Combined Age with Mean Decrease Rates of Total Bilirubin and MELD Score as a Novel and Simple Clinical Predictor on 90-Day Transplant-Free Mortality in Adult Patients with Acute Li... by Di Jin, Kai Kang, Bing-zhu Yan, Jian-nan Zhang, Jun-bo Zheng, Zhi-hui Wang, Di Wu, Yu-jia Tang, Xin-tong Wang, Qi-qi Lai, Yang Cao, Hong-liang Wang, Yang Gao

“…At present, plasma exchange (PE) is the main effective alternative treatment for ALF in ICU clinical practice, and high-volume plasma exchange (HVP) has been listed as a grade I recommendation for ALF management in the American Society for Apheresis (ASFA) guidelines. …”
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Improved Performance of ELISA and Immunochromatographic Tests Using a New Chimeric A2-Based Protein for Human Visceral Leishmaniasis Diagnosis by Maria Marta Figueiredo, Anna R. R. dos Santos, Lara C. Godoi, Natália S. de Castro, Bruno C. de Andrade, Sarah A. R. Sergio, Selma M. B. Jerônimo, Edward J. de Oliveira, Ruth T. Valencia-Portillo, Lucilândia M. Bezerra, Hiro Goto, Maria C. A. Sanchez, Caroline Junqueira, Santuza M. R. Teixeira, Flávio G. da Fonseca, Ricardo T. Gazzinelli, Ana Paula Fernandes

“…Precise identification of infected patients is essential to establish treatment and control measures. Although several VL serological diagnosis advances have been accomplished lately, mainly using recombinant antigens and immunochromatographic tests (ICTs), improvements may still be achieved using multiepitope chimeric proteins in different test platforms. …”
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Twenty years’ experience of midgut malrotation and volvulus in a tertiary center in northern Taiwan: A retrospective study by Wen-Yu Tseng, Ming-Wei Lai, Jin-Yao Lai, Chien-Chang Chen, Hsun-Chin Chao, Jeng-Chang Chen, Shih-Yen Chen, Yung-Ching Ming, Hung-Yu Yeh, Hung-Hsiang Lai, Sze-Ya Ting, Pai-Jui Yeh

“…Conclusions: Prompt diagnosis and surgical treatment of midgut malrotation are vital to prevent bowel resection or mortality. …”
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Hyperthermia suppresses the biological characteristics and migration of chicken primordial germ cells by Yuzhou Gu, Yuzhou Gu, Yuzhou Gu, Kexin Wu, Kexin Wu, Kexin Wu, Bowen Niu, Bowen Niu, Bowen Niu, Zhiting Wang, Zhiting Wang, Zhiting Wang, Yuchen Jie, Yuchen Jie, Yuchen Jie, Zixuan Fan, Zixuan Fan, Zixuan Fan, Junying Li, Junying Li, Congjiao Sun, Congjiao Sun, Congjiao Sun, Zhuo-Cheng Hou, Zhuo-Cheng Hou, Zhuo-Cheng Hou, Li-Wa Shao, Li-Wa Shao, Li-Wa Shao

“…Cell viability, glycogen granule contents, and mRNA expression levels of pluripotency markers (NANOG and POUV), germ cell-specific markers (DAZL and CVH), and telomerase reverse transcriptase (TERT) were reduced in PGCs cultured under high temperatures (43°C for 12, 24, and 48 h). After the heat treatment of donor PGCs (43°C) or recipient embryos (39.5°C), GFP-positive PGCs in gonads were rarely observed. …”
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Evaluation of rheumatoid arthritis-associated interstitial lung disease in patients treated with JAK inhibitors: a MAJIK-SFR cohort study by Adeline Ruyssen-Witrand, Jacques-Eric Gottenberg, Philippe Dieude, Rene-Marc Flipo, Jerome Avouac, Emanuelle Dernis, Anne Tournadre, Marie-Elise Truchetet, Raphaele Seror, André Ramon, Nicolas Roux, André Basch, Pascal Chazerain, Fabienne Coury-Lucas, Richard Damade, Pierre-Antoine Juge, Thao Pham, Clément Prati, Olivier Brocq, Jean Hugues Salmon, Christian hubert roux, Félicien Triboulet, Charles Leské, Émilie Shipley

