Analysis and validation of serum biomarkers in brucellosis patients through proteomics and bioinformatics by Xiao Li, Bo Wang, Xiaocong Li, Juan He, Yue Shi, Rui Wang, Dongwei Li, Ding Haitao, Ding Haitao

“…After ELISA validation, five proteins were ultimately selected.DiscussionThese five proteins are implicated in the innate immune processes of brucellosis, potentially associated with its pathogenic mechanisms and chronicity. …”
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Prediction of post-insertion infections related to totally implantable subcutaneous venous access ports in tumor patients using a nomogram by Sen Wang, Heng Zong, Lei Tang, Yuandong Wei

“…While they play a critical role in reducing patient discomfort, TISVAPs pose a notable risk of post-insertion infections—particularly concerning for oncology patients with compromised immune systems due to aggressive treatment regimens. …”
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Efficacy of Zingibain phyto-protease on growth performance, litter quality and gut microbiota in broilers fed high animal protein concentrates by Muhammad Shahkar Uzair, Asad Sultan, Ziaul Islam, Muqadar Shah, Muhammad Tahir, Shabana Naz, Abdulwahed Fahad Alrefaei, Sheikh Adil, Naseer Khan Momand, Rifat Ullah Khan

“…Carcase yield analysis revealed that diet with 4% APC + GPZ, and diet with 6% APC + GPZ had the highest yields (p < 0.01). Immune organ weights of spleen and bursa of fabricius were significantly increased in groups having 4 and 6% APC with GPZ (p = 0.02). …”
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Polypeptide Globular Adiponectin Ameliorates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Necroptosis by Kaiyi Zhu, Jia Guo, Xiaoxue Yu, Que Wang, Chao Yan, Quan Qiu, Weiqing Tang, Xiuqing Huang, Hongna Mu, Lin Dou, Yunfei Bian, Qinghua Han, Tao Shen, Jian Li, Chuanshi Xiao

“…Adiponectin is a small peptide secreted and a key component of the endocrine system and immune system. Although globular adiponectin protects myocardial ischemia/reperfusion-induced cardiomyocyte injury, the protective mechanisms remain largely unresolved. …”
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Gene expression of psychiatric disorder-related kinesin superfamily proteins (Kifs) is potentiated in alternatively activated primary cultured microglia by Suguru Iwata, Mitsuhiro Hyugaji, Yohei Soga, Momo Morikawa, Tetsuya Sasaki, Yosuke Takei

“…Abstract Objective Reactivity of microglia, the resident cells of the brain, underlies innate immune mechanisms (e.g., injury repair), and disruption of microglial reactivity has been shown to facilitate psychiatric disorder dysfunctions. …”
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Randomized Phase II Study of Docetaxel plus Personalized Peptide Vaccination versus Docetaxel plus Placebo for Patients with Previously Treated Advanced Wild Type EGFR Non-Small-Ce... by Koichi Takayama, Shunichi Sugawara, Yasuo Saijo, Makoto Maemondo, Atsushi Sato, Shinzo Takamori, Taishi Harada, Tetsuro Sasada, Tatsuyuki Kakuma, Junji Kishimoto, Akira Yamada, Masanori Noguchi, Kyogo Itoh, Yoichi Nakanishi

“…Previously treated PS0-1 patients with IIIB/IV EGFR (epidermal growth factor receptor) wild genotype NSCLC were randomly assigned to docetaxel (60 mg/m2 on Day 1) plus PPV based on preexisting host immunity or docetaxel plus placebo. Docetaxel administration was repeated every 3 weeks until disease progression. …”
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IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome by Shujuan Li, Ming Yu, Haifeng Li, Hongliang Zhang, Yanfang Jiang

“…Meanwhile, the elevated levels of these two cytokines in plasma suggest the activation of Th17 and Th22 cells in the systemic immune response of GBS. Our data provide preliminary evidence that GBS is associated with high levels of IL-17 and IL-22 in CSF and plasma. …”
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Cysticerci Drive Dendritic Cells to Promote In Vitro and In Vivo Tregs Differentiation by Laura Adalid-Peralta, Asiel Arce-Sillas, Gladis Fragoso, Graciela Cárdenas, Marcos Rosetti, Didier Casanova-Hernández, Claudia Rangel-Escareño, Laura Uribe-Figueroa, Agnes Fleury, Edda Sciutto

“…Regulatory T cells (Tregs) play a crucial role in immune homeostasis. Treg induction is a strategy that parasites have evolved to modulate the host’s inflammatory environment, facilitating their establishment and permanence. …”
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Gαq Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation by Dashan Wang, Yuan Liu, Yan Li, Yan He, Jiyun Zhang, Guixiu Shi

“…Gαq has been found to play an important role in immune regulation and development of autoimmune disease such as rheumatoid arthritis (RA). …”
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Practical Recommendations of Scientific Society for the Study of Human Microbiome and Russian Gastroenterological Association (RGA) for Probiotics in Treatment and Prevention of Ga... by V. T. Ivashkin, I. V. Mayev, D. I. Abdulganieva, S. A. Alekseenko, N. Yu. Ivashkina, N. V. Korochanskaya, S. N. Mammaev, E. A. Poluektova, A. S. Trukhmanov, Yu. P. Uspensky, V. V. Tsukanov, O. S. Shifrin, O. Yu. Zolnikova, K. V. Ivashkin, T. L. Lapina, R. V. Maslennikov, A. I. Ulyanin

