The Interplay of Aging and PANoptosis in Osteoarthritis Pathogenesis: Implications for Novel Therapeutic Strategies by Liu S, Zhang G, Li N, Wang Z, Lu L

“…Age-related cellular and immune dysfunctions, including cellular senescence, senescence-associated secretory phenotypes (SASPs), and immunosenescence, significantly contribute to joint degeneration. …”
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A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology. by Manasa Kesapragada, Yao-Hui Sun, Kan Zhu, Cynthia Recendez, Daniel Fregoso, Hsin-Ya Yang, Marco Rolandi, Rivkah Isseroff, Min Zhao, Marcella Gomez

“…The motility of macrophages in response to microenvironment stimuli is a hallmark of innate immunity, where macrophages play pro-inflammatory or pro-reparatory roles depending on their activation status during wound healing. …”
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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway: a potential therapeutic approach for neurodegenerative d... by Fengcheng Deng, Dan Yang, Lingxi Qing, Yifei Chen, Jilian Zou, Meiling Jia, Qian Wang, Runda Jiang, Lihua Huang

“…The gut microbiota influences the cAMP-PKA signaling pathway through its metabolites, which activates the vagus nerve and modulates the immune and neuroendocrine systems. Conversely, alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota, creating a dynamic network of microbial-host interactions. …”
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Tissue-Related Hypoxia Attenuates Proinflammatory Effects of Allogeneic PBMCs on Adipose-Derived Stromal Cells In Vitro by Polina I. Bobyleva, Elena R. Andreeva, Aleksandra N. Gornostaeva, Ludmila B. Buravkova

“…Depending on the application mode ASC/allogeneic immune cell interaction can occur in the systemic circulation under plenty high concentrations of O2 and in target tissues at lower O2 levels. …”
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Membrane Bound CRT Fragment Accelerates Tumor Growth of Melanoma B16 Cell In Vivo through Promoting M2 Polarization via TLR4 by Hong-Min Wang, Zhe Zhou, Jie Miao, Bo Zhu, Xiao-Qiu Dai, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…Previously, we demonstrated that soluble recombinant CRT fragment 39-272 (CRT/39-272) exhibited potent immunostimulatory effects as well as immunoregulation effects on immune cells. Here, we constructed stable B16 melanoma cell lines expressing recombinant CRT/39-272 on the membrane (B16-tmCRT/39-272) to investigate the roles of cell surface CRT on tumor progression. …”
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Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation by Chao-Yang Lai, Yu-Wen Su, Kuo-I Lin, Li-Chung Hsu, Tsung-Hsien Chuang

“…The currently approved biological drugs adalimumab, etanercept, infliximab, ustekinumab, ixekizumab, and secukizumab are antibodies against effector cytokines that participate in the initiation and development of psoriasis. Several immune modulatory oligonucleotides and small molecular weight compounds, including IMO-3100, IMO-8400, and CPG-52364, that block the interaction between endosomal TLRs and their ligands are under clinical investigation for their effectiveness in the treatment of psoriasis. …”
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Epidemiological profile of animal bite victims attending anti-rabies clinic in a tertiary care hospital in eastern Rajasthan: An observational study by Ankit Raj, Shalini Singh, Dharmesh Sharma, Rajeev Yadav

“…Conclusion: The study highlights a higher prevalence of category III exposure and monkey bites compared to previous research, along with subpar adherence to prior immunizations. Most animal bite incidents were observed in public areas, particularly on streets and tourist destinations. …”
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FEATURES OF THE CLINICAL COURSE OF PSORIASIS IN PATIENTS WITH OBESITY by Ya.O. Yemchenko, K.Ye. Ischeikin

“…The literature has broadly highlighted the question of the pathogenetic mechanisms of inflammatory processes in psoriasis and obesity that form a vicious circle at the level of the immune system, which must be broken for the successful treatment of these diseases. …”
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Deciphering CSU pathogenesis: Network toxicologyand molecular dynamics of DOTP exposure by Fang Cao, Cui Guo, Jing Guo

“…GO and KEGG analyses were utilized to explore target functions, particularly in inflammation and immune response pathways. AutoDock was employed for molecular docking to predict DOTP's binding to core targets, followed by molecular dynamics simulations with Gromacs to observe detailed interactions and conformational changes in the target proteins. …”
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The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ by Ahmet Basturk, Reha Artan, Aygen Yilmaz

“…Introduction : Celiac disease (CD) is an auto-immune enteropathy that occurs in genetically pre-disposed people as a result of the consumption of gluten-containing foods. …”
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Serum alpha-1 acid glycoprotein and gallstone risk in US adult women: a cross-sectional analysis of the NHANES by Xiaocheng Li, Peiling He