“…Objective To examine the course of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) in France on treatment with Janus kinase inhibitors (JAKis) using the MAJIK-SFR registry.Methods Prospective national multicentre observational study identifying patients with RA-ILD from the MAJIK-SFR registry. …”
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Association of blood group types and clinico-pathological features of gynecological cancers (GCs) by Syed Sameer Aga, Muhammad Anwar Khan, Mubarak Al Mansour, Rana Mohammed Hasosah, Lulu Abdullah Alsubaie, Dala Ahmad Alfaify, Malak Badr Alansari, Shahad Obaidallah Almutairi, Saniya Nissar

“…A comprehensive review of the charts was conducted to gather data including demographics, tumor characteristics, comorbidities, adverse effects, and treatment methods. Results A total of 543 female patients were included in the study. …”
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Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway by Jianbin Sun, Na Sai, Tong Zhang, Chaoying Tang, Shuhang Fan, Qin Wang, Da Liu, Xianhai Zeng, Juanjuan Li, Weiwei Guo, Shiming Yang, Weiju Han

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Positive effects of optimal dietary protein content on the growth, reproductive performance and health of Procambarus clarkii broodstock farming in rice field by Hui Luo, Feng Qin, Yu Li, Chuanbo Xiao, Wenbo Sun, Fan Liu, Guangjun Lv, Hua Ye, Yuanfa He, Wenping He, Feng Xu, Yong Lin, Dapeng Wang, Honghao Jin

“…There were 3 replicates in each treatment and 20 crayfish in each replicate with an initial average body weight of (20.30 ± 0.24) g were fed for 56 days. …”
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Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration by Shuangpeng Jiang, Guangzhao Tian, Xu Li, Zhen Yang, Fuxin Wang, Zhuang Tian, Bo Huang, Fu Wei, Kangkang Zha, Zhiqiang Sun, Xiang Sui, Shuyun Liu, Weimin Guo, Quanyi Guo

“…Unfortunately, current surgical treatment techniques that are commonly used in the clinic cannot regenerate articular cartilage. …”
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Risk Factors for Hospital Readmission Following Noncardiac Surgery: International Cohort Study by Michael H. McGillion, RN, PhD, Flavia K. Borges, MD, PhD, David Conen, MD, MPH, Daniel I. Sessler, MD, Brenda L. Coleman, RN, PhD, Maura Marcucci, MD, MSc, Carley Ouellette, RN, MSc, Marissa Bird, RN, PhD, Carly Whitmore, RN, PhD, Shaunattonie Henry, RN, PhD, Sandra Ofori, MD, MSc, Shirley M. Pettit, RN, Deborah M. Bedini, RN, MHS, Leslie P. Gauthier, MScT, Jennifer Lounsbury, RN(EC), MN, Nancy M. Carter, RN, PhD, Vikas Tandon, MD, Ameen Patel, MD, Teresa Cafaro, MD, MSc, Marko R. Simunovic, MD, John A. Harlock, MD, Diane Heels-Ansdell, MSc, Fadi Elias, MD, MS, Theodore Rapanos, MD, Shawn Forbes, MD, Elizabeth Peter, RN, PhD, Judy Watt-Watson, RN, PhD, Kelly Metcalfe, RN, PhD, Sandra L. Carroll, RN, PhD, Philip J. Devereaux, MD, PhD

“…Multivariable analyses demonstrated that 9 baseline characteristics (eg, cancer treatment in past 6 months; adjusted hazard ratio [HR], 1.44; 95% CI, 1.30–1.59), 5 baseline laboratory and physical measures (eg, estimated glomerular filtration rate or on dialysis; HR, 1.47; 95% CI, 1.24–1.75), 7 surgery types (eg, general surgery; HR, 1.86; 95% CI, 1.61–2.16), 5 index hospitalization events (eg, stroke; HR, 2.21; 95% CI, 1.24–3.94), and 3 other factors (eg, discharge to nursing home; HR, 1.61; 95% CI, 1.33–1.95) were associated with readmission. …”
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J-TAIL-2: A Prospective, Observational Study of Atezolizumab Combined With Carboplatin and Etoposide in Patients With Extensive-Stage SCLC in Japan by Eisaku Miyauchi, MD, PhD, Makoto Nishio, MD, PhD, Kadoaki Ohashi, MD, PhD, Atsushi Osoegawa, MD, PhD, Eiki Kikuchi, MD, PhD, Hideharu Kimura, MD, PhD, Yasushi Goto, MD, PhD, Junichi Shimizu, MD, PhD, Hiroshige Yoshioka, MD, PhD, Ichiro Yoshino, MD, PhD, Toshihiro Misumi, PhD, Nobuyuki Katakami, MD, PhD, Masahide Oki, MD, PhD, Takashi Kijima, MD, PhD, Kenichi Chikamori, MD, PhD, Kazumi Nishino, MD, PhD, Yuki Kobayashi, MS, Asako Miwa, BA, Misa Tanaka, MS, Akihiko Gemma, PhD

