezza, Gea Ciccarelli, Laura Soldovieri, Michela Brunetti, Adriana Avolio, Amelia Splendore, Alfredo Pontecorvi, Andrea Giaccari, Francesca Cinti

“…This review aims to clarify the impact of SGLT2i on adipose tissue, highlighting their role in metabolic health and their potential to transform treatment strategies for T2DM beyond glucose metabolism. …”
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Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model by Xing Tu, Zixing Zou, Jiahui Li, Simiao Zeng, Zhengchao Luo, Gen Li, Yuanxu Gao, Kang Zhang, Jing Ni

“…AI‐enabled drug discovery revealed that HG9-91-01 could serve as a potential treatment for acute glaucoma.…”
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Mutation-guided chemotherapy-free strategy in first-line immunotherapy for low PD-L1-expressing non-squamous NSCLC by Hui Li, Liang Zhang, Yu Xu, Jingjing Liu, Guoqiang Wang, Ying Cheng, Shangli Cai, Xinyue Wang, Peng Cui, Shaowei Lan

“…Biomarkers predicting this necessity can guide chemotherapy-free treatment to minimize unnecessary toxicity.Methods Treated with immune checkpoint inhibitor monotherapy (ICI-mono), chemotherapy, or combination (ICI-chemo), 790 low PD-L1-expressing nsqNSCLCs (in-house: n=83; public: n=707) were analyzed for development and validation of the interaction score for additional chemotherapy (ISAC). …”
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Phase I feasibility study of Magnetic Resonance guided High Intensity Focused Ultrasound-induced hyperthermia, Lyso-Thermosensitive Liposomal Doxorubicin and cyclophosphamide in de... by Elsken van der Wall, Josanne S de Maar, Britt B M Suelmann, Manon N G J A Braat, P J van Diest, H H B Vaessen, Arjen J Witkamp, S C Linn, Chrit T W Moonen, Roel Deckers

“…In the absence of hyperthermia, LTLD leads to a similar biodistribution and antitumour efficacy compared with conventional doxorubicin.Methods and analysis This is a single-arm phase I study in 12 chemotherapy-naïve patients with de novo stage IV HER2-negative breast cancer. Previous endocrine treatment is allowed. Study treatment consists of up to six cycles of LTLD at 21-day intervals, administered during MR-HIFU-induced hyperthermia to the primary tumour. …”
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Comparison of photodynamic therapy and LEEP in women of reproductive age with cervical squamous intraepithelial neoplasia 2 (CIN2): A prospective observational study in China by Cheng Li, Xuanhui Wang, Qiulin Cui, Mian He, Ming Chen

“…Background: Non-invasive treatments, such as 5-Aminolevulinic acid photodynamic therapy (5-ALA-PDT), has gained increasing attention among women with cervical intraepithelial neoplasia grade 2 (CIN2) who have fertility requirements. …”
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Efficacy of mindfulness-based intervention (‘mindfulness-based joyful sleep’) in young and middle-aged individuals with insomnia using a biomarker of inflammatory responses: a pros... by Chen Pan, Xiang Wang, Yunlong Deng, Peihuan Li, Yanhui Liao, Xin Ma, Guo-Ping Yang, Lisha Dai, Qiuping Tang

“…Studies suggest that mindfulness-based interventions (MBIs) are more easily delivered within the community than cognitive behavioural therapy for insomnia (CBT-I) which was recommended as the preferred non-pharmacological treatment by the American Academy of Sleep Medicine, are effective in insomnia treatment and can reduce inflammatory markers level in older individuals with insomnia. …”
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Rechallenge and retreatment with topical imiquimod 5% in transplant recipients: A multicenter experience on actinic keratoses and basal cell carcinomas by Paolo Fava, Gabriele Roccuzzo, Nicole Macagno, Francesco Cavallo, Valentina Celoria, Gianluca Avallone, Elisa Zavattaro, Federica Veronese, Luigi Biancone, Paola Savoia, Pietro Quaglino