“…BackgroundGallstone disease, a common biliary disorder, is linked to inflammation and immune responses. However, the association between serum alpha-1 acid glycoprotein (AGP), a key inflammatory marker, and gallstone risk remains underexplored.MethodsData from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 and 2021–2023 cycles were analyzed. …”
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Portuguese consensus on first line treatment of moderate-to-severe psoriasis with a non-TNF inhibitor therapy – a delphi methodology by Tiago Torres, Sofia Magina, Maria João Paiva Lopes

“…Introduction Psoriasis (PsO) is a common chronic, inflammatory, immune-mediated disease. In 2023, a 4.4% prevalence of PsO was reported in Portugal. …”
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Sustainable Nutritional Strategies for Gut Health in Weaned Pigs: The Role of Reduced Dietary Crude Protein, Organic Acids and Butyrate Production by Kathryn Ruth Connolly, Torres Sweeney, John V. O’Doherty

“…Integrating these strategies can enhance gut integrity, microbial resilience, and immune responses in weaned piglets. Their combination offers a sustainable, antimicrobial-free approach to improving health and productivity in modern pig production systems.…”
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Achyranthes bidentata Polysaccharide along with Anti-IL-5 Antibody Inhibits Allergic Lung Inflammation and Airway Hyperresponsiveness Mice Induced by House Dust Mites by Jian Sun, Shiwei Sheng, Gang Zhao

“…ABPS is reported to have multiple biological functions and acts on the human immune system. ABPS can induce production of TNF-α in macrophage, enhance the killing ability of NK cells, and promote the proliferation of B cells. …”
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Identification of Key Genes and Pathways Involved in Circulating Tumor Cells in Colorectal Cancer by Ruijun Pan, Chaoran Yu, Yanfei Shao, Hiju Hong, Jing Sun, Zhou Zhang, Peiyong Li, Minhua Zheng

“…Hub genes from the network were prognostic analyzed, as well as the association with tumor-infiltrating immune cells. Results. 1353 DEGs were identified between the CTC and control groups, with 403 genes upregulated and 950 downregulated. 32 pathways were significantly enriched in KEGG, with ribosome pathway as top. …”
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Stunting as a Risk Factor of Soil-Transmitted Helminthiasis in Children: A Literature Review by Nisa Fauziah, Muhammad Abdurrahman Ar-Rizqi, Sofia Hana, Nurul Mufliha Patahuddin, Ajib Diptyanusa

“…Increased inflammatory markers and intestinal microbiota dysbiosis might have increased the intensity of STH infection in stunted children that caused impairment in the immune system. While the age from 2 to 5 years along with poor hygiene and sanitation has shown to be the most common risk factors of STH infections in stunted children; currently there are no studies that show direct results of stunting as a risk factor for STH infection. …”
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Bioinformatics Analysis of miRNAs Targeting TRAF5 in DLBCL Involving in NF-κB Signaling Pathway and Affecting the Apoptosis and Signal Transduction by Chunyao Li, Lanshan Huang, Yongqin Wen, Muhua Yi, Min Gao

“…DEGs were significantly concentrated in the NF-κB signaling pathway and cytokine-cytokine receptor interaction, and involved in the process of immune response and protein binding. MiR-15a-5p, miR-147a, miR-192-5p, miR-197-3p, miR-532-5p, and miR-650 were revealed to be targeting TRAF5 and participating in NF-κB signaling pathway and might impact the apoptosis and signal transduction of DLBCL. …”
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Interleukin-1 Receptor-Associated Kinase 4 Deficiency in a Greek Teenager by Panagiota Karananou, Anastasia Alataki, Efimia Papadopoulou-Alataki

“…It is a rare, autosomal recessive immunodeficiency that impairs toll/IL-1R immunity, except for the toll-like receptor (TLR) 3- and TLR4-interferon alpha (IFNA)/beta (IFNB) pathways. …”
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Clinical and Immunological Analysis of Cutaneous Leishmaniasis before and after Different Treatments by José A. O'Daly, Humberto M. Spinetti, Joe Gleason, María B. Rodríguez

“…VT vaccine induced mainly cellular immunity, for remission of lesions and protection from CL infection.…”
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A Challenging Twist in Pulmonary Renal Syndrome by Rajaie Namas, Bernard Rubin, Wamidh Adwar, Alireza Meysami

“…A urine sample revealed red cell casts and a renal biopsy demonstrated pauci-immune, focally necrotizing glomerulonephritis with small crescents consistent with possible anti-neutrophil cytoplasmic antibody-positive renal vasculitis. …”
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