“…Introduction: On the basis of the IMpower133 trial, atezolizumab plus carboplatin and etoposide (CE) is approved as first-line treatment for extensive-stage (ES)-SCLC. The J-TAIL-2 study evaluated atezolizumab plus CE in routine clinical practice settings. …”
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Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary by Madhu Singh, Linda Mileshkin, Penelope Schofield, Bo Gao, Gary Richardson, Andrew Pattison, Rodney J Hicks, Niko Thio, Mark Warren, Colin Wood, Stephen B Fox, Anna DeFazio, Andrew Fellowes, Christopher Steer, David Bowtell, Nicholas Wilcken, Tharani Sivakumaran, Atara Posner, Dariush Etemadmoghadam, Krista Fisher, Samantha Webb, Christos S Karapetis, Ian M Collins, Narayan Karanth, Owen W J Prall, Richard William Tothill

“…Most patients with CUP have limited treatment options and poor survival outcomes. Immune checkpoint inhibitors (ICIs) can be efficacious in some patients with CUP, but the optimal predictive biomarkers are unknown. …”
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Current Application and Meta-analysis of Traditional Chinese Medicine emotional nursing for colorectal cancer patients' psycho-somatic rehabilitation after radical surgery (中医情志护理在... by SUN Lingyun (孙凌云), PENG Rongyan (彭蓉晏), LIU Jiaxi (刘稼玺), YAN Yunzi (闫蕴孜), YANG Yufei (杨宇飞), ZHAO Nan (赵楠)

“…Meta-analysis results showed that TCM emotional nursing could significantly reduce the scores of Self-rating Anxiety Scale (SAS) ［MD=-3. 57, 95% CI: (-4. 02, -3. 12), P＜0. 01］and Self-rating Depression Scale (SDS)［MD=-6. 70, 95% CI: (-7. 28, -6. 11), P＜0. 01］ of patients after intervention compared with conventional nursing, and could improve the quality of life, sleep, pain of patients, and improve the compliance and satisfaction of nursing and cancer treatment. Conclusion TCM emotional nursing could promote the psychosomatic rehabilitation of early-stage colorectal cancer patients after radical surgery, but it still needs to further improve the quality of research, optimize and integrate the nursing practice process and details, and strive to obtain higher level of evidence, so as to better help patients benefit. …”
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Unveiling the antiurolithiatic potentiality of two benzene sulfonamide derivatives against ethylene glycol-induced renal calculi by Ahmed M. Elgendy, Mohamed S. Nafie, Zohour I. Nabil, Nahla S. El-Shenawy, Heba N. Gad El-Hak

“…Therefore, it is advisable to explore alternative treatments that do not have these side effects. The study aimed to reveal the antiurolithiatic potential of two benzene sulfonamide derivatives (SBCl and SBF; A and B, respectively) against ethylene glycol-induced kidney stones. …”
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Effects of Optimized Fertilization and Organic Fertilizer Subsitution Technology on the Growth and Soil Fertility of Chinese Flowering Cabbage by Lan WEI, Zehuang WANG, Weisheng CHEN, Lianxi HUANG, Lihua TIAN, Zhongzhen LIU, Dongtian LAO, Qing HUANG

“…Among them, T6 treatment had the largest difference from conventional fertilization (0.62 units), and the soil organic matter content of all treatments was higher than that of T1 (9.75%-34.31%).…”
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Vaccination strategies for Ebola in the democratic republic of Congo: the who-Ebola modeling collaboration by Marco Ajelli, Jean-Jacques Muyembe, Alhassane Touré, Abdourahamane Diallo, Maria Litvinova, Stefano Merler, Sabué Mulangu, Aminata Bagayoko, Aissatou Bah, Ibrahima Bah, Aissatou Barry, Fatoumata Barry, Mohamed Chérif, Doussou Condé, Alpha A. Diallo, Fatoumata Diallo, Mory Diakité, Kassié Doré, Koundouno A. Mapan, Thérèse Koundouno, Patrice K. Onivogui, Fassou Lamah, Henry Maneno, Alphonse Nomou, Kourouma Sekouba, Ismaila Sani, Abdoulaye Soumah, Mamadou M. Sy, Pierre-Stéphane Gsell, M. Elizabeth Halloran, Ana Maria Henao-Restrepo, Ibrahima Socé Fall, Mike J. Ryan, Peter Salama, Alessandro Vespignani, Ira M. Longini, Jr.

