Sarcoid of the Upper Humerus Found Incidentally on MR Images Obtained for Work-Up of Rotator Cuff Tear Where Compromised Tissue Quality Was a Concern for Surgical Success by Tanner R. Henrie, John G. Skedros

“…The pathogenesis likely includes genetic, immunologic, and environmental factors. The lungs, skin, and eyes are most commonly affected. …”
Get full text

Underestimated latent tuberculosis infection burden among school contacts in China: a cross-sectional study by Jin Yin, Mei Wang, Chengguo Wu, Yaling Shi, Ying Liu, Ya Yu, Qian Su, Zhengyu Zhang, Xueyong Huang, Xiaoshuang Zhang, Jun Fan, Bo Wu

“…TST, creation tuberculin skin test (C-TST), or Interferon-gamma release assays (IGRA) were conducted for immunological diagnostic methods. The LTBI detection gap among school contacts was assessed by comparing with the data implemented by community-level medical and health care institutions from 2021 to 2022. …”
Get full text

Disparities in response to mRNA SARS-CoV-2 vaccines according to sex and age: A systematic review by Michelle Bachmann, Nejla Gültekin, Zeno Stanga, Jan S. Fehr, Ismail I. Ülgür, Patricia Schlagenhauf

“…Comparing the sexes reveals that higher immunological responses were induced in females, and mild to moderate adverse effects (such as injection site discomfort, exhaustion, and headaches) were also more frequently reported in women. …”
Get full text

Safety, Immunogenicity, and Efficacy of Cytomegalovirus Vaccines: A Systematic Review of Randomized Controlled Trials by Manuela Chiavarini, Anita Genga, Giorgia Maria Ricciotti, Marcello Mario D’Errico, Pamela Barbadoro

“…The results were divided into RCTs on healthy individuals and those on transplant recipients, because the CMV-specific immune response to a vaccine is complex and varies depending not only on the type of vaccine, but also on the immunological status of the individual. <b>Conclusions</b>: Challenges remain in achieving broad efficacy across diverse populations, particularly for immunocompromised patients. …”
Get full text

Significant Cytokine mRNA Expression Changes Immediately after Initiation of Cardiopulmonary Resuscitation by Mareen Braunstein, Martina Williamson, Thomas Kusmenkov, Jürgen Landes, Peter Biberthaler, Karl-Georg Kanz, Wolfgang Böcker, Viktoria Bogner

“…The purpose of this study was to evaluate immediate immunological changes following cardiopulmonary resuscitation (CPR). mRNA expression levels of selected immunomodulatory cytokines in out-of-hospital cardiac arrest (OHCA) survivors were detected and correlated to clinical parameter. …”
Get full text

COVID-19 and HIV: Clinical Outcomes and Inflammatory Markers in a Cohort from a Reference Hospital in Rio de Janeiro, Brazil by Nathalia Beatriz Ramos de Sá, Karine Venegas Macieira, Mariana Rosa Inacio Coelho, Milena Neira Goulart, Marcelo Ribeiro-Alves, Leonardo Azevedo da Silva Rosadas, Kim Mattos Geraldo, Maria Pia Diniz Ribeiro, Sandra Wagner Cardoso, Beatriz Grinsztejn, Valdiléa G. Veloso, Andressa da Silva Cazote, Dalziza Victalina de Almeida, Carmem Beatriz Wagner Giacoia-Gripp, Fernanda Heloise Côrtes, Mariza Gonçalves Morgado

“…Conclusions: Overall, critically ill COVID-19 patients exhibited heightened inflammatory responses, while COVID/PLWH demonstrated unique immunological characteristics without increased mortality risk.…”
Get full text

The Effectiveness of Ebselen in Facial Nerve Crush Injury: An Experimental Study by Lütfü Şeneldir, Veysel Alparslan Gölcük, Gökçe Tanyeri Toker, Ayşegül Verim, Pembegül Güneş

“…Background: Ebselen is a neuroprotective drug that protects cellular components from oxidative damage by modulating enzymatic cofactors, metalloproteins, gene expression, antioxidant-anti-inflammatory effects, and immunological systems. Our goal was to compare the efficacy of Ebselen and methylprednisolone on rat facial nerve crush injury. …”
Get full text

CAR-T CELL THERAPY IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA by Ugo Testa, Simona Sica, Elvira Pelosi, Germana Castelli, Giuseppe Leone

“…Finally, recent studies have introduced allogeneic CAR-T cells generated from healthy donors or unmatched, which are opportunely manipulated with gene editing to reduce the risk of immunological incompatibility, with promising therapeutic effects. …”
Get full text

Role of the Kaiso gene in the development of inflammation in Mucin-2 defcient mice by E. A. Litvinova, K. M. Achasova, M. A. Borisova, S. V. Zhenilo, E. B. Prokhortchouk, E. N. Kozhevnikova

“…The main factors that have effects on the etiology of the disease are genetic, environmental and immunological. However, the mechanism of disease development and effective treatment of IBD have not yet been found. …”
Get full text

