Current Views of Torque Teno Virus (TTV) in Liver Diseases by I. V. Maev, T. I. Karlovich, A. I. Burmistrov, I. A. Chekmazov, D. N. Andreev, V. I. Reshetnyak

“…TTV DNA content in blood is proposed as an endogenous immune status marker to observe prior to organ transplantation.Conclusion. …”
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Antitumor immunostimulatory effect via cell-killing action of a novel extracorporeal blood circulating photodynamic therapy system using 5-aminolevulinic acid by Hidetaka Maegawa, Masayuki Kohashi, Yasuo Harada, Akira Tanaka, Shimpei Kajiwara, Takashi Fujimoto, Hidehiro Atagi, Kenta Kaneda

“…Thus, the extracorporeal blood circulating 5-ALA/PDT system has a direct cell-killing effect and an antitumor effect via induced immune activity and illustrates a new therapeutic strategy for hematologic malignancies.…”
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Staphylococcus aureus-specific TIGIT+ Treg are present in the blood of healthy subjects – a hurdle for vaccination? by Jonah Clegg, Jonah Clegg, Malgorzata E. Mnich, Malgorzata E. Mnich, Alberto Carignano, Giovanni Cova, Simona Tavarini, Chiara Sammicheli, Bruna Clemente, Megan Smith, Megan Smith, Emilio Siena, Monia Bardelli, Michela Brazzoli, Fabio Bagnoli, Rachel M. McLoughlin, Elisabetta Soldaini

“…As compared to polyclonally-activated CD4+ T cells, S. aureus-specific Tcon were enriched for the expression of the Th17-type cytokine genes IL17A, IL22 and IL26, while higher percentages of S. aureus-specific Treg expressed the T Cell Immunoreceptor with Ig and ITIM domains (TIGIT), a pleiotropic immune checkpoint. Notably, the antagonistic anti-TIGIT mAb Tiragolumab increased IL-1β production in response to S. aureus in vitro. …”
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Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL by Hao Xu, Qi Li, Yuchen Zhang, Chuan He, Xinyun Zhang, Zhiming Wang, Meifang Zhao, Yali Chai, Wenzhuo Zhuang, Bingzong Li

“…Additionally, morusinol’s ability to hinder M2-like polarization of tumor-associated macrophages suggested its potential in immune response modulation within DLBCL. Collectively, morusinol showcased substantial promise as an anti-tumor agent for potential clinical application in DLBCL management, potentially augmenting established therapeutic strategies. …”
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Nanoengineering of Phosphate/Phosphonate Drugs via Competitive Replacement with Metal‐Phenolic Networks to Overcome Breast Tumor with Lung and Bone Metastasis by Wanrui Shi, Dashuai Liu, Wenjie Feng, Yang Chen, Yonggang Wang, Zhihong Nie, Yi Liu, Hao Zhang

“…The results demonstrate that, by triggering pyroptosis and activating the cGAS‐STING pathway, the nanodrugs exhibit potent cytotoxicity and accurate selectivity in eradicating orthotopic breast tumors, and activate an antitumor immune response against lung and bone metastases. …”
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Nanomaterials–plants–microbes interaction: plant growth promotion and stress mitigation by Gurleen Kaur Sodhi, Tharuka Wijesekara, Kailash Chand Kumawat, Priyanka Adhikari, Kuldeep Joshi, Smriti Singh, Beatrice Farda, Rihab Djebaili, Enrico Sabbi, Fares Ramila, Fares Ramila, Fares Ramila, Devendra Sillu, Gustavo Santoyo, Sergio de los Santos-Villalobos, Ajay Kumar, Marika Pellegrini, Debasis Mitra

“…Concurrently, their antimicrobial and protective properties provide resilience against biotic stressors, including pathogens and pests, by promoting plant immune responses and optimizing microbial-plant symbiosis. …”
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Claudin-4 Undergoes Age-Dependent Change in Cellular Localization on Pig Jejunal Villous Epithelial Cells, Independent of Bacterial Colonization by J. Alex Pasternak, Coral Kent-Dennis, Andrew G. Van Kessel, Heather L. Wilson

“…Newborn piglets are immunologically naïve and must receive passive immunity via colostrum within 24 hours to survive. …”
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Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment by Alberto N. Peón, Yadira Ledesma-Soto, Jonadab E. Olguín, Marcel Bautista-Donis, Edda Sciutto, Luis I. Terrazas

“…Peritoneal inoculation of TcES was able to direct the normal inflammatory cell traffic to the site of injection, thus modulating CNS infiltration, which may work along with Th2 immune polarization and lymphocyte activation impairment to downregulate EAE development.…”
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ST8SIA6 Sialylates CD24 to Enhance Its Membrane Localization in BRCA by Jinxia He, Fengchao Zhang, Baihai Wu, Wengong Yu

“…CD24, a highly sialylated glycosyl-phosphatidyl-inositol (GPI) cell surface protein that interacts with sialic acid-binding immunoglobulin-like lectins (Siglecs), serves as an innate immune checkpoint and plays a crucial role in inflammatory diseases and tumor progression. …”
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Effect of Antifungal-Treated Host Macrophages on Candida glabrata by Hong-Bin Li, Na Li, Shu-Ran Wen, Ming-Yue Qiang, Zheng-Hui Yang, Tian-Xiang Dong, Yu-Ye Li, Yi-Qun Kuang

