NIR‐II emissive biohybrid nanovesicles as mild‐temperature photothermal antibiofilm agents against acute bacterial skin and skin‐structure infections by Ji Wang, Zhihao Wu, Xiaoxi Ma, Zhihui Huang, Haorong Dong, Jinxin Zhang, Xiaoming Liu, Pengfei Zhang, Shuhuai Yao

“…Bacterial biofilms are naturally resistant to antibiotics and the human immune system, making biofilm‐based infections extremely difficult to treat. …”
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Epigenetic profiling for prognostic stratification and personalized therapy in breast cancer by Xiao Guo, Chuanbo Feng, Jiaying Xing, Yuyan Cao, Tengda Liu, Wenchuang Yang, Runhong Mu, Tao Wang

“…Low-MLEM patients exhibited improved prognosis, characterized by enhanced immune cell infiltration and higher responsiveness to immunotherapy. …”
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Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats by Qiujiang Li, Bowen Hu, Linan Wang, Lei Wang, Cong Feng, Zhuang Zhang, Zhipeng Deng, Yang Xiao, Bo Yuan, Xiangdong Zhu, Xiangfeng Li, Xi Yang, Yueming Song, Xingdong Zhang

“…In vitro experiments showed that biomineralized PEEK cages and CaP bioceramics regulate immunity and promote angiogenesis and bone integration via activation of hypoxia-inducible factor 1-alpha and cyclic guanosine monophosphate/protein kinase G signaling pathways. …”
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Improving gut microbiome through diet rich in dietary fibre and polyphenols: The case for orange peels by Ayokunle Olubode Ademosun, Olufunke Florence Ajeigbe, Mary Tosin Ademosun, Omodesola Oluwafisayo Ogunruku, Ganiyu Oboh

“…The gut microbiota is crucial for various physiological functions, such as nutrient absorption, immune system enhancement, gut structural integrity, and detoxifying harmful substances. …”
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Prevalence of Dermatological Presentations of Canine Leishmaniasis in a Nonendemic Area: A Retrospective Study of 100 Dogs by Roberta Perego, Daniela Proverbio, Giada Bagnagatti De Giorgi, Eva Spada

“…In this study dermatological manifestations of CanL were very commonly reported, and their prevalence is similar to previous studies in endemic areas despite the fact that dogs living in nonendemic areas are not exposed to repeated infectious bites and continuous stimulation of the dermal immune system.…”
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First-Trimester Threatened Abortion: Can Red Blood Cell Distribution Width-Standard Deviation Predict Miscarriage? by Sebnem Karagun, Yusuf Dal, Hamza Yildiz, Sefanur Gamze Karaca, Ahmet Zeki Nessar, Ayhan Coskun

“…Notably, no statistically significant differences were identified in the neutrophil-lymphocyte ratio (NLR), derived NLR (DNLR), systemic inflammatory immune index (SII), platelet-to-lymphocyte ratio (PLR), and delta neutrophil index (DNI). …”
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Powdery mildew resistance of barley in Southern Dagestan by B. A. Batasheva, R. A. Abdullaev, O. N. Kovaleva, I. A. Zveinek, E. E. Radchenko

“…Seventeen barley varieties resistant to powdery mildew (predominantly originated from Western Europe) are recommended for use in breeding for immunity.…”
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Lactylation modulation identifies key biomarkers and therapeutic targets in KMT2A-rearranged AML by Dan Liu, Silu Liu, Yujie Ji, Ziyan Jin, Zhewei He, Mengjia Hou, Dongyang Li, Xiao Ma

“…The study also suggested PI3K inhibitors and Pevonedistat as possible therapeutic options to modulate immune cell infiltration. Our findings confirm the critical role of lactylation in KMT2Ar-AML and identify six key genes that may serve as biomarkers for diagnosis and treatment. …”
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A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease by Vladimira Durmanova, Zuzana Parnicka, Juraj Javor, Gabriel Minarik, Lubomir Vrazda, Barbora Vaseckova, Karin Gmitterova, Maria Kralova, Jan Pecenak, Peter Filipcik, Ivana Shawkatova

“…The integrin molecule α4β1, also known as very late antigen 4 (VLA-4), belongs to adhesion molecules that activate the inflammatory process through the migration of immune cells into the CNS. Therefore, the objective of our study was to analyze the association between two polymorphisms located in the ITGA4 gene encoding the α4 subunit of VLA-4 and the risk of AD. 104 late-onset AD patients and 206 control subjects from Slovakia were genotyped for ITGA4 gene SNP polymorphism rs113276800 (−269C/A) and rs1143676 (+3061A/G). …”
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Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy by Xiaopeng Li, Yang Zhong, Pengyuan Qi, Daoming Zhu, Chenglong Sun, Nan Wei, Yang Zhang, Zhanggui Wang

“…This nanodrug combines dual GSH depletion, starvation therapy, and RT to promote immunogenic cell death and stimulate the systemic immune response. In the bilateral tumor model in vivo, distal tumor growth was also well suppressed. …”
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Fenofibrate Enhances the In Vitro Differentiation of Foxp3+ Regulatory T Cells in Mice by Zhou Zhou, Ying Liang, Yanxiang Gao, Wei Kong, Juan Feng, Xian Wang

