First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer by Lini Pandite, Simon Metenou, Debra L Richardson, Erika Hamilton, Linda Van Le, Bo Ma, Fatima Rangwala, Nehal J Lakhani, Justin Call, Daphne Stewart, Lauren E Dockery, Guanfang Wang, Jade Huguet, Elliot Offman

“…Objectives included evaluation of safety, dose-limiting toxicity, recommended phase II dose, pharmacokinetic (PK) and pharmacodynamic (PD) parameters, and antitumor activity.Results 27 patients (median age 66 years (range, 33–85); median of 4 prior systemic therapies (range, 2–9)) with ovarian (70%), fallopian tube (15%), or primary peritoneal (15%) cancer received SL-172154. Treatment-emergent adverse events (TEAEs) were reported for 27 patients (100%), with 24 (88.9%) having a drug-related TEAE and infusion-related reactions being the most common. 12 patients (44.4%) had grade 3/4 TEAEs, and half of these patients (22.2%) had a drug-related grade 3/4 TEAE. …”
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Optimization of salinity range for rearing glass eel Anguilla bicolor bicolor by Ade Yulita Hesti Lukas, Daniel Djokosetiyanto, Tatag Budiardi, Agus Oman Sudrajat, Ridwan Affandi

“…Treatments of 0 g/L salinity was the lowest survival than the others. …”
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Streptococcus intermedius promotes synchronous multiple primary lung cancer progression through apoptosis regulation by Yi Deng, Yi Deng, Yi Deng, Yi Deng, Zhi Xiang Dong, Zhi Xiang Dong, Gao Hua Yang, William S. Krimsky, Yong Hang Tai, Hao Peng, Hao Peng, Hao Peng, Hao Peng, Gui Ting Huang, Gui Ting Huang, Gui Ting Huang, Jia Xin Xu, Jia Xin Xu, Jia Xin Xu, Saiyad A. Sarkar, Jun Peng, Jun Peng, Jun Peng, Jun Peng, Kai Qian, Kai Qian, Kai Qian, Kai Qian

“…This study provides significant new insights into the diagnosis and treatment of sMPLC.…”
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Effect of Yanshiqiangxin Decoction on Cardiomyocyte Apoptosis in Heart Failure Rats Based on PI3K/Akt/Caspase-9 Signaling Pathway by ZHU Sixing, YAN Shiyun, XU Yan, QIN Yan, CHEN Liyun, JIA Meijun

“…ObjectiveTo detect the effect of Yanshiqiangxin decoction on apoptosis of cardiomyocytes in rats with heart failure based on PI3K/Akt/Caspase-9 signalling pathway and to explore the possible mechanism of Yanshiqiangxin decoction in the treatment of heart failure.MethodsA total of 60 Wistar male rats were randomly divided into the normal group, the model group, the low dose Yanshiqiangxin decoction group, the medium dose Yanshiqiangxin decoction group,the high dose Yanshiqiangxin decoction group and the Perindopril group according to the random number table method, with 10 cases in each group. …”
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Advancing early detection of organ damage and cardiovascular risk prevention: the Suzhou cardiometabolic health study protocol - exploring the role of oral microbiome and metabolic... by Mengmeng Zhu, Mengmeng Zhu, Yiwen Li, Wenting Wang, Longkun Liu, Wenwu Liu, Jiayu Yu, Qian Xu, Jing Cui, Yanfei Liu, Keji Chen, Yue Liu, Yue Liu

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Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes by Yong Li, Steven A Rosenberg, Paul F Robbins, Zhiya Yu, Maria Parkhurst, Billel Gasmi, Nikolaos Zacharakis, Todd D Prickett, Jared J Gartner, Sri Krishna, Stephanie L Goff, Satyajit Ray, Frank J Lowery, Sivasish Sindiri, Alakesh Bera, Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Lior Levy, Tiffany Benzine, Robert V Masi, Rafiqul Islam

“…However, harnessing TILs for cancer treatments remains challenging because neoantigen-reactive T cells are often rare and exhausted, and ex vivo expansion can further reduce their frequencies. …”
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Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing by Fuqiang Song, Anqi Ye, Linyuan Jiang, Yang Lu, Yanzhen Feng, Rong Huang, Siting Du, Xiaoyu Dong, Ting Huang, Ping Li, Liangliang Yang, Jinjing Zhang, Mengjia Xu, Li Cheng, Jian Xiao