“…Responses to the second course of treatment were observed in 4 (80%) and 7 (78%) cases in the persistent and new lesion, respectively (p = 0.34). …”
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Expert-Based Narrative Review on Compression UltraSonography (CUS) for Diagnosis and Follow-Up of Deep Venous Thrombosis (DVT) by Mario D’Oria, Laura Girardi, Ahmed Amgad, Mohab Sherif, Gabriele Piffaretti, Barbara Ruaro, Cristiano Calvagna, Philip Dueppers, Sandro Lepidi, Marco Paolo Donadini

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Development and evaluation of a continuous quality improvement programme for antimicrobial stewardship in six hospitals in Uganda by Francis Kakooza, Reuben Kiggundu, Andy Stergachis, JP Waswa, Hilma N Nakambale, Hassan Kassuja, Marion Murungi, Harriet Akello, Seru Morries, Mohan P Joshi, Niranjan Konduri

“…There was an increase in the proportion of patients receiving one antibiotic for the treatment of UTI from 48% during the pre-intervention to 73.2%, p<0.01. …”
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Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response by Jing Sun, Juanjuan Chen, Qinfang Xie, Mengjiao Sun, Wenjing Zhang, Hongxia Wang, Ning Liu, Qi Wang, Manxia Wang

“…Accordingly, the levels of IL-17 A, IL-21, and IgG were increased while IL-10 was decreased in EAMG mice. However, NaB treatment reduced IL-17 A and IL-21 but increased that of IL-10. …”
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Immunohistochemistry‐based molecular subtypes of urothelial carcinoma derive different survival benefit from platinum chemotherapy by Csilla Olah, Oleksandr Shmorhun, Gilbert Georg Klamminger, Josefine Rawitzer, Lara Sichward, Boris Hadaschik, Mulham Al‐Nader, Ulrich Krafft, Christian Niedworok, Melinda Váradi, Peter Nyirady, Andras Kiss, Eszter Szekely, Henning Reis, Tibor Szarvas

“…Statistical evaluation was performed in 199 patients divided into three chemo‐naïve MIBC cohorts: (1) pT3/4 and/or LN+ patients who received radical cystectomy without platinum treatment, (2) patients who received adjuvant chemotherapy (AC), and (3) patients who underwent palliative platinum treatment for metastatic disease or postoperative progression. …”
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Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis by Mengling Wang, Feng Zeng, Fengling Ning, Yinhang Wang, Shilin Zhou, Jiaqi He, Cong Li, Cong Wang, Xiaolin Sun, Dongliang Zhang, Jisheng Xiao, Ping Hu, Svetlana Reilly, Hong Xin, Xudong Xu, Xuemei Zhang

“…Results In the present study, CeNP-PEG treatment significantly ameliorated renal fibrosis by increased E-cadherin protein expression, and decreased α-SMA, Vimentin and Fibronectin expression both in vitro and in vivo. …”
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Evaluating the intended and unintended consequences of opioid-prescribing interventions on primary care in British Columbia, Canada: protocol for a retrospective population-based c... by Tara Gomes, Perry Kendall, M Ruth Lavergne, Dimitra Panagiotoglou, Rita McCracken, Erin C Strumpf, Benedikt Fischer, Austyn Brackett, Cheyenne Johnson

“…During this time the province mobilised a variety of policy levers to encourage physicians to expand access to opioid agonist treatment and the College of Physicians and Surgeons of British Columbia (CPSBC) released a practice standard establishing legally enforceable minimum thresholds of professional behaviour in the hopes of curtailing overdose events. …”
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Replacing rice straw with peanut vine and Broussonetia papyrifera silage in beef cattle feed reduced the use of soybean meal by Xin Yi, Yueming Li, Yue Liu, Minzhe Zhang, Zhenming Zhou, Qingxiang Meng, Hao Wu

“…The remaining roughage for all three treatment groups was supplemented with 25% corn silage (DM basis). …”
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A natural polyphenolic nanoparticle--knotted hydrogel scavenger for osteoarthritis therapy by Qinfeng Ding, Yitong Wang, Tianyou Wang, Chengyao Zhang, Shengbing Yang, Lu Mao, Yiyun Cheng, Yiwen Li, Kaili Lin

“…Exploring highly efficient and cost-effective biomaterials for osteoarthritis (OA) treatment remains challenging, as current therapeutic strategies are difficult to eradicate the excessive reactive oxygen species (ROS) and nitric oxide (NO) at damaged sites. …”
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