Pembrolizumab for the Treatment of Locally Advanced Cutaneous Squamous Cell Carcinoma: Patient Selection and Special Considerations by Stewart M, Geiger JL

“…Matthew Stewart,1 Jessica L Geiger2 1Department of Internal Medicine, Primary Care Institute, Cleveland Clinic Foundation, Cleveland, OH, USA; 2Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USACorrespondence: Matthew Stewart, Department of Internal Medicine, Primary Care Institute Cleveland Clinic Foundation, Cleveland, OH, USA, Email stewarm7@ccf.org Jessica L Geiger, Department of Hematology and Medical Oncology, Taussig Cancer Institute Cleveland Clinic Foundation, Cleveland, OH, USA, Email geigerj@ccf.orgAbstract: The treatment of locally advanced cutaneous squamous cell carcinoma (cSCC) has shifted with the advent of immune checkpoint inhibitors (ICIs). Traditional treatment methods have been met with limited efficacy and durability. …”
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Regulated Spatial Distribution of Cyclooxygenases and Lipoxygenases in Crohn's Ulcer by Yao Mao, Jian'an Ren, Jieshou Li

“…The regulated distribution indicated coordinated interplay between inflammatory cells and parenchymal cells, between arachidonic acid pathways, and between innate and adaptive immunity; and the barrier-like structures indicated protective roles for cyclooxygenase 2 and 15-Lipoxygenase-1 in Crohn's disease.…”
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Fair Trial and the Principles Governing It Internationally and Domestically Focusing on Governmental Discretionary Punishment by Ahmad Asadian, Jahanbakhsh Salariyan

“…Elements and components of a fair trial, which in a limited sense, are considered as legal rights and include: freedom from something (immunity) like the right to non-arbitrary arrest or enjoying something like the right to have a lawyer. …”
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Mechanistic insight of curcumin: a potential pharmacological candidate for epilepsy by Saima Khatoon, Nida Kalam

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Autoimmune Gastrointestinal Paralysis: Failure of Conventional Treatment without Immunomodulation by Craig Weinkauf, Sean McPhillips, Robert Krouse, Ira Levine

“…The ensuing autoimmune neuritis causes aperistalsis and severe gastrointestinal (GI) dysfunction. Immune-directed therapy is not the standard of care but may be paramount for patient recovery. …”
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Regulation of Long Noncoding RNAs Responsive to Phytoplasma Infection in Paulownia tomentosa by Guoqiang Fan, Yabing Cao, Zhe Wang

“…Moreover, we found the expression of the lncRNAs plays vital roles in regulating the genes involved in the reactive oxygen species induced hypersensitive response and effector-triggered immunity in phytoplasma-infected Paulownia. This study indicated that diverse sets of lncRNAs were responsive to Paulownia witches’ broom, and the results will provide a starting point to understand the functions and regulatory mechanisms of Paulownia lncRNAs in the future.…”
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Issues occult hepatitis B virus infection by I. A. Morozov, L. Yu. Ilchenko, N. I. Gromova, I. G. Fyedorov, I. V. Gordeychuk, A. K. Knyazhentseva, E. V. Zverkova, M. I. Mikhaylov

“…HBV and HCV coinfection was accompanied by more severe (in comparison to monoinfection) immune inflammatory response. In 80% of cases presence of TT-like mini virus (TTMV) in blood lymphoid elements was revealed, in two patients this virus was detected in hepatocyte nucleus that proves its hepatotropic properties.Conclusions. …”
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The technique of point visualization of the electric field in space and time by Z. M. Kurbanismailov, A. T. Tarlanov, E. M. Akimov

“…In order to reduce these costs in the modern world, the use of mathematical modeling tools for testing noise immunity and electromagnetic compatibility is becoming popular. …”
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A Severe Case of Overlap of Morphea and Eosinophilic Fasciitis after Burn Injuries by Hania Sami, Faria Sami, Shahzad Ahmed Sami, Abdulqadir J. Nashwan

