Pratiques de l’automédication à l’ère de la pandémie COVID-19 dans trois villes de l’Ouest algérien [Practices of self-medication in the COVID-19 pandemic era in three cities of We... by Derouicha Matmou, Asma Memou, Yassine Merad, Ayoub Bouzid, Sohaïb Abd-El-Koudous Bouzid, Aissa Brik, Mounia Sakouhi

“…English Abstract: Introduction-Faced with the COVID-19 pandemic, and in the absence of an effective andsafe treatment,many drugs were used without medical advice.This study aimed to evaluate the­practices of dispensing non-prescription drugs in three cities in western Algeria. …”
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Non-coding RNAs secreted by renal cancer include piR_004153 that promotes migration of mesenchymal stromal cells by Joanna Bogusławska, Małgorzata Grzanka, Piotr Popławski, Weronika Zarychta-Wiśniewska, Anna Burdzinska, Karolina Hanusek, Helena Kossowska, Roksana Iwanicka-Nowicka, Alex Białas, Beata Rybicka, Anna Adamiok-Ostrowska, Joanna Życka-Krzesińska, Marta Koblowska, Leszek Pączek, Agnieszka Piekiełko-Witkowska

“…Moreover, hsa_piR_004153, hsa_piR_016735, hsa_piR_019521, and hsa_piR_020365 were consistently upregulated in RCC exosomes. piR_004153 (DQ575660.1; aliases: hsa_piRNA_18299, piR-43772, piR-hsa-5938) was the most highly expressed in exosomes from RCC cells when compared with normal kidney cells. Treatment of MSCs with RCC CM resulted in upregulation of piR_004153 expression. …”
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IFN-<inline-formula><math display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> Maintains Immune Tolerance by Promoting M2 Macrophage Polarization... by Xinyu Feng, Cheng Yang, Ting Wang, Jinxin Zhang, Han Zhou, Bin Ma, Ming Xu, Ganzhen Deng

“…After that, we demonstrated that this obviously promoted the bovine macrophages (BoMac) polarized to M2 through enhancing SOCS1 expression with the treatment of IFN-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula>. …”
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Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers by Siyer Roohani, Felix Ehret, Marcus Beck, Danai P. Veltsista, Jacek Nadobny, Sebastian Zschaeck, Sultan Abdel-Rahman, Franziska Eckert, Anne Flörcken, Rolf D. Issels, Stephan Klöck, Robert Krempien, Lars H. Lindner, Markus Notter, Oliver J. Ott, Daniel Pink, Vlatko Potkrajcic, Peter Reichardt, Oliver Riesterer, Mateusz Jacek Spałek, Emanuel Stutz, Rüdiger Wessalowski, Thomas Zilli, Daniel Zips, Pirus Ghadjar, David Kaul

“…Pretherapeutic imaging for RHT treatment planning is used by 10 centers, 9 centers set 40–43 °C as the intratumoral target temperature, and all centers use skin detectors or probes in body orifices for thermometry.Discussion There is disagreement regarding the integration of RHT in contemporary interdisciplinary care of STS patients. …”
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Cholesterol Targeted Catalytic Hydrogel Fueled by Tumor Debris can Enhance Microwave Ablation Therapy and Anti‐Tumor Immune Response by Lin Shen, Zhijuan Yang, Yi Zhong, Yanran Bi, Junchao Yu, Qinwei Lu, Yanping Su, Xiaoxiao Chen, Zhongwei Zhao, Gaofeng Shu, Minjiang Chen, Liang Cheng, Liangzhu Feng, Chenying Lu, Zhuang Liu, Jiansong Ji

“…This study developed a cholesterol‐targeted catalytic hydrogel, DA‐COD‐OD‐HCS, to enhance the synergy between MWA and immune checkpoint inhibitors (ICIs) for HCC treatment. Cholesterol oxidase (COD), modified with dimethyl maleic anhydride (DA) for release in acidic IRTM, is used to degrade cholesterol. …”
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Gut bacteria Prevotellaceae related lithocholic acid metabolism promotes colonic inflammation by Liping Chen, Zhenghao Ye, Junhua Li, Lijia Wang, Yu Chen, Meiping Yu, Jian Han, Jiangeng Huang, Dongyan Li, Yongling Lv, Kai Xiong, De’an Tian, Jiazhi Liao, Ursula Seidler, Fang Xiao

“…Methods Bile acids in fecal samples from patients with IBD and DSS-induced colitis mice, with and without antibiotic treatment, were analyzed using ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). …”
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A Cardiac‐Targeting and Anchoring Bimetallic Cluster Nanozyme Alleviates Chemotherapy‐Induced Cardiac Ferroptosis and PANoptosis by Junyue Xing, Xiaohan Ma, Yanan Yu, Yangfan Xiao, Lu Chen, Weining Yuan, Yingying Wang, Keyu Liu, Zhiping Guo, Hao Tang, Kelong Fan, Wei Jiang