“…Echinocandins may increase their antifungal efficacy by altering the innate immune response of macrophages and attenuating antioxidants of this organism.…”
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The hype around ctDNA guiding an informed perioperative therapeutic strategy in early-stage non-small cell lung cancer by Gaia Passarella, Stefania Canova, Maria Ida Abbate, Giulia Caspani, Luca Sala, Alessandro Russo, Paola Muscolino, Francesca Colonese, Diego Luigi Cortinovis

“…Recently, the introduction of immune checkpoint inhibitors combined with chemotherapy has shown robust efficacy in terms of event-free survival and overall survival. …”
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Prolonged Helium Postconditioning Protocols during Early Reperfusion Do Not Induce Cardioprotection in the Rat Heart In Vivo: Role of Inflammatory Cytokines by Gezina Tanya Mei Ling Oei, Hamid Aslami, Raphaela Priscilla Kerindongo, Renske Johanna Steenstra, Charlotte Jacqueline Peter Beurskens, Anita Maria Tuip-de Boer, Nicole Petra Juffermans, Markus Werner Hollmann, Benedikt Preckel, Nina Claudia Weber

“…Effects of helium postconditioning protocols on infarct size and the ischemia/reperfusion-induced immune response were investigated by measurement of protein and mRNA levels of proinflammatory cytokines. …”
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Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids by Arun Sridhar, Ingunn Bakke, Shreya Gopalakrishnan, Nimo Mukhtar Mohamud Osoble, Emilie Prytz Hammarqvist, Henrik P. Sahlin Pettersen, Arne Kristian Sandvik, Ann Elisabet Østvik, Marianne Doré Hansen, Torunn Bruland

“…However, the impact of immune cell-modulating IBD drugs on epithelial homeostasis and repair is poorly understood. …”
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Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease by Sharifah Intan Qhadijah Syed Ikmal, Hasniza Zaman Huri, Shireene Ratna Vethakkan, Wan Azman Wan Ahmad

“…Malfunctioning of insulin mechanism and endothelial dysfunction leads to innate immune activation and released several biological markers into circulation. …”
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Allogeneic Mesenchymal Stem Cell Treatment Induces Specific Alloantibodies in Horses by Sean D. Owens, Amir Kol, Naomi J. Walker, Dori L. Borjesson

“…It is unknown whether horses that receive allogeneic mesenchymal stem cells (MSCs) injections develop specific humoral immune response. Our goal was to develop and validate a flow cytometric MSC crossmatch procedure and to determine if horses that received allogeneic MSCs in a clinical setting developed measurable antibodies following MSC administration. …”
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Interferon-γ and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0–2 Years Prenatally Exposed to Plasmodium falciparum: Tanzanian Birth Cohort by Boniphace Sylvester, Dinah B. Gasarasi, Said Aboud, Donath Tarimo, Siriel Masawe, Rose Mpembeni, Göte Swedberg

“…However, the effect of that exposure to subsequent immune responses has not been fully elucidated. This study aimed at determining the effect of prenatal exposure to P. falciparum on Interleukin-10 and Interferon-γ responses during clinical malaria episodes in the first 24 months of life. …”
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Performance Analysis of Microwave Photonic Spectral Filters based on Optical Microcombs by Yang Li, Yang Sun, Jiayang Wu, Guanghui Ren, Xingyuan Xu, Bill Corcoran, Sai Tak Chu, Brent E. Little, Roberto Morandotti, Arnan Mitchell, David J. Moss

“…When implemented using microwave photonic (MWP) technologies, also known as MWP transversal filters, they provide competitive advantages over their electrical counterparts, such as large operation bandwidth, strong immunity to electromagnetic interference, and low loss when processing signals at high frequencies. …”
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Method for improving voltage sag tolerance of dual power supply PET based on inter-port power coordination by ZHANG Tengfei, WANG Guanghua, GAO Long, LI Jing, XU Yonghai, WANG Chong

“…Then, from the perspective of power balance, a real-time analysis method of voltage sag immunity of DPSC-PET as well as power coordination method between dual input ports when voltage sag occurs on different power supply are proposed to achieve a perfect recovery of low-voltage DC bus voltage, which means the significant improvement of DPSC-PET to cope with transient disturbances. …”
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Tumor microenvironment–responsive and modulatory manganese-based nanoenzyme for enhanced tumor immunotherapy by Qi Yang, Qiong Wu, Haiyan Liu, Jiandong Wu, Feng Ma, Xiaofeng Tian

“…Besides the photothermal effect and the enhancement of ROS burst-induced immunogenic cell death, combination of Mn2+ released from Mn-based nanoenzyme in acidic TME and programmed death-ligand 1 blockade triggered a significant anti-tumor immune response. A remarkable in vivo synergistic therapeutic effect was achieved with effective inhibition of primary tumor growth and lung metastasis. …”
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Paradoxical Glucose-Sensitizing yet Proinflammatory Effects of Acute ASP Administration in Mice by Alexandre Fisette, Pegah Poursharifi, Katerina Oikonomopoulou, Mercedes N. Munkonda, Marc Lapointe, Katherine Cianflone

“…Acylation stimulating protein (ASP) is an adipokine derived from the immune complement system, which stimulates fat storage and is typically increased in obesity, type 2 diabetes, and cardiovascular disease. …”
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