“…Generalized morphea is a rare fibrosing skin illness that progresses from erythematous, violet-colored skin patches to sclerotic plaques. Another uncommon immune-mediated connective tissue disease called eosinophilic fasciitis (EF) evolves to cause sclerosis and woody skin induration. …”
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Induction of Cell Activation Processes by Low Frequency Electromagnetic Fields by Myrtill Simkó

“…Furthermore, EMF is also shown as a stimulus for immune relevant cells (e.g., macrophages) to release free radicals. …”
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Structure simulation-based comparison of active site variations in fungal ornithine decarboxylases by Min Jeong Kim, Jeong Ho Chang

“…Polyamines play crucial roles in various biological processes, including cell proliferation and differentiation, immune response modulation, and signal transduction. …”
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Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants by Zhongjie Sun, Zhongyan Wu, Xuncheng Su

“…The fusion of Xcl1 also increased immune cell infiltration into the tumor microenvironment. …”
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Identification des Villages à Risque (IVR) : pour un état des lieux de la Trypanosomiase Humaine Africaine au Niger by Jérémi Rouamba, Adamou Salissou, Hassane Sakandé, Vincent Jamonneau, Fabrice Courtin

“…In 2015, 28 localities identified as at risk were visited by the light team, and of the 384 rapid Diagnostic Tests (TDR) carried out, 12 were positive but none responded positively to the specific immune trypanolysis test, discarding the diagnosis of HAT. …”
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Influence of N6-Methyladenosine Modification Gene HNRNPC on Cell Phenotype in Parkinson’s Disease by Wei Quan, Jia Li, Li Liu, Qinghui Zhang, Yidan Qin, Xiaochen Pei, Jiajun Chen

“…The results showed that overexpression of HNRNPC can promote the proliferation of PC12 cells, inhibit their apoptosis, and inhibit the expression of inflammatory factors IFN-β, IL-6, and TNF-α, suggesting that HNRNPC may cause PD by inhibiting the proliferation of dopaminergic nerve cells, promoting their apoptosis, and causing immune inflammation. Our study also has certain limitations. …”
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On the Optimal Control of HIV-TB Co-Infection and Improvement of Workplace Productivity by Baba Seidu, Oluwole Daniel Makinde, Ibrahim Yakubu Seini

“…This is a result of each of the diseases impacting negatively on the immune system of the infected persons. The impact of these diseases on workforce productivity is studied in this paper from the viewpoint of dynamical systems. …”
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Mucus-penetrating microbiota drive chronic low-grade intestinal inflammation and metabolic dysregulation by Melissa C. Kordahi, Noëmie Daniel, Andrew T. Gewirtz, Benoit Chassaing

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The Dweller on the Threshold: Whiteness, the Family and the End of Classical Cinema by Conall Cash

“…Drawing on Deleuze's suggestion that modern cinema promises a new mode of belief in the world, the article argues that such a non-mythic belief can only be realised through an unmaking of whiteness, as a form of life which, being premised upon protection and immunity, denies life itself, and our living connection to the world.…”
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Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus by Utpal Kumar Adhikari, Mourad Tayebi, M. Mizanur Rahman

“…In this report, we identified both T-cell and B-cell epitopes of the most antigenic OROV polyprotein with the potential to induce both humoral and cell-mediated immunity. Eighteen highly antigenic and immunogenic CD8+ T-cell epitopes were identified, including three 100% conserved epitopes (TSSWGCEEY, CSMCGLIHY, and LAIDTGCLY) as the potential vaccine candidates. …”
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Pancreatic Tuberculosis or Autoimmune Pancreatitis by Ayesha Salahuddin, Muhammad Wasif Saif

“…Endoscopic ultrasound-guided fine needle aspiration provides an effective tool for differentiating between benign and malignant pancreatic lesions. The immune processes involved in immunoglobulin G4 related systemic diseases and tuberculosis appear to have some similarities. …”
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Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells by Vaibhav Tiwari, Deepak Shukla

“…Phagocytosis is a major mechanism by which the mediators of innate immunity thwart microbial infections. Here we demonstrate that human herpesviruses may have evolved a common mechanism to exploit a phagocytosis-like entrapment to gain entry into ocular cells. …”
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