Immune microenvironment features underlying the superior efficacy of neoadjuvant immunochemotherapy over chemotherapy in local advanced gastric cancer by Ning Zhang, Chunyu Li, Zehua Zhao, Biying Jiang, Wentao Wang, Fujing Sun, Yong Zhang, Yanmei Zhu

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Autophagy Contributes to Host Immunity and Protection against Zika Virus Infection via Type I IFN Signaling by Yuyi Huang, Yujie Wang, Shuhui Meng, Zhuohang Chen, Haifan Kong, Ting Pan, Gen Lu, Xuefeng Li

“…Recent studies have indicated that the Zika virus (ZIKV) has a significant impact on the fetal brain, and autophagy is contributing to host immune response and defense against virus infection. …”
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Requirement of Innate Immunity in Tumor-Bearing Mice Cured by Adoptive Immunotherapy Using Tumor-Draining Lymph Nodes by John Ammori, Khaled Hamzeh, Hallie Graor, Julian Kim

“…These results identify the cellular effectors involved in tumor regression following adoptive transfer and demonstrate the requirement for intact innate immunity within the tumor-bearing host.…”
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A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas by Kun Xiao, Yan Cao, Zhihai Han, Yuxiang Zhang, Laurence Don Wai Luu, Liang Chen, Peng Yan, Wei Chen, Jiaxing Wang, Ying Liang, Xin Shi, Xiuli Wang, Fan Wang, Ye Hu, Zhengjun Wen, Yong Chen, Yuwei Yang, Haotian Yu, Lixin Xie, Yi Wang

“…The heterogeneity of immune responses in bacterial pneumonia was observed, with distinct immune cell profiles related to disease severity. …”
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Noninvasive diagnosis model for predicting significant liver inflammation in patients with chronic hepatitis B in the immune-tolerant phase by Shanshan Chen, Lu Huang, Yili Chu, Jiangshan Lian, Hui Shao, Tingting Wang, Xuehan Zou, Haijun Huang

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Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost by Bo Zhang, Youyi Fong, Lauren Dang, Jonathan Fintzi, Shiyu Chen, Jing Wang, Nadine G. Rouphael, Angela R. Branche, David J. Diemert, Ann R. Falsey, Daniel S. Graciaa, Lindsey R. Baden, Sharon E. Frey, Jennifer A. Whitaker, Susan J. Little, Satoshi Kamidani, Emmanuel B. Walter, Richard M. Novak, Richard Rupp, Lisa A. Jackson, Chenchen Yu, Craig A. Magaret, Cindy Molitor, Bhavesh Borate, Sydney Busch, David Benkeser, Antonia Netzl, Derek J. Smith, Tara M. Babu, Angelica C. Kottkamp, Anne F. Luetkemeyer, Lilly C. Immergluck, Rachel M. Presti, Martín Bäcker, Patricia L. Winokur, Siham M. Mahgoub, Paul A. Goepfert, Dahlene N. Fusco, Robert L. Atmar, Christine M. Posavad, Jinjian Mu, Mat Makowski, Mamodikoe K. Makhene, Seema U. Nayak, Paul C. Roberts, Peter B. Gilbert, Dean Follmann, Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team

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Efficacy of Aeromonas hydrophila formalin-killed cells and lipopolysaccharides vaccines in maternal immunity of tilapia broodstock and the offspring resistance by Rahma Mulyani, Sukenda Sukenda, Sri Nuryati

“…ABSTRACT   The study aimed to analyze the efficacy of Aeromonas hydrophila formalin-killed cells (FKC) and lipopolysaccharides (LPS) vaccines in maternal immunity of tilapia broodstock and the resistance of the offsprings. …”
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Systemic immune inflammation index as a predictor of disease severity in tetanus patients: A retrospective observational study. by Dai Cheng, Ding Wenying, Huang Jizheng, Sun Wei, Li Liang, Han Guolei, Yang Hao

“…<h4>Objective</h4>This study aimed to analyze the predictive value of the systemic immune inflammation index (SII) for the severity of disease in tetanus patients.…”
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Screen of propionate-producing probiotic strains in attenuating murine colitis by modulating immune response and restoring the intestinal barrier by Ting Shu, Xizi Song, Silu Zhang, Xiaoli Zhou, Zhizhu Zhang, Pengfei Wang, Hu Canying, Jie Pan, Xiaoshuang Dai, Yan Tan, Wu Xiyang, Huicui Meng, Guoxun Xiao, Huaijie Hao