“…These cardiac‐targeted bimetallic cluster nanozymes, with their anchoring capability, effectively reduce DOX‐induced cardiomyocyte ferroptosis and PANoptosis without compromising tumor treatment efficacy. Thus, the therapeutic approach demonstrates significant reductions in chemotherapy‐induced cardiac cell death and improvements in cardiac function, accompanied by exceptional in vivo biocompatibility and stability. …”
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Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (<i>Pinus densiflora</i>) in Sprague-Dawley Rats with Loperamide-Induced Constipation by Hee-Jin Song, Ayun Seol, Jumin Park, Ji-Eun Kim, Tae-Ryeol Kim, Ki-Ho Park, Eun-Seo Park, Su-Jeong Lim, Su-Ha Wang, Ji-Eun Sung, Youngwoo Choi, Heeseob Lee, Dae-Youn Hwang

“…Furthermore, significant improvements in the stool parameters, gastrointestinal (GI) transit, intestine length, and histopathological structure of the mid colon were detected in the Lop-induced constipation rats after MPC treatment. The other parameters, including the regulators for the adherens junction (AJ) and tight junction (TJ), and GI hormone secretion for laxative effects, were improved significantly in Lop+MPC-treated SD rats. …”
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Tumor Site‐Specific In Vivo Theranostics Enabled by Microenvironment‐Dependent Chemical Transformation and Self‐Amplifying Effect by Yunfei Zuo, Pei Li, Wen‐Jin Wang, Changhuo Xu, Shuting Xu, Herman H. Y. Sung, Jianwei Sun, Guorui Jin, Weiping Wang, Ryan T. K. Kwok, Jacky W. Y. Lam, Ben Zhong Tang

“…Abstract Precise tumor diagnosis and treatment remain complex challenges. While numerous fluorescent probes have been developed for tumor‐specific imaging and therapy, few exhibit effective function in vivo. …”
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Lower incidence of hepatocellular carcinoma with tenofovir alafenamide in chronic hepatitis B: Evidence from a large-scale cohort by Hye-Jin Yoo, Jae-Young Kim, Jeong-Ju Yoo, Hye Won Lee, Sang Gyune Kim, Young Seok Kim

“…Methods: In total, 75,816 patients with treatment-naïve HBV were included in the study and divided into TAF (n = 25,680), TDF (n = 26,954), and ETV (n = 23,182) groups after exclusions. …”
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Mulberry leaf extract reduces damage by regulating the oxidative response, immune response and intestinal flora of largemouth bass (Micropterus salmoides) under chronic heat stress by Bing Fu, Donglai Zhou, Xiaotong Qiu, Xiaotong Qiu, Jieqiu Zheng, Jieqiu Zheng, Qiong Yang, Yang Xiao, Sentai Liao, Qingrong Li, Dongxu Xing

“…In conclusion, dietary supplementation with 9 g/kg MLE could improve the growth, immunity, and diversity of intestinal flora in heat-stressed largemouth bass, and alleviate hepatic injuries by regulating inflammation, oxidative stress, and apoptosis, providing a theoretical basis for the development of MLE as a treatment against HS.…”
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Control of BKPyV-DNAemia by a Tailored Viro-Immunologic Approach Does Not Lead to BKPyV-Nephropathy Progression and Development of Donor-Specific Antibodies in Pediatric Kidney Tra... by Michela Cioni, Stella Muscianisi, Marica De Cicco, Sabrina Basso, Hans H. Hirsch, Iris Fontana, Laura Catenacci, Jessica Bagnarino, Mariangela Siciliano, Oriana Montana Lampo, Gloria Acquafredda, Lou Tina Diana Boti, Jessica Rotella, Eleonora Bozza, Jennifer Zumelli, Kristiana Mebelli, Fausto Baldanti, Massimo Cardillo, Marco Zecca, Arcangelo Nocera, Mario Luppi, Enrico Verrina, Fabrizio Ginevri, Patrizia Comoli

“…In the absence of effective antiviral treatments, current therapeutic approaches rely on immunosuppression (IS) reduction, possibly at the risk of inducing alloimmunity. …”
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Radiotherapy-induced Hypothalamic-Pituitary axis dysfunction in adult Brain, head and neck and skull base tumor patients – A systematic review and Meta-Analysis by J.M.J. Paulissen, C.M.L. Zegers, R.M. Houben, D. Hofstede, M. Kars, H.M. van Santen, F.J.P. Hoebers, D.K.M. De Ruysscher, D.B.P. Eekers

“…Besides clinical and treatment variables, reported insufficiencies for adrenocorticotrophic hormone, thyroid stimulating hormone, growth hormone, prolactin and follicle stimulating hormone and luteinizing hormone and for insufficiency of any axis were extracted. …”
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Use of inpatient palliative care in metastatic testicular cancer patients undergoing critical care therapy: insights from the national inpatient sample by Cristina Cano Garcia, Reha-Baris Incesu, Francesco Barletta, Simone Morra, Lukas Scheipner, Andrea Baudo, Stefano Tappero, Mattia Luca Piccinelli, Zhe Tian, Fred Saad, Shahrokh F. Shariat, Carlo Terrone, Ottavio De Cobelli, Luca Carmignani, Sascha Ahyai, Nicola Longo, Derya Tilki, Alberto Briganti, Severine Banek, Luis A. Kluth, Felix K. H. Chun, Pierre I. Karakiewicz