“…Foxp3+ regulatory T cells (Tregs) play a critical role in maintaining immune self-tolerance. Reduced number and activity of Tregs are usually found in autoimmune and inflammatory diseases, and enhancing the differentiation of Tregs may be a promising therapeutic strategy. …”
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Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis by Min Zhang, Wenting Su, Jiahui Deng, Bin Zhai, Gaizhi Zhu, Ran Gao, Qi Zeng, Jinming Qiu, Ziqing Bian, He Xiao, Guoming Luan, Renxi Wang

“…Abstract Background Psoriasis is a common chronic, recurrent, immune-mediated disease involved in the skin or joints or both. …”
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Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila by Miaomiao Pan, Chenglang Qian, Shaoye Huo, Yuchen Wu, Xinyi Zhao, Yueming Ying, Boyu Wang, Hao Yang, Anaguli Yeerken, Tongyao Wang, Mengwei Fu, Lihong Wang, Yuhuan Wei, Yunhua Zhao, Chunhai Shao, Huijing Wang, Chao Zhao

“…The gut microbiota plays a pivotal role in anxiety regulation through pathways involving neurotransmitter production, immune signaling, and metabolic interactions. Among these, gut-derived serotonin (5-hydroxytryptamine, 5-HT), synthesized from tryptophan metabolism, has been identified as a key mediator. …”
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Lipidomic Signature of Pregnant and Postpartum Females by Longitudinal and Transversal Evaluation: Putative Biomarkers Determined by UHPLC-QTOF-ESI⁺-MS by Alexandra Traila, Marius Craina, Carmen Socaciu, Andreea Iulia Socaciu, Diana Nitusca, Catalin Marian

“…These adaptations impact various systems, including immune tolerance, metabolism, and endocrine function. …”
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Effects of synergistic fermentation of tea bee pollen with bacteria and enzymes on growth and intestinal health of Apis cerana cerana by Panpan Xue, Le Xu, Yakai Tian, Mingkui Lv, Pingping Fang, Kun Dong, Qiuye Lin, Zhenhui Cao

“…Concurrently, the relative expression levels of immune-related genes including Abaecin, PPO, Defensin, and Vg were significantly upregulated. …”
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Dynamic hierarchical ligand anisotropy for competing macrophage regulation in vivo by Kanghyeon Kim, Sunhong Min, Ramar Thangam, Kyong-Ryol Tag, Hyun-Jeong Lee, Jeongyun Heo, Hwapyung Jung, Thet Thet Swe, Iman Zare, Guosheng Song, Alireza Hassani Najafabadi, Junmin Lee, Hyun-Do Jung, Jong Seung Kim, Sunghoon Hur, Hyun-Cheol Song, Sung-Gyu Park, Kunyu Zhang, Pengchao Zhao, Liming Bian, Se Hoon Kim, Juyoung Yoon, Jae-Pyoung Ahn, Hong-Kyu Kim, Heemin Kang

“…Diverse connective tissues exhibit hierarchical anisotropic structures that intricately regulate homeostasis and tissue functions for dynamic immune response modulation. In this study, remotely manipulable hierarchical nanostructures are tailored to exhibit multi-scale ligand anisotropy. …”
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Bone Marrow Mesenchymal Stem Cells Enhance the Differentiation of Human Switched Memory B Lymphocytes into Plasma Cells in Serum-Free Medium by Guillaume Bonnaure, Catherine Gervais-St-Amour, Sonia Néron

“…The differentiation of human B lymphocytes into plasma cells is one of the most stirring questions with regard to adaptive immunity. However, the terminal differentiation and survival of plasma cells are still topics with much to be discovered, especially when targeting switched memory B lymphocytes. …”
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MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers by Yixin Yang, Christopher Alderman, Ayoub Sehlaoui, Yuan Xiao, Wei Wang

“…Since aberrant expressions of miRNAs are found in gastroenterological cancers and miRNAs have been shown to regulate antitumor immunity, the combination therapy combining the traditional antibody-based immunotherapy and novel miRNA-based immunotherapy is promising for achieving clinical success. …”
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Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis by Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen, Yeelo Cheung, Yu Zhao, Ting Xie, Bénédicte Chazaud, Hao Sun, Huating Wang

“…Further analysis reveals YY1 loss induces expression of immune genes in MuSCs, including C-C motif chemokine ligand 5 (Ccl5). …”
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A Case of Spontaneously Improving Secondary Hemophagocytic Lymphohistiocytosis in an Adult Associated with T-Cell Histiocyte-Rich Large B-Cell Lymphoma by Cyrus Askin, Ashley Burris, Clifton Layman, Brian Haney, Jordan Hall

“…Secondary hemophagocytic lymphohistiocytosis (HLH) in adults is a rare, often fatal syndrome characterized by widespread immune dysregulation. It is seen as a complication of infections, autoimmune diseases, and malignancies. …”
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