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Genetic association between immune-mediated inflammatory diseases and peripheral artery disease: a Mendelian randomization study by Haichao Wu, Dandan Zheng, Long Zhou, Qiang Wang, Tao Wang, Siyuan Liang

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Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation by Meritxell Boada-Pérez, Meritxell Boada-Pérez, Meritxell Boada-Pérez, Cristina Berastegui, Cristina Berastegui, Cristina Berastegui, Marta Erro, Marta Erro, Piedad Ussetti, Elena Crespo, Elena Crespo, Laura Donadeu, Laura Donadeu, Oriol Bestard, Oriol Bestard, Oriol Bestard, Gabriel Anguera, Amparo Solé, Ricardo Ponz Mir, Brian Molloy, Eva Revilla-López, Eva Revilla-López, Víctor Monforte, Víctor Monforte, Víctor Monforte, Susana Gómez-Ollés, Susana Gómez-Ollés, Susana Gómez-Ollés

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Letter to the editor, “Inhibition of anti-tumour reactivity of immune cells in the salivary gland cancer: A proteomic approach.” by Geetha Shanmugam

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Role of CD4+ T and CD8+ T Lymphocytes-Mediated Cellular Immunity in Pathogenesis of Chronic Obstructive Pulmonary Disease by Weilin Xue, Jianying Ma, Yue Li, Chunxia Xie

“…This work was to explore the changes of T lymphocyte subsets in peripheral blood of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) (AECOPD) and the role of cellular immunity mediated in the disease process. Eighty-six patients with AECOPD who visited Qingdao Hiser Medical Center from June 2020 to December 2021 and 30 healthy people (controls) who underwent health examination in the same period were selected. …”
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The Critical Role of Bach2 in Shaping the Balance between CD4+ T Cell Subsets in Immune-Mediated Diseases by Lingyi Yang, Shuli Chen, Qiuyu Zhao, Ying Sun, Hong Nie

“…Here, we reveal a critical role of Bach2 in regulating T cell biology and the correlation with these immune-mediated diseases.…”
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Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity by Saber Imani, Parham Jabbarzadeh Kaboli, Ali Babaeizad, Mazaher Maghsoudloo

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Sustained response off treatment after fostamatinib in refractory immune thrombocytopenia: A series of four case reports by Waleed Ghanima, Francisco Javier Lucas Boronat, Valentina Carrai, Stefan Rackwitz

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CD4+ T Cells Mediate Dendritic Cell Licensing to Promote Multi‐Antigen Anti‐Leukemic Immune Response by Luis Gil‐de‐Gómez, Joseph J. Mattei, Jessica H. Lee, Stephan A. Grupp, Gregor S. D. Reid, Alix E. Seif

“…In contrast, tolerance is characterized by in vivo increased expression of negative immune checkpoints (IC) which may suppress rather than license DC. …”
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ÜRİNER SİSTEM ENFEKSİYONU OLAN TİP 2 DİABETES MELLİTUS HASTALARINDA SİSTEMİK İMMÜN-İNFLAMASYON İNDEKSİNİN DEĞERLENDİRİLMESİ by Nuri Çakır, Işıl Çakır

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Protocol for Immune Cell Isolation, Organoid Generation, and Co-culture Establishment from Cryopreserved Whole Human Intestine by Enrique Gamero-Estevez, Inga Hensel, Michelle Steinhauer, Olivia Müllertz, Elizaveta Savochkina, Ibrahim Sektioglu, Bilgenaz Stoll, Shaghayegh Derakhshani, Sarah Devriese, Kyungbo Kim, Martin Resnik-Docampo

“…We describe how to generate a biobank that can be used to isolate specific immune cell subtypes, generate organoid lines, and establish autologous immune cell-organoid co-cultures.…”
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TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders by Nincy Debeuf, Sahine Lameire, Manon Vanheerswynghels, Julie Deckers, Caroline De Wolf, Wendy Toussaint, Rein Verbeke, Kevin Verstaen, Hamida Hammad, Stijn Vanhee, Bart N Lambrecht

“…Identified TCR sequences were inserted as synthetic DNA into an expression vector and transgenic CORSET8 donor mice were created. After immunization with Spike/CpG-motifs, mRNA vaccination or SARS-CoV-2 infection, CORSET8 T cells strongly proliferated and showed signs of T cell activation. …”
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