“…The main functions of probiotics include the support for colonisation resistance, the metabolism of food substrates and utilisation of end metabolites, the production of substrates necessary for the macro-organism, as well as the regulation of local and adaptive immune responses. Probiotics can be registered in the Russian Federation as biologically active food additives (BAFA) or as pharmaceutical products (drugs) in accordance with the microbiological standards and legislative requirements of the Russian Federation. …”
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Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain by Chae-Jeong Lee, Seung Hyun Jang, Jiwoo Lim, Hyunju Park, So-Hee Ahn, Seon Young Park, Hyangmi Seo, Soo-Jin Song, Jung-A Shin, Chulhee Choi, Heon Yung Gee, Youn-Hee Choi

“…In aged mouse brains, the number of infiltrating immune cells increases, and the key transcription factor associated with increased chemokine levels is nuclear factor kappa B (NF-κB). …”
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Characterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma by Zeynep Kacar, Eric Slud, Doron Levy, Julián Candia, Anuradha Budhu, Marshonna Forgues, Xiaolin Wu, Arati Raziuddin, Bao Tran, Jyoti Shetty, Yotsawat Pomyen, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Chirayu Auewarakul, Suleeporn Sangrajrang, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin Wei Wang

“…Furthermore, we observe significant B cell enrichment in linear trees compared to non-linear trees suggesting the need for further research to uncover potential variations in immune cell types within genomically determined phylogeny types. …”
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Practical Recommendations of Scientific Society for the Study of Human Microbiome and the Russian Gastroenterological Association on Use of Probiotics, Prebiotics, Synbiotics and F... by V. T. Ivashkin, I. V. Maev, D. I. Abdulganieva, S. A. Alekseenko, A. V. Gorelov, I. N. Zakharova, O. Yu. Zolnikova, N. Yu. Ivashkina, N. V. Korochanskaya, S. N. Mammayev, E. A. Poluektova, A. S. Trukhmanov, D. V. Usenko, Yu. P. Uspensky, V. V. Tsukanov, O. S. Shifrin, I. V. Berezhnaya, K. V. Ivashkin, T. L. Lapina, R. V. Maslennikov, S. V. Nikolaeva, N. G. Sugyan, A. I. Ulyanin

“…The mechanism of probiotic action comprises the quorum resistance maintenance, nutrient substrate metabolism and end metabolite recycling, macroorganism-sustaining substrate production, as well as the mediation of local and adaptive immune responses.The Russian Federation regulates market differently for biologically active food additives (BAFA), medicinal products (drugs) and functional food products (FFP). …”
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Importance of NAB2-STAT6 Fusion in the Diagnosis of Pancreatic Solitary Fibrous Tumor with Hamartoma-Like Features: A Case Report and Review of the Literature by Kei Tanaka, Takashi Kishimoto, Masayuki Ohtsuka, Yukio Nakatani, Masaru Miyazaki

“…The fibroblastic cells in the stroma were immune-positive for CD34, CD99, and bcl-2. But these expressions were not decisive in the differentiation between solitary fibrous tumor and pancreatic hamartoma, because CD34 was positive for both tumors, and CD99 and bcl-2 expressions were not elucidated in the previous cases of pancreatic hamartomas. …”
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Lung-homing nanoliposomes for early intervention in NETosis and inflammation during acute lung injury by Jungbum Kim, Donghyuk Seo, So-Yeol Yoo, Hye-Jin Lee, Jisun Kim, Ji Eun Yeom, Jae-Young Lee, Wooram Park, Kyung Soo Hong, Wonhwa Lee

“…Abstract Acute lung injury (ALI) is characterized by severe inflammation in lung tissue, excessive immune response and impaired lung function. In hospitalized high-risk patients and cases of secondary infection due to surgical contamination, it can lead to higher mortality rates and require immediate intervention. …”
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Investigating proteogenomic divergence in patient-derived xenograft models of ovarian cancer by Jesenia M. Perez, Jolene M. Duda, Joohyun Ryu, Mihir Shetty, Subina Mehta, Pratik D. Jagtap, Andrew C. Nelson, Boris Winterhoff, Timothy J. Griffin, Timothy K. Starr, Stefani N. Thomas

“…Analysis of differentially abundant proteins revealed enrichment of distinct biological pathways with major downregulated processes including extracellular matrix organization and the immune system. Finally, we investigated the relative abundances of ovarian cancer-related proteins identified from the Cancer Gene Census across serially passaged PDXs, and found their protein levels to be unstable across PDX models. …”
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Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population by Hatice Gül Dursun, Hüseyin Osman Yılmaz, Recep Dursun, Sevsen Kulaksızoğlu

“…Psoriasis is a common, chronic, and autoimmune skin disease in which dysregulation of immune cells, particularly T cells, is thought to play an important role in the pathogenesis. …”
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Whole exome analysis of primary immunodeficiency by E. S. Rahmani, Н. Azarpara, M. Karimipoor, Н. Rahimi

“…The human primary immunodeficiency diseases (PIDs) refer to a rare heterogeneous group of single-gene inherited disorders causing malfunctions in the immune system, and thus the affected patients have a predisposition to severe life-threatening infections. …”
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The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia by Beatrice Arosio, Paolo Dionigi Rossi, Evelyn Ferri, Ernesto Consorti, Simona Ciccone, Tiziano Angelo Lucchi, Nicola Montano

“…Background: During aging, there is a progressive impairment of immune cell function that triggers the production of pro-inflammatory cytokines causing the so-called “inflammaging”. …”
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Use of Hemadsorption in a Case of Pediatric Toxic Shock Syndrome by Andrea Berkes, Edit Szikszay, János Kappelmayer, Adrienne Kerényi, Tamás Szabó, László Ujhelyi, Krisztina Bari, György Balla, József Balla

“…As previous attempts of immune modulation therapy were unsuccessful, renal replacement therapy was supplemented by the cytokine absorber CytoSorb. …”
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