“…To simulate Ebola virus transmission, we used a spatially explicit agent-based model with households, health care facilities, and Ebola treatment units. Model parameters were calibrated using data collected under the ring-vaccination expanded-access protocol implemented during the outbreak. …”
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Brief Report: Clinical Characteristics and Outcomes of Patients With Thoracic SMARCA4-Deficient Undifferentiated Tumors by Alissa J. Cooper, MD, Andrea Arfe, PhD, Biagio Ricciuti, MD, Andréanne Gagné, MD, PhD, Lynette M. Sholl, MD, Alessandro Di Federico, MD, Mark M. Awad, MD, PhD, Mihaela Aldea, MD, PhD, Maria Rosa Ghigna, MD, Miruna Grecea, MD, Phoebe Clark, MS, Jamie E. Chaft, MD, Mark G. Kris, MD, Gregory J. Riely, MD, Charles M. Rudin, MD, PhD, Ibiayi Dagogo-Jack, MD, Mari Mino-Kenudson, MD, Lingzhi Hong, MD, PhD, Neda Kalhor, MD, Natalie Vokes, MD, Anita Bowman, MS, Soo-Ryum Yang, MD, Natasha Rekhtman, MD, PhD, Adam J. Schoenfeld, MD

“…Of patients with metastatic disease, 58 (78%) received first-line systemic treatment. Most often, patients received chemo and immunotherapy combination (41%), chemotherapy alone (33%), or immunotherapy alone (16%). …”
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Clinical observation of external application of compound Baiyu powder in treating cracked nipples during lactation period and related nursing management (复方白玉散外敷治疗哺乳期乳头皲裂临床疗效观察及护理)... by CHEN Shuangshuang (陈双双), WANG Yuan (王媛), YOU Tingli (游婷李), CHEN Juan (陈娟)

“…Objective To investigate the effect of external application of Traditional Chinese Medicine compound Baiyu powder in treating cracked nipples during lactation period, and summarized related nursing measures during treatment. Methods A total of 120 women with cracked nipples during lactation period were randomly divided into group A, group B and control group, with 40 cases in each group. …”
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Dual specific STAT3/5 degraders effectively block acute myeloid leukemia and natural killer/T cell lymphoma by Daniel Pölöske, Helena Sorger, Anna Schönbichler, Elvin D. deAraujo, Heidi A. Neubauer, Anna Orlova, Sanna H. Timonen, Diaaeldin I. Abdallah, Aleksandr Ianevski, Heikki Kuusanmäki, Marta Surbek, Elisabeth Heyes, Thomas Eder, Christina Wagner, Tobias Suske, Martin L. Metzelder, Michael Bergmann, Maik Dahlhoff, Florian Grebien, Roman Fleck, Christine Pirker, Walter Berger, Emir Hadzijusufovic, Wolfgang R. Sperr, Lukas Kenner, Peter Valent, Tero Aittokallio, Marco Herling, Satu Mustjoki, Patrick T. Gunning, Richard Moriggl

“…Both JPX‐0700/−0750 treatment reduced leukemic cell growth in human AML or NKCL xenograft mouse models significantly, being well tolerated by mice. …”
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A phase 1b clinical trial to determine the safety, tolerability and immunogenicity of simian adenovirus and poxvirus vectored vaccines against Mycobacterium avium complex subspecie... by Jeremy Sanderson, Jeremy Aboagye, Rebecca Makinson, Katerina Rapi, Samuel Provstgaard-Morys, Lisa Stockdale, Alison Lawrie, Isabelle Lanigan, Nishat Halim, Abdel Douiri, Emily Greenlay, Rayka Malek, Emma Gray, Lindsey West, Fatima El Oulidi, Paul Ian Cross, Michael Stallibrass, Sarah C. Gilbert, Adrian V.S. Hill, Katie J. Ewer

“…It is the causative pathogen of the granulomatous inflammatory enteritis in ruminants, Johne’s Disease. A developing treatment approach is utilising heterologous prime-boost viral vectored vaccines. …”
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