“…Here, we introduce a hydrogel incorporating polydopamine-coated bioactive glass (BGs@PDA) on reduced graphene oxide (rGO) with photothermal therapy (PTT) and silver nanoclusters (AgNCs) for synergistic antibacterial treatment. This design enables rapid bacterial eradication and controlled release. …”
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Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice by Qirong Lu, Qirong Lu, Luyao Wang, Luyao Wang, Xueping Jiang, Xueping Jiang, Wantong Han, Wantong Han, Pu Guo, Pu Guo, Yu Liu, Yu Liu, Shulin Fu, Shulin Fu, Jianglin Xiong, Jianglin Xiong, Zhongyuan Wu, Zhongyuan Wu, Yinsheng Qiu, Yinsheng Qiu

“…Hence, GA exhibits therapeutic potential in the treatment of vascular injury.…”
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An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma by Michele Massimino, Elena Tirrò, Stefania Stella, Cristina Tomarchio, Sebastiano Di Bella, Silvia Rita Vitale, Chiara Conti, Marialuisa Puglisi, Rosa Maria Di Crescenzo, Silvia Varricchio, Francesco Merolla, Giuseppe Broggi, Federica Martorana, Alice Turdo, Miriam Gaggianesi, Livia Manzella, Andrea Russo, Giorgio Stassi, Rosario Caltabiano, Stefania Staibano, Paolo Vigneri

“…Background: Despite advances in uveal melanoma (UM) diagnosis and treatment, about 50% of patients develop distant metastases, thereby displaying poor overall survival. …”
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Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch re... by Heather Lin, Vivek Subbiah, Siqing Fu, Aung Naing, Courtney Nicholas, Shubham Pant, Chad Tang, Michael A Curran, David S Hong, Ying Yuan, Sarina A Piha-Paul, Jordi Rodon Ahnert, Timonthy A Yap, Apostolia M Tsimberidou, Daniel D Karp, Anupallavi Srinivasamani, Coline Couillault, Genevieve P Hartley, James Dai, Ecaterina E Ileana Dumbrava, Paola Guerrero, Sarah Dhebat, Theresa Proia

“…Within tumour-infiltrating lymphocytes there was expansion of CD4 and PD-1+ CD8 populations with STAT3 ASO.Thirty-seven patients (29 PDAC, 7 NSCLC and 1 MRD CRC) from a single institution started treatment on trial between April 2017 and March 2020. …”
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Comparative and synergistic impacts of lime and biochar on soil properties, nitrogen transformation, and microbial function in acidic soils under tobacco cropping by Bianhong Zhang, Lina Tang, Zhicheng Chen, Xiaoyan Chen, Lindong You, Ruixin Pan, Ting Chen, Yifei Liu, Wenxiong Lin, Wenxiong Lin, Jinwen Huang

“…Biochar (B) was more effective than lime (L), and the combined treatment (L+B) showed comparable effects to biochar alone. …”
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Surgical interventions for spontaneous supratentorial intracerebral haemorrhage: a systematic review and network meta-analysisResearch in context by Jiayidaer Huan, Minghong Yao, Yu Ma, Fan Mei, Yanmei Liu, Lu Ma, Xiaochao Luo, Jiali Liu, Jianguo Xu, Chao You, Hunong Xiang, Kang Zou, Xiao Liang, Xin Hu, Ling Li, Xin Sun

“…However, the superiority of surgery over conservative medical treatment (CMT) and the comparative benefits of different surgical procedures remain unclear. …”
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High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa by Yan Yang, Xue Li, Lang Sun, Xiu-Kun Wang, You-Wen Zhang, Jing Pang, Guo-Qing Li, Xin-Xin Hu, Tong-Ying Nie, Xin-Yi Yang, Jian-Hua Liu, Gerrit Brandis, Xue-Fu You, Cong-Ran Li

“…These findings highlight the interplay of different mutations in causing non-carbapenemase carbapenem-resistance in P. aeruginosa.IMPORTANCEThe emergence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) poses a significant global health threat, complicating treatment options for infections caused by this pathogen. …”
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Association between PM2.5 components and poor ovarian response in assisted reproductive technology patients: A retrospective cohort study identifying sensitive exposure windows in... by Rui-Ling Liu, Zhi-Lei Xu, Yu-Ling Hu, Xing-Yu Lv, Quan-Zi Yao, Jia-Liang He, Li-Juan Fu, Li-Hong Geng, Tong Wang, Zhao-Hui Zhong, Yi-Jian Zhu, Yu-Bin Ding