“…This could enhance the integration of IPC in the treatment of advanced cancer, potentially improving quality of life and care outcomes for survivors.…”
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Deep Learning-Based Identification of Echocardiographic Abnormalities From Electrocardiograms by Goro Fujiki, MD, Satoshi Kodera, MD, PhD, Naoto Setoguchi, MD, Kengo Tanabe, MD, PhD, Kotaro Miyaji, MD, PhD, Shunichi Kushida, MD, PhD, Mike Saji, MD, PhD, Mamoru Nanasato, MD, PhD, Hisataka Maki, MD, PhD, Hideo Fujita, MD, PhD, Nahoko Kato, MD, PhD, Hiroyuki Watanabe, MD, PhD, Minami Suzuki, MD, Masao Takahashi, MD, PhD, Naoko Sawada, MD, PhD, Jiro Ando, MD, Masataka Sato, MD, Shinnosuke Sawano, MD, PhD, Susumu Katsushika, MD, PhD, Hiroki Shinohara, MD, PhD, Norifumi Takeda, MD, PhD, Katsuhito Fujiu, MD, PhD, Hiroshi Akazawa, MD, PhD, Hiroyuki Morita, MD, PhD, Issei Komuro, MD, PhD

“…This model has potential to serve as an adjunct for early diagnosis and treatment of previously undetected cardiac disease.…”
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Transcriptomic Profiling and Tumor Microenvironment Classification Reveal Unique and Dynamic Immune Biology in HIV-Associated Kaposi Sarcoma by Jihua Yang, Ayse Ece Cali Daylan, Aleksei Shevkoplias, Ekaterina Postovalova, Meng Wang, Andrey Tyshevich, Matthew Lee, Hiba Narvel, Ksenia Zornikova, Nara Shin, Nikita Kotlov, Luca Paoluzzi, Changcheng Zhu, Balazs Halmos, Xingxing Zang, Haiying Cheng

“…Although antiretroviral therapy (ART) has improved KS control in people with HIV (PWH), treatment options for advanced KS remain limited. This study investigates the tumor microenvironment (TME) of KS through whole-transcriptomic profiling, analyzing changes over time and differences based on HIV status. …”
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Klebsiella pneumoniae induces dose-dependent shock, organ dysfunction, and coagulopathy in a nonhuman primate critical care model by Jeffrey R. Strich, Marcos J. Ramos-Benitez, Seth Warner, Heather Kendall, Sydney Stein, Andrew P. Platt, Sabrina C. Ramelli, Shelly J. Curran, Izabella Lach, Kiana Allen, Ashley Babyak, Luis J. Perez-Valencia, Mahnaz Minai, Junfeng Sun, Kevin M. Vannella, Derron Alves, Richard Herbert, Daniel S. Chertow

“…Our model provides an opportunity to study pathogenesis and investigate novel therapeutics for the treatment of bacterial sepsis in the setting of modern supportive care.IMPORTANCEThere is currently a disconnect between the efficacy of sepsis therapies in pre-clinical animal models and human clinical trials. …”
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Effect of gender on the ocular surface after trabeculectomy by A.V. Antonova, V.P. Nikolaenko, V.V. Brzheskiy, A.Ya. Vuks

“…They are characterized by strict adherence to treatment (manifested in lower initial IOP compared with men) but more frequent eye drop instillations and greater cumulative preservative load on the ocular surface. …”
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Effect of Sunflower (Helianthus annus L.) Hulls with Different Particle Sizes on Growth Performance and Physiological Responses of Broiler Chickens Fed Different Levels of Protein by Najibeh Beigzadeh, Smayyeh Salari, Faegheh Zaefarian, Shima Hosseinifar

“…A completely randomized design based on a 3 × 2 factorial arrangement, comprising 6 treatments (6 replicates per treatment, 10 birds per replicate). …”
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Increased rate of multidrug-resistant gram-negative bacterial infections in hospitalized immunocompromised pediatric patients by Sarah Khafaja, Sarah Khafaja, Yara Salameh, Celina F. Boutros, Cherine Awad, Kawthar Faour, Nadim Tfaily, Sarah Merhi, Zeinab El Zein, Zeinab El Zein, Samer Bou Karroum, Dana Oweini, Danielle Fayad, George F. Araj, George F. Araj, George F. Araj, Ramia Zakhour, Ghassan S. Dbaibo, Ghassan S. Dbaibo

“…This necessitates the frequent revisiting of treatment guidelines in these high-risk patients and the implementation of judicious antimicrobial stewardship programs and infection control policies to stabilize or decrease the prevalence of these infections.…”
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