A new vaccination approach for Salmonellosis employing a multi-epitope vaccine based on live microbial cell factory from Lactococcus lactis by Reyhaneh Sadat Moosavi-Kohnehsari, Mahnaz Jafari-Sohi, Tohid Piri-Gharaghie, Shakiba Tolou-Shikhzadeh-Yazdi, Mona Aghassizadeh-Sherbaf, Romina Hosseinzadeh

“…The results provide a fresh method for creating new immunological candidate multi-epitome genes by using the food-grade, non-pathogenic Lactococcus lactis as a protein cell factory. …”
Get full text

Does Clostridium Perfringens Epsilon Toxin Mimic an Auto-Antigen Involved in Multiple Sclerosis? by Marie-Lise Gougeon, Valérie Seffer, Cezarela Hoxha, Elisabeth Maillart, Michel R. Popoff

“…They rather argue for a cross immunological reactivity with an antigen, possibly an autoantigen, mimicking ETX. …”
Get full text

GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo. by Lara Vojnov, Mauricio A Martins, Jorge R Almeida, Zachary Ende, Eva G Rakasz, Matthew R Reynolds, Enrique J Leon, Kim L Weisgrau, Benjamin J Burwitz, Joy M Folkvord, Marlon G Veloso de Santana, Patrícia C Costa Neves, Elizabeth Connick, Pamela J Skinner, Emma Gostick, David H O'Connor, Nancy A Wilson, Myrna C Bonaldo, Ricardo Galler, David A Price, Danny C Douek, David I Watkins

“…We carried out a series of immunological and virological assays to understand why these Gag-specific CD8(+) T cells could not control virus replication in vivo. …”
Get full text

DeepDrug as an expert guided and AI driven drug repurposing methodology for selecting the lead combination of drugs for Alzheimer’s disease by Victor O. K. Li, Yang Han, Tushar Kaistha, Qi Zhang, Jocelyn Downey, Illana Gozes, Jacqueline C. K. Lam

“…Firstly, it incorporates expert knowledge to extend candidate targets to include long genes, immunological and aging pathways, and somatic mutation markers that are associated with AD. …”
Get full text

Fulminant Diabetes in a Patient with Advanced Melanoma on Nivolumab by Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe

“…Anti-PD-1 agents can breach immunologic tolerance. Fulminant diabetes is an immune endocrinopathy that results from a violent immune attack leading to complete destruction of pancreatic beta cells in genetically predisposed people. …”
Get full text

A rare case of temporal arteritis in a young Indian male by Debaditya Roy, Susmita Rakshit, Azeez Pasha, Abhishek Patil

“…The evaluation revealed normal routine laboratory parameters and inflammatory markers. Immunological and viral markers' workup was also normal. …”
Get full text

Evaluation of Protocol Biopsy Utility 12 Months after Renal Transplantation: A Multicenter Observational Analysis by Bruno Moulin, Pierre Merville, Karine Renaudin, David Buob, Sophie Ferlicot, Michel Delahousse, Jacques Dantal, Laetitia Albano, Christelle Barbet, Georges Mourad, Laure-Hélène Noel

“…Globally, most recipients in both cohorts were at low immunological risk (<10% of patients with PRA ≥30%). …”
Get full text

Role of Soluble CD23 in Patients with Hyperthyroidism: Case–Control Study by Salim Hussein Hassan, Aqeel S. Abd Al-Salam, Nawras A. Esmaeel

“…Regarding the age groups of GD, more patients were in the 25–44 years age group than in the other age groups. The immunological marker sCD23 is higher in the patients’ group when compared with the control group (486.16 ± 185.39, 166.64 ± 61.15, respectively) and no correlation between levels of it and T3, T4, TSH, and vitamin D. …”
Get full text

Clinical Features and Dynamics of T Cells-Related Markers in Immunocompetent Patients with Cytomegalovirus Hepatitis by Takuya Komura, Takashi Kagaya, Hideo Takayama, Masahiro Yanagi, Takatoshi Yoshio, Saiho Sugimoto, Michiko Nishino, Noriaki Orita, Yoshiro Asahina, Masashi Nishikawa, Shuichi Kaneko, Masashi Unoura

“…We evaluated the pathophysiology and immunological aspects of CMV hepatitis in recently immunocompetent adult patients. …”
Get full text

Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage by Anastasiia Razdaibiedina, Mykhaylo Khobzey, Victoria Tkachenko, Iryna Vorobiova

“…Spontaneous abortion is a complex, multifactorial pathology, where various genetic, neural, endocrine, and immunological factors are involved. Cytokines, Toll-like receptors, and progesterone receptors play critical roles in embryonic implantation and development. …”
Get full text

Gut microbiota and atrial cardiomyopathy by Tingting Sun, Beibei Song, Bo Li

“…Its etiology involves a number of factors, including genetic, infectious, immunologic, and metabolic factors. Recent research has highlighted the critical role of the gut microbiota in the pathogenesis of atrial cardiomyopathy, and this is consistent with the gut–heart axis having major implications for cardiac health. …”
Get full text