“…In this retrospective cohort study, we included 38,619 patients undergoing their first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, defining POR as the primary outcome based on the POSEIDON criteria. …”
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Hypertension Subtypes among Thai Hypertensives: An Analysis of Telehealth-Assisted Instrument in Home Blood Pressure Monitoring Nationwide Pilot Project by Sakolwat Montrivade, Pairoj Chattranukulchai, Sarawut Siwamogsatham, Yongkasem Vorasettakarnkij, Witthawat Naeowong, Patchaya Boonchayaanant, Anut Sakulsupsiri, Aekarach Ariyachaipanich, Vorarit Lertsuwunseri, Voravut Rungpradubvong, Sudarat Satitthummanid, Sarinya Puwanant, Somchai Prechawat, Suphot Srimahachota, Jarkarpun Chaipromprasit, Wacin Buddhari, Smonporn Boonyaratavej, Surapun Sitthisook, Peera Buranakitjaroen, Apichard Sukonthasarn, Somkiat Sangwatanaroj

“…HT subtypes were classified according to the treatment status, CBP (≥or <140/90 mmHg), and mean HBP (≥or <135/85 mmHg) into the following eight subtypes: in nonmedicated hypertensives, there are four subtypes that are normotension, white-coat HT, masked HT, and sustained HT; in treated hypertensives, there are four subtypes that are well-controlled HT, HT with white-coat effect, masked uncontrolled HT, and sustained HT. …”
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Dynamic changes and future trend predictions of the global burden of anxiety disorders: analysis of 204 countries and regions from 1990 to 2021 and the impact of the COVID-19 pande... by Si Chen, Wei Huang, Min Zhang, Yan Song, Chunshan Zhao, Hongwei Sun, Yanyu Wang, Jihong Wang, Yali Sun, Lei Zhou, Yan Zhu, HongYuan Wang, ZhengYang Xu, YuRui Bai, Cheng Chang

“…There is an urgent need for the adoption of targeted prevention and treatment strategies on a global scale, especially in high SDI regions, to effectively address the escalating issue of anxiety disorder burden. …”
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Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to Promote Peripheral Nerve Regeneration In Vivo by Rui D. Alvites, Mariana V. Branquinho, Ana C. Sousa, Irina Amorim, Rui Magalhães, Filipa João, Diogo Almeida, Sandra Amado, Justina Prada, Isabel Pires, Federica Zen, Stefania Raimondo, Ana L. Luís, Stefano Geuna, Artur S. P. Varejão, Ana C. Maurício

“…The therapeutic combinations studied show promising outcomes and should be the target of new future works to overcome some irregularities found in the results and establish the combination of nerve guidance conduits and olfactory mucosa mesenchymal stem/stromal cells as viable options in the treatment of peripheral nerves after injury.…”
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Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Lev... by Fabiana Corsi-Zuelli, Gary Donohoe, Siân Lowri Griffiths, Cristina M. Del-Ben, Andrew J. Watson, Tom Burke, Paris A. Lalousis, Declan McKernan, Derek Morris, John Kelly, Colm McDonald, Saahithh R. Patlola, Carmine Pariante, Nicholas M. Barnes, Golam M. Khandaker, John Suckling, Bill Deakin, Rachel Upthegrove, Maria R. Dauvermann

“…Cognitive deficits, reduced brain cortical thickness and volumes, and inflammation may contribute to depressive and negative symptoms, but pharmacological treatment and disease progression may confound the associations. …”
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Mechanical Activation of cPLA2 Impedes Fatty Acid β‐Oxidation in Vein Grafts by Linwei Fan, Yuanjun Tang, Jian Liu, Yueqi Liu, Yiwei Xu, Jiayu Liu, Han Liu, Wei Pang, Yuxuan Guo, Weijuan Yao, Tao Zhang, Qin Peng, Jing Zhou

“…Inadequate fatty acid oxidation caused by knockdown of CPT1B or YY1, or etomoxir treatment, increased nuclear membrane tension, orchestrating the activation of cPLA2. …”
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A pharmacoinformatic approach for studying Atractylodes Lancea DC’s anticancer potential and control ROS-mediated apoptosis against prostate cancer cells by Chi-Hoon Ahn, Ji Soo Myong, Kazi Rejvee Ahmed, Md Ataur Rahman, Md. Maharub Hossain Fahim, Min Choi, Muntajin Rahman, Jinwon Choi, Kiryang Kim, Seungjoon Moon, Seungjoon Moon, Mohammed Dalli, Mohammed Dalli, Rony Abdi Syahputra, Sang-Won Shin, Abdel Halim Harrath, Moon Nyeo Park, Bonglee Kim, Hwa-Seung Yoo

“…ALD’s ability to engage multiple path-ways highlights its therapeutic potential as a selective and multifaceted treatment for ag-gressive prostate cancer.…”
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